Search clinical trials for: Mechanism of Action

Total 429039 results

Merck Sharp & Dohme LLC

Not yet recruiting

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Metastatic Breast Cancer
University of Virginia

Recruiting

Role of TXA in Patients Undergoing Breast Free Flap Reconstruction

Breast Cancer | Blood Loss, Surgical

United States
AbbVie

Not yet recruiting

A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia
The First Affiliated Hospital of Soochow University

Recruiting

Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML

Acute Myeloid Leukemia

China
University of Miami
Medtronic

Not yet recruiting

STARLITE for Unresectable High-Grade Gliomas (STARLITE)

High Grade Glioma

United States
Ain Shams University

Recruiting

The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

Intraoperative Bleeding

Egypt
Merck Sharp & Dohme LLC

Not yet recruiting

A Clinical Study of MK-2870 Alone or With Chemotherapy to Treat Gastrointestinal Cancers (MK-9999-02A)

Colorectal Cancer | Biliary Tract Cancer | Pancreatic Ductal Carcinoma
Novartis Pharmaceuticals

Not yet recruiting

Clinical Study of Asciminib in Previously Treated Indian Patients With Ph+ CML-CP Without T315I Mutation and in Patients With Ph+ CML-CP With T315I Mutation (ASC4INDIA)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Galderma R&D

Recruiting

A Restylane Treatment Algorithm Approach for Participants With Appearance of Insufficient Bone Structure in the Lower Face Alone or in Combination With Facial Soft Tissue Deficiencies (ARTIST)

Chin Augmentation

Canada
Thanawan Longsuwan

Not yet recruiting

Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF)

Surgical Wound | Degenerative Spine Diseases
Zhuhai Beihai Biotech Co., Ltd

Not yet recruiting

An Relative Bioavailability Study of BH006 for Injection in Healthy Subjects

Bioavailability
Duke University
Temple University

Not yet recruiting

ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments

Amyotrophic Lateral Sclerosis ALS

United States
Peking University Third Hospital
Jilin Provincial Tumor Hospital; Affiliated Hospital of Hebei University; Hebei...

Not yet recruiting

Nab-Paclitaxel Plus Cisplatin With Concurrent Radiotherapy for Patients With Locally Advanced Cervical Cancer: A Multicentre, Single-arm, Phase II Trial.

Cervical Cancer
Tanta University

Not yet recruiting

Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity

Breast Cancer | Doxorubicin Induced Cardiomyopathy

Egypt
Universidad de Almeria
Leiden University Medical Center; ETH Zurich (Switzerland)

Not yet recruiting

Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women (DEBATE)

Cardiometabolic Diseases

Spain
Henan Cancer Hospital

Not yet recruiting

This is a Phase II, Open-label, Multicentre Study of Zanubrutinib-containing Regimens in Patients With Newly Diagnosed Mantle Cell Lymphoma

Lymphoma, Non-Hodgkin | Lymphoma, Mantle-Cell
University Hospital, Ghent

Recruiting

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) (PADECMO)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin | Cefazolin

Belgium
Ain Shams University
Misr International University; University of Nizwa

Recruiting

Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic for Internal Derangement (TMJ)

TMJ Disc Disorder

Egypt
West China Hospital

Recruiting

Fruquintinib Plus S-1 and Raltitrexed (RSF) for mCRC

Fruquintinib | S-1 | Raltitrexed

China
Celgene

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma (GOLSEEK-2)

Lymphoma, Follicular

United States, Australia, Brazil, Canada, Chile, France, Germany, Italy, Korea, Republic of, Poland, Spain, Taiwan, United Kingdom
Peking University Cancer Hospital & Institute

Not yet recruiting

A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma

Melanoma | Metastatic Melanoma | Mucosal Melanoma

China
Massachusetts Eye and Ear Infirmary

Not yet recruiting

The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative Vitreoretinopathy

Rhegmatogenous Retinal Detachment | Proliferative Vitreoretinopathy | Proliferative Vitreo-Retinopathy
Peking Union Medical College Hospital

Not yet recruiting

Luspatercept Plus CsA vs CsA for the Treatment of Newly Diagnosed Non-Transfusion-Dependent NSAA

Aplastic Anemia

China
Ewha Womans University Seoul Hospital

Not yet recruiting

Comparison of the Improvement and Safety of the Ankle Brachial Arterial Pressure Index of Sarpogrelate and Clopidogrel in Stroke Patients With Decreased Ankle Brachial Arterial Pressure Index and Intermittent Claudication of Lower Limb Vascular Atherosclerosis.

Stroke | Atherosclerosis
Stanford University
American Heart Association

Not yet recruiting

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries (MVP-ANOCA)

Angina Pectoris | Microvascular Angina | Vasospastic Angina | Myocardial Bridge of Coronary Artery

United States
Boehringer Ingelheim

Not yet recruiting

A Study to Test Whether BI 690517 in Combination With Empagliflozin Helps People With Heart Failure

Heart Failure
Peking University
Jiangsu Nhwa Pharmaceutical Co., Ltd.

Recruiting

Effects of Lithium on Suicide Prevention in Adolescents and Young Adults With Bipolar Disorder in China

Bipolar Disorder | Suicidal Ideation | Suicide, Attempted | Nonsuicidal Self Injury

China
Semmelweis University

Recruiting

Digital vs Conventional Impression in Capturing the Emergence Profile Around Maxillary Anterior Implant-supported Crowns

Dental Implants, Single-Tooth | Dental Impression Technique

Hungary
Finis Terrae University

Recruiting

Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity (RESTORENAD)

Metabolic Diseases | Healthy Aging | Lifestyle-related Condition

Chile
Ascentage Pharma Group Inc.

Not yet recruiting

A Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients With CML (POLARIS-2)

Chronic Myeloid Leukemia | CML | CML, Chronic Phase

United States
Medical University of South Carolina

Not yet recruiting

Study of Fingolimod

Non Small Cell Lung Cancer | Small-cell Lung Cancer
Emory University
National Cancer Institute (NCI)

Not yet recruiting

Gemcitabine, Cisplatin and Nab-Paclitaxel as Neoadjuvant Treatment for Patients With Resectable or Borderline Resectable Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage I Pancreatic Cancer AJCC v8 | Resectable Pancreatic Adenocarcinoma | Borderline Resectable Pancreatic Ductal Adenocarcinoma

United States
Tanta University

Recruiting

Preoperative Ondansetron Lozenge for Prevention of Postoperative Nausea and Vomiting in Pediatrics Undergoing Squint Surgeries

Postoperative Nausea and Vomiting | Pediatrics | Squint | Ondansetron Lozenge

Egypt
Afyonkarahisar Health Sciences University

Recruiting

Postoperative Pain Control Following Hysteroscopy

Postoperative Pain | Analgesia | Postoperative Nausea

Turkey
Tanta University

Recruiting

Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section

Cesarean Section | Ondansetron Lozenge | Post-Spinal Shivering

Egypt
Sunnybrook Health Sciences Centre

Not yet recruiting

Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE) (RELIFE)

Knee Osteoarthritis

Canada
Mayo Clinic

Not yet recruiting

Insulin and Insulin Pulses During Fasting

PreDiabetes

United States
Zhejiang Cancer Hospital

Recruiting

Sequential Tegafur-gimeracil-oteracil Potassium Capsule (s-1) and Serplulimab Following Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (Stars)

Locally Advanced Inoperable Esophageal Squamous Cell Carcinoma

China
National Cancer Institute (NCI)

Not yet recruiting

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Undifferentiated Pleomorphic Sarcoma | Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
AstraZeneca
Premier HealthCare Solutions Inc.

Recruiting

Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (ANCHOR)

Asthma

United States
Instituto Nacional de Cancerologia de Mexico

Recruiting

Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients

Hematologic Neoplasms | Neutropenia

Mexico
Fundació Eurecat
University Rovira i Virgili

Not yet recruiting

Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers (CIRCAFENOL)

Cardiovascular Diseases | Cholesterol Level, High | Circadian Rhythm Sleep Disorder, Shift Work Type

Spain
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-M07D1+PD-1 Monoclonal Antibody and BL-M07D1+PD-1 Monoclonal Antibody+Capecitabine in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma

HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma

China
Radboud University Medical Center

Not yet recruiting

The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II (RAID-II)

Inflammation | Diabetes Mellitus, Type 1
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Echocardiographic Measurement of Myocardial Work (MYOLOAD)

Intensive Care Unit Syndrome | Cardiovascular Physiological Phenomena

France
Benha University

Recruiting

Articaine Plus Dexmedetomidine in Supraclavicular Block

Post Operative Pain, Acute

Egypt
Chen Xiaoping

Not yet recruiting

Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model

HCC
Ain Shams University

Recruiting

Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease Patients

Chronic Kidney Diseases

Egypt
University of Santiago de Compostela
Hospital Clinico Universitario de Santiago

Not yet recruiting

An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures

Bacteremia | Endocarditis

Spain
Merck Sharp & Dohme LLC

Not yet recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

NSCLC | Non-small Cell Lung Cancer

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