Search clinical trials for: Genetically attenuated sporozoites

Total 609 results

National Institute of Allergy and Infectious Diseases...

Completed

Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO Sporozoites

Plasmodium Falciparum Infection

United States
Sanaria Inc.
Radboud University Medical Center; Leiden University Medical Center

Completed

Safety and Protective Efficacy of Genetically Attenuated PfSPZ-GA1 Vaccine in Healthy Dutch Volunteers

Malaria

Netherlands
National Institute of Allergy and Infectious Diseases...
Malaria Research and Training Center, University of Science Techniques and...

Completed

Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in Mali

Malaria

Mali
Leiden University Medical Center

Completed

Safety and Preliminary Protective Efficacy of Genetically Attenuated GA2 Parasites.

Plasmodium Falciparum Malaria

Netherlands
National Institute of Allergy and Infectious Diseases...
Sanaria Inc.; Malaria Research and Training Center, Bamako, Mali

Completed

Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Natural Transmission Season in Healthy African Adults in Mali

Malaria

Mali
National Institute of Allergy and Infectious Diseases...

Completed

Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali

Malaria

Mali
U.S. Army Medical Research and Development Command
Bill and Melinda Gates Foundation; Seattle Children's Research Institute (SCRI)

Completed

Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites (IMRAS)

Malaria

United States
Sanofi Pasteur, a Sanofi Company

Recruiting

Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers (CORAL)

RSV Immunization

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Next-Generation alzheImer'S Therapeutics (ENERGISE)

Alzheimer Disease

Italy
Roswell Park Cancer Institute

Recruiting

Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies

Recurrent Mantle Cell Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Chronic Lymphocytic Leukemia | Refractory Mantle Cell Lymphoma | Recurrent High Grade B-Cell Lymphoma | Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell... and other conditions

United States
CARsgen Therapeutics Co., Ltd.

Not yet recruiting

Anti-GPRC5D CAR-T Cells (CT071) in Participants With RRMM or RRpPCL

Multiple Myeloma | Primary Plasma Cell Leukemia
Chiang Mai University
Faculty of Medicine, Chiang Mai University

Not yet recruiting

Immunogenicity and Safety of Inactivated and Live-attenuated HAV Vaccine Among Thai Healthy Children and Adolescents (HAV-RCT)

Hepatitis A | Vaccine-Preventable Diseases | Hep A | HAV
Leiden University Medical Center

Not yet recruiting

Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)

Malaria,Falciparum
Changchun BCHT Biotechnology Co.
Hu Bei province Center for Disease control and prevention; The Inner Mongolia...

Recruiting

Post-marketing Study of Lyophilized Nasal Spray Live Attenuated Influenza Vaccine

Influenza Prevention

China
Public Health Vaccines LLC
Biomedical Advanced Research and Development Authority

Recruiting

Study to Evaluate the Recombinant Vesicular Stomatitis Virus (rVSV)-Marburg Virus Vaccine Candidate (PHV01) in Healthy Adult Subjects (PHV01)

Marburg Virus Disease

United States
S.LAB (SOLOWAYS)
Center of New Medical Technologies

Recruiting

Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels. (PERBIO-HC)

Hyperhomocysteinemia

Russian Federation
National Cancer Institute (NCI)

Recruiting

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Gastrointestinal Cancer | Genitourinary Cancer | Metastatic Solid Cancers

United States
Public Health Vaccines LLC
Coalition for Epidemic Preparedness Innovations

Recruiting

Study to Evaluate Safety and Immunogenicity of a Prime-Boost Regimen of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects

Nipah Virus Infection

United States
University of Copenhagen
Gentofte Hospital, Denmark

Recruiting

The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function (H-21044858)

Incretin Effect

Denmark
M.D. Anderson Cancer Center

Recruiting

Phase I/II Trial of Cord Blood-Derived NK Cells Genetically Engineered With NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma

Myeloma

United States
University of Udine
National Research Council (CNR), Institute of Biomolecular Chemistry (ICB)...

Recruiting

Endocannabinoid Activity Remodulation for Psychosis Liability in Youth (EARLY)

Clinical High Risk for Psychosis | Ultra High Risk for Psychosis | Attenuated Psychotic Symptoms

Italy
GlaxoSmithKline

Recruiting

Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Rotarix Porcine Circovirus (PCV)-Free Liquid Compared to Rotarix Liquid Given in 2-doses in Healthy Chinese Infants Starting at Age 6-16 Weeks

Gastroenteritis

China
Eveliqure Biotechnologies GmbH

Not yet recruiting

ShigETEC Vaccine Study in Bangladesh

Healthy Volunteers

Bangladesh
University Health Network, Toronto
Takara Bio Inc.

Recruiting

Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-transduced T Lymphocytes) for Relapsed or Refractory CD19+ B-cell Lymphoma, CLL/SLL

Relapsed or Refractory Chronic Lymphocytic Leukemia | Relapsed or Refractory Small Lymphocytic Lymphoma | Relapsed or Refractory CD19+ B-cell Lymphoma

Canada
University of Chile
Bharat Biotech International Limited

Recruiting

The Efficacy of Three Doses of Live Attenuated, Oral Rotavirus Vaccine 116E

Rotavirus Gastroenteritis

Chile
Shanghai Municipal Center for Disease Control and...
China National Biotec Group Company Limited

Not yet recruiting

Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine Coadministered With Two Attenuated Vaccines

Measles | Rubella | Mumps | Varicella | SARS-CoV-2 Infection

China
Dartmouth-Hitchcock Medical Center

Recruiting

Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor (GERTRUDE)

Advanced Breast Cancer

United States
DalCor Pharmaceuticals
The Montreal Health Innovations Coordinating Center (MHICC)

Recruiting

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS (dal-GenE-2)

Acute Coronary Syndrome

United States, Canada, Puerto Rico
Adam Kittai

Recruiting

Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndrome

Recurrent Transformed Non-Hodgkin Lymphoma | Recurrent Transformed B-Cell Non-Hodgkin Lymphoma | Refractory Transformed Non-Hodgkin Lymphoma | Refractory Transformed B-cell Non-Hodgkin Lymphoma | Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma | Recurrent Transformed... and other conditions

United States
Peter MacCallum Cancer Centre, Australia

Recruiting

Genetically Risk-Stratified Venetoclax, Ibrutinib, Rituximab (± Navitoclax) in Relapsed/Refractory Mantle Cell Lymphoma

Mantle Cell Lymphoma Refractory

Australia
Emory University
Defense Advanced Research Projects Agency

Recruiting

Systems Biological Assessment of the Durability of Vaccine Responses (DARPASB)

Vaccine Response

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma

Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | High Grade B-Cell Non-Hodgkin's Lymphoma | Intermediate Grade B-Cell Non-Hodgkin's Lymphoma

United States
Fox Chase Cancer Center

Recruiting

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Lung Cancer | Non Small Cell Lung Cancer | Small-cell Lung Cancer

United States
St. Jude Children's Research Hospital

Recruiting

Long-term Follow-up After Adoptive Transfer of Genetically Modified Cell Products

Refractory Hematologic Malignancy | Relapsed Hematologic Malignancy

United States
Hospital Israelita Albert Einstein
Miltenyi Biotec, Inc.

Not yet recruiting

A Phase I Clinical Trial Using Genetically Engineered Autologous T Cells to Express Chimeric Antigen Receptor (CAR) for Treatment of Patients With Refractory or Relapsed CD19-positive B Lymphoid Malignancies (CARTHIAE-1)

Acute Lymphoblastic Leukemia, in Relapse | B-cell Lymphoma Refractory | B-cell Lymphoma Recurrent | Chronic Lymphocytic Leukemia Recurrent | Chronic Lymphocytic Leukemia Refractory | Acute Lymphoblastic Leukemia Refractory

Brazil
National Institutes of Health Clinical Center (CC)

Not yet recruiting

Imaging Characterization of the Biomechanical Coupling of Brain and Skull

Traumatic Brain Injury (Tbi) | Traumatic Meningeal Enhancement (Tme)

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation

Richter Syndrome | Recurrent Transformed Chronic Lymphocytic Leukemia | Refractory Transformed Chronic Lymphocytic Leukemia

United States
In8bio Inc.

Recruiting

A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma

Glioblastoma

United States
PATH
Bill and Melinda Gates Foundation; Centers for Disease Control and Prevention; PT Bio Farma and other collaborators

Recruiting

Study of a Novel Type 3 Oral Poliomyelitis Vaccine in Panama

Poliomyelitis

Panama
PATH
Bill and Melinda Gates Foundation; Centers for Disease Control and Prevention; PT Bio Farma and other collaborators

Recruiting

Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh

Poliomyelitis

Bangladesh
SWOG Cancer Research Network
National Cancer Institute (NCI); Genentech, Inc.

Recruiting

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B-Cell Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Grade 3b Follicular Lymphoma | Transformed Follic Lymph to Diff Large B-Cell Lymphoma | Transformed Marg Zone Lymph to Diff...

United States
Universidade do Porto

Not yet recruiting

Menthol Mouth Rinsing and Performance Responses of Elite Football Referees in the Heat

Exercise Induced Hyperthermia | Performance Demands of Exercising in the Heat
Adaptimmune
GOG Foundation

Recruiting

ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

Ovarian Cancer

United States, Spain, France, Canada, United Kingdom
Vanderbilt University Medical Center

Recruiting

Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals (RARE-PAH)

Idiopathic Pulmonary Arterial Hypertension | Heritable Pulmonary Arterial Hypertension | Unaffected Mutation Carriers: Healthy Participants With a Known BMPR2 Gene Mutation and Normal Pulmonary Pressure and RV Function on Echo | Healthy Individuals With no Cardiopulmonary Disease

United States
Singapore General Hospital
Duke-NUS Graduate Medical School

Recruiting

An Experimental Medicine Decipher of a Minimum Correlate of Cellular Immunity

Japanese Encephalitis | Infectious Disease | Yellow Fever | Viral Infection

Singapore
Cancer Institute and Hospital, Chinese Academy...
Beijing ChineoMedical Technology Co., Ltd

Not yet recruiting

A Phase I Clinical Study to Evaluate the Safety, the Tolerability, the Pharmacokinetic Characteristics and the Efficacy of ScTIL Injection (Genetically Modified Tumor Infiltrating Lymphocytes) in the Treatment of Advanced Malignant Solid Tumors

Advanced Tumor of Digestive Tract or Urinary System

China
Hospital Universitario Dr. Jose E. Gonzalez

Recruiting

Effectiveness and Safety of Therapy Based on Attenuated ATO Plus Low-Dose ATRA in Patients With APL

Promyelocytic Leukemia

Mexico
University of California, San Francisco
Parker Institute for Cancer Immunotherapy; The V Foundation; Alliance for Cancer...

Recruiting

Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (PNOC018)

Diffuse Midline Glioma, H3 K27M-Mutant

United States
Mahidol University

Not yet recruiting

Safety, Virological and Immunological Assessment of Live Attenuated Dengue Serotype 2 rDEN2delta30-7169. (DHIT)

Dengue

Thailand
Leiden University Medical Center

Recruiting

Coadministration of GA2 Sporozoites With Adjuvants (CoGA)

Malaria,Falciparum

Netherlands

Search clinical trials for: Genetically attenuated sporozoites

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