Search clinical trials for: DAT occupancy in healthy volunteers

Total 459892 results

Sunovion

Completed

A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Steady State in Healthy Subjects

Healthy

United States
Massachusetts General Hospital

Completed

PET Study Examining the Dopaminergic Activity of Armodafinil in Adults

Healthy

United States
AbbVie

Not yet recruiting

Study of Oral ABBV-932 Capsules to Evaluate Dopamine D2 and D3 Receptor Occupancy in Brain in Adult Healthy Volunteers

Healthy Volunteers
Intra-Cellular Therapies, Inc.

Recruiting

PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects

Healthy Volunteers

United States
Novartis Pharmaceuticals
Eckert & Ziegler Radiopharma GmbH

Recruiting

A Prospective, Open-label Study of [68Ga]Ga-DOTA-TATE in Patients With Neuroendocrine Neoplasms (NENs) and Healthy Volunteers in Japan

Neuroendocrine Neoplasms

Japan
Neuronetrix, Inc.

Recruiting

Normative QEEG/ERP Data for Healthy Volunteers

Healthy

United States
BrainCheck, Inc.

Recruiting

Normative Database and Test-Retest Reliability for BrainCheck Assessments (NDTR)

Cognitive Change | Cognitive Decline | Cognitive Deterioration | Neurocognitive Deficit

United States
Trellis Bioscience LLC
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

Study to Evaluate Safety and Activity of TRL345 in Healthy Volunteers

Healthy Volunteers

United States
Xfibra, Inc.

Not yet recruiting

A First-in-human Study of the Safety, Tolerability, and PK of XFB-19 in Healthy Adult Volunteers

Idiopathic Pulmonary Fibrosis (IPF)
University of Leipzig

Recruiting

Laboratory Study for the Acquisition of Spectral and Photoplethysmographic Data (LabStud_MSI)

Healthy Volunteers

Germany
University Hospital, Strasbourg, France

Recruiting

Transposition of Dynamic MRI Data From Healthy Subjects to an in Vitro Swallowing Simulator (SWALL-E)

Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers | Create Operating Algorithms | Apply the Imaging Data of MRI to a Swallowing Simulator

France
University of Michigan
Food and Drug Administration (FDA)

Recruiting

Pharmacokinetic Study of Single-Dose Modified Release Glipizide in Healthy Volunteers

Human Gastrointestinal Physiology Data

United States
Vladikavkaz Scientific Center of the Russian Academy...

Recruiting

Medico-ecological Monitoring ((CSM, MCTQ, SPAQ, PSQI, HRV, Spirometry; Anthropometry, BP) of the Different Population Groups (Students, Schoolchildren, Volunteers) in North Caucasus

Conditionally Healthy Persons | Persons With a High Body Mass Index

Russian Federation
University of Maryland, Baltimore

Recruiting

Vasopressin and Pain Perception in the Brain

Acute Pain

United States
National Institute on Deafness and Other Communication...

Recruiting

Normal Values in Hearing and Balance Testing

Healthy Volunteer

United States
National Institute of Mental Health (NIMH)

Active, not recruiting

Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

Healthy Volunteer

United States
Taipei Veterans General Hospital, Taiwan
Apollo Medical Optics, Ltd

Completed

The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability

Nevus | Healthy Skin

Taiwan
Hanmi Pharmaceutical Company Limited

Completed

A Study to Evaluate the Pharmacokinetics and Safety Between HCP2001 and Co-administration of Each Component in Healthy Volunteers

Healthy

Korea, Republic of
Stanford University
National Cancer Institute (NCI)

Completed

Integrin Alpha-v-Beta and [18F]-R01-MG-F2 PET/CT in Measuring Response in Patients With Pancreatic Cancer and Healthy Volunteers

Pancreatic Carcinoma | Healthy Subject

United States
GE Healthcare
PPD

Completed

A Study to Evaluate the Safety, Biodistribution, Internal Radiation Dosimetry, and Effective Dose of DaTSCAN™ Ioflupane (123I) Injection in Chinese Healthy Volunteers.

Healthy Subjects (HS)

China
National Institute of Mental Health (NIMH)

Completed

Impact on Anxiety and Motivation of COVID-19 and Predictors of Individual Responses

Anxiety | Healthy Volunteers

United States
GAP Innovations, PBC

Completed

A Biomarker Database to Investigate Blood-Based and Digital Biomarkers in Participants Screened for Alzheimer's Disease (Bio-Hermes)

Alzheimer Disease | Mild Cognitive Impairment | Alzheimer Disease, Early Onset | Memory Disorders | Memory Impairment | Memory Loss

United States
University of Oxford
National Institute for Health Research, United Kingdom; Zogenix International...

Completed

Fenfluramine and Cognition (FEN&Cognition)

Cognitive Function

United Kingdom
Pipeline Therapeutics, Inc.

Completed

PET Study to Determine the Relationship Between Plasma Concentrations and Muscarinic Type 1 Receptor (M1AChR) Occupancy of PIPE-307 in Healthy Volunteers

Multiple Sclerosis

United Kingdom
Topcon Medical Systems, Inc.

Completed

Topcon 3D OCT-1 Maestro Reference Database Study II

Healthy

United States
LB Pharmaceuticals Inc.
Washington University School of Medicine

Completed

Receptor Occupancy of LB-102 Using Positron Emission Tomography (PET) in Healthy Volunteers

Schizophrenia

United States
Mayo Clinic

Completed

A Study to Evaluate Endoflip Normal Ranges Data in Healthy Volunteers

Healthy

United States
Bioverativ, a Sanofi company
Assign Data Management and Biostatistics GmbH; Quest Diagnostics-Nichols Insitute and other collaborators

Completed

Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders (BIVV009-01)

End-stage Renal Disease (ESRD) | Cold Agglutinin Disease (CAD) | Bullous Pemphigoid (BP) | Warm Autoimmune Hemolytic Anemia (WAIHA)

Austria
AbbVie

Terminated

A Non-Drug Study Detecting And Quantifying Nocturnal Scratch Behaviors From Wrist Actigraphy Data In Adult Healthy Volunteers And Participants With Atopic Dermatitis (AD)

Atopic Dermatitis

United States
St. Petersburg Research Institute of Vaccines and...

Completed

The Objectives of This Study Are Study the Safety, Reactogenicity and Obtain Preliminary Data on the Immunogenicity of Flu-M Quadro, 4-valent Inactivated Split Influenza Vaccine, in Healthy Volunteers

Influenza

Russian Federation
University Ghent
University Hospital, Ghent; AZ Sint-Jan AV; Algemeen Ziekenhuis Maria Middelares and other collaborators

Completed

Analysis of the Radiation Safety Climate in the Hybrid Angiography Suite

Healthy Volunteers | Aortic Aneurysm, Abdominal

Belgium
Prilenia

Completed

A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease

Health Volunteers, Huntington Disease

Germany
AstraZeneca

Completed

PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium

Healthy Volunteers

Sweden
Takeda

Terminated

A Study With [18F]MNI-1054 to Determine Lysine -Specific Demethylase 1A (LSD1) Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Participants

Healthy Volunteers

United States
Fudan University

Unknown

Ntraperitoneal Thermal Perfusion Combined With Chemotherapy Versus Chemotherapy

Advanced Pancreatic Cancer

China
AO GENERIUM

Completed

Safety and Pharmacokinetics of GNR-038 in Healthy Volunteers

Hereditary Angioedema

Russian Federation
Concert Pharmaceuticals
Celerion

Completed

Drug-drug Interaction Study of CTP-543 and Oral Contraceptives in Healthy Female Subjects

Healthy Volunteers

United States
University College, London
University of Portsmouth; University of Wollongong

Unknown

Thirst-guided Subject-controlled Rehydration in Healthy Volunteers

Dehydration Hypertonic

United Kingdom
Invicro

Completed

D1 Receptor Occupancy (RO) Following a Single Dose of PF-06412562

Healthy Male Volunteers

United States
Seagen Inc.

Completed

A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin

Drug-drug Interaction

United States
Molecular NeuroImaging

Completed

Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain

Alzheimer Disease | Healthy Volunteers | Progressive Supranuclear Palsy

United States
Pfizer
Yale University

Completed

A Phase I, Healthy Volunteer Positron Emission Tomography Study

Healthy

United States
Newcastle University

Completed

Assessing the Glycaemic Index of Two Different Cultivars of Date Fruit

GI Glycaemic Index Healthy Volunteers | GL Glycaemic Load Healthy Volunteers

United Kingdom
Human Genome Sciences Inc.
GlaxoSmithKline; Emergent BioSolutions

Completed

A Study to Evaluate the Safety and Tolerability of Raxibacumab in Healthy Subjects

Healthy
Akebia Therapeutics

Completed

Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects

Healthy

United States
Rennes University Hospital

Unknown

OSS-IRM: Optimization of MRI Sequences in Healthy Volunteers (OSS-IRM)

Healthy

France
GlaxoSmithKline

Completed

An Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain DAT and SERT Occupancy,Pharmacokinetics and Safety of Single Oral Doses of GSK1360707, Using 11C- PE2I and 11C-DASB as PET Ligands

Depressive Disorder

United Kingdom
Lumos Labs, Inc.
Collaborative Neuroscience Network

Completed

Validity of an Online Neurocognitive Test Battery, the Brain Performance Test (BPT), in Normal Healthy Adults

Healthy Volunteers

United States
Pearson/Clinical Assessment

Completed

Reference Database Development for the Quotient® System iPad Test

Healthy Volunteers

United States
Universitätsklinikum Hamburg-Eppendorf

Completed

Single and Multiple Doses of an Oral Formulation of L-Homoarginine in Healthy Human Subjects

Healthy

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