Search clinical trials for: Healthy Recreational CNS Depressant Users

Total 74562 results

Takeda

Completed

A Study of Soticlestat in Healthy Adult Nondependent Recreational Drug Users With Central Nervous System (CNS) Depressant Experience

Healthy Volunteers

United States
AstraZeneca

Completed

Study to Evaluate the Abuse Potential of AZD7325 in Healthy Recreational Central Nervous System (CNS) Depressant Users

Recreational CNS Depressant Use

Canada
Azurity Pharmaceuticals

Completed

An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users

Abuse Potential

United States
Azurity Pharmaceuticals

Completed

Evaluation of Abuse Potential of HORIZANT Taken Alone and With Oxycodone in Healthy, Nondependent Recreational Opioid Users

Abuse Potential

United States
Viatris Specialty LLC

Completed

Study Evaluating the Abuse Potential of NEURONTIN® in Healthy Non-drug Dependent, Recreational Opioid Users

Abuse Potential

United States
Viatris Specialty LLC

Completed

Study Evaluating Abuse Potential of Lyrica® in Healthy Non-Drug Dependent Recreational Opioid Users

Abuse Potential

United States
Janssen Research & Development, LLC

Completed

A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem

Healthy Non-dependent, Recreational Sedative Users | Abuse Potential

United States
Nektar Therapeutics

Terminated

A Study Using fMRI Imaging to Evaluate the Effect of NKTR-181 on Brain Activity in Healthy, Non-physically Dependent Recreational Opioid Users.

Moderate to Severe Chronic Pain

United States
Eisai Inc.
Purdue Pharma LP

Completed

A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users

Insomnia Disorders

Canada
Paion UK Ltd.
PRA Health Sciences

Completed

Abuse Potential of Intravenous Remimazolam Compared to Midazolam and Placebo in Recreational CNS Depressant Users

Abuse, Drug

United States
Idorsia Pharmaceuticals Ltd.

Completed

Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users

Healthy Recreational Drug Users

United States, Canada
SK Life Science, Inc.

Completed

A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users

Healthy Volunteer

United States, Canada
Bioprojet

Completed

Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users

Healthy | Drug Abuse

Canada
Endo Pharmaceuticals
Kendle Early Stage - Toronto

Completed

Study to Compare Oxymorphone Extended-Release (Opana ER) Versus Oxycodone Controlled-Release (Oxycontin)

Healthy

Canada
Pfizer
Syneos Health

Completed

A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted

Healthy

Canada
Hoffmann-La Roche

Completed

A Study of The Abuse Liability Potential of RO4917838 in Recreational Drug Users

Healthy Volunteer

United States
Alkermes, Inc.

Completed

A Study of the Abuse Liability Potential of ALKS 5461 in Healthy, Non-Dependent, Recreational Opioid Users

Healthy

United States
Alkermes, Inc.

Completed

A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users

Healthy Volunteers

United States
Pfizer
Lifetree Clinical Research Center, Salt Lake City, Utah

Completed

A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users

Healthy

United States
Pfizer
Medivation, Inc.

Completed

A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug Users

Alzheimer's Disease | Huntington's Disease
AstraZeneca

Withdrawn

Study in Healthy Recreational Polydrug Users to Measure the Abuse Potential of TC-5214 (TC-5214)

Healthy | Drug Abuse
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

A Study to Evaluate Abuse Potential of Istradefylline

Drug Abuse

United States
Haisco-USA Pharmaceuticals, Inc.

Completed

Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

General Anesthesia

United States
AstraZeneca

Completed

A Study to Assess the Effect of AZD4041 on Respiratory Drive in Recreational Opioid Users.

Opioid Use Disorder

United States
Ensysce Biosciences
Dr. Vince Clinical Research

Completed

A Study to Evaluate the Oral Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users

Recreational Drug Use

United States
Ensysce Biosciences

Completed

A Study to Evaluate the Intranasal Abuse Potential of PF614 in Non-Dependent Recreational Opioid Users

Recreational Drug Use

United States
Washington University School of Medicine

Terminated

Pgp Transporter and CNS Biodistribution of Ondansetron in Healthy Volunteers

Neuropathic Pain

United States
Neurana Pharmaceuticals, Inc.

Completed

Effects of Tolperisone on Measures of Drowsiness and Cognitive Function

Healthy

United States
Tris Pharma, Inc.

Completed

A Trial to Evaluate the Abuse Potential of 3 Doses of GRT6005 in Adult Non-dependent Recreational Opioid Users

Abuse, Drug

Canada
Neurocrine Biosciences
Takeda

Completed

A Study to Evaluate Central Nervous System (CNS) Pharmacodynamic Activity of TAK-653 in Healthy Participants Using Transcranial Magnetic Stimulation (TMS)

Healthy Volunteers

Netherlands
Eli Lilly and Company

Completed

A Study of the Abuse Potential of Lasmiditan in Participants Who Are Recreational Drug Users

Prescription Drug Abuse (Not Dependent) | Recreational Drug Use

United States
Charleston Laboratories, Inc

Completed

A Study in Opioid-Experienced, Non-Dependent Recreational Drug Users to Determine the Abuse Potential and Safety of CL-108 Tablets Administered Via the Oral Route

Pain | Nausea | Vomiting
Paion UK Ltd.
PRA Health Sciences

Completed

Oral Remimazolam With and Without Alcohol in Healthy Female Subjects

Safety Issues

United States
Eisai Inc.

Completed

Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users

Healthy | Drug Abuse

Canada
Acura Pharmaceuticals Inc.
King Pharmaceuticals is now a wholly owned subsidiary of Pfizer

Completed

Study of the Relative Abuse Potential of Acurox Tablets in Non-Dependent Recreational Opioid Users

Opioid Abuse

United States
Acura Pharmaceuticals Inc.

Completed

Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users

Opioid-Related Disorders

United States
Pfizer
Syneos Health

Completed

A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers

Healthy

Canada
Tetra Discovery Partners

Completed

Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers

Alzheimer Disease

United States
Biotie Therapies Inc.
Acorda Therapeutics

Terminated

A Study to Determine the Abuse Potential of Tozadenant Relative to D-Amphetamine and Placebo When Administered Orally in Healthy, Non-Dependent, Recreational Polydrug Users

Abuse Potential

Canada
Janssen Sciences Ireland UC

Completed

A Study in Healthy Female Participants to Investigate the Effect of JNJ-56136379 at Steady-state on the Single-dose Pharmacokinetics of Ethinylestradiol and Drospirenone (Oral Contraceptive) and on the Single-dose Pharmacokinetics of Midazolam (Probe Substrate for Cytochrome P450 3A4)

Healthy

Belgium
Tehran University of Medical Sciences

Completed

The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects

Multiple Sclerosis | Oxidative Stress

Iran, Islamic Republic of
Janssen Research & Development, LLC

Completed

Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users

Drug Abuse

United States
Aziende Chimiche Riunite Angelini Francesco S.p.A
Cross Research S.A.

Completed

Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg

Healthy
Midnight Pharma, LLC

Completed

Study to Evaluate the Relative Abuse Potential of Almorexant in Recreational Drug Users

Abuse Potential Study
GlaxoSmithKline

Terminated

SPECT Investigation Of The NMDA Receptor System In Healthy Volunteers And Patients With Schizophrenia

Schizophrenia

Spain
Neurovance, Inc.

Completed

A Study to Evaluate the Abuse Potential of EB-1020 Immediate-Release in Healthy Recreational Stimulant Users

Healthy Volunteers | Drug Users

United States
Seoul National University Hospital
Seoul National University Bundang Hospital

Completed

Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs

Healthy

Korea, Republic of
Cephalon

Completed

A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users

Drug Abuse

United States, Canada
James J. Prisciandaro
National Institute on Drug Abuse (NIDA)

Completed

Brain Imaging of Cocaine Craving in Recreational Cocaine Users

Cocaine Related Disorders

United States
Pfizer

Completed

Abuse Potential of Orally Administered Crushed Embeda Compared to Crushed Controlled-Release Morphine and Placebo in Non-Dependent Recreational Opioid Users

Nondependent Opioid Abuse, Episodic

United States

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