Search clinical trials for: MAPK pathway
Total 1435 results
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Fondazione Policlinico Universitario Agostino Gemelli...RecruitingNoonan Syndrome | Costello Syndrome | RASopathy | Cardio-Facio-Cutaneous SyndromeItaly
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Nested Therapeutics, IncRecruitingGlioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene MutationUnited States, Australia
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Suzhou Genhouse Bio Co., Ltd.Shanghai East Hospital; Shandong Tumor HospitalRecruitingAdvanced Solid Tumors With MAPK Signal Pathway MutantChina
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Deciphera Pharmaceuticals LLCRecruitingMelanoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | BRAF Gene Mutation | RAS Mutation | NF1 Mutation | RAF Mutation | CRAF Gene MutationUnited States
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Ikena OncologyRecruitingColorectal Cancer | Pancreatic Cancer | Thyroid Carcinoma | Solid Tumor, Adult | Malignant Melanoma | Non-Small Cell Lung Carcinoma | BRAF Gene Mutation | Gliomas, Malignant | Ras (Kras or Nras) Gene Mutation | CRAF Gene MutationUnited States
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D3 Bio (Wuxi) Co., LtdRecruitingAdvanced Solid Tumors With MAPK Pathway MutationsAustralia, China, United States
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Mirati Therapeutics Inc.RecruitingSolid Tumor | Non Small Cell Lung Cancer | Advanced Solid Tumor | Colo-rectal CancerUnited States, Puerto Rico
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Jazz PharmaceuticalsRecruitingSolid Tumor | Metastatic Cancer | Advanced CancerUnited States
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Qilu Pharmaceutical Co., Ltd.RecruitingAdvanced Solid Tumors Harboring MAPK Pathway AlterationsChina
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Navire Pharma Inc., a BridgeBio companyAmgenRecruitingNon Small Cell Lung Cancer | Metastatic Solid Tumor | Solid Tumor, Adult | Metastatic NSCLCSpain, Australia, France, Denmark, Greece, Italy, Netherlands
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Navire Pharma Inc., a BridgeBio companyBristol-Myers SquibbRecruitingSolid Tumor | Non Small Cell Lung CancerUnited States
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Deciphera Pharmaceuticals LLCRecruitingNon-Small Cell Lung Cancer | Advanced Solid Tumor | Metastatic Solid TumorUnited States
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National Cancer Institute (NCI)RecruitingNoonan Syndrome | Legius Syndrome | Cardiofaciocutaneous Syndrome | Costello Syndrome | Capillary Arteriovenous Malformation Syndrome | RASopathyUnited States
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MapKure, LLCRecruitingSolid Tumor | B-Raf Mutation-Related TumorsUnited States, Australia
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St. Jude Children's Research HospitalNovartis PharmaceuticalsCompletedGlioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditionsUnited States
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National Cancer Institute (NCI)Active, not recruitingAdvanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Histiocytic and Dendritic Cell Neoplasm | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Solid Neoplasm | Recurrent... and other conditionsUnited States, Puerto Rico
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National Cancer Institute (NCI)Active, not recruitingAdvanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Refractory Non-Hodgkin Lymphoma | Refractory Primary Central Nervous System Neoplasm | Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma and other conditionsUnited States, Puerto Rico
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Navire Pharma Inc., a BridgeBio companyActive, not recruitingTumor, SolidUnited States
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JS InnoPharm, LLCSuspended
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St. Justine's HospitalCHU de Quebec-Universite Laval; Montreal Children's Hospital of the MUHCActive, not recruitingLow-grade Glioma | Plexiform Neurofibroma | Central Nervous System GliomaCanada
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BioXcel Therapeutics IncCognitive Research CorporationCompletedOpioid WithdrawalUnited States
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xCuresCancer CommonsAvailableExpanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered MalignanciesMelanoma | Head and Neck Cancer | Glioblastoma | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Small Bowel Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Bladder Cancer | Thyroid Cancer | ERK Mutation | MAPK Gene Mutation | KRAS Activating... and other conditionsUnited States
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Erasca, Inc.CompletedAdvanced Non-squamous Non-small-cell Lung CancerUnited States
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Haihe Biopharma Co., Ltd.TerminatedMelanoma | Erdheim-Chester Disease | Non-Small-Cell Lung Cancer | Advanced Tumors | Other RAS/RAF/MEK/ERK Mutated TumorsUnited States, China
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Novartis PharmaceuticalsTerminatedMelanoma | Ovarian Cancer | NSCLC | Other Solid TumorsItaly, Spain, Netherlands, France, Korea, Republic of, Switzerland, Germany, Japan, United States, Canada
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Erasca, Inc.WithdrawnAcute Myeloid LeukemiaUnited States
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Academisch Medisch Centrum - Universiteit van Amsterdam...CompletedMetastatic Pancreatic Cancer | Locally Advanced Pancreatic CancerNetherlands
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The Netherlands Cancer InstituteMerck Sharp & Dohme LLCUnknownMetastatic MelanomaNetherlands
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Basque Health ServiceHealth Department of the Basque GovernmentRecruitingAsthma in Children | Implementation Science | Inappropriate PrescribingSpain
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Xie KangjieRecruitingDiabetes | Postoperative DeliriumChina
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Mayo ClinicNot yet recruitingStage III Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Cholangiocarcinoma | Refractory Cholangiocarcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Advanced CholangiocarcinomaUnited States
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Hitit UniversityRecruiting
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University of AlbertaNot yet recruitingCardiovascular Disease | Diabetes | Dyslipidemia | Blood Pressure | Cardiovascular Risk Factors
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Assistance Publique Hopitaux De MarseilleRecruitingLung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 YearsFrance
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The Cleveland ClinicNot yet recruitingPrenatal DisorderUnited States
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Mayo ClinicNot yet recruitingRecurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate CarcinomaUnited States
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University of AlbertaAlberta Innovates Health SolutionsNot yet recruiting
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Stony Brook UniversityMassachusetts General Hospital; Mclean HospitalRecruitingBipolar Disorder | Bipolar Disorder Type 1United States
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University Hospital, ToulouseJanssen, LP; Ligue contre le cancer, FranceNot yet recruiting
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Medical College of WisconsinNot yet recruiting
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University of Alabama at BirminghamNot yet recruitingConvulsion, Non-Epileptic | Functional Neurological Disorder | Functional SeizureUnited States
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Tianjin Medical University Cancer Institute and...RecruitingNon-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle DeregulationChina
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Chinese University of Hong KongNot yet recruitingProstate CancerHong Kong
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Institut Jean-GodinotUniversité de Reims Champagne-ArdenneNot yet recruiting
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University of MichiganNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Not yet recruiting
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Karolinska University HospitalNot yet recruitingCritical Illness | Hypophosphatemia | Refeeding SyndromeSweden, Czechia, Italy
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ElsanNot yet recruitingIndividualised Physical Activity Program | Coronary Patient
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Pr. Nicolas GIRERDRecruiting
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University of AlbertaAlberta Health servicesRecruitingStaph Aureus BacteremiaCanada
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Fondazione del Piemonte per l'OncologiaRecruiting