Search clinical trials for: Clinical exacerbation

Total 60132 results

AstraZeneca
Premier HealthCare Solutions Inc.

Recruiting

Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (ANCHOR)

Asthma

United States
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Adenocarcinoma

United States
NuvoAir Medical PC
Optum, Inc.

Not yet recruiting

The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events

COPD | COPD Exacerbation | Cardio/Pulm: Heart Failure
Barcelona Institute for Global Health
University of Pisa; Universidad Politecnica de Madrid; Fondazione C.N.R./Regione... and other collaborators

Recruiting

COPD Exacerbation Modelling Using Unobtrusive Sensors - the TOLIFE Clinical Study A (CSA)

Chronic Obstructive Pulmonary Disease (COPD)

Italy, Germany, Spain
Altesa Biosciences, Inc.
Virtus Respiratory Research

Recruiting

RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases | Lung Diseases | Pulmonary Disease, Chronic Obstructive | Enterovirus Infections | Copd | Pulmonary Disease | Respiratory Disease | Respiratory Complication | Upper Respiratory Tract Infections | Respiratory Viral Infection | ... and other conditions

United Kingdom
Peking University People's Hospital

Recruiting

A Clinical Study on the Efficacy and Safety of Xuanfei Baidu Granule in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Acute Exacerbation of Chronic Obstructive Pulmonary Disease

China
Peking University Third Hospital
West China Hospital; Peking University Shougang Hospital; The First Affiliated... and other collaborators

Recruiting

The Clinical Characteristics, Treatment and Prognosis of Tuberculosis-associated COPD

COPD

China
GlaxoSmithKline

Not yet recruiting

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study (REIMAGINE)

Asthma
AstraZeneca

Recruiting

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations (MIRANDA)

Chronic Obstructive Pulmonary Disease (COPD)

China, United States, Denmark, Italy, Canada, Germany, Hungary, Netherlands, Spain, United Kingdom, Belgium, Argentina, Bulgaria, India, Japan, Vietnam, Malaysia, Thailand, Korea, Republic of, Mexico, Brazil, Greece, Poland, France, Peru, Chil... and more
Lady Reading Hospital, Pakistan
Pakistan Chest Society, Pakistan

Recruiting

Clopidogrel for the Prevention of Exacerbations in Severe COPD (CLOPEX)

COPD | COPD Exacerbation Acute

Pakistan
my mhealth Ltd
University of Southampton; University Hospitals Bristol and Weston NHS Foundation... and other collaborators

Recruiting

A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD (PROPEL myCOPD)

Chronic Obstructive Pulmonary Disease

United Kingdom
Dr Ian B Wilkinson
University College London Hospitals; Imperial College London; Newcastle University and other collaborators

Recruiting

Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations (OPACE)

Chronic Obstructive Pulmonary Disease

United Kingdom
Rochester General Hospital
Takeda

Recruiting

Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prevention

COPD Exacerbation Acute

United States
University of Minho
GlaxoSmithKline

Not yet recruiting

Exploring Clinical Predictors of COPD Exacerbation in a Community Cohort (EPISODE)

COPD Exacerbation
AstraZeneca

Recruiting

Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO). (PROSPERO)

Chronic Obstructive Pulmonary Disease (COPD)

China, Denmark, United States, Australia, Canada, Germany, Netherlands, Poland, Spain, United Kingdom, Korea, Republic of, Philippines, Italy, Argentina, Belgium, Bulgaria, Czechia, Finland, Hungary, India, Japan, Mexico, Norway, Port... and more
Queen Mary Hospital, Hong Kong

Recruiting

N-acetylcysteine (NAC) for the Treatment of Acute Exacerbation of COPD

Chronic Obstructive Pulmonary Disease

Hong Kong
AstraZeneca
Parexel

Recruiting

A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA) (DOMINICA)

Asthma

Korea, Republic of, Spain, United States, Argentina, France, Italy, Taiwan, Germany, United Kingdom, Poland, Canada
Vertex Pharmaceuticals Incorporated
Moderna, Inc

Recruiting

A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)

Cystic Fibrosis

United States, United Kingdom, Australia, Canada
University of British Columbia
Vancouver Coastal Health Research Institute

Not yet recruiting

Application of Telehealth Technology in Asthma Management

Quality of Life | Medication Adherence | Asthma Exacerbation

Canada
The University of Texas Medical Branch, Galveston

Recruiting

Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitalized With Heart Failure Exacerbation. (A-KHALIFE)

Heart Failure; With Decompensation | Lower Extremity Edema | Heart Failure，Congestive

United States
Elpen Pharmaceutical Co. Inc.

Recruiting

Clinical Study for the Effectiveness of Roflumilast Treatment in COPD Greek Patients Based on Standard Clinical Practice. (ARGO)

Copd | COPD Exacerbation

Greece
Daiichi Sankyo

Recruiting

A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

COPD Exacerbation Acute

China
National Institute of Allergy and Infectious Diseases...
Regeneron Pharmaceuticals; Childhood Asthma in Urban Settings (CAUSE); Rho Federal...

Recruiting

Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents (PANDA)

Asthma

United States
AstraZeneca

Recruiting

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations (OBERON)

Chronic Obstructive Pulmonary Disease (COPD)

United States, Canada, Czechia, Denmark, Hungary, Netherlands, Spain, Korea, Republic of, Argentina, Belgium, Bulgaria, Finland, India, Japan, Mexico, Norway, Sweden, Turkey, Vietnam, Portugal, Puerto Rico
AstraZeneca

Recruiting

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)

Chronic Obstructive Pulmonary Disease (COPD)

United States, Australia, Germany, United Kingdom, China, Philippines, Italy, Chile, Taiwan, Thailand, France, Puerto Rico, Israel, Peru, Colombia, Poland, Brazil, Russian Federation, Romania, Greece
Healthy Networks
University of Manchester; Belarusian Medical Academy of Post-Graduate Education

Recruiting

Differentiation of Asthma/COPD Exacerbation and Stable State Using Automated Lung Sound Analysis With LungPass Device

Asthma | COPD

Belarus
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Recruiting

A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD (SUMMER)

COPD

United Kingdom
Atlantic Health System

Not yet recruiting

Prevalence of OSA in COPD and the Clinical Impact of OSA Diagnosis and Treatment

Prevalence of OSA in Patients Hospitalized With COPD Exacerbation
Salmaniya Medical Complex

Recruiting

Phase 3 Clinical Study Evaluating Nitric Oxide Nasal Spray (NONS) Efficacy To Treat and Prevent the Exacerbation of Infection in Individuals With Documented Asymptomatic or Mild COVID-19

Covid19

Bahrain
Imperial College London

Recruiting

Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting (EHD-Pred PK)

Vasculitis | Asthma | Thyroid Eye Disease | Inflammatory Disease | COPD Exacerbation Acute

United Kingdom
University of Birmingham
Salford Royal Foundation Trust

Recruiting

Sputum Colour Charts to Guide Antibiotic Self-treatment of Acute Exacerbation of COPD (Colour COPD)

Pulmonary Disease, Chronic Obstructive

United Kingdom
Chiesi Farmaceutici S.p.A.

Recruiting

A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD (TRITON)

COPD | COPD Exacerbation

United States, Bulgaria, Hungary, Poland, Argentina, Czechia, Mexico, Canada, Puerto Rico, Romania
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

Asthma

United States
Guangzhou Institute of Respiratory Disease

Recruiting

Sputum Microbiota and the Association With Clinical Parameters in Steady-state, Acute Exacerbation and Convalescence of Bronchiectasis (BISER-2)

Bronchiectasis

China
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Longitudinal Observational Study of Severe Asthma

Asthma

United States
Université de Sherbrooke
Fonds de la Recherche en Santé du Québec; BioMérieux; Réseau de Recherche en... and other collaborators

Completed

Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks (PRISMA)

Asthma

Canada
Laval University

Completed

Clinical Evaluation of FreeO2 (Version 4) in All Patients Receiving Oxygen (FreeO24G)

Pneumonia | Respiratory Failure | Asthma | COPD Exacerbation | Respiratory Disease

Canada
AstraZeneca

Active, not recruiting

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE)

Chronic Obstructive Pulmonary Disease

United States, Austria, Canada, Denmark, Germany, Italy, Spain, United Kingdom, Belgium, Vietnam, Brazil, Hungary, Philippines, China, Korea, Republic of, Argentina, Australia, Poland, Turkey, Japan, Greece, Netherlands, Czechia, Mexico, Bulgar... and more
Vertex Pharmaceuticals Incorporated

Completed

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Cystic Fibrosis

United States, Belgium, Netherlands, United Kingdom, Canada, Australia, France, Germany, Italy, Czechia, Austria, Sweden, Greece
Schön Klinik Berchtesgadener Land
GlaxoSmithKline GmbH & Co. KG (Munich, Germany); Coordinating Center for Clinical... and other collaborators

Active, not recruiting

Predictors of Acute Exacerbation in Patients With COPD - an Observational Study (PACE)

Chronic Obstructive Pulmonary Disease | COPD | COPD Exacerbation | COPD Exacerbation Acute

Germany
Samara State Medical University
City Clinical Hospital No.1 named after N.I. Pirogov

Active, not recruiting

Prediction of Outcomes in Patients With Chronic Heart Failure Based on Tissue Raman Spectroscopy (PROMETHEUS)

Chronic Heart Failure

Russian Federation
Parc de Salut Mar

Active, not recruiting

Asthma Research in Children and Adolescents (ARCA)

Asthma in Children | Persistent Asthma | Asthma Exacerbation

Spain
EpiEndo Pharmaceuticals
CTC Clinical Trial Consultants AB

Completed

Clinical Trial to Assess Effect of Verapamil on Systemic Exposure of EP395 and Effect of EP395 on Systemic Exposure of Midazolam and Digoxin

COPD | Chronic Obstructive Pulmonary Disease Exacerbation

Sweden
AstraZeneca
Iqvia Pty Ltd; Premier Inc.

Withdrawn

IKANOS: Breztri Maintenance Versus Any Non-Triple Inhaled Therapy After Hospitalization for a COPD Exacerbation in the US (IKANOS)

COPD

United States
University of Oxford

Active, not recruiting

Acute Exacerbations Treated With BenRAlizumab (The ABRA Study) (ABRA)

Asthma | COPD

United Kingdom
Zhang Zhijie

Completed

Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Qingkepingchuan Granules Clinical Observation of Phlegm-Heat and Lung Depletion

Chronic Obstructive Pulmonary Disease

China
Hoffmann-La Roche

Completed

A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder

Schizophrenia, Schizoaffective Disorder

United States, Japan, Ukraine, Russian Federation
Hennepin Healthcare Research Institute

Completed

Peak Expiratory Flow Rate for Emergency Department Management of Acute Asthma Exacerbation

Asthma

United States
Ifakara Health Institute
Swiss Tropical & Public Health Institute; National Institute for Medical Research... and other collaborators

Completed

Safety and Efficacy of Maytenus Senegalensis for the Treatment of Uncomplicated Malaria (MALHERBAL)

Malaria

Tanzania
Respira Labs, Inc
Palo Alto Medical Foundation

Terminated

Clinical Feasibility of a Non-invasive Wearable Acoustic Device for Measuring Air Trapping in COPD

COPD | COPD Exacerbation

United States

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