Search clinical trials for: Drug interactions (Cytochrome P450 and p-glycoprotein)

Total 471163 results

Rennes University Hospital
Ministry of Health, France

Completed

Cytochrome P450 2E1 and Iron Overload

Insulin Resistance | Iron Overload

France
Comercial Quimica Masso, S.A
Université Catholique de Louvain

Recruiting

Evaluation of the Effect of a Combination of Plants to Regulate Mood

Mood Regulation

Belgium
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of Cytochrome P450 1A2 Induction by Ritonavir on BMS-986165 Drug Levels and Effects in Healthy Participants

Healthy Participants

United States
Alexion

Completed

Phase 1 Study of ALXN1840 on the Metabolism of a CYP2C9 Substrate in Healthy Participants.

Wilson Disease

United States
National Institute of Environmental Health Sciences...

Completed

p450 Mediated Lung Toxicity

Pulmonary Disease
National Institute of Mental Health (NIMH)

Terminated

Mild Neurocognitive Disorder in HIV Infection of the Brain

HIV-Associated Cognitive Motor Complex

United States
Xact Robotics Ltd.

Completed

Evaluation of the Safety, Effectiveness & Usability of the XACT Robotic System for Image Guided Percutaneous Procedures

CT-guided Minimally Invasive Procedures e.g., Biopsies

Israel, United States
Centers for Disease Control and Prevention

Completed

Assessing the Efficacy of Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria Infection in Children

P. Falciparum Malaria

Tanzania
Oregon Health and Science University
Society of Family Planning

Completed

The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle

Ovulation (Follicular Rupture Yes/no) | Menstrual Cycles (Total Length, Bleeding Days) | Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)

United States
Gangnam Severance Hospital
SAMJIN PHARM

Completed

Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke

Acute Ischemic Stroke

Korea, Republic of
Janssen-Cilag International NV

Completed

A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults

Healthy

Belgium
Mutual Pharmaceutical Company, Inc.
Cetero Research, San Antonio

Completed

Drug-Drug Interaction Study Between Quinine Sulfate and Rosiglitazone

Healthy

United States
Galderma R&D

Completed

Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes

P Acnes Colonization

United States
Neovii Biotech

Completed

Study in EpCAM Positive Patients With Symptomatic Malignant Ascites Using Removab Versus an Untreated Control Group

Malignant Ascites | EpCam Positive Tumor (e.g.Ovarian, Gastric, Colon, Breast)
Fondation Lenval

Completed

Pharmacogenetics Anomaly Research in Children and Adolescents With Pharmacological Resistance to Psychotropic Drugs (M4P)

Psychotropic Drugs | Drug Resistance

France
Merck KGaA, Darmstadt, Germany

Completed

Effect of Tepotinib on PK of CYP3A Substrate Midazolam

Healthy

Germany
North Dakota State University
Neuropsychiatric Research Institute, Fargo, North Dakota

Terminated

Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone

Gastric Bypass
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

Malaria

United Kingdom
SK Life Science, Inc.

Completed

Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs as a Means of Predicting Drug-drug Interactions

Healthy

United States
Taichung Veterans General Hospital

Completed

Evaluation of Exercise Tolerance and Cardiac Output in Patients With Heart Failure After Intervention of Rehabilitation Program

Heart Failure With or Without CRT-P/D
Theravance Biopharma

Completed

A Fixed-Sequence, Two-Period, Open-Label Drug-Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD-1211

Healthy

United States
Jazz Pharmaceuticals

Completed

Phase 3 Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms: Open-label Extension Phase (GWPCARE7)

Infantile Spasms

United States, Poland
Hospital Universitario Getafe

Completed

Circulating Anti-Beta2-glycoprotein Antibodies and Endothelial Dysfunction

Peripheral Arterial Disease

Spain
Jazz Pharmaceuticals

Completed

An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol

Epilepsy

Spain, United Kingdom
University of Oxford
World Health Organization

Completed

SPK Study in Afghanistan

Uncomplicated P. Falciparum Malaria

Afghanistan
St George's, University of London
European Union

Completed

Reactogenicity and Immunogenicity of Cervico-vaginal CN54gp140-hsp70 Conjugate Vaccine (TL01)

HIV Infections

United Kingdom
Federal Center of Cerebrovascular Pathology and...

Unknown

Russian Prospective Multicenter Registry Study of Intravenous Thrombolytic Therapy for Acute Ischemic Stroke (IVT-AIS-R)

The Aim the Study is to Collect and Analyze Data on Patients With Acute Ischemic Stroke During Intravenous Thrombolytic Therapy With Alteplase

Russian Federation
Hospital de Mataró

Unknown

The Effect of Beta-blockers in Substance P Levels and the Swallowing Function (BETASP)

Swallowing Disorder | Beta Blockers | Substance P

Spain
University of Washington
Bastyr University

Completed

Resveratrol and Midazolam Metabolism

Healthy

United States
MedImmune LLC

Completed

Phase 1 Randomized Double-blind Placebo Controlled Study to Evaluate Safety and PK of MEDI3902 in Healthy Adults

MEDI3902 for Prevention of P. Aeruginosa Pneumonia

United States
University College, London
National Institute of Allergy and Infectious Diseases (NIAID)

Unknown

CMV Glycoprotein B Vaccine in Allograft Recipients

Cytomegalovirus Infections

United Kingdom
Sulaiman AlRajhi Colleges

Unknown

The Association Between Serum β-hydroxybutyrate and Levels of Systemic Hypertension (BHB-RCT)

Hypertension, Essential | β-hydroxybutyrate
Woman's Health University Hospital, Egypt
Luxor International Hospital

Unknown

Kidney Injury Biomarkers in Preeclampsia

Hypertension, Pregnancy-Induced
Centre Hospitalier Universitaire, Amiens
Roche Pharma AG; Astellas Pharma Inc

Completed

TACrolimus in Renal Transplantation: Individualization by Pharmacogenetic

Kidney Transplantation

France
University Hospital, Basel, Switzerland

Recruiting

Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents (EryAdo)

Insulin Resistance | Body Composition | Glucose Tolerance | Gastrointestinal Tolerance | Thrombocyte Aggregation | Blood p-Selectin | Blood Erythritol

Switzerland
Jazz Pharmaceuticals

Completed

Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms (GWPCARE7)

Infantile Spasms

United States, Poland
National Institute of Diabetes and Digestive and...
University of Pennsylvania; George Washington University

Unknown

Gut Microbiome and p-Inulin in CKD - TarGut CKD Study (TarGut)

Chronic Kidney Diseases

United States
Jazz Pharmaceuticals

Completed

A Randomized Controlled Trial to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol

Epilepsy

Spain, United Kingdom
Pfizer

Completed

Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants

Healthy Volunteers | Adult | Drug Interactions | Humans

Belgium
HK inno.N Corporation

Completed

Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis

GERD | Erosive Esophagitis

Korea, Republic of
Weleda AG

Unknown

Bryophyllum vs. Nifedipine

Tocolysis

Switzerland
Milton S. Hershey Medical Center
Genzyme, a Sanofi Company

Completed

Effects of a Non-Calcium Based Phosphate Binder on FGF23 Levels in Chronic Kidney Disease

Chronic Kidney Disease

United States
Centre Muraz
Institute of Tropical Medicine, Belgium

Completed

Artemether-lumefantrine (AL) Versus Artesunate + Amodiaquine (ASAQ) for the Treatment of Uncomplicated Falciparum Malaria in Burkina Faso (ACTE)

Uncomplicated P. Falciparum Malaria in Children

Burkina Faso
London School of Hygiene and Tropical Medicine
Medical Research Council Unit, The Gambia

Completed

Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum

Asymptomatic P.Falciparum Malaria

Gambia
National Human Genome Research Institute (NHGRI)

Recruiting

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

Myoclonus | Neurological Regression | Cherry Red Spot | Brain Atrophy

United States
University College, London

Completed

CMV Glycoprotein B (gB) Vaccine Long Term Antibody Response

Viraemia

United Kingdom
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery

Pain | Impacted Third Molar Tooth | Other Surgical Procedures | Cytochrome P450 CYP2C9 Enzyme Deficiency
Pfizer
London School of Hygiene and Tropical Medicine; Medicines for Malaria Venture

Terminated

Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa

Intermittent Preventive Treatment In Pregnancy (IPTp)

Malawi, Benin, Kenya, Tanzania, Uganda
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers

Healthy Volunteers

United States
Chemical Resources

Completed

Evaluation of Furosap in Human Volunteers

Hypogonadism

India

Search clinical trials for: Drug interactions (Cytochrome P450 and p-glycoprotein)

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