Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

May 7, 2024 updated by: Rania Hassan Metwaly, Sohag University

The present study will aim to evaluate:

  1. The presence of Hypoxia Inducible Factor in vitiligo patient
  2. Defect of Autophagy Related Genes in vitiligo patient
  3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Reham E El-Sharkawy, Professor
  • Phone Number: 01006809003

Study Locations

  • Egypt
      • Sohag, Egypt
        • Recruiting
        • Sohag University hospitals
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Adult >18 years
  • With non segmental vitiligo
  • A group of participants will be included as a control group

Exclusion Criteria:

  • Pregnancy
  • Patient with chronic inflammatory skin disorders
  • patient on anti-oxidant or anti-inflammatory drugs
  • patient on topical or systemic treatment for vitiligo in last 4 weeks
  • patients with other autoimmune diseases
  • patients with diabetes mellitus

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: skin biopsy from vitiligo lesion in vitiligo patient
punch biopsy 5mm from vitiligo patch in vitiligo patient
Device: Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
Active Comparator: skin biopsy from normal skin in vitiligo patient
punch biopsy 5mm from normal skin patch in vitiligo patient
Device: Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy
Active Comparator: skin biopsy from normal skin in normal person
punch biopsy 5mm from normal skin patch in normal person
Device: Punch Biopsy 5mm
Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of Autophagy Related genes in Vitiligo patients
Time Frame: 2 months
Assess Autophagy Related genes levels in skin biopsy of vitiligo patient
2 months
Assessment of Hypoxia Inducible Factor in Vitiligo patients
Time Frame: 2 months
Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient
2 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sohag University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 25, 2024

Primary Completion (Estimated)

July 25, 2024

Study Completion (Estimated)

July 25, 2024

Study Registration Dates

First Submitted

May 2, 2024

First Submitted That Met QC Criteria

May 7, 2024

First Posted (Actual)

May 13, 2024

Study Record Updates

Last Update Posted (Actual)

May 13, 2024

Last Update Submitted That Met QC Criteria

May 7, 2024

Last Verified

May 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Soh-Med-24-04-014MS

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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