Search clinical trials for: Number of steps

Total 428576 results

Merck Sharp & Dohme LLC

Recruiting

Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)

HIV | HIV Pre-exposure Prophylaxis

United States, South Africa, Israel
Merck Sharp & Dohme LLC

Recruiting

A Study of MK-3475A (Pembrolizumab Formulated With MK-5180) in Japanese Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC) or Locally Advanced (LA) Unresectable cSCC (MK-3475A-E39)

Squamous Cell Carcinoma

Japan
Sanofi

Recruiting

Real-world Effectiveness Study of Long-term Treatment With Dupilumab in Participants ≥6 Years With Atopic Dermatitis (PROTYPE2)

Atopic Dermatitis

Germany
China National Center for Cardiovascular Diseases
Shanghai Children's Medical Center; Chinese Academy of Medical Sciences, Fuwai... and other collaborators

Recruiting

Study of Innovative Strategies for Mitral Valve Repair

Congenital Mitral Insufficiency

China
Universidad Complutense de Madrid
Ministerio de Economía y Competitividad, Spain

Recruiting

Impact of Periodontal Therapy on Mental Health Parameters (LeakBrainRCT)

Depression | Periodontitis

Spain
Merck Sharp & Dohme LLC

Recruiting

Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)

Solid Tumor | Endometrial Cancer | Cutaneous Squamous Cell Carcinoma

Canada, Australia, Taiwan, Malaysia, United States, Netherlands, Turkey, France
Sanofi

Recruiting

Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study (RIVER-ASTHMA)

Asthma

Korea, Republic of, Argentina, Chile, South Africa, United States, Hungary, Poland, Turkey, United Kingdom, Canada, Japan
Genentech, Inc.

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Locally Advanced Solid Tumors | Metastatic Solid Tumors | Recurrent Solid Tumors

Australia, United States, Canada
Zhejiang Cancer Hospital

Not yet recruiting

Radiotherapy Combined With ICIs as Treatment for LA-NSCLC After Failing Induction Immunochemotherapy

Non-small Cell Lung Cancer Stage III
Sanofi
Kymera Therapeutics, Inc.

Recruiting

A Phase 2 Study to Evaluate the Efficacy and Safety of SAR444656 Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa (ZEN)

Hidradenitis Suppurativa

Spain, United States, Germany, Greece, Poland
Sanofi

Recruiting

A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme (SHORTEN)

Fabry's Disease

United States
Sanofi

Recruiting

A Study to Investigate Vaccine Responses in Subcutaneous Amlitelimab Treated Atopic Dermatitis Participants Aged 18 Years and Older Compared With Placebo (HYDRO)

Dermatitis Atopic

Canada, United States
Merck Sharp & Dohme LLC

Recruiting

MK-0616 (Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes

Arteriosclerosis | Hypercholesterolaemia

United States, Taiwan, Canada, Israel, New Zealand, Hong Kong, Argentina, Korea, Republic of, Turkey, Australia, Chile, Brazil, Japan, Colombia, China, United Kingdom, Mexico, Peru
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of RO7589831 in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States, Belgium, Spain, France, United Kingdom, Canada, Denmark
Amunix, a Sanofi Company

Recruiting

Safety, Pharmacokinetics, and Preliminary Efficacy of AMX-500 in Metastatic Castration Resistant Prostate Cancer (mCRPC)

Hormone-refractory Prostate Cancer

Australia, Spain, United Kingdom
Rehman Medical Institute - RMI
Gandhara University

Recruiting

The Effect of Number of Micro-osteo-perforations on the Rate of Tooth Movement. (MOPs)

Orthodontic Tooth Movement

Pakistan
Sanofi
Regeneron Pharmaceuticals

Recruiting

Real-World Effectiveness of Dupilumab in Patients With Prurigo Nodularis: An Observational Study (GLOBOSPIN)

Prurigo Nodularis

United States
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

Hemophilia A

Spain, Canada, United States, New Zealand, Italy, Poland
Hoffmann-La Roche

Recruiting

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Participants With Thyroid Eye Disease

Thyroid Eye Disease | TED

Japan, Australia, Singapore, United States, Argentina, Germany, Italy, Hong Kong
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Study of Long-term Effect of Dupilumab on Skin Barrier Function in Pediatric Participants With Atopic Dermatitis (PELISTAD-EX2)

Dermatitis Atopic

United States, United Kingdom
Hospices Civils de Lyon

Recruiting

Cosmetic and Functional Sequelae in Hand Burns. (AdipoSCAR)

Hand Burn

France
Sanofi

Recruiting

A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria

Phenylketonuria

Turkey, United States
Bill & Melinda Gates Medical Research Institute
Global Alliance for TB Drug Development; Janssen Pharmaceutica; Otsuka Pharmaceutical...

Recruiting

Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa, Philippines
Manchester University NHS Foundation Trust

Not yet recruiting

Evaluation of Patients' Requirements for Improved Advice and Guidance on Vision Standards for Driving in Glaucoma (D&G)

Glaucoma

United Kingdom
ART Fertility Clinics LLC

Not yet recruiting

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

Miscarriage, Recurrent | Miscarriage | Infertility, Female | IVF

United Arab Emirates
Genentech, Inc.
BioNTech SE

Recruiting

A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected Pancreatic Ductal Adenocarcinoma (IMCODE003)

Adenocarcinoma, Pancreatic Ductal

United States
University of British Columbia

Not yet recruiting

Small Steps for Big Changes - Recipe for Health (RFH)

PreDiabetes | Prediabetic State

Canada
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Comparing a 6-month vs Long-term Course of Rezvilutamide With ADT Plus Chemotherapy in mHSPC

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

China
Genentech, Inc.

Recruiting

Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer

Colorectal Cancer | Non-Small Cell Lung Cancer

Korea, Republic of, Australia, Canada, United States
Merck Sharp & Dohme LLC

Recruiting

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010)

Leukemia, Lymphocytic, Chronic, B-Cell | Lymphoma, Small Lymphocytic | CLL | SLL | Small-Cell Lymphoma | Leukemia, Chronic Lymphocytic

Italy, Argentina, Chile, Brazil, Israel, South Africa, United States, Australia, Puerto Rico, Spain, Canada, Germany, France, United Kingdom, Colombia
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Safety and Effectiveness of Trastuzumab Emtansine (T-DM1) as Therapy in Chinese Participants With HER2 Positive Advanced Breast Cancer

Breast Cancer

China
Beth Israel Deaconess Medical Center
University of Michigan; Brigham and Women's Hospital; VA Boston Healthcare System

Not yet recruiting

Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

Chronic Obstructive Pulmonary Disease | Chronic Heart Failure

United States
Merck Sharp & Dohme LLC
ModernaTX, Inc.

Recruiting

A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Melanoma

Spain, Italy, Poland, Brazil, Australia, Chile, Canada, Portugal, Turkey, Germany, Greece, Israel, Sweden, New Zealand, United States, Belgium, France, Taiwan, United Kingdom, Switzerland, South Africa, Denmark, Argentina
National Children's Hospital, Vietnam
Anabio R&D

Recruiting

Efficacy of LiveSpo Navax in Supportive Treatment of Pneumonia in Children With RSV and Bacterial Co-infections

Pneumonia | Respiratory Syncytial Virus (RSV) | Acute Respiratory Tract Infections

Vietnam
Sanofi Pasteur, a Sanofi Company

Recruiting

Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy

Healthy Volunteers | Meningococcal Infection

Argentina
Hoffmann-La Roche

Recruiting

A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease

Parkinson Disease

United States, Netherlands, United Kingdom
Sanofi

Recruiting

A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A

Hemophilia A

United States
Hoffmann-La Roche

Recruiting

A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma

Carcinoma, Hepatocellular

Korea, Republic of, Taiwan, United States, France, Spain, New Zealand, United Kingdom
Immunovant Sciences GmbH

Recruiting

A Proof-of-Concept Study to Assess Batoclimab in Participants With Graves' Disease

Graves Disease

Germany
Sanofi

Recruiting

Implementation and Evaluation of a Rare Disease Algorithm to Identify Persons at Risk of Gaucher Disease Using Data From Electronic Health Records (EHRs) in the United States (Project Searchlight)

Gaucher Disease

United States
Hoffmann-La Roche
Chugai Pharmaceutical

Recruiting

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152) (SKYSCRAPER-14)

Carcinoma, Hepatocellular

United States, Canada, Korea, Republic of, Taiwan, Brazil, Belgium, China, Puerto Rico, Japan, New Zealand, Mexico, Spain, Germany, Poland, Thailand, Singapore, Hong Kong, France, Turkey, Italy, United Kingdom, South Africa, Côte D'Ivoire
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Korea, Republic of, Spain, Canada, Brazil, China, Singapore, Turkey, India, Argentina, Australia, Belgium, Finland, Hong Kong, South Africa, Italy, United Kingdom, Poland, Taiwan, Colombia, France, Germany, Mexico
University of Turin, Italy

Recruiting

Timing of Re-evaluation After Steps I-II of Periodontal Therapy

Periodontitis

Italy
Bill & Melinda Gates Medical Research Institute

Recruiting

Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults

Malaria

United States
CHU de Quebec-Universite Laval
Canadian Institutes of Health Research (CIHR); Quebec Breast Cancer Foundation

Recruiting

Pilot Study of PACHA Program to Enhance Adherence to Adjuvant Endocrine Therapy Among Breast Cancer Survivors (PACHA)

Breast Cancer | Breast Neoplasms

Canada
Xiangya Hospital of Central South University
Jiangsu Simcere Pharmaceutical Co., Ltd.

Not yet recruiting

Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke (EARLYS)

Ischemic Stroke, Acute | Treatment Outcome

China
Massachusetts General Hospital
National Cancer Institute (NCI)

Recruiting

Testing the Integrated mHealth App Intervention "SiS-H"

Smoking Cessation

United States
Merck Sharp & Dohme LLC

Recruiting

A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)

Non-alcoholic Fatty Liver Disease | NAFLD | Nonalcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis | Fatty Liver, Nonalcoholic

Canada, United States, Puerto Rico, Japan, Korea, Republic of, Taiwan, Spain, Israel, Chile, France, Italy, Hungary, Switzerland, Belgium, China, Singapore, Czechia, Portugal, Austria, United Kingdom, Thailand, Hong Kong, Turkey, Colo...
GlaxoSmithKline

Recruiting

A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease (BLISSc-ILD)

Scleroderma, Systemic | Systemic Sclerosis Associated Interstitial Lung Disease

United States, Australia, France, Italy, Japan, Spain, Belgium, Greece, Korea, Republic of, China, Mexico, United Kingdom, Finland, Israel, Germany, Argentina, Brazil, Canada, Denmark
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United States, Belgium, Australia, Israel, Spain, France, United Kingdom, Denmark, Argentina, Germany, New Zealand, South Africa, Korea, Republic of, Poland, Bulgaria, Canada, Chile, Czechia, Netherlands, Romania, Sweden, Mexico

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