Search clinical trials for: HER2-ve metastatic

Total 14413 results

Enliven Therapeutics

Recruiting

ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer (HER2)

HER2-positive Metastatic Breast Cancer | HER2 Gene Mutation | HER2 Mutant Non-small Cell Lung Cancer | HER2 Amplification

Spain, United States, Korea, Republic of, Taiwan, Italy, Australia, France
SOLTI Breast Cancer Research Group
Novartis; Alliance Foundation Trials, LLC.

Recruiting

Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype (HARMONIA)

Metastatic Breast Cancer

United States, Spain, Portugal
Jazz Pharmaceuticals
BeiGene, Ltd.

Active, not recruiting

A Study of ZW25 (Zanidatamab) in Subjects With Advanced or Metastatic HER2-Amplified Biliary Tract Cancers (HERIZON-BTC-01)

HER2-amplified Biliary Tract Cancers

United States, Spain, United Kingdom, Korea, Republic of, Canada, China, Italy, Chile, France
AstraZeneca

Enrolling by invitation

Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Olaparib (ROSY-O)

Breast Cancer | Ovarian Cancer

Italy, Spain, United States, Canada, Belgium, Denmark, Korea, Republic of, Czechia, Turkey, China, United Kingdom, Taiwan, Brazil, Israel, France, Hungary, Poland, Portugal, Germany, Russian Federation, Bulgaria, Finland, Slovenia, Sw...
US Oncology Research
AbbVie; Pharmacyclics LLC.

Active, not recruiting

Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer

Breast Neoplasms | Malignant Neoplasm of Breast

United States
G1 Therapeutics, Inc.

Active, not recruiting

G1T38, a CDK 4/6 Inhibitor, in Combination With Fulvestrant in Hormone Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

Breast Cancer | Breast Neoplasm | Carcinoma, Ductal, Breast

United Kingdom, Bulgaria, Georgia, Moldova, Republic of
AstraZeneca

Completed

To Study Clinical Effectiveness and Safety of Olaparib Monotherapy in Metastatic Breast Cancer Patients.

HER2-ve Metastatic Breast Cancer | Germline BRCA1/2 Mutations | Somatic BRCA1/2 Mutations

Italy, Spain, Poland, Taiwan, Canada, France, Germany, Korea, Republic of, Hungary, Japan, Russian Federation, Turkey, United Kingdom, United States, Bulgaria
G1 Therapeutics, Inc.

Completed

G1T48, an Oral SERD, Alone and in Combination With Palbociclib in ER-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer | Advanced Breast Cancer | Breast Neoplasm | Metastatic Breast Cancer | Stage IV Breast Cancer | Carcinoma, Ductal, Breast | Breast Cancer Female

United States, Belgium, Bulgaria, Georgia, Netherlands, Moldova, Republic of, Ukraine
Novartis Pharmaceuticals

Terminated

Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer

Neoplasms, Breast

Spain, United States, Argentina, Austria, Italy, Russian Federation, Thailand, Brazil, Peru, Philippines, Hong Kong, Mexico
AstraZeneca
Quintiles; University of Tubingen - Germany

Completed

International Breast Cancer Biomarker,Standard of Care and Real World Outcomes Study (BREAKOUT)

Breast Cancer

United States, Bulgaria, Italy, Korea, Republic of, Russian Federation, Spain, Turkey, Canada, Poland, Australia, Hungary, Taiwan, Japan, Germany, United Kingdom
Puma Biotechnology, Inc.

Completed

Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer

Breast Cancer

Spain, United Kingdom, France, United States, Denmark, Hong Kong
Centre Henri Becquerel

Not yet recruiting

Dynamic 68Ga-PSMA and 18F-FDG PET/CT Analysis Prior to 177Lu-PSMA (PYPET)

Prostate Cancer Metastatic

France
Blokhin's Russian Cancer Research Center

Recruiting

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Colorectal Cancer (GENCONCOR-1)

Colorectal Cancer Metastatic | Brain Metastases, Adult | HER2 Gene Mutation | MSI | BRAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation

Russian Federation
Anhui Provincial Hospital
First Affiliated Hospital of Wannan Medical College

Recruiting

Local Liver Treatment for Multi-organ Colorectal Cancer Metastases

Metastatic Malignant Neoplasm in the Liver | Metastatic Colorectal Carcinoma | Multi-organ Metastatic Colorectal Cancer

China
UNICANCER
Natera, Inc.

Not yet recruiting

Decreasing Treatment for Metastatic HER2-Positive Breast Cancer With Undectable Cancer Levels in Blood Tests. (HEROES)

Metastatic Breast Cancer | HER2-positive Breast Cancer
Pfizer

Recruiting

A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In Combination (LTbR)

Melanoma | Colorectal Cancer | Non-Small Cell Lung Cancer | Urothelial Cancer | Advanced or Metastatic Solid Tumors

United States, Puerto Rico
Zhongda Hospital

Recruiting

Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM

Colorectal Cancer Metastatic

China
Sichuan Kelun Pharmaceutical Research Institute...

Recruiting

A Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

HER2-positive Breast Cancer

China
University Hospital, Rouen

Not yet recruiting

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND)

Metastatic Colon Cancer
Uppsala University
Sahlgrenska University Hospital, Sweden; University Hospital, Umeå; Uppsala University... and other collaborators

Not yet recruiting

The Case of "Triple" Versus "Double" Therapy for Patients With High Volume Metastatic Hormone Sensitive Prostate Cancer (Lead4Care)

Prostate Cancer

Sweden
Revolution Medicines, Inc.

Recruiting

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Colorectal Cancer | Pancreatic Ductal Adenocarcinoma | Gastrointestinal Cancer | CRC | Metastatic Pancreatic Ductal Adenocarcinoma | PDAC

United States
Fudan University

Recruiting

Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA

Colorectal Cancer Metastatic

China
University Hospital, Brest

Not yet recruiting

Impact of Respiratory Rehabilitation on Quality of Life in Patients With Metastatic Non-small Cell Lung Cancer Treated With Immunotherapy and Chemotherapy in the Maintenance Phase (REHABIM)

Cancer
Angiex, Inc.

Recruiting

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Cancer | Pancreatic Adenocarcinoma | Triple Negative Breast Cancer | Metastatic Solid Tumor | Advanced Cancer | Pancreas Cancer | Locally Advanced Carcinoma

United States
National Cancer Institute (NCI)

Not yet recruiting

Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

Metastatic Urothelial Carcinoma | Unresectable Urothelial Carcinoma
Canadian Cancer Trials Group
Canadian Institutes of Health Research (CIHR)

Not yet recruiting

Platinum and Taxane Chemo in Met Castration Resistant Prostate Cancer Patients With Alterations in DNA Damage Response Genes (OPTION-DDR)

Metastatic Prostate Cancer | Metastatic Castration-resistant Prostate Cancer
MediLink Therapeutics (Suzhou) Co., Ltd.

Not yet recruiting

A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of YL202 in Patients With BC

Locally Advanced or Metastatic Breast Cancer

China
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Recruiting

TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic Osteosarcoma and Other Solid Tumors

Osteosarcoma | Other Solid Tumors

China
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

Lymphocyte Support to SBRT in Patients With Oligo-metastatic Solid Cancer (LySATRA)

Solid Tumor, Adult | Oligometastatic Disease

France
Dana-Farber Cancer Institute
Johns Hopkins University; Translational Breast Cancer Research Consortium

Not yet recruiting

The SAPPHO Study: A Single-Arm, Phase II Study of Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Breast Cancer | HER2-positive Breast Cancer | Stage IV Breast Cancer | Breast Cancer Female | Breast Cancer Metastatic | Estrogen Receptor-positive Breast Cancer

United States
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors

Head and Neck Squamous Cell Carcinoma

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Study and Modulation of Immune Responses in Primary and Metastatic Colon Cancers (I-COMET)

Colon Cancer | Peritoneal Carcinoma

France
Roswell Park Cancer Institute

Not yet recruiting

Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma | Locally Advanced Unresectable Triple-Negative Breast Carcinoma

United States
Peking University Cancer Hospital & Institute

Not yet recruiting

Molecular Imaging of Gastric Cancer Metastatic Lymph Nodes with 99mTc-3PRGD2 Probe.

Stomach Neoplasm | Lymph Node Metastasis | RADIONUCLIDE IMAGING
S.LAB (SOLOWAYS)
Center of New Medical Technologies

Not yet recruiting

Clinical Trial Protocol: Randomized Placebo-Controlled Pilot Study of GcMAF (Soloways TM) in Patients With Metastatic Breast Cancer

Breast Cancer

Russian Federation
Jazz Pharmaceuticals

Not yet recruiting

A Phase 3, Randomized, Open-label, Controlled Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Metastatic HER2-positive Breast Cancer
Sun Yat-sen University

Not yet recruiting

Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer

Colorectal Cancer

China
Ba Yi
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Clinical Study of Irinotecan Hydrochloride Liposome Combined With Capecitabine for Second-line Treatment in Patients With Advanced or Metastatic Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
Nanjing First Hospital, Nanjing Medical University

Recruiting

Safety and Efficacy of Recombinant Human Thyroid Stimulating Hormone for Adjuvant Diagnosis in Patients With Locally Advanced/Metastatic Differentiated Thyroid Cancer

Recombinant Human Thyroid Stimulating Hormone

China
Medical University of Vienna
Lund University; Ziekenhuis Netwerk Antwerpen (ZNA); St. Antonius Hospital; Azienda... and other collaborators

Not yet recruiting

Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study (OLIGOMET)

Prostate Cancer | Prostate Cancer Metastatic | Oligometastasis | Prostate Neoplasm | Oligometastatic Disease | Prostate Cancer Metastatic to Bone
Paul Viscuse

Not yet recruiting

Remotely Monitored Exercise Interventions in Patients With mCSPC Undergoing ADT (Prostate 006)

Metastatic Prostate Cancer | Castrate Sensitive Prostate Cancer

United States
AstraZeneca

Not yet recruiting

A PROSPECTIVE, MULTI-CENTER, PHASE 4 STUDY TO ASSESS THE SAFETY OF TRASTUZUMAB DERUXTECAN, AN ANTI-HER2-ANTIBODY DRUG CONJUGATE IN INDIAN PATIENTS WITH UNRESECTABLE OR METASTATIC HER2-POSITIVE BREAST CANCER WHO HAVE RECEIVED A PRIOR ANTI-HER2-BASED REGIMEN (STRIDE)

BREAST CANCER
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Study of SHR-A1811 in First-line Treatment of Patients With Advanced or Metastatic Non-small Cell Lung Cancer With HER2 Mutations

Non-Small Cell Lung Cancer With HER2- Mutations

China
Necmettin Erbakan University
Health Institutes of Türkiye (TUSEB)

Not yet recruiting

The Impact of Probiotic on Survival and Treatment Response in Metastatic Non-small Cell Lung Cancer Patients

Metastatic Non-small Cell Lung Cancer

Turkey
Merck Sharp & Dohme LLC

Not yet recruiting

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Metastatic Breast Cancer
BeiGene

Not yet recruiting

A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumors

Metastatic Solid Tumor | Advanced Hepatocellular Carcinoma | Metastatic Hepatocellular Carcinoma | Alpha-fetoprotein (AFP)-Producing Gastric Cancer | Extragonadal Yolk Sac Tumors | Glypican-3 (GPC3)-Positive Squamous Non-small Cell Lung Cancer
Western University

Recruiting

[18F] PSMA-1007 PET/CT in Metastatic Clear Cell Renal Cell Carcinoma

Metastatic Clear Cell Renal Cell Carcinoma

Canada
National Cancer Institute (NCI)

Not yet recruiting

Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy

Pheochromocytoma | Somatostatin Receptor Positive | Paragangliomas | Gastrointestinal Neuroendocrine Tumors

United States
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM

Gastric Cancer, Metastatic

Search clinical trials for: HER2-ve metastatic

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