Search clinical trials for: Epithelial Sodium Channel Inhibitor

Total 93040 results

Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2 (MsDR 2)

Heart Failure

United States
Cambridge University Hospitals NHS Foundation Trust
Medical Research Council

Recruiting

Comparison of Optimal Hypertension Regimens (AIMHY-INFORM)

Hypertension

United Kingdom
Sarcoma Oncology Research Center, LLC
Tyme, Inc

Active, not recruiting

SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma (HopES)

Sarcoma | Sarcoma, Ewing

United States
University Hospital Tuebingen

Terminated

Amiloride in Nephrotic Syndrome (AMILOR)

Edema | Nephrotic Syndrome | Sodium Retention

Germany
GlaxoSmithKline

Completed

Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions

Hypertension

South Africa
University of Utah
Boston University; University of Pennsylvania; Northwestern University; Columbia... and other collaborators

Completed

ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

Hypertension | COVID

United States
Guangdong Provincial People's Hospital

Completed

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein (ANTI-UPRO)

Chronic Kidney Diseases

China
University College, London
University of Leeds; University of Sheffield; Medical Research Council; Queen Mary... and other collaborators

Completed

MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART)

Secondary Progressive Multiple Sclerosis

United Kingdom
Hospital de Clinicas de Porto Alegre
Instituto de Cardiologia do Rio Grande do Sul

Unknown

Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.

Hypertension

Brazil
Hospices Civils de Lyon

Completed

Microcirculation & ASICs

Physiological Conditions

France
Sao Jose do Rio Preto Medical School

Completed

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension (ResHypOT)

Hypertension Resistant to Conventional Therapy

Brazil
Hospital de Clinicas de Porto Alegre

Completed

Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea (DOSA-2)

Hypertension | Sleep Apnea

Brazil
University of New Mexico
University of Pittsburgh; Dialysis Clinic, Inc.

Terminated

Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes

Hypertension | Proteinuria | Type II Diabetes

United States
Erasmus Medical Center

Completed

DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease (DD)

Chronic Kidney Disease

Netherlands
University of Colorado, Denver
University of Aarhus

Completed

Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus

United States, Denmark
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

Action to Control Cardiovascular Risk in Diabetes (ACCORD) (ACCORD)

Cardiovascular Diseases | Coronary Disease | Hypertension | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Atherosclerosis | Hypercholesterolemia

United States, Canada
Central Finland Hospital District
Biosense Webster, Inc.

Unknown

Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Ischemic Ventricular Tachyarrhythmias (MANTRA-VT)

Myocardial Infarction | Ventricular Tachyarrhythmia

Finland
Hospital de Clinicas de Porto Alegre

Completed

Effect of Antihypertensive Agents Over Sleep Apnea

Hypertension | Obstructive Sleep Apnea

Brazil
Gilead Sciences

Withdrawn

A Phase 1 Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS 9411 in Subjects With Cystic Fibrosis (CF)

Cystic Fibrosis | Mucociliary Clearance

Australia
St George's, University of London

Terminated

Extracellular Fluid in Resistant Hypertension

Hypertension

United Kingdom
Medical University of Vienna

Unknown

Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve

Optic; Neuritis, With Demyelination

Austria
Hospital de Clinicas de Porto Alegre
Financiadora de Estudos e Projetos

Completed

Hypertension Prevention in Pre-Hypertensive Individuals (PREVER)

Hypertension | Cardiovascular Disease | Pre-hypertension

Brazil
Hospital de Clinicas de Porto Alegre
Financiadora de Estudos e Projetos

Completed

Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension (PREVER)

Hypertension | Cardiovascular Disease

Brazil
University of California, San Francisco
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Diuretics, Hypertension, and Arrhythmias Clinical Trial

Heart Diseases | Cardiovascular Diseases | Hypertension | Heart Arrest | Death, Sudden, Cardiac
University of Carabobo
Clinical Research Unit at the Instituto Docente de Urologia; Northern Metropolitan... and other collaborators

Unknown

Novel Treatment for Coronary Artery Disease

Coronary Artery Disease

Venezuela
Chinese Academy of Medical Sciences, Fuwai Hospital

Unknown

Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients (CHIEF)

Essential Hypertension

China
University of Carabobo
Northern Metropolitan Hospital; Venezuelan Foundation of Heart Failure; Clinical...

Completed

Treatment of Coronary Heart Disease With Amiloride

Coronary Heart Disease

Venezuela
Eurofarma Laboratorios S.A.

Unknown

Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension (CARD)

Arterial Hypertension

Brazil
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Physiopathology of Sodium Retention in Acromegaly (AcromEnaC)

Acromegaly

France
Radboud University Medical Center

Completed

The Influence of Rosiglitazone on the Diuretic Effect of Furosemide and Amiloride

Insulin Resistance

Netherlands
Gilead Sciences

Completed

A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Trial of GS-9411 in Healthy Volunteers

Cystic Fibrosis | Mucociliary Clearance | Airway Hydration

Australia
Gilead Sciences

Completed

Trial to Assess the Safety, Tolerability and Pharmacokinetics of GS-9411 in Healthy Male Volunteers

Cystic Fibrosis

Australia
Gilead Sciences

Completed

A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS-9411 in Healthy Male Volunteers

Cystic Fibrosis | Mucociliary Clearance | Airway Hydration

Australia
University of Aarhus
Novartis; Danish Heart Foundation; Danish Cardiovascular Research Academy

Terminated

Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris

Hypertension | Microvascular Angina

Denmark
University of Cambridge
British Heart Foundation

Unknown

Double Blind Crossover Comparison of Diuretics in the Young

Low-Renin Hypertension

United Kingdom
Hospital de Clinicas de Porto Alegre

Completed

Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril

Hypertension

Brazil
Sun Yat-sen University
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

PD-1 Antibody and Sapropterin Dihydrochloride in Patients With PDAC

Pancreatic Adenocarcinoma Metastatic

China
Eyestem Research Pvt. Ltd.

Not yet recruiting

Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.

Eye Diseases | Age-Related Macular Degeneration | Macular Degeneration | Geographic Atrophy | Retinal Disease
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
Bayer

Recruiting

A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United States
DICE Therapeutics, Inc., a wholly owned subsidiary...
Eli Lilly and Company

Recruiting

A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants

Healthy

United States
Nantes University Hospital

Recruiting

Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation (EDearly AF)

Atrial Fibrillation

France
Yuhan Corporation

Recruiting

Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension

Essential Hypertension

Korea, Republic of
National Institute of Cardiology, Warsaw, Poland

Recruiting

Optimal Medical Treatment of Difficult-to-treat Hypertension (OPTIMAL-HT)

Hypertension

Poland
Police General Hospital, Thailand

Not yet recruiting

Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response

Atrial Fibrillation
Servier Russia

Not yet recruiting

Evaluation of the Antihypertensive effectIveness, Tolerability, and Adherence With Amlodipine/ Indapamide/ Perindopril Triple Single-pill Combination in Hypertensive Patients Without Concomitant Antihypertensive Therapy (TRIPTYCH) (TRIPTYCH)

Arterial Hypertension | HTN
Ohio State University Comprehensive Cancer Center

Recruiting

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

Merkel Cell Carcinoma | Cutaneous Melanoma | Skin Squamous Cell Carcinoma

United States
Taipei Medical University Shuang Ho Hospital

Recruiting

Steroid Injection With Exercise for Subacromial Bursitis

Shoulder Bursitis

Taiwan
Beijing Suncadia Pharmaceuticals Co., Ltd

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of SHR-2004 Injection in Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery

Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery
iN Therapeutics Co., Ltd.

Recruiting

A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.

Pain | Osteoarthritis | Chronic Pain | Neuropathic Pain | Post Herpetic Neuralgia

Australia

Search clinical trials for: Epithelial Sodium Channel Inhibitor

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