Search clinical trials for: Mitochondrial genes

Total 3841 results

Lexeo Therapeutics

Recruiting

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

Friedreich Ataxia | Cardiomyopathy, Secondary

United States, Canada
Weill Medical College of Cornell University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Phase IA Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia

Myocardial Fibrosis | Cardiomyopathies | Friedreich Ataxia | Cardiac Hypertrophy

United States
University of Leicester

Recruiting

A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery (Ob-Card)

C.Surgical Procedure; Cardiac

United Kingdom
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
GenSight Biologics

No longer available

EAP_GS010_single Patient

Leber Hereditary Optic Neuropathy (Optic, Atrophy, Hereditary, Leber)
Byron Lam
National Eye Institute (NEI)

Active, not recruiting

Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy

United States
Centre Hospitalier Universitaire de Nice

Completed

Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip (ACPA HR)

Mitochondrial Diseases

France
University Hospital, Bordeaux
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Testing of NBIA Genes: Analysis of Genetic Heterogeneity and Validation of Mitochondrial Markers for Assessing Causality of Sequence Variants. (NBIA MITO)

Neurodegeneration With Brain Iron Accumulation (NBIA)

France
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy
GenSight Biologics

Completed

REALITY LHON Registry (REALITY)

Leber Hereditary Optic Neuropathy

United States, France, Italy, Spain, United Kingdom
Igenomix

Unknown

Study for the Evaluation of "MitoScore" Marker in the Diagnosis of Embryo Viability in Euploids Embryos (MitoScore)

Infertility

Spain
University Hospital Heidelberg

Not yet recruiting

Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor (PAMSARC)

Synovial Sarcoma | Desmoplastic Small Round Cell Tumor

Germany
Sixth Affiliated Hospital, Sun Yat-sen University

Not yet recruiting

SUperior Hypogastric Plexus Block During Laparoscopic hysterEctomy (SUBTLE) (SUBTLE)

Hysterectomy
Verve Therapeutics, Inc.

Not yet recruiting

Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

Hypercholesterolemia
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Bioequivalence Study of Two Different Dosage Form of Genakumab

Gouty Arthritis (GA)

China
Khondrion BV

Not yet recruiting

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases (KH176-301)

Mitochondrial Diseases | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Maternally Inherited Diabetes and Deafness (MIDD) | Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
Bayer

Not yet recruiting

A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2)

Advanced Non-small Cell Lung Cancer | HER2 Mutation

United States, Korea, Republic of, Belgium, China, Japan, Taiwan, Denmark, Germany, Israel, Italy, United Kingdom, Bulgaria, Portugal, Switzerland, Greece, Turkey, Sweden, France, Singapore, Mexico, Spain, Netherlands, Poland, Brazil, A... and more
Anhui Medical University

Not yet recruiting

Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases

Mitochondrial Diseases
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Efficacy and Pharmacokinetic Behavior of Leuprolide Injectable Emulsion for Premenopausal Breast Cancer Subjects.

Breast Cancer Subjects

China
Ascidian Therapeutics, Inc

Recruiting

Prescreening Study to Identify Potential Participants for ACDN-01 Clinical Trials

Stargardt Disease | Stargardt Disease 1 | Juvenile Macular Degeneration | Cone Rod Dystrophy

United States
Jiaxing Pharmadax Genesis Pharmaceutical Technology...

Not yet recruiting

Technetium [99mTc]-H7ND in Patients With Gastrointestinal Malignancies and Healthy Volunteers

Solid Tumor
University Hospital, Angers

Not yet recruiting

Gene Therapy Development and Validation for Huntington's Disease Fibro TG-HD (FibroTG-HD)

Huntington Disease

France
Canadian Cancer Trials Group
Canadian Institutes of Health Research (CIHR)

Not yet recruiting

Platinum and Taxane Chemo in Met Castration Resistant Prostate Cancer Patients With Alterations in DNA Damage Response Genes (OPTION-DDR)

Metastatic Prostate Cancer | Metastatic Castration-resistant Prostate Cancer
Enloe Health
Robert A. Winn Diversity in Clinical Trials Award Program

Not yet recruiting

A Pilot Study of Genetic Testing Uptake Through Enhanced Oncology Nurse-Led Intervention (GENESIS)

Solid Tumor, Adult
Hospital Universitari Vall d'Hebron Research Institute
Hospital General Universitario Gregorio Marañon; Hospital Clinic of Barcelona; Germans Trias i Pujol Hospital and other collaborators

Recruiting

Zinc Supplementation to Improve Prognosis in Patients With Compensated Advanced Chronic Liver Disease.

Hepatocellular Carcinoma | Portal Hypertension | Advanced Chronic Liver Disease

Spain
University Hospital of Ferrara
University of Milano Bicocca

Not yet recruiting

Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction (FRAMITO)

Chronic Disease | Frailty | Aging | Mitochondrial Dysfunction
Biohaven Therapeutics Ltd.

Recruiting

BHV-7000 Acute Treatment of Bipolar Mania

Bipolar Disorder

United States
Chang Gung Memorial Hospital

Recruiting

Exercise Therapy on Mitochondrial Functions of Lymphocyte in Hemodialysis

Hemodialysis Complication

Taiwan
Sohag University

Recruiting

Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Vitiligo

Egypt
Tisento Therapeutics

Not yet recruiting

A Phase 2b Study of Zagociguat in Patients With MELAS (PRIZM)

Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)

United States, Australia, Italy, Germany, Canada, United Kingdom
Hospital Universitari Vall d'Hebron Research Institute
Universitat Pompeu Fabra; IDIAPJgol

Recruiting

Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden. (StopALD)

Alcohol Use Disorder | Alcohol-related Liver Disease | Metabolic and Alcohol Related/Associated Liver Disease | Metabolic Disfunction Associated Steatotic Liver Disease

Spain
University of British Columbia

Recruiting

Impact of Exercise Intensity on Fitness, Extracellular Vesicles, Inflammation, and Metabolism (CEX)

Exercise Training

Canada
Peking Union Medical College Hospital

Not yet recruiting

A Study to Evaluate the Safety and Tolerability of GEN6050X in Duchenne Muscular Dystrophy. (GEN6050XIIT)

Duchenne Muscular Dystrophy (DMD)
The Affiliated Hospital Of Guizhou Medical University

Not yet recruiting

Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Bioavailability Study of Two Different PEG-rhGH Preparations.

Pediatric Growth Hormone Deficiency (PGHD)

China
Ataturk University

Not yet recruiting

The Effect of Mobile-Based Education on Postoperative Recovery and Quality of Life in Thyroidectomy Patients

Thyroid Diseases | Thyroid | Healthy Lifestyle
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
University of Exeter
Innovate UK; Mitocholine Ltd

Recruiting

The Effects of a Novel Mitochondrial Substrate Supplement on Exercise Performance and Cognitive Function (MCh1)

Cognitive Function | Exercise Performance

United Kingdom
Sensorion

Not yet recruiting

A Phase I/II Clinical Trial With SENS-501 in Children Suffering From Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations (AUDIOGENE)

Otorhinolaryngologic Diseases | Ear Diseases | Hearing Disorders | Deafness | Hearing Loss, Sensorineural | Congenital Deafness | DFNB9 | OTOF Gene Mutation

France
Children's Hospital of Philadelphia

Not yet recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

Beta-Thalassemia

United States
National Cancer Institute (NCI)

Not yet recruiting

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL)

Leukemia, Lymphocytic, Chronic, B-Cell | B-Cell Chronic Lymphocytic Leukemia | B-Lymphocytic Leukemia, Chronic

United States
Ractigen Therapeutics.

Recruiting

A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) Therapy

Non-Muscle-Invasive Bladder Cancer (NMIBC)

Australia
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Federico II University; Istituto Auxologico Italiano; Università degli Studi...

Recruiting

Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks

Beckwith-Wiedemann Syndrome

Italy
Fondazione Policlinico Universitario Agostino Gemelli...
IRCCS Azienda Ospedaliero-Universitaria di Bologna; Federico II University; Azienda... and other collaborators

Not yet recruiting

Transgender and Gender Diverse Individuals Screening for Breast Cancer (GENESIS)

Breast Cancer
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Effect of Probiotics Before Cesarean Section on Postoperative Recovery in Pregnant Women

Microbiota | Postoperative Recovery

China
Ataturk University

Recruiting

Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial

Postoperative Recovery

Turkey
Jirair Krikor Bedoyan
Ultragenyx Pharmaceutical Inc

Recruiting

Triheptanoin for Children With Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency

Pyruvate Dehydrogenase Complex Deficiency

United States
Pfizer

Recruiting

A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function

Liver Diseases

United States
Kaohsiung Veterans General Hospital.

Recruiting

Male Supplements for Sperm Quality and Aging

Unrecognized Condition

Taiwan
Ahmet Yuksek

Recruiting

Bispectral Index, Suppression Rate and Emergence Agitation in Spine Surgeries

Emergence Agitation | Anesthesia Recovery | Bispectral Index Monitor

Turkey

Search clinical trials for: Mitochondrial genes

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