Search clinical trials for: High surgical risk

Total 40241 results

Ning Xu
The First Affiliated Hospital of Nanchang University; Zhongshan Hospital Xiamen... and other collaborators

Not yet recruiting

Posterior Extra-fascial RARP in Intermediate or High Risk Prostate Cancer

Prostate Cancer | Surgical Procedure, Unspecified
Tanta University

Recruiting

Trendelenburg Maneuver Versus Passive Leg Raising Test for Fluid Responsiveness in High-Risk Surgical Patients

Passive Leg Raising | High-Risk Surgical Patients | Trendelenburg Maneuver

Egypt
Aswan University

Recruiting

Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients

Critical Illness | Acute Kidney Injury

Egypt
University of Calgary

Not yet recruiting

Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT

Ankle Fractures
Odense University Hospital
Karolinska University Hospital

Not yet recruiting

The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients. (EPICURE)

Gastric Cancer | Peritoneal Metastases | Chemotherapy, Adjuvant | Minimally Invasive Surgical Procedures

United States, Sweden, Denmark, France, Germany
Hospital del Mar

Not yet recruiting

Complications of Cholecystostomy in ACC (Chole_ACC)

Cholecystitis
Institut d'Investigació Biomèdica de Girona Dr....

Recruiting

Comparing PP and PVDF Meshes in Midline Laparotomy Closure for High-risk Colorectal Surgery. Impact on Incisional Hernia and Surgical Wound Infection. (PROFIMESH)

Colorectal Cancer | Wound Infection | Hernia Incisional

Spain
Frantz Viral Therapeutics, LLC
The Cleveland Clinic

Recruiting

Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3) (ART-VIN IIB)

Vulvar Diseases | HPV Infection | Vulvar HSIL | High Grade Intraepithelial Neoplasia | HPV Disease | Pre-Cancerous Dysplasia | Vin II | Vin III | VIN, Usual Type | VIN 2 of Usual Type | VIN 3 of Usual Type | VIN Grade 2 | VIN Grade 3

United States
National Cancer Institute (NCI)

Recruiting

Durvalumab With Gemcitabine and Cisplatin for the Treatment of High Risk Resectable Liver Cancer Before Surgery

Intrahepatic Cholangiocarcinoma

United States
Fred Hutchinson Cancer Center
ImmunoGen, Inc.

Recruiting

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm | Mixed Phenotype Acute Leukemia

United States
University of Washington
Eli Lilly and Company

Not yet recruiting

Evaluation of Abemaciclib and Radiation Therapy Before Surgery for the Treatment of High-Risk Adipocytic Retroperitoneal Sarcoma

Retroperitoneal Sarcoma

United States
St. Jude Children's Research Hospital

Recruiting

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Rhabdomyosarcoma

United States
Niguarda Hospital

Recruiting

Ischemic And Bleeding Risk Assessment After TAVR (FOCUS ONE)

Aortic Valve Stenosis | Transcatheter Aortic Valve Replacement

Italy, Belgium, Czechia, Chile, Spain
Elsan

Recruiting

Rotator Cuff Repair Under Isolated Loco-regional Anesthesia (AGORA)

Shoulder Cuff Surgical Repair

France
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

Prostate Adenocarcinoma | Stage IIIB Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8

United States
Rijnstate Hospital
University Medical Center Groningen; Maastricht University Medical Center; Leiden... and other collaborators

Recruiting

Effects of Preoperative Multidisciplinary Team Meetings for High-risk, Adult, Noncardiac Surgical Patients (PREPARATION)

Postoperative Complications | Interdisciplinary Communication | Surgical Procedures, Operative | Preoperative Care | Cost-Benefit Analysis | Noncardiac Surgery | Comorbidities and Coexisting Conditions | Patient Care Team

Netherlands
Balgrist University Hospital
Industry (Schülke & Mayr AG, Switzerland and Germany)

Recruiting

General Decolonization With Octenisan® Set Before Elective Orthopedic Surgery (BALGDEC)

Elective Surgery | High Risk | Prevention of Surgical Site Infections | Randomized-controlled Trial

Switzerland
Humanitas Clinical and Research Center
Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva

Recruiting

HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery (HISTAP)

Blood Pressure | Complication,Postoperative | Intraoperative Hypotension

Italy
Rigshospitalet, Denmark
Hvidovre University Hospital; Bispebjerg Hospital; The Novo Nordic Foundation; Aalborg... and other collaborators

Recruiting

The Fast-track Centre for Hip and Knee Replacement Database (FCD)

Patient Satisfaction | Hip | Knee | Fast-track Surgery | Enhanced Recovery After Surgery | Perioperative Medicine | Ambulatory Surgical Procedures | Perioperative/Postoperative Complications

Denmark
Peking University Cancer Hospital & Institute
Shanghai Ming Ju Biotechnology Co., Ltd.

Recruiting

Relmacabtagene Autoleucel as First-Line Therapy for High-Risk Large B-Cell Lymphoma

B-cell Lymphoma

China
Balgrist University Hospital

Recruiting

Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery (BAPTIST)

Microbial Colonization | Surgical Site Infection | Antibiotic Resistant Infection

Switzerland
Bayer

Recruiting

A Study to Learn More About How Safe Darolutamide is and How Well it Works Under Real World Conditions When Taken in Addition to Standard Androgen Deprivation Therapy (ADT) in Indian Participants With High-risk Non-metastatic Castration-resistant Prostate Cancer (nmCRPC)

Non-metastatic Castration-resistant Prostate Cancer

India
Second Affiliated Hospital, School of Medicine,...
Hangzhou Neoantigen Therapeutics Co., Ltd.

Recruiting

Neoantigen Vaccine in Esophagus Cancer Patients Following Neoadjuvant Therapy and Surgical Resection

Resectable Esophageal Cancer

China
Deborah Farr, MD

Recruiting

Safety and Feasibility of Robotic SP Nipple Sparing Mastectomy

Breast Cancer | High Risk of Breast Cancer

United States
Istituto Ortopedico Galeazzi

Not yet recruiting

Efficacy of PICO Compared to Opsite Post-Op Visible on Surgical Wound in Patients at High Risk of Local Complications, Undergoing Hip Arthroplasty (PICO-PTA)

Evaluate Postsurgical Hematoma

Italy
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Relationship Between Lymph Node Dissection and Prognosis in High-risk NMIBC

Bladder Cancer

China
University of Bordeaux

Recruiting

Percutaneous Edge To Edge Repair for the Treatment of Severe Tricuspid Valve Regurgitation in High-surgical Risk Patients With Systemic Right Ventricle : a Multicentric French Cohort (PETER-TRESRIV) (PETER-TRESRIV)

Congenital Heart Disease | Tricuspid Regurgitation | Systemic Right Ventricle

France
John Paul II Hospital, Krakow

Recruiting

Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients (SIM-GUARD)

Myocardial Infarction | Coronary Artery Disease | Carotid Stenosis | Valvular Heart Disease | Pulmonary Edema With Heart Failure

Poland
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula

Intubation | Cardiovascular Surgical Procedure

United States
Hoffmann-La Roche

Recruiting

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy (IMvigor011)

Muscle-invasive Bladder Cancer

Belgium, Korea, Republic of, Japan, Brazil, China, United States, Singapore, France, United Kingdom, Canada, Greece, Italy, Spain, Turkey, Russian Federation, Ukraine, Israel, Czechia, Colombia, Hong Kong, Argentina, Germany, Ireland, Polan... and more
Major Extremity Trauma Research Consortium
United States Department of Defense

Recruiting

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

Post Operative Surgical Site Infection

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Seagen Inc.

Recruiting

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC... and other conditions

United States, Canada, Puerto Rico
University of Southern California
National Cancer Institute (NCI)

Recruiting

A PD-1 Checkpoint Inhibitor (Cemiplimab) for High-Risk Localized, Locally Recurrent, or Regionally Advanced Skin Cancer

Recurrent Skin Squamous Cell Carcinoma | Resectable Skin Squamous Cell Carcinoma | Stage I Skin Cancer | Stage II Skin Cancer | Stage III Skin Cancer

United States
National Cancer Institute (NCI)

Recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States, Canada
University of Birmingham

Recruiting

Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery (PENGUIN)

Pathologic Processes | Pneumonia | Postoperative Complications | Surgical Wound Infection | Surgical Site Infection | Wound Infection | Anesthesia | Infection | Laparotomy | Communicable Disease | Perioperative Complication | Chlorhexidine

South Africa
NRG Oncology
National Cancer Institute (NCI)

Recruiting

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma

United States, Korea, Republic of
Medical College of Wisconsin

Recruiting

Cemiplimab in High Risk or Locally Advanced Hormone Receptor Positive HER2 Negative or Triple-Negative Breast Cancer

Invasive Breast Cancer

United States
Frantz Viral Therapeutics, LLC
M.D. Anderson Cancer Center; University of Michigan; The Cleveland Clinic; Amarex... and other collaborators

Recruiting

Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3) (ART-CIN_IIB)

HPV Infection | CIN 2/3 | Cervical Dysplasia | Pre-Cancerous Dysplasia | HPV Related Disease

United States
HighLife SAS
ICON plc

Recruiting

Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

Mitral Regurgitation

Belgium, France, Germany, Australia, United Kingdom, Poland
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Smoldering Plasma Cell Myeloma

United States
Intuitive Surgical

Recruiting

Robotic-Assisted da Vinci Xi Prophylactic Nipple-Sparing Mastectomy

Nipple Sparing Mastectomy

United States
Lawson Health Research Institute

Not yet recruiting

Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions (VAPEX)

Breast Fibroadenoma | Lobular Carcinoma in Situ | Atypical Ductal Hyperplasia | Phyllodes Breast Tumor | Atypical Lobular Hyperplasia | Flat Epithelial Atypia | Phyllodes; Fibroadenoma | Radial Scar | Breast Papilloma | Complex Sclerosing Papillary Lesion of the Breast
The University of Hong Kong

Recruiting

Evaluating the Efficacy and Safety of Intra-wound Vancomycin Powder in High Risk Patients

Trauma | Surgical Site Infection | Spinal Tumor | Spinal Deformity

Hong Kong
RenJi Hospital

Recruiting

Preventive Effects of Aspirin as Adjuvant Therapy in Patients With Locally Advanced Renal Cell Carcinoma

Aspirin as Adjuvant Therapy in Patients With Surgically Treated High Risk Renal Cell Carcinoma

China
Nantes University Hospital
Abbott; Ministère de la Santé

Recruiting

Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery (MITRA-HR)

Mitral Regurgitation

France, Monaco
University Hospital, Rouen
Federation Francophone de Cancerologie Digestive

Recruiting

Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk (ASPIK French)

Colorectal Cancer

France
St. Anna Kinderkrebsforschung
Assistance Publique - Hôpitaux de Paris; Australian & New Zealand Children's... and other collaborators

Recruiting

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Acute Lymphoblastic Leukaemia

Italy, Israel, Spain, Argentina, Australia, Austria, Belarus, Belgium, Canada, Chile, Croatia, Czechia, Denmark, Finland, Greece, Malaysia, Mexico, Netherlands, Norway, Poland, Romania, Saudi Arabia, Slovakia, Sweden, Switzerland, Turkey, F... and more
Frantz Viral Therapeutics, LLC
University of California, San Francisco; Laser Surgery Care; Amarex CRO; Anal Dysplasia...

Active, not recruiting

Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL (anal HSIL HIV-)

HPV Infection | Anal Dysplasia | Anal High Grade Squamous Intraepithelial Lesion | Anal Precancerous Condition | AIN 2/3 | HPV Disease

United States
National Cancer Institute (NCI)
Canadian Cancer Trials Group

Active, not recruiting

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Anal Basaloid Squamous Cell Carcinoma

United States, Canada
National Cancer Institute (NCI)
NRG Oncology

Active, not recruiting

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

Endometrial Endometrioid Adenocarcinoma | Stage I Uterine Corpus Cancer AJCC v8 | Stage II Uterine Corpus Cancer AJCC v8

United States, Puerto Rico

Search clinical trials for: High surgical risk

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