Search clinical trials for: MC4R Pathway

Total 1412 results

Rhythm Pharmaceuticals, Inc.

Recruiting

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Obesity | Genetic Obesity

United States, Spain, Germany, Netherlands, United Kingdom, Greece, Puerto Rico, Canada, France, Israel
Rhythm Pharmaceuticals, Inc.

Active, not recruiting

DAYBREAK: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Genetic Obesity

United States, Spain, Netherlands, Germany, United Kingdom, Canada, Israel, Greece
Rhythm Pharmaceuticals, Inc.

Completed

Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Patients With Specific Gene Defects in the MC4R Pathway

Bardet-Biedl Syndrome | POMC Deficiency

Netherlands, United States, Germany, Canada, Puerto Rico, United Kingdom
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Participants With Moderate to Severe Obesity

Bardet Biedl Syndrome (BBS) | Alström Syndrome (AS)

United States, United Kingdom, France, Canada, Puerto Rico, Spain
Rhythm Pharmaceuticals, Inc.

Completed

Setmelanotide for the Treatment of Early-Onset Pro-Opiomelanocortin (POMC) Deficiency Obesity

Pro-opiomelanocortin (POMC) Deficiency Obesity

Belgium, United States, Canada, France, Germany, Spain, United Kingdom
Rhythm Pharmaceuticals, Inc.

Completed

The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry

Genetic Forms of Extreme Obesity

United States, Canada
Association APPROCHE
Société Neuradom; IMT Atlantique Brest

Recruiting

Impact of a Self-rehabilitation and Tele-rehabilitation Program on the Post-stroke Care Pathway (AUTONHOME)

Ischemic Stroke | Hemorrhagic Unilateral Cortico-subcortical Hemispheric Stroke

France
University of Alberta

Not yet recruiting

Indigenous-Led Transition Pathway for Young Adults

Chronic Diseases in Adolescence

Canada
Basque Health Service
Health Department of the Basque Government

Recruiting

Asthma Crisis in Paediatrics: Impact of a Care Pathway in Primary and Hospital Care

Asthma in Children | Implementation Science | Inappropriate Prescribing

Spain
Xie Kangjie

Recruiting

Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD on Diabetes Patients

Diabetes | Postoperative Delirium

China
Mayo Clinic

Recruiting

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Cholangiocarcinoma | Refractory Cholangiocarcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Advanced Cholangiocarcinoma

United States
Hitit University

Recruiting

Schroth Treatment and Proprioception Pathway

Adolescent Idiopathic Scoliosis

Turkey
University of Alberta

Not yet recruiting

Pharmacist Case Finding and Intervention for Vascular Prevention Trial (PRxOACT)

Cardiovascular Disease | Diabetes | Dyslipidemia | Blood Pressure | Cardiovascular Risk Factors
Assistance Publique Hopitaux De Marseille

Recruiting

Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway (BIOCEPTION)

Lung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 Years

France
The Cleveland Clinic

Not yet recruiting

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes (OPUS)

Prenatal Disorder

United States
Mayo Clinic

Recruiting

Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)

Recurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate Carcinoma

United States
University of Alberta
Alberta Innovates Health Solutions

Not yet recruiting

Digital Health Pathway for Children With Medical Complexity Requiring Tracheostomy (DECIDE-T)

Tracheostomy

Canada
Stony Brook University
Massachusetts General Hospital; Mclean Hospital

Recruiting

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Bipolar Disorder | Bipolar Disorder Type 1

United States
University Hospital, Toulouse
Janssen, LP; Ligue contre le cancer, France

Not yet recruiting

Real-life Management of Patients Eligible for CAR-T Cell Therapy (CARAVAGE)

Hemopathy

France
Medical College of Wisconsin

Not yet recruiting

Molecular Analyses to Identify Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer

Breast Cancer

United States
University of Alabama at Birmingham

Not yet recruiting

Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND

Convulsion, Non-Epileptic | Functional Neurological Disorder | Functional Seizure

United States
Tianjin Medical University Cancer Institute and...

Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Non-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle Deregulation

China
Chinese University of Hong Kong

Not yet recruiting

To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence

Prostate Cancer

Hong Kong
Institut Jean-Godinot
Université de Reims Champagne-Ardenne

Not yet recruiting

Development of a Questionnaire on Patients' Perception of Their Oncology Care Pathway (Onco-PREMs) (OncoPREMs)

Cancer
Karolinska University Hospital

Not yet recruiting

Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome

Critical Illness | Hypophosphatemia | Refeeding Syndrome

Sweden, Czechia, Italy
Elsan

Not yet recruiting

Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post-cardiac Rehabilitation (APIC)

Individualised Physical Activity Program | Coronary Patient
Pr. Nicolas GIRERD

Recruiting

PAtient Treatment Analysis: Hospital and Wide-ranging Out-of-hospital Care Assessment Yields Insights Into Heart Failure Outcomes (PATHWAY-HF)

Heart Failure

France
University of Alberta
Alberta Health services

Recruiting

Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)

Staph Aureus Bacteremia

Canada
Fondazione del Piemonte per l'Oncologia

Recruiting

INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations (INSIDE)

Prostate Cancer

Italy
Ziauddin University

Not yet recruiting

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (MROSF)

Oral Submucous Fibrosis

Pakistan
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies (3776)

Noonan Syndrome | Costello Syndrome | RASopathy | Cardio-Facio-Cutaneous Syndrome

Italy
University of Edinburgh

Not yet recruiting

Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology (ORACLE)

Coronary Artery Disease | Angina, Stable
Nested Therapeutics, Inc

Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628)

Glioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene Mutation

United States, Australia
University of Alabama at Birmingham

Not yet recruiting

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway (VITAL-IMPACT)

Cardiovascular Diseases | Obesity | Insulin Sensitivity/Resistance | Metabolic Disease | Energy Expenditure | Metabolism

United States
Black Hills State University
National Institute of General Medical Sciences (NIGMS)

Not yet recruiting

Examination of Psychological and Physiological Pathways Linking Gratitude and Pain

Acute Pain | Emotions | Positive Thinking
Beijing Anzhen Hospital

Not yet recruiting

Efficacy of Pharmacist Interventions Through the "Medication Therapy Management Pathway in Hypertensive Patients" (PharmMTMH)

Hypertension | Medication Therapy Management

China
Suzhou Genhouse Bio Co., Ltd.
Shanghai East Hospital; Shandong Tumor Hospital

Recruiting

A Phase I/II Clinical Study to Evaluate The Safety, PK, PD of GH55 in Patients With MAPK Mutant Advanced Solid Tumors

Advanced Solid Tumors With MAPK Signal Pathway Mutant

China
Imperial College London
Barking, Havering and Redbridge University Hospitals NHS Trust; Imperial College... and other collaborators

Recruiting

Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors (MAPLES)

Quality of Life | Oesophageal Cancer | Bacterial Overgrowth

United Kingdom
University of Arkansas
Intimate Pathways Center for Sexual Health

Not yet recruiting

Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors

Sexual Dysfunction | Menopause, Premature | Body Image | Cancer, Breast | Women's Health: Neoplasm of Breast
Peking University

Not yet recruiting

County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial (RISIMA)

Cardiovascular Diseases | Hypertension | Diabetes Mellitus Type 2
Pasithea Therapeutics Corp.

Recruiting

PAS-004 in Patients With Advanced Solid Tumors

Advanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF Mutation

United States
University of California, San Francisco
National Center for Advancing Translational Sciences (NCATS)

Not yet recruiting

Human-centered Injury Thrivorship Pathway for Survivors of Physical Trauma

Trauma Injury | Survivorship | Injury Traumatic

United States
Deciphera Pharmaceuticals LLC

Recruiting

Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway

Melanoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | BRAF Gene Mutation | RAS Mutation | NF1 Mutation | RAF Mutation | CRAF Gene Mutation

United States
IRCCS Fondazione Stella Maris
University of Pisa; University of Florence; Anastasis Società Cooperativa Sociale

Not yet recruiting

Personalized Innovative Intervention Pathways to Promote EF in Children With CP

Executive Functions in Cerebral Palsy

Italy
M.D. Anderson Cancer Center

Not yet recruiting

Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms

Myeloproliferative Neoplasm | Myelodysplastic Neoplasm | Pathway Mutant Myelodysplastic Syndromes

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Angiogenesis Analytics

Recruiting

Prostate Cancer Detection Rate of Targeted Biopsies With PCaVision

Prostate Cancer

Netherlands
KU Leuven
Universitaire Ziekenhuizen KU Leuven

Not yet recruiting

Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary (Treatable)

Rectal Cancer | LARS - Low Anterior Resection Syndrome
Murdoch Childrens Research Institute

Recruiting

The Egg Up Trial - Testing a New Treatment Pathway for Infants With Newly Diagnosed Egg Allergy

Food Allergy | Food Allergy in Infants

Australia
Ikena Oncology

Recruiting

Study of IK-595 in RAS- or RAF-altered Advanced Tumors

Colorectal Cancer | Pancreatic Cancer | Thyroid Carcinoma | Solid Tumor, Adult | Malignant Melanoma | Non-Small Cell Lung Carcinoma | BRAF Gene Mutation | Gliomas, Malignant | Ras (Kras or Nras) Gene Mutation | CRAF Gene Mutation

United States
Johannes Gutenberg University Mainz

Not yet recruiting

Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment (ASPERA-ANOCA)

Microvascular Coronary Artery Disease

Germany

Search clinical trials for: MC4R Pathway

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