Search clinical trials for: Donor Specific Cell-Free DNA

Total 15695 results

Sheba Medical Center
Dan Hauzenberger M.D., Ph.D. Assoc. Professor, Karolinska University Hospital...

Not yet recruiting

Study for Detection of Donor-derived Cell-free DNA After Renal Transplantation Using Devysers NGS-based Chimerism Assay.

Cell-Free Nucleic Acids
Medical College of Wisconsin
National Heart, Lung, and Blood Institute (NHLBI); University of California... and other collaborators

Completed

Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study) (DTRT)

Cardiovascular Disease | Heart Transplant Failure and Rejection | Cardiac Transplant Rejection | Acute Rejection of Cardiac Transplant

United States
Liverpool University Hospitals NHS Foundation Trust
Kidney Research United Kingdom

Not yet recruiting

Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients (HLA-AB)

Frailty | Kidney Transplant Rejection | Renal Transplant | Diagnosis | Kidney Transplant; Complications | Kidney Transplant | Renal Transplant Failure | Transplant Dysfunction

United Kingdom
Tongji Hospital
Anapure BioScience; Caibo MedTech; SKM BioTech

Recruiting

Dynamic Changes of Torquetenovirus (TTV) Load in Chinese Renal Transplant Recipients (TTV)

Kidney Transplant Infection | Kidney Transplant Rejection | Immunosuppression | Virus

China
Beijing Friendship Hospital

Recruiting

Clinical Study of Donor EBV-CTL Infusion in Patients With CAEBV and EBV-HLH After Allo-HSCT

Chronic Active Epstein-Barr Virus Infection | Virus-Associated Hemophagocytic Syndrome

China
CareDx

Not yet recruiting

HeartCare Immuno-optimization in Cardiac Allografts (MOSAIC) (MOSAIC)

Immunosuppression | Allograft | Heart Transplant
Nationwide Children's Hospital

Recruiting

Pilot Study of Haploidentical Donor Adenovirus Specific T-lymphocytes to Treat Refractory Adenovirus Infections (ADV-VSTS)

Adenovirus Infection

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Re-evaluation of Donor-specific Anti-HLA Alloantibodies Immunoassay After Organ Transplantation, From Antigen Level to Epitope Level (ACORG-HLA)

Organ Transplantation
Sumithira Vasu

Recruiting

Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT

Cytomegalovirus | Adenovirus | Donor | Allogeneic Hematopoietic Stem Cell Transplantation Recipient | Solid Organ Transplantation Recipient

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Donor T Cell Therapy in Treating Immunocompromised Patients With Adenovirus-Related Disease

Hematopoietic and Lymphoid Cell Neoplasm | Immunocompromised

United States
Memorial Sloan Kettering Cancer Center

Recruiting

Trial of Third Party Donor Derived CMVpp65 Specific T-cells for The Treatment of CMV Infection or Persistent CMV Viremia After Allogeneic Hematopoietic Stem Cell Transplantation

CMV Infection | Persistent CMV Viremia

United States
University Hospital, Basel, Switzerland

Recruiting

A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System® (CCS)

Cytomegalovirus Infections | EBV | Adenovirus Infection | Cytokine Capture System | Allogenic Disease

Switzerland
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Donor Cytomegalovirus-Specific Cytotoxic T-Lymphocytes in Treating Patients With a Persistent Cytomegalovirus Infection

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Cytomegaloviral Infection

United States
Paul Szabolcs

Enrolling by invitation

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT)

Chronic Granulomatous Disease (CGD) | Wiskott-Aldrich Syndrome | Severe Chronic Neutropenia | Severe Combined Immunodeficiency (SCID) | Immunodeficiency With Predominant T-cell Defect, Unspecified | Hyper IgE Syndromes | Hyper IgM Deficiencies | Mendelian Susceptibility to Mycobacterial Disease | Common...

United States
National Institute of Neurological Disorders and...

Completed

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Progressive Multifocal Leukoencephalopathy

United States
Shanghai General Hospital, Shanghai Jiao Tong University...
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China

Completed

CMV-CTL for the Treatment of CMV Infection After HSCT

Cytomegalovirus Infections | Hematological Disease

China
CareDx

Withdrawn

KidneyCare Immuno-optimization in Renal Allografts (KIRA)

Immunosuppression | Kidney Transplant | Allograft
Atara Biotherapeutics
Memorial Sloan Kettering Cancer Center

Completed

Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV-Associated Malignancies

EBV-induced Lymphomas | EBV-associated Malignancies | Transplant Patients With EBV Viremia at High Risk for Developing a Recurrent EBV Lymphoma

United States
Memorial Sloan Kettering Cancer Center
Atara Biotherapeutics

Completed

Primary Transplant Donor Derived CMVpp65 Specific T-cells for The Treatment of CMV Infection or Persistent CMV Viremia After Allogeneic Hematopoietic Stem Cell Transplantation

Cytomegalovirus

United States
Memorial Sloan Kettering Cancer Center

Completed

Trial of Donor T Cells Sensitized With Pentadecapeptides of the CMV-PP65 Protein for the Treatment of Cytomegalovirus (CMV) Infections Following Allogeneic Hematopoietic Stem Cell Transplants

Cytomegalovirus Infections

United States
Peking University People's Hospital

Completed

Preemptive Therapy With CMV-specific T Cells Infusion to Prevent Refractory CMV Infection Post Transplantation

CMV Infection

China
Assistance Publique - Hôpitaux de Paris

Unknown

Immunization Anti HLA in the Liver Transplant Recipients (DSATH) (DSATH)

Liver Transplantation | Graft Failure

France
University College, London

Suspended

Study of Adoptive Immunotherapy With Donor-derived CMV-specific T Cells for Recipients of Allo-HSCT (CMV_TCR-001)

CMV Infection | Haematological Malignancies

United Kingdom
Cell Medica Ltd
University of Birmingham; Leukaemia Lymphoma Research; National Health Service...

Completed

Alternate Donor Study of Pre-Emptive Cellular Therapy (CMV-ACE/ASPECT)

Cytomegalovirus Infection

United Kingdom
New York Medical College
Johns Hopkins University; M.D. Anderson Cancer Center; Baylor College of Medicine and other collaborators

Terminated

Allogeneic Stem Cell Transplantation With Adoptive Immunotherapy in Epstein-Barr Virus Positive Recurrent/Refractory Hodgkins Lymphoma

Hodgkins Lymphoma

United States
Maimónides Biomedical Research Institute of Córdoba
QIAGEN Gaithersburg, Inc

Unknown

Impact of the Lack of CMV-Specific CD8+ T Cell Response in CMV-Seropositive Donors in CMV Reactivation After Hematopoietic Stem Cells Transplant in CMV-Seropositive Recipients (CYTHEMAT)

Cytomegalovirus Infection | HSCT

Spain
Nelson Chao

Terminated

Trial of CMV Specific DLIs From 3-6/6 HLA Matched Family Member Following Nonmyeloablative Allo SCT

Cytomegalovirus Infections

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

HIV Infection | Unspecified Childhood Solid Tumor, Protocol Specific | Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal... and other conditions

United States
Baylor College of Medicine
M.D. Anderson Cancer Center; Massachusetts General Hospital; National Heart,... and other collaborators

Completed

Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) (CHALLAH)

EBV Infection | Adenovirus Infection

United States
Hoffmann-La Roche

Completed

A Prospective Study to Evaluate the Specificity of the Cobas TaqScreen MPX Test for Use on the Cobas s 201 System for Screening Plasma Pools From Source Plasma Donors for the Presence of HBV DNA, HCV RNA, and HIV-1 RNA

Healthy Volunteer

United States
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Completed

Giving Epstein-Barr Virus (EBV) Specific Killer T Lymphocytes to Patients Who Have Had Donor Marrow Grafts (ETNA)

Epstein-Barr Virus Infections

United States
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Completed

Safety, Toxicity and MTD of One Intravenous IV Injection of Donor CTLs Specific for CMV and Adenovirus (ACT-CAT)

Cytomegalovirus Infection | Adenovirus Infection

United States
Milton S. Hershey Medical Center
National Cancer Institute (NCI)

Unknown

Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections

Cancer

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

No longer available

Emergency Use of Adoptive Immunotherapy With CMV-Specific T Cells After Donor Bone Marrow Transplant of an Infant With Immunodeficiency Syndrome and CMV Infection

Infection | Precancerous/Nonmalignant Condition

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Janssen Research & Development, LLC

Not yet recruiting

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Lymphoma | Multiple Myeloma | Hodgkin Lymphoma | Myelofibrosis | Non Hodgkin Lymphoma | Chronic Myeloid Leukemia | Hematologic Malignancy | Aplastic Anemia | Myelodysplastic Syndromes (MDS) | Acute Myeloid Leukemia (AML) | Bone Marrow Transplant Rejection | Acute Lymphoblastic Leukemia (ALL), Adult
Peking University People's Hospital

Not yet recruiting

Kinectics of Donor-specific Anti-HLA Antibody After HLA-incompatible Allogeneic Haematopoietic Stem Cell Transplantation

Haematological Malignancy
Ciusss de L'Est de l'Île de Montréal

Recruiting

Donor-Derived EBV-Specific T Cells for Life Threatening EBV-lymphoma (OLIP-EBV-TCL-01-HMR01)

EBV Associated Lymphoma

Canada
bioLytical Laboratories
St Vincent's Hospital Melbourne

Not yet recruiting

A Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Sites

Hepatitis B | Hepatitis B Infection

Australia
bioLytical Laboratories

Recruiting

Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Site Settings

Hepatitis B | Hepatitis B Infection

South Africa
Cairo University

Recruiting

Accuracy& Orbital Volume Using Patient Specific Titanium Implant Vs Zirconia for Orbital Floor Reconstruction

Orbital Fractures | Orbital Floor Fracture | Orbital Trauma | Blow-Out Fractures

Egypt
University of Aarhus
Aarhus University Hospital

Recruiting

Circulating Tumor DNA in Peripheral T-cell Lymphomas (CIRCULATE)

Peripheral T-cell Lymphoma | NK/T-Cell Lymphoma

Denmark
Fondazione IRCCS Policlinico San Matteo di Pavia

Not yet recruiting

Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy.

Occult Hepatitis B Infection in Cancer Patients

Italy
University Hospital, Grenoble

Not yet recruiting

Quantiferon CMV to Identify Treatment Need For Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT) (QUANTIFOT)

Liver Transplantation | Kidney Transplantation | Heart Transplantation | Cytomegalovirus Infections | Lung Transplantation

France
Mayo Clinic

Recruiting

Validation of DNA Methylation Markers for Universal and Site-specific Guided Cancer Detection, VANGUARD Study

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
University Hospital, Rouen

Not yet recruiting

Screening for Subclinical Antibody Mediated Rejection and Efficacy of Belatacept in the Context of de Novo Donor Specific Antibody After Kidney Transplantation (BELA-M-R) (BELA-M-R)

Kidney Transplant Rejection
Peking University Third Hospital
Beijing Tsinghua Changgeng Hospital

Recruiting

Evaluation of diagnostiC Capacity of eccDNAs as Biomarkers in Indetermined biLiary Stricture(ECCBILE) (ECCBILE)

Bile Duct Cancer | Pancreas Cancer | Biliary Stricture

China
Methodist Health System

Recruiting

Analysis of Donor-derived Cell Free DNA in Liver Transplant Patients

Liver Transplant Failure

United States
Mayo Clinic

Recruiting

A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Ruijin Hospital

Recruiting

Safety and Efficacy of LPE in Clearing DSA in Patients Who Received Allo-HSCT

Leukemia

China
University of Central Florida

Recruiting

Cell-Free DNA Chromatin Immunoprecipitation (ChIP) for Diagnosing Cancer

Cancer of Pancreas

United States

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