Search clinical trials for: Low density lipoprotein cholesterol (LDL-c)

Total 52380 results

China National Center for Cardiovascular Diseases

Recruiting

LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)

Atherosclerotic Cardiovascular Disease | LDL Cholesterol | Older Patients

China
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Elevated LDL-Cholesterol (LDL-C)

United Kingdom
Ikaria Bioscience Pty Ltd

Recruiting

Adult Subjects With Elevated Low-Density Lipoprotein-Cholesterol to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects

To Reduce the LDL-C Level in Hypercholesteremia Adult Patients | Combination for Subgroup High LDL-c Patients With Other Comorbidities

Australia
Yonsei University

Not yet recruiting

Exploring Approaches With Lower Targets of Blood Pressure and Lipid for Improving Renal Outcome in Advanced Chronic Kidney Disease (EXCELSIOR-CKD)

Hypertension | Chronic Kidney Diseases | Dyslipidemias

Korea, Republic of
Odense University Hospital

Not yet recruiting

Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection. (FIND)

Familial Hypercholesterolemia

Denmark
Perrigo CSCI
Analyze & Realize

Recruiting

Effects of Arterin Cholesterol for Reduction of Lipid Levels

Blood Cholesterol Lowers | LDL-C

Germany
Novartis Pharmaceuticals

Active, not recruiting

Efficacy and Safety of Inclisiran as Monotherapy in Chinese Adults With Low or Moderate ASCVD Risk and Elevated Low-density Lipoprotein Cholesterol. (V-Mono China)

Primary Hypercholesterolemia or Mixed Dyslipidemia

China
Jordan Collaborating Cardiology Group
The Cardiovascular Academy Group of the JCS; The Jordan Cardiac Society (JCS); Istishari Hospital Department of Clinical Research

Terminated

Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age (CREATE)

Atherosclerotic Cardiovascular Risk | Low-density-lipoprotein (LDL) Cholesterol

Jordan
Chinese Academy of Medical Sciences, Fuwai Hospital

Recruiting

Intensive Lipid-lowering for Plaque and Major Adverse Cardiovascular Events in Low to Intermediate 10-year ASCVD Risk Population (ILLUMINATION)

Coronary Artery Disease Progression

China
University of Reading
Wellcome Trust

Completed

Study Into Genetic Influence on Cholesterol Response to Dietary Fat (Satgene)

Cardiovascular Diseases

United Kingdom
The Cooper Institute
Cargill

Completed

Phytosterol Supplementation and Cardiovascular Risk

Hypercholesteremia

United States
Chung Shan Medical University

Completed

Efficacy of Probiotic Milk Formula on Blood Lipid and Intestinal Function

Healthy
The Medicines Company

Completed

Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH) (ORION-9)

Elevated Cholesterol | Heterozygous Familial Hypercholesterolemia

United States, Canada, Czechia, Denmark, Netherlands, South Africa, Spain, Sweden
The Medicines Company

Completed

Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol (ORION-10)

Elevated Cholesterol | ASCVD

United States
The Medicines Company

Completed

Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein Cholesterol (ORION-11)

Risk Factor, Cardiovascular | Elevated Cholesterol | ASCVD

Germany, Czechia, Hungary, Poland, South Africa, Ukraine, United Kingdom
Institute of Health Information and Statistics...
Centre of Cardiovascular and Transplantation Surgery, Czech Republic; The Central... and other collaborators

Recruiting

Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic (CzeCH-IN)

Familial Hypercholesterolaemia

Czechia
Alnylam Pharmaceuticals
The Medicines Company

Completed

A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Hypercholesterolemia

United Kingdom
Mackay Memorial Hospital
Amgen

Recruiting

Observation of Blood Lipid Outcomes in Lipid Clinic

Dyslipidemias

Taiwan
Amgen

Completed

Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study Enrollment

Hypercholesterolemia

France, Germany, United States, Czechia, Italy, Australia, Spain, United Kingdom
Amgen

Completed

Study to Assess In-home Use of Evolocumab (AMG 145) Using a Prefilled Syringe or a Prefilled Autoinjector/Pen

Mixed Dyslipidemia | Primary Hypercholesterolemia

United States, Canada
Jordan Collaborating Cardiology Group

Terminated

Tracking of Lipid Lowering Therapy in Jordan (JoLLA)

Dyslipidemias | Atherosclerotic Cardiovascular Disease

Jordan
Pfizer

Completed

Single Dose Manufacturing Site (Pfizer vs. BIP) And Device (Prefilled Syringe vs. Prefilled Pen) Comparability Study For Bococizumab In Healthy Volunteers

Healthy

United States
Amgen

Completed

Study of Low-Density Lipoprotein Cholesterol (LDL-C) Reduction Using Evolocumab (AMG 145) in Japanese Patients With Advanced Cardiovascular Risk (AMG145)

Hyperlipidemia or Mixed Dyslipidemia at High Risk for Cardiovascular Events

Japan
AstraZeneca

Completed

Investigation Into the RAtio of LDL-CHolestEroL to HDL-Cholesterol Improvement After Statin Treatment in Korean Patients (RACHEL)

Dyslipidemias
Assiut University

Not yet recruiting

the No-reflow in Diabetic Patients Treated With Primary Percutaneous Coronary Intervention (PCI)

No-Reflow Phenomenon
AstraZeneca
Parexel

Recruiting

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 in Healthy Subjects

Dyslipidemia

United States, United Kingdom
Otsuka Pharmaceutical Co., Ltd.

Active, not recruiting

A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Yang I. Pachankis

Active, not recruiting

COVID-19 Vaccination Detoxification in LDL-C

COVID-19 Respiratory Infection | COVID-19 Stress Syndrome | COVID-19 Vaccine Adverse Reaction | COVID-19-Associated Thromboembolism | COVID-19 Post-Intensive Care Syndrome | COVID-19-Associated Stroke

China
Emory University
Kaneka Medical America LLC

Completed

Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid Markers (INFLAME)

Familial Hypercholesterolemia

United States
Nantes University Hospital

Completed

Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia (HYPOPSY)

Hypobetalipoproteinemia

France
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Evaluate Efficacy and Safety of LIB003 in Patients on Lipid-Lowering Therapy Needing Additional LDL-C Reduction

LDL Cholesterol

United States
Amgen

Completed

Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pen

Mixed Dyslipidemia | Primary Hypercholesterolemia

United States, Canada
Ikaria Bioscience Pty Ltd
SHANGHAI RONA Therapeutics Co.,Ltd.

Not yet recruiting

the Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects in Adult Subjects With Elevated LDL-C

To Reduce the LDL-C Level in Hypercholesteremia Patients
Akeso
AD Pharmaceuticals Co., Ltd.

Completed

A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFH

Homozygous Familial Hypercholesterolemia

China
Akeso
AD Pharmaceuticals Co., Ltd.

Completed

A Study of PCSK9 Inhibitor AK102 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)

Heterozygous Familial Hypercholesterolemia

China
Otsuka Pharmaceutical Co., Ltd.

Completed

A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
AstraZeneca

Completed

Compare the Efficacy of Rosuvastatin to Atorvastatin in High Risk Patients With Hypercholesterolemia

Hypercholesterolemia

China
El Zahraa Gamal

Not yet recruiting

Metabolic Profile as a Predictor of No-reflow in Diabetic Patients

Acute Myocardial Infarction (AMI)
NewAmsterdam Pharma

Completed

A Dose-Finding Study in Japanese Patients to Evaluate the Effect of Obicetrapib as an Adjunct to Stable Statin Therapy.

Dyslipidemia | Hypercholesterolemia | High Cholesterol

Japan
University of Manitoba
The Association of Rehabilitation Medicine in Manitoba

Completed

Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels

Spinal Cord Injury | Tetraplegia | Quadraplegia | Low HDL-c | High LDL-c

Canada
Ferrer Internacional S.A.

Terminated

A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol

Elevated LDL Cholesterol

United States
Clinical Research Center for End Stage Renal Disease...
Ministry of Health & Welfare, Korea

Completed

The Effects of Lowering Low-density Lipoprotein Cholesterol Levels to New Targets on Cardiovascular Complications in Peritoneal Dialysis Patients

Hypercholesterolemia

Korea, Republic of
Beijing Luhe Hospital

Recruiting

Effects of PCSK-9 Inhibitor Treatment Prior to Undergoing Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction

STEMI

China
B. Braun Medical Inc.

Completed

Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. Therapy (Secura)

Familial Hypercholesterolemia
Danone Japan

Completed

"A Clinical Study for Evaluating the Effect of a Plant Sterol-enriched Fermented Dairy Product on Blood Lipoprotein Profile in Japanese Adults"

Subjects With High LDL-Cholesterol

Japan
AstraZeneca

Completed

A Study to Evaluate the Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial Hypercholesterolemia

Homozygous Familial Hypercholesterolemia (HoFH)

Malaysia, Canada, Taiwan, Belgium, Denmark, Israel
AstraZeneca

Completed

CEntralized Pan-Russian Survey of tHE Undertreatment of hypercholeSterolemia II (CEPHEUS II) (CEPHEUSII)

Dyslipidaemia

Russian Federation
Guelph Food Research Centre
University of Guelph; Glycemic Index Laboratories, Inc; Canadian Centre for Agri-Food...

Completed

A Human Trial to Assess the Low Density Lipoprotein Cholesterol (LDL-C) Lowering Effect of Soy (SOY-LDL)

Cardiovascular Disease | Hypercholesterolemia | CRP

Canada
AstraZeneca

Completed

A Study to Evaluate the Efficacy and Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial Hypercholesterolemia (HYDRA)

Homozygous Familial Hypercholesterolemia (HoFH)

Malaysia, Canada, Israel, Netherlands, Taiwan, Belgium, Denmark

Search clinical trials for: Low density lipoprotein cholesterol (LDL-c)

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