Search clinical trials for: Mutated BRCA2 Gene

Total 267887 results

Institut Paoli-Calmettes

Unknown

Triple Negative Breast Cancer: Study of Molecular and Genetic Factors

Breast Cancer

France
Data Collection Analysis Business Management
PAS Research Services

Unknown

Increase Surveillance for Breast and Ovarian Cancers, Also to Determine Targeted Risk-reducing and Preventative Strategies

Hereditary Cancer

United States
University of Utah
National Cancer Institute (NCI)

Completed

Risk Education and Assessment for Cancer Heredity (REACH)

Breast Cancer | Ovarian Cancer | Genetic Predisposition

United States
Centre Hospitalier Universitaire de la Réunion

Not yet recruiting

Contribution of Oncogenetics in Breast Cancer in Reunion Epidemiology of Breast Cancer in Reunion: Study of the Reunion Mutation on BRCA2 (CanSeR-OGen)

Breast Cancer | BRCA2 Mutation | Genetic Disease
Lund University

Completed

Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast Cancer (BRCAsearch)

Hereditary Breast Cancer

Sweden
Weill Medical College of Cornell University
Basser Research Center for BRCA

Recruiting

FaCT Trial (Facilitated Cascade Testing Trial)

BRCA1 Mutation | BRCA2 Mutation

United States
National Cancer Institute (NCI)

Completed

A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

BRCA1 Gene | BRCA2 Gene

United States
Massachusetts General Hospital

Recruiting

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Lynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR Mutation

United States
Institut Curie

Recruiting

COsegregation of VARiants in Panel of Genes (COVAR)

Genetic Predisposition | Gene Mutation-Related Cancer

France, Guadeloupe, Martinique, Réunion
Medical College of Wisconsin

Active, not recruiting

Evaluating the Effects of Genetic Testing on Patients' Stress Levels

Breast Cancer

United States
pharmaand GmbH

Terminated

A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes (LODESTAR)

Solid Tumor

United States
Georgetown University

Completed

The Genetic Education for Men Trial: Web-Based Education vs. Standard Care (GEM)

Pancreatic Cancer | Breast Neoplasm | BRCA1 Mutation | BRCA2 Mutation | Prostate Carcinoma

United States
Sierra Oncology LLC - a GSK company

Completed

A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer

Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)

United Kingdom
Priyanka Sharma
Bristol-Myers Squibb; Celgene Corporation

Active, not recruiting

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Breast Cancer | Triple-Negative Breast Cancer

United States
Georgetown University
National Cancer Institute (NCI); National Human Genome Research Institute (NHGRI)

Completed

Decision Support Following Genetic Testing for Breast-Ovarian Cancer Susceptibility

Breast Cancer | Ovarian Cancer

United States
National Human Genome Research Institute (NHGRI)

Completed

Is it Feasible?: Self-Affirmation for Hereditary Breast and Ovarian Cancer Genetic Counseling

Breast Cancer

United States
University of Michigan
National Cancer Institute (NCI)

Completed

Why do Oral Contraceptives Prevent Ovarian Cancer?

Ovarian Cancer Risk | Risk-reducing Surgery | Fallopian Tube Fimbriae | Ovarian Cortical Inclusion Cysts

United States, Canada
National Human Genome Research Institute (NHGRI)

Terminated

Family Communication of Hereditary Breast and Ovarian Cancer Risk Among African Americans

Breast Cancer | Ovarian Neoplasm | Cancer Genetics

United States
National Human Genome Research Institute (NHGRI)
Johns Hopkins Bloomberg School of Public Health

Completed

Adaptation to Living With a BRCA1/2 Mutation

Cancer Genetics

United States
Rabin Medical Center

Unknown

The Link Between BRCA Mutation and Endothelial Function

BRCA1 Gene Mutation | BRCA2 Gene Mutation

Israel
OncoNano Medicine, Inc.

Recruiting

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas. (ON-5001)

Lymphoma, Non-Hodgkin | Follicular Lymphoma | Carcinoma in Situ | Mantle Cell Lymphoma | Metastatic Cancer | Bladder Cancer | Skin Cancer | Triple Negative Breast Cancer | Cervix Cancer | Diffuse Large B Cell Lymphoma | Head and Neck Squamous Cell Carcinoma | Tumor, Solid | Tumor Recurrence | Uveal Melanoma, Recurrent

United States
National Cancer Institute (NCI)

Recruiting

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Pancreatic Acinar Cell Carcinoma | Pancreatic Adenosquamous Carcinoma | Pancreatic Squamous Cell Carcinoma | Resectable Pancreatic Acinar Cell Carcinoma | Resectable Pancreatic Adenocarcinoma | Resectable Pancreatic Adenosquamous Carcinoma | Resectable Pancreatic Carcinoma

United States
University Health Network, Toronto
Women's College Hospital; Jewish General Hospital; IWK Health Centre; British Columbia... and other collaborators

Recruiting

Cell-free DNA in Hereditary And High-Risk Malignancies (CHARM)

Hereditary Cancer Syndrome

Canada
Icahn School of Medicine at Mount Sinai

Recruiting

Pancreas Registry and High Risk Registry

Pancreatitis | Chronic Pancreatitis | Pancreas Cancer | Pancreatic Cyst | Genetic Mutations | Family History of Pancreas Cancer

United States
Institute of Cancer Research, United Kingdom

Recruiting

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations (GENPROS)

Prostate Cancer

United Kingdom
Centre Oscar Lambret
CTD-CNO; Laboratoire PRISM

Active, not recruiting

Radical Fimbriectomy for Young BRCA Mutation Carriers (Fimbriectomy)

BRCA1 Mutation | BRCA2 Mutation | Hereditary Breast and Ovarian Cancer

France
Hellenic Cooperative Oncology Group
NIPD Genetics

Completed

Tumor Molecular Profiling in Patients With Prostate Cancer

Prostate Cancer | Metastatic Prostate Adenocarcinoma

Greece
National Human Genome Research Institute (NHGRI)

Completed

Analysis of Data From the Women's Contraceptive and Reproductive Experiences (CARE) Study

Breast Cancer

United States
University Health Network, Toronto
Hamilton Health Sciences Corporation; Mount Sinai Hospital, Canada

Completed

Breast Cancer Risk Assessment Using Optical Breast Spectroscopy (OBS)

Breast Cancer

Canada
Ohio State University Comprehensive Cancer Center

Recruiting

Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

BRCA1 Gene Mutation | BRCA2 Gene Mutation

United States
Nuvation Bio Inc.

Recruiting

NUV-868 as Monotherapy and in Combination With Olaparib or Enzalutamide in Adult Patients With Advanced Solid Tumors

Breast Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Breast Carcinoma | Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Advanced Solid Tumor | Cancer of the Ovary | Pancreas Cancer | Triple-negative Breast Cancer | Cancer of Pancreas | Pancreas Neoplasm | Prostate Neoplasm | Cancer... and other conditions

United States, Australia
General Oncology, Inc.
Myriad Genetics, Inc.

Recruiting

SHARON: A Clinical Trial for Metastatic Cancer With a BRCA or PALB2 Mutation Using Chemotherapy and Patients' Own Stem Cells

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Pancreatic Cancer Stage IV | Breast Cancer Stage IV | BRCA1 Mutation | BRCA2 Mutation | Pancreatic Acinar Cell Carcinoma | Metastatic Pancreatic Cancer | Breast Cancer Metastatic | HER2-negative Breast Cancer | Metastatic Pancreatic Ductal Adenocarcinoma and other conditions

United States
AbbVie

Completed

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

Metastatic Breast Cancer

United States, Argentina, Australia, Austria, Belarus, Belgium, Canada, Chile, Colombia, Czechia, Denmark, Estonia, Finland, France, Germany, Hungary, Israel, Italy, Korea, Republic of, Latvia, Lithuania, Mexico, Netherlands, Norway, Po... and more
University of Washington
National Cancer Institute (NCI)

Active, not recruiting

Genetic Testing for Men With Metastatic Prostate Cancer (GENTleMEN)

Metastatic Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8

United States
Artios Pharma Ltd

Active, not recruiting

A Study of ART4215 for the Treatment of Advanced or Metastatic Solid Tumors

Breast Cancer | Metastatic Cancer | Advanced Cancer

United States, United Kingdom
Mayo Clinic

Enrolling by invitation

GENetic Risk Estimation of Breast Cancer Prior to Decisions on Preventive Therapy Uptake, Risk Reducing Surgery or Intensive Imaging Surveillance (GENRE2)

Breast Cancer

United States
Georgetown University
George Washington University

Enrolling by invitation

Genetic Education in BRCA Families

BRCA1 Mutation | BRCA2 Mutation

United States
Sierra Oncology LLC - a GSK company

Completed

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Advanced Solid Tumors

Spain, United Kingdom
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust; Cancer Research UK; Ronald and Rita McAulay...

Active, not recruiting

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer

Prostate Cancer in BRCA1 and BRCA2 Carriers

United Kingdom
Revolution Medicines, Inc.
Sanofi; Amgen

Active, not recruiting

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Non-Small Cell Lung Cancer

United States, Korea, Republic of, Canada, Taiwan, Spain, United Kingdom, Italy, Australia, France, Germany
University of Washington

Completed

Genes Contributing to Hereditary Ovarian Cancer in Women and BRCA1/2 Wildtype Families

Ovarian Cancer

United States
Centre Hospitalier Universitaire de Besancon

Completed

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA) (IMBASSA)

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

France
Memorial Sloan Kettering Cancer Center
American Cancer Society, Inc.

Completed

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Breast Cancer

United States
IDEAYA Biosciences

Recruiting

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Breast Cancer | Ovarian Cancer | Prostate Cancer | Pancreas Cancer | Advanced or Metastatic Solid Tumors

United States
Beth Israel Deaconess Medical Center
Washington University School of Medicine; Rush University Medical Center; Wake... and other collaborators

Recruiting

Pancreatic Cancer Screening for At-risk Individuals (PancreasScan)

Pancreatic Cancer, Adult

United States
Calithera Biosciences, Inc

Terminated

Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors

Clear Cell Renal Cell Carcinoma | Colorectal Cancer | Solid Tumor | CRC | TNBC - Triple-Negative Breast Cancer | ccRCC | RCC

United States
European Institute of Oncology

Completed

Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing (BRCA-MEN)

BRCA1 Mutation | BRCA2 Mutation | Psychosocial Factors

Italy
University of California, San Francisco
American Cancer Society, Inc.

Completed

Prospective Research of Outcomes After Salpingo-oophorectomy (PROSper)

BRCA1 Gene Mutation | BRCA2 Gene Mutation

United States
Alexandru Eniu
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival

To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer

Romania
University of Pennsylvania

Recruiting

Evaluating Cascade Communication Methods (ECHO)

BRCA1 Mutation | BRCA2 Mutation

United States

Search clinical trials for: Mutated BRCA2 Gene

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