Search clinical trials for: Cytosine methylation

Total 853 results

Therapeutic Advances in Childhood Leukemia Consortium
Gateway for Cancer Research

Completed

A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML

Lymphoblastic Leukemia, Acute, Childhood | Myelogenous Leukemia, Acute, Childhood

United States, Canada, Australia
Montefiore Medical Center
American Diabetes Association

Completed

Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants

Adiposity | Environmental Exposures | Full Term Infants

United States
Nanjing University
Peking Union Medical College Hospital; The Affiliated Nanjing Drum Tower Hospital...

Recruiting

DNA Methylation Biomarkers to Predict Survival After Surgery for Lung Adenocarcinoma

Surgery | Lung Adenocarcinoma | Prognostic Cancer Model

China
City of Hope Medical Center

Recruiting

Predicting Early Tumor Recurrence in Patients With ESCC

Recurrence | Esophageal Cancer | DNA Methylation

Japan
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With Prenatal Onset (FOETEPISIGN)

Congenital Malformation | Rare Fetal Genetic Diseases

France
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute Leukemias

Refractory Acute Leukemia | Relapsed Acute Leukemia

United States
University of Cyprus

Recruiting

Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies (NicoGen)

Smoking Cessation | Epigenetics | Nicotine Addiction | Smoking Cessation Intervention | Molecular Biology | Genetic Epidemiology

Cyprus
Changhai Hospital
RenJi Hospital; Tongji Hospital; First Hospital of China Medical University

Not yet recruiting

Performance Evaluation of Urine DNA Methylation Testing for the Detection of Urothelial Carcinoma in Patients With Hematuria

Bladder Cancer | Urothelial Carcinoma | Ureter Cancer | Hematuria | Renal Pelvis Cancer

China
Sun Yat-sen University
Wuzhou Red Cross Hospital; Fujian Cancer Hospital; Zhongshan People's Hospital... and other collaborators

Recruiting

Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
Institute of Hematology & Blood Diseases Hospital...

Recruiting

VMAC+DLI Treatment of Patients With Relapse of AML After Allo-HSCT (VMAC+DLI)

Relapse Acute Myeloid Leukemia

China
University Hospital of Ferrara
Azienda Ospedaliera Universitaria Policlinico; Azienda Ospedaliera di Padova; Fondazione IRCCS San Gerardo dei Tintori

Not yet recruiting

Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN) (INFRAGEN)

Inflammation | Frailty | Aging | Telomere Shortening | Hospital Infection
The First Affiliated Hospital of Soochow University

Recruiting

Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML

Acute Myeloid Leukemia

China
Changhai Hospital

Not yet recruiting

Urine DNA Methylation Detection for Hematuria Evaluation

Bladder Cancer | Urothelial Carcinoma | Ureter Cancer | Hematuria | Renal Pelvis Cancer

China
St. Jude Children's Research Hospital
AbbVie

Not yet recruiting

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

T-cell Lymphoma | T-cell Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States
University of Rome G. Marconi
University of Bologna; University of the Italian Switzerland

Not yet recruiting

Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health (MOTHERS)

Stress | Insomnia | Postpartum Depression

Italy
Obstetrics & Gynecology Hospital of Fudan University
Peking Union Medical College Hospital; First Affiliated Hospital of Xinjiang... and other collaborators

Not yet recruiting

Role of Methylation Test Triage in HPV Positive Women (MTTRIHPW)

Precancerous Cervical Lesion

China
Shanghai Chest Hospital

Recruiting

Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan

Carcinoma | Non-small Cell Lung Cancer

China
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Federico II University; Istituto Auxologico Italiano; Università degli Studi...

Recruiting

Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks

Beckwith-Wiedemann Syndrome

Italy
National Cancer Institute (NCI)

Not yet recruiting

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

B Acute Lymphoblastic Leukemia | Acute Leukemia of Ambiguous Lineage
City of Hope Medical Center

Recruiting

Stage II/III Colorectal Cancer Recurrence (CENSURE)

Colorectal Cancer | Colorectal Adenocarcinoma | Colorectal Cancer Stage II | Colorectal Cancer Stage III | Colorectal Cancer Recurrent

Spain, United States, China
Maximilian Stahl, MD
Syndax Pharmaceuticals

Not yet recruiting

Revumenib in Combination With 7+3 + Midostaurin in AML

Acute Myeloid Leukemia | Leukemia | AML | AML, Adult | AML With Gene Mutations

United States
Mayo Clinic

Recruiting

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Central Arkansas Veterans Healthcare System
United States Department of Defense; University of Arkansas

Recruiting

DNA Methylation Markers in Veterans Exposed to Open Burn Pits

Open Burn Pit Exposure

United States
H. Lee Moffitt Cancer Center and Research Institute
National Institutes of Health (NIH)

Recruiting

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC) (BASH OPC)

Oropharyngeal Cancer | HPV-Related Carcinoma

United States
St. Jude Children's Research Hospital

Not yet recruiting

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma | Mixed Phenotype Acute Leukemia

United States
Pennington Biomedical Research Center

Recruiting

Diet-Induced Changes in GEnetic Material (DIG 'EM)

Body Weight | Diet, Healthy | Metabolic Disturbance

United States
Children's Oncology Group

Not yet recruiting

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Recurrent Juvenile Myelomonocytic Leukemia | Refractory Juvenile Myelomonocytic Leukemia
Meyer Children's Hospital IRCCS
Careggi Hospital; University of Florence

Not yet recruiting

The Epigenomic Signature of Eosinophilic Granulomatosis With Polyangiitis (EPI-EGPA)

Eosinophilic Granulomatosis With Polyangiitis
Shanghai Weihe Medical Laboratory Co., Ltd.
Peking University People's Hospital

Recruiting

a PROspective Case Control Study to Develop and Validate a Blood Test FOr mUlti-caNcers Early Detection（PROFOUND） (PROFOUND)

Cancer

China
The First Affiliated Hospital with Nanjing Medical...

Recruiting

DNA Methylation Combined With Artificial Intelligence Imaging to Identify Lung Nodules (MAGIC)

Lung Cancer Diagnosis

China
Singlera Genomics Inc.
Shanghai Zhongshan Hospital

Recruiting

Clinical Research on Dynamic Monitoring MRD Via Plasma ctDNA After Systemic Therapy of Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Sir Run Run Shaw Hospital

Recruiting

Circulating Tumor DNA Methylation Guiding Postoperative Adjuvant Chemotherapy in Stage III Colorectal Cancer (cmPAT)

Colorectal Cancer

China
Sun Yat-sen University
The First Affiliated Hospital of Anhui Medical University; Peking University... and other collaborators

Recruiting

PaCIFiC-CUP Classifies Cancer of Unknown Primary

Unknown Primary Tumors | DNA Methylation

China
National Cancer Institute (NCI)

Not yet recruiting

A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia
Air Force Military Medical University, China

Recruiting

A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles

Bile Duct Diseases | Bile Duct Neoplasms | Jaundice, Obstructive

China
Dartmouth-Hitchcock Medical Center

Recruiting

Immune Profiling for Cancer Immunotherapy Response

Cancer | Hematologic Malignancy | Blood Cancer | Tumor, Solid

United States
First Affiliated Hospital of Zhejiang University

Not yet recruiting

Reduced Intensive Idarubicin and Cytarabine Plus Venetoclax as First-line Treatment for Adults AML and MDS

Acute Myeloid Leukemia | Myelodysplastic Syndromes
Hospital Clinico Universitario de Santiago
Hospital Arquitecto Marcide

Not yet recruiting

Nutritional Intervention-induced Weight Loss During the Oncological Treatment of Obesity-related Breast Cancer (NUTOBREST)

Obesity | Breast Cancer | Weight Change, Body | Epigenetic Disorder
Air Force Military Medical University, China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; The First Affiliated... and other collaborators

Recruiting

Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing

Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreas Cancer | Liver Cancer | Esophagus Cancer | Cancer Diagnosis | LungCancer

China
Fred Hutchinson Cancer Center
ImmunoGen, Inc.

Recruiting

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm | Mixed Phenotype Acute Leukemia

United States
Weill Medical College of Cornell University
National Cancer Institute (NCI); University of Sao Paulo; H. Lee Moffitt Cancer... and other collaborators

Recruiting

Optimization of Cervical Cancer Screening Among Women Living With HIV in Latin American Countries

HIV Infections | Cervix Cancer | HPV Infection | Cervical High Grade Squamous Intraepithelial Lesion

Brazil, Mexico
Xijing Hospital

Recruiting

A Population-based, Multicenter Cohort Study of Combined Screening for Gastrointestinal Tumors

Digestive Disease

China
Fudan University

Recruiting

Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer

Stage III Colorectal Cancer | High-risk Stage II Colorectal Cancer | Circulating Tumor DNA Methylation

China
Shanghai Zhongshan Hospital

Recruiting

Consistency of Carotid Doppler Blood Flow and Thermodilution Technique

Cardiac Surgery

China
RenJi Hospital

Not yet recruiting

Multiomics Study of Fibrosis Factors After Liver Transplantation and Exploration of Fibrosis Methylation Biomarkers

Liver Fibrosis

China
Affiliated Hospital of Guangdong Medical University

Recruiting

Safety and Efficacy Study of KL-7SHRNA Injection Solution in the Treatment of AIDS Patients With Lymphoma

HIV Infections | Lymphoma

China
Mahidol University

Not yet recruiting

Effects of Kimchi Supplementation on Gut Microbiota, DNA Methylation and Serum Proteomes

Obesity

Thailand
Fudan University

Recruiting

Circulating Tumor DNA Methylation Guided Postoperative Follow-up Strategy for Non-metastatic Colorectal Cancer

Non-metastatic Colorectal Cancer | Circulating Tumor DNA Methylation

China
National Cancer Institute (NCI)

Recruiting

Testing the Addition of an Anti-cancer Drug, SNDX-5613, to the Standard Chemotherapy Treatment (Daunorubicin and Cytarabine) for Newly Diagnosed Patients With Acute Myeloid Leukemia That Has Changes in NPM1 or MLL/KMT2A Gene

Acute Myeloid Leukemia With KMT2A Rearrangement | Acute Myeloid Leukemia With NPM1 Mutation

United States
Queen Mary University of London
National Cancer Institute (NCI)

Recruiting

HPV Self-testing in Transgender Individuals (Self-TI)

HPV Infection

United Kingdom

Search clinical trials for: Cytosine methylation

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