Search clinical trials for: Mammalian target of rapamycin

Total 430633 results

Sun Yat-sen University
Hainan General Hospital

Recruiting

Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma

Neuroblastoma

China
University of Miami

Recruiting

Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer

Breast Cancer | Metastatic Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer

United States
Aadi Bioscience, Inc.

Active, not recruiting

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Malignant Solid Neoplasm | Neoplasms | Cancer | Neoplasm Metastasis | Solid Tumor | Metastatic Cancer | Metastasis | Advanced Solid Tumor | Metastatic Solid Tumor | Advanced Cancer | Tumor | Malignant Neoplasm | Malignant Tumor | Tumors | Cancer Metastatic | Tumor, Solid | Malignant Solid Tumor | TSC | TSC1 | TSC2 | Metastatic Neoplasm

United States, Korea, Republic of, Puerto Rico
Shanghai Jiatan Pharmatech Co., Ltd

Completed

A Study of WXFL10030390 in Patients With Advanced Solid Tumors or Lymphoma

Advanced Cancer

China
Washington University School of Medicine

Active, not recruiting

Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling (mTOR)

Dietary Protein

United States
University of Toledo Health Science Campus
Novartis Pharmaceuticals

Completed

Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction

Renal Transplant

United States
Radboud University Medical Center

Active, not recruiting

Treatment of Congenital Vascular Malformations Using Sirolimus: Improving Quality of Life (Sirolimus)

Vascular Malformations

Netherlands
Peking Union Medical College Hospital
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Air Force...

Unknown

Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome

Peutz-Jeghers Syndrome

China
Peking Union Medical College Hospital
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Air Force...

Unknown

Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation

Blue Rubber Bleb Nevus Syndrome | Venous Malformation

China
Medical University of Vienna

Unknown

Pulsed Oral Sirolimus in Autosomal Dominant Polycystic Kidney Disease (RAP)

Polycystic Kidney, Type 1 Autosomal Dominant Disease | Polycystic Kidney, Type 2 Autosomal Dominant Disease

Austria
Abramson Cancer Center of the University of Pennsylvania

Completed

Phase 1 Trial of the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus Plus Radiation Therapy (RT) for Salvage Treatment of Biochemical Recurrence in Prostate Cancer Patients Following Prostatectomy

Prostate Cancer Patients With Detectable PSA Following Prostatectomy

United States
Children's Hospital Medical Center, Cincinnati
Novartis

Completed

Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC)

Epilepsy | Tuberous Sclerosis Complex

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) (EXIST-2)

Lymphangioleiomyomatosis (LAM) | Tuberous Sclerosis Complex (TSC)

United States, United Kingdom, Germany, Italy, Russian Federation, Netherlands, Japan, Canada, Poland, France, Spain
M.D. Anderson Cancer Center

Terminated

Phosphatidylinositol 3 Kinase and Mammalian Target of Rapamycin (PI3K-mTOR) in Advanced Cancer Patients

Advanced Cancers

United States
Cliniques universitaires Saint-Luc- Université...

Completed

Efficacy and Safety of the Mammalian Target of Rapamycin (mTor Rapamycin) Inhibitor in Vascular Malformations (vasca-LM)

Cardiovascular Abnormalities

Belgium
Chinese University of Hong Kong

Completed

Everolimus Rescue Immunosuppression in the Treatment of Chronic Allograft Dysfunction in Renal Transplant Recipients

Chronic Allograft Dysfunction in Renal Transplantation

Hong Kong
Josep M Cruzado

Terminated

Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise (EXETOR)

Muscle Strength | Disorder Related to Renal Transplantation | Exercise, Aerobic

Spain
Merck Sharp & Dohme LLC
Ariad Pharmaceuticals

Completed

Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)

Sarcoma, Soft Tissue | Osteosarcoma | Leiomyosarcoma | Liposarcoma | Metastases
Instituto do Cancer do Estado de São Paulo

Unknown

A Pilot Study of Metformin Treatment in Patients With Well-differentiated Neuroendocrine Tumors (MetNet)

Well-differentiated Neuroendocrine Tumors

Brazil
Children's Hospital Medical Center, Cincinnati
Novartis

Completed

Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex

Tuberous Sclerosis | Subependymal Giant Cell Astrocytoma

United States
Children's Hospital Medical Center, Cincinnati
Novartis Pharmaceuticals

Completed

RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM

Tuberous Sclerosis | Lymphangioleiomyomatosis

United States
Medical University of Vienna

Completed

The Vienna RAP Pilot Study (RAP)

ADPKD

Austria
University of Nottingham
University of Oxford

Recruiting

Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune) (Rapamune)

Muscle Atrophy | Age-Related Sarcopenia

United Kingdom
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Recruiting

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Acute Leukemia | Myelodysplastic Syndrome

United States
Peking Union Medical College Hospital

Recruiting

Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis

Uterine Fibroids

China
Shanghai MicroPort Medical (Group) Co., Ltd.

Active, not recruiting

TARGET-PREMIER Trail in Evaluating the Safety and Efficacy of the Rapamycin Target Eluting Stent in CAS Treatment (T-P)

Coronary Artery Disease | Coronary Stenosis

China
Shanghai MicroPort Medical (Group) Co., Ltd.

Completed

Non-inferiority Study Comparing Firehawk Stent With Abbott Xience Family Stent (TARGET-AC)

Coronary Artery Disease

Denmark
Shanghai MicroPort Medical (Group) Co., Ltd.

Completed

Evaluation of New Specifications (38mm) of FirehawkTM in the Treatment of Coronary Heart Disease (Firehawk_38)

Coronary Heart Disease

China
Shanghai MicroPort Medical (Group) Co., Ltd.

Active, not recruiting

Firehawk Rapamycin Target Eluting Coronary Stent North American Trial (TARGET-IV_NA)

Coronary Artery Disease

United States, Denmark, Canada, Belgium, Netherlands
National Cancer Institute (NCI)

Completed

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

Advanced Malignant Solid Neoplasm

United States
Incyte Corporation

Completed

A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3)

Graft-versus-host Disease (GVHD)

Belgium, Italy, Spain, Saudi Arabia, Turkey, United Kingdom, Germany, Greece, Canada, Austria, France, Israel, Netherlands, Sweden, Switzerland, Korea, Republic of, Bulgaria, Japan, Norway, Czechia, Russian Federation, Jordan, Hungary, Ind... and more
Celcuity, Inc.

Completed

A Study To Assess The Tolerability And Clinical Activity Of Gedatolisib In Combination With Palbociclib/Letrozole Or Palbociclib/Fulvestrant In Women With Metastatic Breast Cancer

Breast Cancer

United States
University of Regensburg

Completed

Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma

Pineoblastoma

Germany
Restorbio Inc.

Terminated

Phase 2 Study to Determine if RTB101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes

COVID19

United States
Restorbio Inc.
National Institute on Aging (NIA)

Active, not recruiting

A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults

Covid19

United States
University of Regensburg

Completed

Multimodal Molecular Targeted Therapy to Treat Relapsed or Refractory High-risk Neuroblastoma (RIST-rNB-2011)

Neuroblastoma Recurrent

Germany
Abramson Cancer Center of the University of Pennsylvania
University of Pittsburgh; Rutgers Cancer Institute of New Jersey

Completed

Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma

Metastatic Clear Cell Renal Cell Carcinoma

United States
National Cancer Institute (NCI)

Terminated

Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma

Mesothelioma

United States
Restorbio Inc.

Withdrawn

Effect of RTB101 on Illness Associated With Respiratory Tract Infections in the Elderly

Clinically Symptomatic Respiratory Illness
Shanghai MicroPort Medical (Group) Co., Ltd.

Completed

The First-In-Man Pilot Study of Firehawk

Coronary Heart Disease
Shanghai MicroPort Medical (Group) Co., Ltd.

Completed

Observational Registry Study: FIREHAWK DES for Treating Coronary Artery Disease (CAD)

Coronary Artery Disease

China
National Institute of Dental and Craniofacial Research...

Completed

Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma

Head and Neck Neoplasms | Carcinoma, Squamous Cell | Mouth Neoplasms | Tongue Neoplasms

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1) (EXIST-1)

Tuberous Sclerosis | Subependymal Giant Cell Astrocytoma

United States, Belgium, Canada, Germany, Italy, Russian Federation, Netherlands, Poland, Australia, United Kingdom
Hong Kong Metropolitan University

Not yet recruiting

Effects of Inspiratory Muscle Training on Respiratory and Diaphragmatic Functions, Balance Control, Exercise Capacity and Quality of Life in People After Stroke

Stroke
University of Milan
Kolfarma s.r.l. - Italy; Fondazione Telethon

Recruiting

Targeting the Gut to Improve Seizure Control in CDKL5 Deficiency Disorder (CDD) (NUTRIENT)

CDKL5

Italy
Hartford Hospital

Recruiting

Target ADHD Executive Working Memory Replication Study

ADHD

United States
University Hospital, Rouen

Not yet recruiting

De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND)

Metastatic Colon Cancer
M.D. Anderson Cancer Center
Rigel Pharmaceuticals,Inc.

Not yet recruiting

Phase 1b/2 Study of Decitabine and Venetoclax in Combination With the Targeted Mutant IDH1 Inhibitor Olutasidenib

Mutant IDH1 Inhibitor Olutasidenib

United States
Peking University Cancer Hospital & Institute

Not yet recruiting

First Human Trial of Targeting MDM2/MDMX PET Imaging

Nuclear Medicine | MDM2/MDMX Gene Mutation | Positron Emission Tomography Imaing
Osaka University
Japan Agency for Medical Research and Development

Recruiting

Clinical Trial of Targeted Alpha Therapy for Prostate Cancer (Alpha-PS1)

Prostate Cancer

Japan

Search clinical trials for: Mammalian target of rapamycin

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Chile

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations