Search clinical trials for: Human Challenge Trial

Total 63742 results

Hvivo
Pfizer

Recruiting

Dose, Safety, and Pathogenicity of a New Influenza B Strain

Influenza B

United Kingdom
Humanitas Clinical and Research Center
Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva

Recruiting

HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery (HISTAP)

Blood Pressure | Complication,Postoperative | Intraoperative Hypotension

Italy
Dalhousie University
National Institute of Allergy and Infectious Diseases (NIAID); Vanderbilt University... and other collaborators

Recruiting

Establishing a Controlled Human Infection Model of Bordetella Pertussis

Pertussis

Canada
GlaxoSmithKline

Completed

Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma

Pulmonary Disease, Chronic Obstructive

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z)

Ebola Disease | Immunisation

United States
GlaxoSmithKline

Withdrawn

A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants

Colitis, Ulcerative

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Participants

Healthy

Australia
National Institute of Allergy and Infectious Diseases...

Completed

Trial to Evaluate L9LS in Healthy Adults (VRC 614)

Malaria

United States
Hvivo
Pfizer

Completed

Dose, Safety, and Pathogenicity of a New Influenza H1N1 Challenge Strain

Influenza A H1N1

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Trial to Evaluate CIS43LS in Healthy Adults

Malaria

United States
Cerevel Therapeutics, LLC

Completed

A Trial of the Effect of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subjects

Panic Disorder

Netherlands
National Institute of Allergy and Infectious Diseases...

Completed

Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)

Gonococcal Infection

United States
National Institute of Allergy and Infectious Diseases...

Completed

H1N1v Virus Challenge Study in Healthy Subjects

Influenza

United States
Human Development Research Foundation, Pakistan
Autism Speaks; World Health Organization; Grand Challenges Canada; University of... and other collaborators

Completed

Family Networks (FaNs) for Children With Developmental Disorders and Delays (FaNs)

Neurodevelopmental Disorders | Developmental Disabilities

Pakistan
U.S. Army Medical Research and Development Command
United States Department of Defense; Walter Reed Army Institute of Research...

Completed

Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans (Pvivax)

Plasmodium Vivax Malaria

United States
Sanaria Inc.
Swiss Tropical & Public Health Institute; Ifakara Health Institute; Tanzania...

Completed

Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults

Malaria | Plasmodium Falciparum Malaria

Tanzania
Emory University
Johns Hopkins University

Completed

Infectivity of Norovirus in Groundwater-Human Challenge Study

Healthy

United States
Emory University
Virginia Polytechnic Institute and State University

Completed

Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study (Shellfish)

Healthy

United States
Oxagen Ltd

Completed

OC000459 Dose Finding Study in Hay Fever Sufferers.

Allergic Rhinitis

Austria
Shanghai Bovax Biotechnology Co., Ltd.

Not yet recruiting

A Phase I Clinical Trial to Evaluate the Safety of 15-valent HPV Vaccine in Healthy Chinese People Aged 18-45 Years

HPV Infection | HPV-Related Carcinoma | Genital Wart | HPV-Related Intraepithelial Neoplasia

China
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Not yet recruiting

The Clinical Trial of TQB2102 for Injection Against Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer

Breast Cancer

China
Bayer

Not yet recruiting

A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)

Advanced Non-small Cell Lung Cancer | HER2 Mutation

United States, Korea, Republic of, Belgium, China, Japan, Taiwan, Denmark, Germany, Israel, Italy, United Kingdom, Bulgaria, Portugal, Switzerland, Greece, Turkey, Sweden, France, Singapore, Mexico, Spain, Netherlands, Poland, Brazil, A... and more
Regeneron Pharmaceuticals

Not yet recruiting

A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults

Healthy Volunteers
Tris Pharma, Inc.

Not yet recruiting

A Study to Assess the Abuse Potential of Intranasal Cebranopadol

Abuse, Drug

United States
StimLabs
SerenaGroup, Inc.

Not yet recruiting

Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs (CAMPSTIM)

Diabetic Foot | Foot Ulcer | Ulcer Foot | Diabetic Foot Ulcer (DFU)

United States
Peking University Cancer Hospital & Institute

Not yet recruiting

First Human Trial of Targeting MDM2/MDMX PET Imaging

Nuclear Medicine | MDM2/MDMX Gene Mutation | Positron Emission Tomography Imaing
Boston Medical Center
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Simulation Trial of Telemedical Support for Paramedics (R01)

Emergencies | Acute Respiratory Failure | Status Epilepticus | Cardiopulmonary Arrest

United States
Pfizer

Recruiting

A Study About Modified RNA Vaccines Against Influenza in Healthy Adults

Influenza, Human

United States
GlaxoSmithKline

Recruiting

A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults

Influenza, Human

United States
Third Harmonic Bio, Inc.

Recruiting

A First in Human Trial Evaluating THB335 in Healthy Participants

Healthy

United States
GlaxoSmithKline
PPD; Laboratory Corporation of America

Not yet recruiting

Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers

Hepatitis B

United States
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

Durvalumab With Carboplatin and Etoposide Chemotherapy in Pulmonary Large-cell Neuroendocrine Carcinoma (LCNEC) (DUPLE)

Pulmonary Large-cell Neuroendocrine Carcinoma

Italy
Vaxxas Pty Ltd
Biomedical Advanced Research and Development Authority

Not yet recruiting

Influenza A (H7N9) Vaccine Delivered Intradermally by High-density Microarray Patch (HD-MAP) (HD-MAP)

H7N9 Influenza

Australia
Regeneron Pharmaceuticals

Not yet recruiting

A First-In Human (FIH) Trial to Find Out if REGN10597 is Safe and How Well it Works for Adult Participants With Advanced Solid Organ Malignancies

Melanoma | Advanced Solid Tumors | Clear-Cell Renal-Cell Carcinoma (ccRCC)
Centre for Human Drug Research, Netherlands

Recruiting

Deep Phenotyping of Cutaneous Lupus Erythematosus

Cutaneous Lupus Erythematosus

Netherlands
M.D. Anderson Cancer Center

Not yet recruiting

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Hormone Receptor-positive Human Epidermal Growth Factor 2-negative | Metastatic Invasive LObular Carcinoma

United States
University of Cologne

Recruiting

Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges (RESERVE)

Hyponatremia

Germany
University of Auckland, New Zealand
Health Research Council, New Zealand; Auckland City Hospital; Kitea Health Ltd

Not yet recruiting

First-in-human Trial of Home Brain Pressure Measured Using Kitea ICP Sensor, Placed During Hydrocephalus Shunt Surgery. (HomeICP)

Hydrocephalus

New Zealand
Mediar Therapeutics
ICON plc

Recruiting

A First-in-Human Safety Trial of MTX-463

Healthy

United States
Humanitas Clinical and Research Center
European Society of Intensive Care Medicine

Not yet recruiting

Fluid Challenge in Intensive Care The FENICE II Study (FENICE II)

Critical Illness | Septic Shock

Italy
Eli Lilly and Company

Not yet recruiting

A First-In-Human Study of LY3985297 in Healthy Participants

Healthy

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial (PALETTE)

Sepsis
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States
University Hospitals Cleveland Medical Center

Not yet recruiting

eHealth for Breastfeeding Support - the HOTSPOT Trial

Breast Feeding

United States
Vall d'Hebron Institute of Oncology

Recruiting

Status of HRD That Lead to a Benefit From Olaparib in Combination With Bevacizumab (STROBE Trial) (STROBE)

Ovarian Cancer

Spain
Shanghai Unicar-Therapy Bio-medicine Technology...
Peking University People's Hospital; The First Affiliated Hospital of Soochow...

Not yet recruiting

Clinical Trial of ssCART-19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)

Relapsed or Refractory Acute Lymphoblastic Leukemia

China
Tufts Medical Center
Boston Medical Center; Northeastern University

Not yet recruiting

Conversational Agents to Improve HPV Vaccine Acceptance in Primary Care (ECA-HPV) Clinical Trial

Human Papilloma Virus

United States
bioLytical Laboratories

Recruiting

Trial of Hepatitis C Self-Testing in the Hands of Untrained Lay Users

Hepatitis C

South Africa
Sanofi Pasteur, a Sanofi Company

Recruiting

A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above

Influenza Immunization

United States, Puerto Rico
AdjuTec Pharma AS
CTC Clinical Trial Consultants AB

Not yet recruiting

A First-in-human Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of APC148 in Healthy Adults

Healthy Subjects

Sweden

Search clinical trials for: Human Challenge Trial

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