Search clinical trials for: Clinical activity score

Total 69671 results

Novartis Pharmaceuticals

Recruiting

24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up

Chronic Spontaneous Urticaria

United States, Singapore, Spain, Germany, Turkey, Italy, Hong Kong, China, Argentina, Malaysia, Thailand, Poland, Japan, Netherlands, Chile, Canada
Novartis Pharmaceuticals

Recruiting

An Extension Study of Long-term Efficacy, Safety and Tolerability of Remibrutinib in Chronic Spontaneous Urticaria Patients Who Completed Preceding Studies With Remibrutinib

Chronic Spontaneous Urticaria

United States, Korea, Republic of, Spain, France, Germany, Bulgaria, United Kingdom, China, Hungary, Czechia, Turkey, Argentina, Colombia, Italy, Denmark, Japan, Taiwan, Australia, Singapore, Switzerland, Russian Federation, Thailand and more
Novartis Pharmaceuticals

Completed

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1- Antihistamines (REMIX-2)

Chronic Spontaneous Urticaria

United States, India, Malaysia, Taiwan, Poland, United Kingdom, China, Thailand, Switzerland, Germany, Vietnam, Brazil, Russian Federation, Slovakia, Denmark, Canada, South Africa, Austria
Novartis Pharmaceuticals

Completed

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1 Antihistamines (REMIX-1)

Chronic Spontaneous Urticaria

United States, Hungary, Taiwan, Spain, Italy, Korea, Republic of, Australia, France, Bulgaria, Czechia, Turkey, India, Argentina, Mexico, Japan, Colombia, Russian Federation, Puerto Rico, Singapore
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224

Steatohepatitis, Nonalcoholic

United States, Puerto Rico
Paediatric Neuroimaging Research Group
University of Oxford; Wellcome Trust; BLISS charity

Completed

Parental Touch Trial (Petal) (Petal)

Parents | Pain, Procedural | Infant Development

United Kingdom
Mirum Pharmaceuticals, Inc.

Terminated

Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)

Non-Alcoholic Steatohepatitis

United States, United Kingdom, Canada, Puerto Rico
FH Campus Wien, University of Applied Sciences
Medical University of Vienna; Shire

Completed

Gait Examination in Patients With Hemophilia in Austria (JOSEPHA)

Hemophilia

Austria
GlaxoSmithKline
Parexel

Terminated

Safety, Clinical Activity, Pharmacokinetics (PK) and Pharmacodynamics Study of GSK2879552, Alone or With Azacitidine, in Subjects With High Risk Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes | Myelodysplastic Syndrome

United States, Spain
Universitaire Ziekenhuizen KU Leuven

Unknown

Response to Ustekinumab for Anti-tnf Induced Psoriasiform Skin Lesions (STRAUSS)

Inflammatory Bowel Diseases | Psoriasis
Rabin Medical Center

Withdrawn

Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy

Graves Ophthalmopathy
Instituto Nacional de Cardiologia Ignacio Chavez

Completed

Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu Arteritis

Takayasu Arteritis

Mexico
Universidade Estadual da Paraiba
University of Campinas, Brazil

Unknown

Exercise and Pregnancy: Randomized Clinical Trial

Preeclampsia | Gestational Diabetes

Brazil
Ankara University

Unknown

The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy

Graves' Ophthalmopathy

Turkey
Jinghui Wang

Recruiting

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Lung Cancer

China
Insel Gruppe AG, University Hospital Bern
Monash University

Not yet recruiting

CPAx: Responsiveness and Minimal Clinically Important Difference

Muscle Weakness | Critical Illness Myopathy | Physical Inactivity | Critical Illness Polyneuropathy | Critical Illness Polyneuromyopathy

Switzerland
Q32 Bio Inc.

Not yet recruiting

A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G

IgA Nephropathy | Lupus Nephritis (LN) | C3 (Complement Component 3) Glomerulopathy
Samara State Medical University
Regional Samara Clinical Hospital n. a. V.D.Seredavin

Recruiting

Cardiovascular Risk Stratification on the Basis of Surface Enhanced Raman Spectroscopy (CRUISERS)

Coronary Atherosclerosis of Native Coronary Artery

Russian Federation
Adam S. Kibel, MD
National Cancer Institute (NCI)

Recruiting

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer (PRS)

Prostate Cancer | Polygenic Risk Score

United States
Chinese PLA General Hospital

Not yet recruiting

Chidamide+Decitabine Plus Anti-PD-1 Antibody in PD-1 Inhibitor Failed Patients With Classical Hodgkin Lymphoma.

PD-1 Inhibitor Failed Patients With Classical Hodgkin Lymphoma
Ohio State University Comprehensive Cancer Center

Not yet recruiting

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

Metastatic Renal Cell Carcinoma | Metastatic Cutaneous Melanoma | Stage IV Renal Cell Cancer AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
National Cancer Center, Korea

Recruiting

The Clinical Effectiveness and Safety of Intravesical Mitomycin-C and Gemcitabine Sequential Therapy (IMGeS)

Bladder Cancer

Korea, Republic of
Assembly Biosciences

Not yet recruiting

A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes

Recurrent Genital Herpes Simplex Type 2

New Zealand
Boston Immune Technologies and Therapeutics

Not yet recruiting

A Clinical Trial in Adults With Non-Hodgkin Lymphoma (NHL), With a Particular Emphasis on Cutaneous T Cell Lymphoma (CTCL), Testing the Safety and Activity of a Novel Drug to Inhibit a Protein Called Tumor Necrosis Factor Receptor 2 That Drives Both Lymphoma Growth and Escape of the Immune System

Peripheral T-cell Lymphoma | NHL | Cutaneous T Cell Lymphoma
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
Regeneron Pharmaceuticals
Intellia Therapeutics

Not yet recruiting

A Trial to Learn if REGV131-LNP1265 is Safe and Works to Help the Body Make Clotting Factor in Pediatric, Adolescent and Adult Patients With Hemophilia B (BEYOND-9)

Hemophilia B
University of Illinois at Chicago

Recruiting

Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.

Kidney Diseases | Frailty | Pain, Chronic | Dialysis; Complications

United States
Katelyn Atkins

Not yet recruiting

Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

Oligometastatic Disease

United States
Bezirkskrankenhaus Schwaz

Not yet recruiting

ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws

Anterior Cruciate Ligament Rupture | Anterior Cruciate Ligament Reconstruction | Anterior Cruciate Ligament Injury

Austria
Jasper Therapeutics, Inc.

Recruiting

A Dose Escalation Trial of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of Briquilimab in Adult Patients With Chronic Inducible Urticaria (CIndU) Who Remain Symptomatic Despite Treatment With H1- Antihistamines (SPOTLIGHT)

Chronic Inducible Urticaria

Germany
GC Cell Corporation

Not yet recruiting

Phase 1 Clinical Trial to Evaluate the Safety and Anti-Tumor Activity of AB-201

Breast Cancer | Gastric Cancer | Gastroesophageal Junction Adenocarcinoma

Australia
BioNTech SE
DualityBio Inc.

Not yet recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Endometrial Cancer
Hospices Civils de Lyon

Not yet recruiting

Characterization of New Phenotypes of Patients With Spinal Muscular Atrophy Treated With SMN Restoring Therapy (PHENO SMART)

Spinal Muscular Atrophy

France
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Outreach Project to Connect Underrepresented Populations to Clinical Trials at Ohio State University, CUSP2CT Project Trial

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
University Hospital, Toulouse

Not yet recruiting

Home Grip Assistance Glove on the Use of the Upper Limb and Compliance Factors in Brain-injured Adults (ECO-HAND-AVC)

Stroke

France
Merck Sharp & Dohme LLC

Recruiting

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Non Small Cell Lung Cancer

United States, Israel, Taiwan, Korea, Republic of, Switzerland
Pamukkale University

Not yet recruiting

Clinical Interpretation and Cutoff Scores for ABILHAND Questionnaire in Rheumatoid Arthritis

Rheumatoid Arthritis
Massachusetts General Hospital

Not yet recruiting

A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

Healthy

United States
Merck Sharp & Dohme LLC

Recruiting

A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)

Malaria

Australia
M.D. Anderson Cancer Center

Not yet recruiting

Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab

B-cell Acute Lymphocytic Leukemia | Relapsed/Refractory

United States
Advesya SAS

Not yet recruiting

An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia (RESOLVE AML001)

Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory

France, Sweden, Spain, Germany
Centre Hospitalier Universitaire, Amiens
University Hospital, Strasbourg, France; University Hospital, Brest; University... and other collaborators

Recruiting

Radiofrequency Fields in Neonatology: Exposure and Impact on the Nervous System (CHARLINE)

Preterm Newborn

France
Iuliu Hatieganu University of Medicine and Pharmacy

Not yet recruiting

Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy

Otosclerosis

Romania
Massachusetts General Hospital
BioSensics

Recruiting

Physical Activity Monitoring in Myasthenia Gravis

Myasthenia Gravis

United States
Combined Military Hospital, Pakistan

Recruiting

Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis (children)

Acute Bronchiolitis Due to Respiratory Syncytial Virus

Pakistan
Al-Kindy College of Medicine

Recruiting

Linguistic and Clinical Validation of the Arabic Version of Acute Cystitis Symptom Score (ACCS)

Cystitis Acute

Iraq
AbbVie

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis

Ulcerative Colitis

United States
AbbVie

Recruiting

Observational Study of Oral Cariprazine Capsules to Assess Change in Disease Activity in Adult Participants With Bipolar I Disorder (CReW BP-I)

Bipolar I Disorder

Canada
Assiut University

Not yet recruiting

Clinical Risk Scores in Prediction Outcome of Acute UGIT Bleeding in Non Cirrhotic Patients

Upper GI Bleeding
Pauls Stradins Clinical University Hospital

Recruiting

Selective Coronary Revascularization in Peripheral Artery Disease Patients (SCOREPAD Trial)

Coronary Artery Disease | Peripheral Arterial Disease

Latvia

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