A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

A Phase III Open-Label Extension Study to Evaluate the Long-Term Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease

The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment period in parent studies GB43311 or GB44332.

Study Overview

• Status: Recruiting
• Conditions: Chronic Obstructive Pulmonary Disease
• Intervention / Treatment: Drug: Astegolimab

• Study Type: Interventional
• Enrollment (Estimated): 2000
• Phase: Phase 3

Contacts and Locations

• Study Contact: Name: Reference Study ID Number: GB43374 https://forpatients.roche.com/; Phone Number: 888-662-6728; Email: global-roche-genentech-trials@gene.com
• Study Contact Backup: Name: Fastest response: use the inquiry form. No email attachments. https://www.gene.com/contact-us/submit-medical-inquiry

Study Locations

• Argentina
  • Buenos Aires, Argentina, C1121ABE
    • Recruiting
    • Fundacion CIDEA
  • Buenos Aires, Argentina, C1122AAK
    • Recruiting
    • Fundacion Faicep
  • Buenos Aires, Argentina, 1425
    • Recruiting
    • Consultorios Medicos Organizacion de Buen Ayre SRL
  • Buenos Aires, Argentina, C1425
    • Recruiting
    • Instituto de Investigaciones En Alergia Y Enfermedades Respiratorias
  • Buenos Aires, Argentina, 7240
    • Recruiting
    • Centro de Investigaciones Clínicas Belgrano
  • Buenos Aires, Argentina, C1430
    • Recruiting
    • AES - AS - Glenny Corp. S.A. Buenos Aires
  • CABA, Argentina, C1414AIF
    • Recruiting
    • CARE - Centro de Alergia y Enfermedades Respiratorias
  • Ciudad Autonoma Buenos Aires, Argentina, C1025ABI
    • Recruiting
    • Nexo Salud Investigacion Clinica - Riobamba 429
  • Ciudad Autonoma Buenos Aires, Argentina, C1056ABI
    • Recruiting
    • CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC
  • Ciudad Autonoma Buenos Aires, Argentina, C1426ABP
    • Recruiting
    • Centro Médico Dra de Salvo
  • Concepción del Uruguay, Argentina, 3260
    • Recruiting
    • Centro de Medicina Respiratoria
  • Córdoba, Argentina, X5003DCE
    • Recruiting
    • Instituto de Medicina Respiratoria, IMeR
  • Córdoba, Argentina, X5000BSQ
    • Recruiting
    • Sanatorio de la Cañada
  • Entre Ríos, Argentina, E3100BBJ
    • Recruiting
    • Centro Privado de Medicina Respiratoria
  • La Plata, Argentina, 1900
    • Recruiting
    • Framingham Centro Medico
  • La Plata, Argentina, B1900BNN
    • Recruiting
    • Centro Platense en Investigaciones Respiratorias
  • Mar del Plata, Argentina, B7600FYK
    • Recruiting
    • Centro de Investigaciones Medicas Mar del Plata
  • Mar del Plata, Argentina, B7600FZN
    • Recruiting
    • Instituto de Investigaciones Clinicas-Mar del Plata
  • Mar del Plata, Argentina, B7602DCK
    • Recruiting
    • Instituto Ave Pulmo
  • Mendoza, Argentina, 5500
    • Recruiting
    • Centro Medico Dharma
  • Mendoza, Argentina, M5500AXR
    • Recruiting
    • Fundación Scherbovsky
  • Mendoza, Mendoza City, Argentina, M5500CCG
    • Recruiting
    • INSARES
  • Quilmes, Argentina, B1878FNR
    • Recruiting
    • Centro Respiratorio Quilmes
  • Ranelagh, Berazategui, Argentina, 1886
    • Recruiting
    • Sala de primeros auxilios Alberto Mignaburu
  • Rosario, Argentina, S2000DEJ
    • Recruiting
    • Instituto Medico de la Fundacion Estudios Clinicos
  • Rosario, Argentina, S2013SBK
    • Recruiting
    • Centro Medico IPAM
  • Rosario, Argentina, S2013JKR
    • Recruiting
    • Servicio de Investigacion de Patologias Alergicas-Instituto ABC
  • Rosario, Argentina, S2000KZD
    • Recruiting
    • Sanatorio Parque de Rosario
  • Rosario, Argentina, S2002OJP
    • Recruiting
    • Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
  • San Fernando, Argentina, B1646EBJ
    • Recruiting
    • Centro Médico Respire
  • San Miguel de Tucumán, Argentina, T4000CHE
    • Recruiting
    • Centro Integral de Medicina Respiratoria (CIMER)
  • San Miguel de Tucumán, Argentina, 4000
    • Recruiting
    • Instituto De Patologias Respiratorias
  • San Miguel de Tucumán, Argentina, T4000IFL
    • Recruiting
    • Centro Modelo de Cardiologia
  • San Nicolás de los Arroyos, Argentina, B2900
    • Recruiting
    • Centro Medico San Nicolas Grupo Orono
  • San Salvador, Argentina, E3218CHH
    • Recruiting
    • CEPROSS- Centro Profesional San Salvador
  • Santa Fe, Argentina, 3000
    • Recruiting
    • Instituto Del Buen Aire
  • Santa Fe, Argentina, S3000
    • Recruiting
    • Centro de Diagnostico Y Rehabilitacion
  • Villa Vatteone, Argentina, B1853AIK
    • Recruiting
    • Instituto De Enfermedades Respiratorias E Investigacion Medica
  • Buenos Aires
    • La Plata, Buenos Aires, Argentina, B1900
      • Recruiting
      • Centro Medico Capital
    • Lobos, Buenos Aires, Argentina, B7240KJB
      • Recruiting
      • CEMLO - Centro de Especialidades Médicas Lobos - Patagones 94
• Australia
  • South Australia
    • Bedford Park, South Australia, Australia, 5042
      • Recruiting
      • Flinders Medical Centre
  • Victoria
    • Box Hill, Victoria, Australia, 3128
      • Recruiting
      • Box Hill Hospital
  • Western Australia
    • Midland, Western Australia, Australia, 6056
      • Recruiting
      • Institute for Respiratory Health Inc
    • Spearwood, Western Australia, Australia, 6163
      • Recruiting
      • TrialsWest Pty Ltd
• Austria
  • Feldbach, Austria, 8330
    • Recruiting
    • Ordination Dr. Robert Voves
  • Linz, Austria, 4020
    • Recruiting
    • Ordination fur Lungenkrankheiten
• Belgium
  • Bruges, Belgium, 8000
    • Recruiting
    • AZ Sint-Jan Brugge-Oostende
  • Brussels, Belgium, 1090
    • Recruiting
    • Universitair Ziekenhuis Brussel
  • Edegem, Belgium, 2650
    • Recruiting
    • Antwerp University Hospital
  • Erpent, Belgium, 5101
    • Recruiting
    • Private Practice Dr Jean Benoit Martinot
  • Leuven, Belgium, 3000
    • Recruiting
    • UZ Leuven
  • Liège, Belgium, 4000
    • Recruiting
    • CHU de Liège
  • Mechelen, Belgium, 2800
    • Recruiting
    • AZ Sint-Maarten
  • Roeselare, Belgium, 8800
    • Recruiting
    • AZ Delta
  • Thuin, Belgium, 6534
    • Recruiting
    • Office of Marc De Meulemeester
  • Yvoir, Belgium, 5530
    • Recruiting
    • CHU UCl Namur asbl - Site Godinne
• Brazil
  • Rio de Janeiro, Brazil, 20241-180
    • Recruiting
    • IBPCLIN Instituto Brasil de Pesquisa Clinica
  • Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil, 90480-000
      • Recruiting
      • LMK Servicos Medicos SS
    • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
      • Recruiting
      • Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)
  • São Paulo
    • Santo André, São Paulo, Brazil, 09060-650
      • Recruiting
      • Faculdade de Medicina do ABC - FMABC
    • São Bernardo do Campo, São Paulo, Brazil, 09715-090
      • Recruiting
      • CEMEC - Centro Multidisciplinar de Estudos Clínicos
• Bulgaria
  • Blagoevgrad, Bulgaria, 2700
    • Recruiting
    • Multiprofile Hospital for Active Treatment Puls AD PPDS
  • Dimitrovgrad, Bulgaria, 6400
    • Recruiting
    • Multiprofile Hospital For Active Treatment Sveta Ekaterina - Dimitrovgrad EOOD
  • Dupnitsa, Bulgaria, 2600
    • Recruiting
    • Medical Centre "Asklepii", OOD
  • Haskovo, Bulgaria, 6300
    • Active, not recruiting
    • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases - Haskovo EOOD
  • Lovech, Bulgaria, 5500
    • Active, not recruiting
    • Medical Centre Pratia EOOD branch Lovech
  • Montana, Bulgaria, 3400
    • Recruiting
    • Medical Center Hera EOOD
  • Pazardzhik, Bulgaria, 4400
    • Recruiting
    • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Dr.Nikola Penchev-Paza
  • Pernik, Bulgaria, 2300
    • Recruiting
    • Specialized Hospital for Active Treatment of Pulmonary Diseases- Pernik EOOD
  • Pleven, Bulgaria, 5800
    • Active, not recruiting
    • Medical center Medconsult Pleven OOD
  • Plovdiv, Bulgaria, 4003
    • Recruiting
    • Multiprofile Hospital for Active Treatment Plovdiv
  • Plovdiv, Bulgaria, 4023
    • Active, not recruiting
    • Medical Center Unimed Eood
  • Plovdiv, Bulgaria, 4002
    • Completed
    • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
  • Shumen, Bulgaria, 9700
    • Recruiting
    • Multiprofile Hospital for Active Treatment Shumen
  • Silistra, Bulgaria, 7500
    • Recruiting
    • Multiprofile Hospital for Active Treatment - Silistra AD
  • Smolyan, Bulgaria, 4700
    • Recruiting
    • Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD
  • Sofia, Bulgaria, 1510
    • Recruiting
    • Medical Center Hera EOOD
  • Sofia, Bulgaria, 1606
    • Active, not recruiting
    • University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD
  • Sofia, Bulgaria, 1680
    • Recruiting
    • Diagnostic- Consultative Center Convex EOOD
  • Sofia, Bulgaria, 1784
    • Completed
    • AES DRS Medical Center Synexus Sofia EOOD
  • Stara Zagora, Bulgaria, 6003
    • Recruiting
    • Medical Center New Rehabilitation Center EOOD
  • Varna, Bulgaria, 9000
    • Recruiting
    • Medical Center Researchexpert OOD
  • Veliko Tarnovo, Bulgaria, 5000
    • Recruiting
    • Medical Center Tara OOD
  • Vratsa, Bulgaria, 3000
    • Active, not recruiting
    • Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases-Vratsa
  • Sofia-Grad
    • Sofia, Sofia-Grad, Bulgaria, 1233
      • Recruiting
      • MHAT Knyaginya Klementina Sofia EAD
    • Sofia, Sofia-Grad, Bulgaria, 1431
      • Recruiting
      • Diagnostic-Consultative Center Aleksandrovska EOOD
• Canada
  • Québec, Canada, G1V 4G5
    • Recruiting
    • Centre Hospitalier de l'Université Laval
  • Alberta
    • Edmonton, Alberta, Canada, T5J 3S9
      • Recruiting
      • Edmonton Respiratory Consultants
    • Sherwood Park, Alberta, Canada, T8H 0N2
      • Recruiting
      • Synergy Respiratory & Cardiac Care - Synergy Wellness Centre Location
  • British Columbia
    • Vancouver, British Columbia, Canada, V5Z 1L8
      • Recruiting
      • Vancouver General Hospital
  • Ontario
    • Ajax, Ontario, Canada, L1S 2J5
      • Recruiting
      • Dynamic Drug Advancement Ltd.
    • Burlington, Ontario, Canada, L7N 3V2
      • Recruiting
      • Burlington Lung Clinic
    • Sarnia, Ontario, Canada, N7T 4X3
      • Recruiting
      • Bluewater Clinical Research Group
    • Toronto, Ontario, Canada, M5T 3A9
      • Recruiting
      • Inspiration Research
    • Windsor, Ontario, Canada, N8X 1T3
      • Recruiting
      • Dr. Syed Anees Medicine Profession Corporation
    • Windsor, Ontario, Canada, N8X 5A6
      • Recruiting
      • Dr Anil Dhar Professional Medicine Corporation
  • Quebec
    • Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
      • Recruiting
      • Clinique de pneumologie et du sommeil de Lanaudière
  • Saskatchewan
    • Saskatoon, Saskatchewan, Canada, S7N 5A2
      • Recruiting
      • University of Saskatchewan
• Chile
  • Pavie Gallegos, Chile, 2340000
    • Recruiting
    • Centro Respiratorio Integral LTDA. (CENRESIN)
  • Providencia, Chile, 7500000
    • Recruiting
    • Sociedad Médica SyG SpA
  • Providencia, Chile, 7500587
    • Recruiting
    • Enroll SpA - PPDS
  • Santiago, Chile, 8420383
    • Completed
    • Centro Internacional de Estudios Clínicos (CIEC)
  • Talca, Chile
    • Recruiting
    • Centro de Investigación del Maule
  • Valparaíso, Chile, 2340000
    • Recruiting
    • Hospital Carlos Van Buren
  • Vitacura, Chile, 7630000
    • Recruiting
    • Fundacion Medica San Cristobal
  • Viña del Mar, Chile, 2531172
    • Recruiting
    • Centro de Investigación de Enfermedades Respiratorias e Inmunológicas
  • Ñuñoa, Chile, 7750495
    • Recruiting
    • Centro de Estudios Clinicos
  • Ñuñoa, Chile, 7750000
    • Recruiting
    • Centro de Investigaciones Medicas Respiratorias CIMER
• China
  • Beijing, China, 100029
    • Recruiting
    • China-Japan Friendship Hospital
  • Beijing, China, 100020
    • Recruiting
    • Beijing Chaoyang Hospital Capital Medical University
  • Beijing, China, 100042
    • Recruiting
    • Beijing Jingmei Group General Hospital
  • Beijing, China, 100006
    • Recruiting
    • Beijing Hospital
  • Changchun, China, 130021
    • Recruiting
    • The First Hospital of Jilin University
  • Changsha, China
    • Withdrawn
    • The Third Hospital of Changsha
  • Chengdu, China, 610041
    • Recruiting
    • West China Hospital, Sichuan University
  • Chengdu, China, 611130
    • Recruiting
    • Chengdu Fifth People's Hospital
  • Chongqing, China, 400038
    • Recruiting
    • The Southwest Hospital of Army Medical University
  • Chongqing, China, 400042
    • Recruiting
    • Army Medical Center of PLA(Daping Hospital)
  • Guangdong, China, 524023
    • Recruiting
    • Affiliated Hospital of Guangdong Medical University
  • Guangzhou, China, 510120
    • Recruiting
    • The First Affiliated Hospital of Guangzhou Medical University
  • Guangzhou, China, 510180
    • Recruiting
    • Guangzhou First People's Hospital
  • Guangzhou, China, 510150
    • Recruiting
    • The Third Affiliated Hospital of Guangzhou Medical University
  • Hangzhou, China, 310006
    • Recruiting
    • Hangzhou First People's Hospital
  • Huizhou, China, 516001
    • Recruiting
    • Huizhou Central People's Hospital
  • Lianyungang, China, 222023
    • Recruiting
    • The First People's Hospital of Lian Yun Gang
  • Linhai, China, 317000
    • Recruiting
    • Taizhou Hospital of Zhejiang Province
  • Nanchang, China, 330006
    • Recruiting
    • Jiangxi Provincial People's Hospital
  • Nanjing, China, 210009
    • Recruiting
    • Zhongda Hospital Affiliated to Southeast University
  • Tianjin, China, 300052
    • Recruiting
    • Tianjin Medical University General Hospital
  • Wuxi, China, 214023
    • Recruiting
    • Wuxi People's Hospital
  • Wuxi, China, 214400
    • Recruiting
    • Jiangyin People's Hospital
  • Xi'an, China, 710100
    • Active, not recruiting
    • Xi'an International Medical Center Hospital
  • Xiamen, China, 361004
    • Recruiting
    • Zhongshan Hospital Xiamen University
  • Xinxiang, China, 453000
    • Recruiting
    • Xinxiang First People's Hospital
  • Zhuhai, China, 519001
    • Recruiting
    • The Fifth Affiliated Hospital Sun Yat-Sen University
  • Anhui
    • Hefei, Anhui, China, 230022
      • Recruiting
      • Anhui Chest Hospital
  • Beijing Municipality
    • Beijing, Beijing Municipality, China, 100144
      • Recruiting
      • Peking University Shougang Hospital
  • Guizhou
    • Zunyi, Guizhou, China, 563000
      • Recruiting
      • Affiliated Hospital Of Zunyi Medical University
  • Hubei
    • Wuhan, Hubei, China, 430014
      • Recruiting
      • The Central Hospital of Wuhan
  • Hunan
    • Changsha, Hunan, China, 410005
      • Withdrawn
      • The First Hospital of Changsha
  • Jiangsu
    • Xuzhou, Jiangsu, China, 221002
      • Recruiting
      • The Affiliated Hospital of Xuzhou Medical University
  • Jiangxi
    • Pingxiang, Jiangxi, China, 337055
      • Recruiting
      • Jiangxi Pingxiang People's Hospital
  • Shanghai Municipality
    • Shanghai, Shanghai Municipality, China, 200040
      • Recruiting
      • Huadong Hospital Affiliated of Fudan University
  • Sichuan
    • Zigong, Sichuan, China, 643000
      • Recruiting
      • Zigong First People's Hospital - East Campus
• Czechia
  • Brandýs nad Labem-Stará Boleslav, Czechia, 250 01
    • Recruiting
    • Plicní ambulance MUDr. I. Cierná Peterová s.r.o.
  • Hradec Králové, Czechia, 500 05
    • Recruiting
    • Fakultni nemocnice Hradec Kralove
  • Jind?ich?v Hradec, Czechia, 377 01
    • Recruiting
    • MediTrial s.r.o.
  • Kralupy nad Vltavou, Czechia, 278 01
    • Recruiting
    • Plicni Ambulance Kralupy nad Vltavou
  • Opava, Czechia, 746 01
    • Recruiting
    • Odborna plicni ambulance Opava s.r.o
  • Prague, Czechia, 110 00
    • Recruiting
    • Ordinace chorob plicních s.r.o.
  • Prague, Czechia, 120 00
    • Recruiting
    • AES - DRS - Synexus Czech s.r.o.
  • Teplice, Czechia, 415 01
    • Recruiting
    • Plicni stredisko Teplice s.r.o.
  • Tábor, Czechia, 390 02
    • Recruiting
    • KASMED s.r.o.
  • Tábor, Czechia, 390 03
    • Recruiting
    • Nemocnice Tabor, a.s.
• Denmark
  • Aalborg, Denmark, 9000
    • Recruiting
    • Aalborg Universitetshospital
  • Hellerup, Denmark, 2900
    • Completed
    • Gentofte Hospital
  • Hvidovre, Denmark, 2650
    • Recruiting
    • Hvidovre Hospital
  • Odense C, Denmark, 5000
    • Recruiting
    • Odense Universitetshospital
  • Roskilde, Denmark, 4000
    • Recruiting
    • Sjaellands Universitetshospital, Roskilde
  • Vejle, Denmark, 7100
    • Recruiting
    • Sygehus Lillebælt, Vejle
• France
  • Amiens, France, 80090
    • Recruiting
    • Clinique de L'Europe
  • Lyon, France, 69004
    • Recruiting
    • Hopital de la croix rousse
  • Marseille, France, 13285
    • Recruiting
    • Hopital Saint Joseph - Marseille
  • Nice, France, 06000
    • Recruiting
    • Hopital Pasteur II
  • Pessac, France, 33600
    • Recruiting
    • Hôpital Haut Levêque
  • Strasbourg, France, 67091
    • Recruiting
    • Nouvel Hopital Civil - CHU Strasbourg
• Germany
  • Augsburg, Germany, 86150
    • Recruiting
    • Zentrum fuer Pneumologie, Onkologie und Schlafmedizin am Diako
  • Bamberg, Germany, 96049
    • Recruiting
    • Gemeinschaftspraxis fuer Herz und Lunge am Bruderw
  • Bendorf, Germany, 56170
    • Recruiting
    • KPPK Studienzentrum Kroker-Schmidt
  • Berlin, Germany, 12203
    • Recruiting
    • MECS Research GmbH
  • Berlin, Germany, 10119
    • Recruiting
    • Studienpraxis Berlin-Brandenburg, Berlin
  • Berlin, Germany, 10367
    • Recruiting
    • Praxis fur Kardiologie und Pneumologie Dr. med. Karin Forster
  • Berlin, Germany, 13187
    • Recruiting
    • Clinical Studies Pankow
  • Berlin, Germany, 12627
    • Withdrawn
    • AES - DRS - Synexus Berlin Research Centre
  • Darmstadt, Germany, 64283
    • Recruiting
    • Lungenzentrum Darmstadt
  • Deggingen, Germany, 73326
    • Recruiting
    • MVZ Jung GbR - Deggingen
  • Essen, Germany, 45355
    • Recruiting
    • Medizentrum Essen Borbeck
  • Frankfurt, Germany, 60596
    • Recruiting
    • Universitaetsklinikum Frankfurt
  • Frankfurt am Main, Germany, 60389
    • Recruiting
    • Praxis Dr med Claus Keller
  • Hamburg, Germany, 22299
    • Recruiting
    • ME Clinical Respiratory Research Hamburg GmbH
  • Hanover, Germany, 30173
    • Recruiting
    • Pneumologicum
  • Heidelberg, Germany, 69120
    • Recruiting
    • University Clinic Heidelberg
  • Immenhausen, Germany, 34376
    • Recruiting
    • Lungenfachklinik Immenhausen
  • Landsberg, Germany, 86899
    • Recruiting
    • Asklepios MVZ Bayern GmbH
  • Leipzig, Germany, 04207
    • Recruiting
    • Salvus-Klinische Studien GmbH
  • Leipzig, Germany, 04299
    • Recruiting
    • BAG Prof. Dr. G. Hoheisel Dr. A. Bonitz
  • Lübeck, Germany, 23552
    • Recruiting
    • KLB Gesundheitsforschung Lubeck GmbH
  • Magdeburg, Germany, 39120
    • Recruiting
    • SMO.MD GmbH
  • Mainz, Germany, 55128
    • Recruiting
    • IKF Pneumologie Mainz
  • Marburg, Germany, 35037
    • Completed
    • Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup
  • München, Germany, 80539
    • Recruiting
    • Praxis Dr. med. Jan Feimer
  • Neu-Isenburg, Germany, 63263
    • Recruiting
    • Institut fur klinische Forschung GmbH
  • Peine, Germany, 31224
    • Recruiting
    • Studienzentrum Dr Med Schlenska
  • Rheine, Germany, 48431
    • Recruiting
    • Framol-Med GmbH
  • Rosenheim, Germany, 83022
    • Recruiting
    • RoMed Klinikum Rosenheim-Pettenkoferstr. 10
• Greece
  • Athens, Greece, 106 76
    • Recruiting
    • Evangelismos General Hospital of Athens
  • Athens, Greece, 175 62
    • Recruiting
    • Iatriko Palaiou Falirou
  • Athens, Greece, 115 21
    • Recruiting
    • Navy Hospital of Athens
  • Heraklion, Greece, 711 10
    • Recruiting
    • University General Hospital of Heraklion
  • Ioannina, Greece, 455 00
    • Recruiting
    • University General Hospital of Ioannina
  • Thessaloniki, Greece, 570 10
    • Recruiting
    • Georgios Papanikolaou General Hospital of Thessaloniki
• Hong Kong
  • Hong Kong, Hong Kong
    • Recruiting
    • Tuen Mun Hospital
• Hungary
  • Pest County
    • Budapest, Pest County, Hungary, 1036
      • Recruiting
      • Obudai Egeszsegugyi Centrum Kft.
• India
  • Andhra Pradesh
    • Hyderabad, Andhra Pradesh, India, 500084
      • Recruiting
      • Yashoda Hospitals Hitec City
    • Hyderabad, Andhra Pradesh, India, 500018
      • Recruiting
      • Paarthiv Lung Care Center
  • Gujarat
    • Ahmedabad, Gujarat, India, 380059
      • Recruiting
      • GMERS Medical College and Hospital, Sola
  • Haryana
    • Faridabad, Haryana, India, 121012
      • Recruiting
      • ESIC Medical College and Hospital - Faridabad
  • Karnataka
    • Hubli, Karnataka, India, 580021
      • Recruiting
      • Karnataka Institute of Medical Sciences (KIMS), Hubbali
  • Maharashtra
    • Nagpur, Maharashtra, India, 440009
      • Recruiting
      • Shree Hospital And Critical Care Centre
    • Pune, Maharashtra, India, 411038
      • Recruiting
      • Kothrud Hospital
  • Rajasthan
    • Ajmer, Rajasthan, India, 305001
      • Recruiting
      • Jawaharlal Nehru Medical College (JNMC)
    • Jaipur, Rajasthan, India, 302039
      • Recruiting
      • Maharaja Agrasen Super Speciality Hospital
    • Jaipur, Rajasthan, India, 302004
      • Recruiting
      • Sawai Man Singh Hospital and Medical College
  • Uttar Pradesh
    • Aligarh, Uttar Pradesh, India, 202002
      • Recruiting
      • Jawaharlal Nehru Medical College (JNMC)
    • Kanpur, Uttar Pradesh, India, 208001
      • Recruiting
      • Apollo Spectra Hospital
    • Lucknow, Uttar Pradesh, India, 226018
      • Recruiting
      • MV Hospital and Research Centre
• Israel
  • Ashdod, Israel, 7747629
    • Recruiting
    • Assuta Ashdod Medical Center
  • Ashkelon, Israel, 7830604
    • Recruiting
    • Barzilai Medical Center
  • Beersheba, Israel, 8410101
    • Recruiting
    • Soroka University Medical Centre
  • Be’er Ya‘aqov, Israel, 7033001
    • Recruiting
    • Shamir Medical Center Assaf Harofeh
  • Haifa, Israel, 3436212
    • Recruiting
    • Lady Davis Carmel Medical Center
  • Haifa, Israel, 3109601
    • Recruiting
    • Rambam Medical Center - PPDS
  • Jerusalem, Israel, 91031
    • Recruiting
    • Shaare Zedek Medical Center
  • Jerusalem, Israel, 9112001
    • Recruiting
    • Hadassah Medical Center
  • Kfar Saba, Israel, 4428164
    • Recruiting
    • Meir Medical Center
  • Petach Tiqwa, Israel, 4941492
    • Recruiting
    • Rabin Medical Center
  • Ramat Gan, Israel, 52621
    • Recruiting
    • Sheba Medical Center - PPDS
  • Rehovot, Israel, 76100
    • Recruiting
    • Kaplan Medical Center
  • Tel Aviv, Israel, 6423906
    • Recruiting
    • Tel Aviv Sourasky Medical Center PPDS
• Italy
  • Campania
    • Naples, Campania, Italy, 80131
      • Recruiting
      • Azienda Ospedaliera dei Colli
  • Emilia-Romagna
    • Cona, Ferrara, Emilia-Romagna, Italy, 44124
      • Recruiting
      • Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
  • Lombardy
    • Pavia, Lombardy, Italy, 27100
      • Completed
      • Fondazione IRCCS Policlinico San Matteo di Pavia
  • Sicily
    • Catania, Sicily, Italy, 95123
      • Recruiting
      • Azienda Ospedaliero Universitaria Policlinico G.Rodolico - San Marco
    • Palermo, Sicily, Italy, 90127
      • Recruiting
      • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
• Japan
  • Asahikawa-shi, Japan, 070-8644
    • Recruiting
    • Asahikawa Medical Center
  • Chikushino-shi, Japan, 818-8502
    • Recruiting
    • Fukuoka University Chikushi Hospital
  • Chūō, Japan, 104-0031
    • Recruiting
    • Fukuwa Clinic
  • Fukuoka, Japan, 814-0180
    • Recruiting
    • Fukuoka University Hospital
  • Fukuoka-Shi Nishi-Ku, Japan, 819-8555
    • Recruiting
    • Nishi Fukuoka Hospital
  • Fukushima, Japan, 960-1295
    • Recruiting
    • Fukushima Medical University Hospital
  • Fushimi-ku, Kyoto, Japan, 612-8555
    • Recruiting
    • National Hospital Organization Kyoto Medical Center
  • Himeji, Japan, 670-0849
    • Recruiting
    • Terada Respiratory and Internal Clinic
  • Hiroshima, Japan, 734-8530
    • Recruiting
    • Hiroshima Prefectural Hospital
  • Jōyō, Japan, 610-0113
    • Recruiting
    • National Hospital Organization Minami Kyoto Hospital
  • Kagoshima, Japan, 890-0062
    • Recruiting
    • Kagoshima Kouseiren Hospital
  • Kanagawa, Japan, 236-0051
    • Recruiting
    • Kanagawa Cardiovascular and Respiratory Center
  • Kanagawa, Japan, 252-0392
    • Recruiting
    • Sagamihara National Hospital
  • Kawachinagano-Shi, Japan, 586-8521
    • Recruiting
    • Osaka-Minami Medical Center
  • Kishiwada-Shi, Japan, 596-8501
    • Recruiting
    • Kishiwada City Hospital
  • Kumamoto, Japan, 861-4193
    • Recruiting
    • Saiseikai Kumamoto Hospital
  • Kōtō City, Japan, 136-0075
    • Recruiting
    • Juntendo Tokyo Koto Geriatric Medical Center
  • Okayama, Japan, 701-1192
    • Recruiting
    • National Hospital Organization Okayama Medical Center
  • Okayama-Shi Minami-ku, Japan, 702-8055
    • Recruiting
    • Okayama Rosai Hospital
  • Omuta, Japan, 837-0911
    • Recruiting
    • Omuta National Hospital
  • Sakaide-Shi, Japan, 762-8550
    • Recruiting
    • Sakaide City Hospital
  • Sapporo-shi Chuo-ku, Japan, 064-0804
    • Recruiting
    • Idaimae Minami 4-Jo Internal Medicine
  • Shibuya-ku, Japan, 150-8935
    • Recruiting
    • Japanese Red Cross Medical Center
  • Takamatsu, Japan, 761-8073
    • Recruiting
    • Kamei Internal medicine and Respiratory Clinic
  • Yanagawa, Japan, 832-0059
    • Recruiting
    • Nagata Hospital
  • Yokohama, Japan, 232-0024
    • Recruiting
    • Yokohama City University Medical Center
  • Yokohama-Shi Totsuka-Ku, Japan, 245-8575
    • Recruiting
    • National Hospital Organization - Yokohama Medical Center
  • Yokohama-shi Aoba-ku, Japan, 227-8501
    • Recruiting
    • Showa University Fujigaoka Hospital
  • Aichi-ken
    • Nagoya, Aichi-ken, Japan, 457-8511
      • Recruiting
      • Social Medical Corporation Daido Clinic
  • Hokkaido
    • Toyohira-ku, Sapporo City, Hokkaido, Japan, 062-8618
      • Recruiting
      • Japan Community Health care Organization Hokkaido Hospital
  • Mie-ken
    • Matsusaka-Shi, Mie-ken, Japan, 515-8544
      • Recruiting
      • Matsusaka City Hospital
  • Osaka
    • Sakai-shi Kita-ku, Osaka, Japan, 591-8555
      • Recruiting
      • National Hospital Organization Kinki-Chuo Chest Medical Center
  • Shizuoka
    • Shizuoka-Shi Aoi-Ku, Shizuoka, Japan, 420-8630
      • Recruiting
      • Shizuoka City Shizuoka Hospital
• Kenya
  • Kilifi, Kenya, 80108
    • Recruiting
    • KEMRI-MTWAPA Clinical Trial Site
  • Machakos, Kenya, 90100
    • Recruiting
    • Clinical Research Health Network (CREA-N)
  • Nairobi, Kenya, 00100
    • Recruiting
    • KEMRI CRDR Clinical Research Clinic Nairobi
  • Nairobi, Kenya, 202
    • Recruiting
    • University of Nairobi Clinical Research Centre
  • Thika, Kenya, 01000
    • Recruiting
    • Center for Research In Tropical Medicine and community development
• Latvia
  • Daugavpils, Latvia, LV-5417
    • Recruiting
    • Daugavpils Regional Hospital
  • R?ga, Latvia, LV-1002
    • Recruiting
    • Pauls Stradins Clinical University Hospital
  • Riga, Latvia, LV-1001
    • Recruiting
    • Riga 1st Hospital
  • Riga, Latvia, LV-1010
    • Recruiting
    • ConsiliumMedicum
• Mexico
  • Guadalajara, Mexico, 44220
    • Recruiting
    • Unidad Medica de Occidente
  • Monterrey, Mexico, 64718
    • Recruiting
    • Unidad de Investigacion Clinica En Medicina (Udicem) S.C.
  • Jalisco
    • Guadalajara, Jalisco, Mexico, 44200
      • Active, not recruiting
      • CICUM San Miguel
    • Santa Cecilia, Jalisco, Mexico, 44700
      • Active, not recruiting
      • Instituto Jalisciense de Investigacion Clinica S.A. de C.V.
• Netherlands
  • Amersfoort, Netherlands, 3813 TZ
    • Recruiting
    • Meander Medisch Centrum
  • Breda, Netherlands, 4818 CK
    • Recruiting
    • Amphia Ziekenhuis
  • Eindhoven, Netherlands, 5623 EJ
    • Recruiting
    • Catharina Hospital
  • Hoorn, Netherlands, 1624 NP
    • Recruiting
    • Dijklander Ziekenhuis - loc Hoorn
  • Zwolle, Netherlands, 8011 JW
    • Recruiting
    • Isala Klinieken
• New Zealand
  • Auckland, New Zealand, 1051
    • Recruiting
    • NZ Respiratory & Sleep Institute
  • Auckland, New Zealand, 2025
    • Recruiting
    • Aotearoa Clinical Trials Trust
  • Auckland, New Zealand, 1051
    • Recruiting
    • Greenlane Clinical Centre
  • Christchurch, New Zealand, 8011
    • Recruiting
    • Canterbury Respiratory Research Group
  • Dunedin, New Zealand, 9054
    • Recruiting
    • Dunedin Hospital
  • Hamilton, New Zealand, 3240
    • Recruiting
    • Waikato Hospital
  • Wellington Region
    • Waikanae, Wellington Region, New Zealand, 5036
      • Recruiting
      • P3 Research - Kapiti - PPDS
• Peru
  • Lima, Peru, 15084
    • Recruiting
    • Medicentro Biociencias Peru S.R.L.
  • Lima, Peru, 15001
    • Recruiting
    • Clinica Internacional - PPDS
  • San Isidro, Peru, 15036
    • Recruiting
    • Clinica Ricardo Palma - PPDS
  • Lima region
    • San Miguel, Lima region, Peru, 15088
      • Recruiting
      • Clinica Providencia (Inverconsult Sociedad Anonima) - PPDS
• Philippines
  • Caloocan, Philippines, 1442
    • Recruiting
    • Manila Central University-Filemon D Tanchoco Medical Foundation
  • Dasmariñas, Philippines, 4114
    • Recruiting
    • CARE CT Group Inc.
  • Iloilo City, Philippines, 5000
    • Recruiting
    • West Visayas State University Medical Center
  • Iloilo City, Philippines, 5000
    • Recruiting
    • Healthlink Medicalsurgicaldental Clinic and Diagnostic Center
  • Lipa City, Philippines, 4217
    • Recruiting
    • Mary Mediatrix Medical Center
  • Quezon City, Philippines, 1109
    • Recruiting
    • Quirino Memorial Medical Center
  • Quezon City, Philippines, 1100
    • Recruiting
    • Philippine Heart Center
• Poland
  • Bia?ystok, Poland, 15-044
    • Recruiting
    • Centrum Medycyny Oddechowej Mroz sp. j.
  • Bydgoszcz, Poland, 85-796
    • Recruiting
    • Centrum Medyczne Bydgoszcz- PRATIA - PPDS
  • Bydgoszcz, Poland, 85-079
    • Recruiting
    • Vitamed Galaj I Cichomski sp.j.
  • Bydgoszcz, Poland, 85-231
    • Recruiting
    • Medical Center Kermed
  • Chojnice, Poland, 89-600
    • Recruiting
    • Centrum Medyczne Lukamed Joanna Luka-Wendrowska
  • Gdynia, Poland, 81-537
    • Recruiting
    • Synexus Polska Sp. z o.o. Oddzial w Gdyni
  • Grudzadz, Poland, 86-300
    • Completed
    • Centrum Medyczne CLW-med Aneta Cichomska , Joanna Luka -Wendrowska
  • Katowice, Poland, 40-081
    • Recruiting
    • Centrum Medyczne Katowice - PRATIA - PPDS
  • Kielce, Poland, 25-751
    • Recruiting
    • Indywidualna Specjalistyczna Praktyka Lekarska lek.
  • Krakow, Poland, 30-033
    • Recruiting
    • Centrum Medyczne ALL-MED
  • Krakow, Poland, 31-559
    • Recruiting
    • Diamond Clinic
  • Krakow, Poland, 31-637
    • Completed
    • Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
  • Ksawerów, Poland, 95-054
    • Recruiting
    • Praktyka Lekarska Adam Smialowski
  • Lodz, Poland, 90-127
    • Recruiting
    • AES - DRS - Synexus Polska Sp. Z o.o. Oddzial w Lodzi
  • Lodz, Poland, 90-302
    • Completed
    • ETG Lodz
  • Lublin, Poland, 20-412
    • Recruiting
    • ETG Lublin
  • Lublin, Poland, 20-078
    • Recruiting
    • Clinical Best Solutions - Lublin
  • Lublin, Poland, 20-089
    • Recruiting
    • NZOZ Przychodnia Alergologiczno-pulmonologiczna
  • Nowa Sól, Poland, 67-100
    • Recruiting
    • Twoja Przychodnia Centrum Medyczne Nowa Sol
  • Ostrowiec Swietokrzysk, Poland, 27-400
    • Active, not recruiting
    • Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olec-Cudzik
  • Poznan, Poland, 60-214
    • Recruiting
    • Centrum Alergologii Teresa Hofman
  • Radom, Poland, 26-600
    • Completed
    • ABC-Pulmo NZOZ Agnieszka Dobielska, Jaroslaw Dobie
  • Rzeszów, Poland, 35-205
    • Recruiting
    • EMED Centrum Uslug Medycznych Ewa Smialek
  • Siedlce, Poland, 08-110
    • Recruiting
    • ETG Siedlce
  • Sopot, Poland, 81-741
    • Recruiting
    • Centrum Medyczne KARDIOTEL
  • Sosnowiec, Poland, 41-200
    • Recruiting
    • Kiepury Clinic
  • Sosnowiec, Poland, 41-208
    • Recruiting
    • PULMAG Grzegorz Gasior Marzena Kociolek Spolka Cywilna
  • Szczecin, Poland, 70-111
    • Recruiting
    • Gabinet Pulmonologii i Diagnostyki Chorob Alergicznych Dorota Malosek
  • Tarnów, Poland, 33-100
    • Recruiting
    • CenterMed Bandrowskiego
  • Warsaw, Poland, 01-192
    • Recruiting
    • AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie
  • Wroc?aw, Poland, 51-162
    • Recruiting
    • Centrum Badan Klinicznych Piotr Napora lekarze spolka partnerska
  • Wroc?aw, Poland, 53-301
    • Recruiting
    • Dobrostan Gabinety Lekarskie
  • Lower Silesian Voivodeship
    • Trzebnica, Lower Silesian Voivodeship, Poland, 55-100
      • Recruiting
      • Viltis Medica Sp. Z o.o.
    • Wroclaw, Lower Silesian Voivodeship, Poland, 54-239
      • Recruiting
      • Lekarze Specjalisci J. Malolepszy i Partnerzy
  • Lódzkie
    • Lodz, Lódzkie, Poland, 90-349
      • Completed
      • Appletreeclinics Network Sp. z o.o.
    • Lodz, Lódzkie, Poland, 90-602
      • Recruiting
      • Prywatny Gabinet Lekarski Ginekologia i Poloznictwo Ultrasonografia Prof. Jacek Suzin
• Puerto Rico
  • Guaynabo, Puerto Rico, 00968
    • Recruiting
    • Allianze Pulmonary Research LLC
• Romania
  • Brasov, Romania, 500283
    • Recruiting
    • Neomed Out-Patient Treatment and Diagnosis Medical Center SRL
  • Bucharest, Romania, 030301
    • Recruiting
    • Dr. Victor Babes Foundation
  • Cluj-Napoca, Romania, 400371
    • Recruiting
    • Leon Daniello Pneumophthisiology Clinical Hospital
  • Suceava, Romania, 720224
    • Active, not recruiting
    • Sf. Ioan cel Nou Emergency County Hospital
• South Africa
  • Bloemfontein, South Africa, 9301
    • Recruiting
    • Iatros International
  • Cape Town, South Africa, 7700
    • Recruiting
    • University of Cape Town Lung Institute
  • City of Cape Town, South Africa, 7764
    • Recruiting
    • Dr. Ismail Abdullah Private Practice
  • City of Johannesburg, South Africa, 2001
    • Recruiting
    • Newtown Clinical Research Centre
  • City of Tshwane, South Africa, 0186
    • Recruiting
    • Clinical Trial Systems
  • Durban, South Africa, 4001
    • Recruiting
    • St Augustines Hospital
  • Ekurhuleni, South Africa, 1500
    • Recruiting
    • Lakeview Hospital
  • Ekurhuleni, South Africa, 1501
    • Recruiting
    • Dr A.C Wilhase practice-Reimed
  • Ekurhuleni, South Africa, 1619
    • Recruiting
    • CLINRESCO, ARWYP Medical Suites
  • Kraaifontein, South Africa, 7570
    • Recruiting
    • Langeberg Clinical Trials
  • Pretoria, South Africa, 0183
    • Recruiting
    • Medicross Pretoria West, Jongaie Research
  • Pretoria, South Africa, 0184
    • Withdrawn
    • AES - DRS - Synexus Watermeyer Clinical Research Centre
  • Somerset West, South Africa, 7130
    • Completed
    • AES - DRS - Synexus - Helderberg Clinical Research Centre
  • Welkom, South Africa, 9459
    • Recruiting
    • Dr Yacoob AK Private Practice
  • Gauteng
    • City of Tshwane, Gauteng, South Africa, 0157
      • Recruiting
      • Johese Clinical Research
• South Korea
  • Bucheon-si, South Korea, 420-767
    • Recruiting
    • Soon Chun Hyang University Hospital Bucheon
  • Daegu, South Korea, 42415
    • Recruiting
    • Yeungnam University Hospital
  • Gyeonggi-do, South Korea, 13496
    • Recruiting
    • CHA Bundang Medical Center
  • Incheon, South Korea, 21431
    • Recruiting
    • Catholic Univ. of Incheon St.Mary's Hospital
  • Jeollabuk-do, South Korea, 54907
    • Recruiting
    • Chonbuk National University Hospital
  • Seoul, South Korea, 05030
    • Recruiting
    • Konkuk University Medical Center
  • Seoul, South Korea, 02841
    • Recruiting
    • Korea University Anam Hospital
  • Seoul, South Korea, 06591
    • Recruiting
    • The Catholic University of Korea, Seoul St. Mary's Hospital
  • Seoul, South Korea, 03181
    • Recruiting
    • Kangbuk Samsung Hospital
  • Seoul, South Korea, 06351
    • Recruiting
    • Samsung Medical Center - PPDS
  • Seoul, South Korea, 05505
    • Recruiting
    • Asan Medical Center - PPDS
  • Seoul, South Korea, 06973
    • Recruiting
    • Chung-Ang University Hospital
  • Wŏnju, South Korea, 220-701
    • Recruiting
    • Yonsei University Wonju Severance Christian Hospital
• Spain
  • Barcelona, Spain, 08025
    • Recruiting
    • Hospital De La Santa Creu I Sant Pau
  • Granada, Spain, 18012
    • Recruiting
    • Hospital Universitario Virgen de Las Nieves
  • Madrid, Spain, 28007
    • Recruiting
    • Hospital General Universitario Gregorio Marañon
  • Madrid, Spain, 28040
    • Recruiting
    • Hospital Universitario Fundacion Jimenez Diaz.
  • Madrid, Spain, 28046
    • Recruiting
    • Hospital Universitario La Paz - PPDS
  • Málaga, Spain, 29010
    • Recruiting
    • Hospital Universitario Virgen de la Victoria
  • Seville, Spain, 41013
    • Recruiting
    • Hospital Universitario Virgen del Rocío
  • Valencia, Spain, 46010
    • Recruiting
    • Hospital Clinico Universitario de Valencia
  • Badajoz
    • Mérida, Badajoz, Spain, 06800
      • Recruiting
      • Hospital de Mérida
  • Balearic Islands
    • Palma de Mallorca, Balearic Islands, Spain, 07120
      • Recruiting
      • Hospital Universitario Son Espases
  • Cantabria
    • Santander, Cantabria, Spain, 39008
      • Recruiting
      • Hospital Universitario Marqués de Valdecilla
  • LA Coruna
    • Santiago de Compostela, LA Coruna, Spain, 15706
      • Recruiting
      • Hospital Clínico Universitario de Santiago
  • Madrid
    • Torrejón de Ardoz, Madrid, Spain, 28850
      • Recruiting
      • Hospital Universitario De Torrejon
  • Malaga
    • Benalmádena Costa, Malaga, Spain, 29630
      • Recruiting
      • Vithas Xanit International Hospital
  • Valencia
    • Alzira, Valencia, Spain, 46600
      • Recruiting
      • Hospital de la Ribera
• Sweden
  • Lidingö, Sweden, 181 61
    • Recruiting
    • Fysikalisk Medicin i Stockholm AB
  • Linköping, Sweden, 582 13
    • Recruiting
    • Clinical Trial Consultants - Linkoping
  • Malmö, Sweden, 211 52
    • Recruiting
    • PharmaSite
  • Stockholm, Sweden, 117 27
    • Recruiting
    • Akardo AB
  • Stockholm, Sweden, 114 37
    • Recruiting
    • ProbarE i Stockholm AB
• Switzerland
  • Zurich, Switzerland
    • Recruiting
    • Zurcher Reha Zentren Wald
• Taiwan
  • Chang-hua, Taiwan, 500
    • Recruiting
    • Changhua Christian Hospital
  • Kaoshiung City, Taiwan, 807
    • Recruiting
    • Kaohsiung Medical University Hospital
  • New Taipei City, Taiwan, 220
    • Recruiting
    • Far East Memorial Hospital
  • Taipei, Taiwan, 11490
    • Recruiting
    • Tri-Service General Hospital
  • Taipei, Taiwan, 112
    • Recruiting
    • Taipei Veterans General Hospital
  • Taipei, Taiwan, 110
    • Recruiting
    • Taipei Medical University Hospital
• Thailand
  • Khon Kaen, Thailand, 40002
    • Recruiting
    • Srinagarind Hospital, Khon Kaen University
  • Muang, Thailand, 11000
    • Recruiting
    • Central Chest Institute of Thailand
• Turkey (Türkiye)
  • Adana, Turkey (Türkiye), 1330
    • Recruiting
    • Cukurova University Medical Faculty Balcali Hospital
  • Kirikkale, Turkey (Türkiye), 71100
    • Recruiting
    • Kirikkale Universitesi Tip Fakultesi Hastanesi
  • Rize Merkez, Turkey (Türkiye), 53020
    • Recruiting
    • Rize Recep Tayyip Erdogan University Training and Research Hospital
• United Kingdom
  • Bellshill, United Kingdom, ML4 3NJ
    • Recruiting
    • AES - DRS - Synexus Scotland Clinical Research Centre
  • Bradford, United Kingdom, BD9 6RJ
    • Recruiting
    • Bradford Royal Infirmary
  • Cardiff, United Kingdom, CF15 9SS
    • Completed
    • AES - DRS - Synexus Wales Clinical Research Centre
  • Chesterfield, United Kingdom, S40 4AA
    • Recruiting
    • Royal Primary Care - Ashgate Manor
  • Chorley, United Kingdom, PR7 7NA
    • Completed
    • AES - DRS - NW Consortium Lancashire
  • Cottingham, United Kingdom, HU16 5JQ
    • Recruiting
    • Castle Hill Hospital
  • Edgbaston, United Kingdom, B15 2SQ
    • Completed
    • AES - DRS - Synexus Midlands Clinical Research Centre
  • Hexham, United Kingdom, NE46 1QJ
    • Completed
    • AES - DRS - Synexus Hexham Clinical Research Centre
  • Leicester, United Kingdom, LE3 9QP
    • Recruiting
    • Glenfield Hospital
  • Liverpool, United Kingdom, L32 2AN
    • Recruiting
    • AES - DRS - NW Consortium Merseyside
  • London, United Kingdom, W1G 8HU
    • Recruiting
    • Queen Anne Street Medical Centre
  • London, United Kingdom, N12 8BU
    • Recruiting
    • Velocity Clinical Research North London - Percy Road - PPDS
  • Cambridgeshire
    • Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
      • Recruiting
      • Addenbrooke's Hospital
  • Middlesex
    • London, Middlesex, United Kingdom, SE1 9RT
      • Recruiting
      • Guys Hospital
• United States
  • Alabama
    • Birmingham, Alabama, United States, 35205-2610
      • Recruiting
      • UAB Lung Health Center
    • Dothan, Alabama, United States, 36305
      • Recruiting
      • SEC Clinical Research LLC - Dothan 2 - ClinEdge - PPDS
    • Jasper, Alabama, United States, 35501
      • Recruiting
      • Jasper Summit Research LLC
    • Mobile, Alabama, United States, 36608-3135
      • Recruiting
      • Pulmonary Associates of Mobile PC
  • Arizona
    • Phoenix, Arizona, United States, 85027-5163
      • Recruiting
      • Pulmonary Associates Deer Valley Office
    • Tucson, Arizona, United States, 85741-3118
      • Recruiting
      • AES - DRS - Synexus Clinical Research US, Inc. - Tucson
  • California
    • Bakersfield, California, United States, 93301-4205
      • Recruiting
      • Kern Allergy and Medical Research
    • Poway, California, United States, 92064-2419
      • Recruiting
      • Cadena Care Institute, Llc
    • San Diego, California, United States, 92120
      • Completed
      • Apex Clinical Research
  • Florida
    • Clearwater, Florida, United States, 33765
      • Recruiting
      • St Francis Medical Institute ClinEdge PPDS
    • Greenacres City, Florida, United States, 33467-2979
      • Recruiting
      • Finlay Medical Research Corporation
    • Leesburg, Florida, United States, 34748-5077
      • Recruiting
      • Flourish Research - Leesburg - PPDS
    • Loxahatchee Groves, Florida, United States, 33470-9272
      • Recruiting
      • Advanced Pulmonary Research Institute
    • Miami, Florida, United States, 33014
      • Recruiting
      • San Marcus Research Clinic Inc.
    • Miami, Florida, United States, 33173
      • Recruiting
      • Research Institute of South Florida Inc
    • Miami, Florida, United States, 33144-2155
      • Recruiting
      • Oceane7 Medical & Research Center, Inc.
    • Miami, Florida, United States, 33175-3434
      • Recruiting
      • Diverse Clinical Research, LLC
    • Miami, Florida, United States, 33126-1941
      • Recruiting
      • Finlay Medical Research Corporation
    • Orlando, Florida, United States, 32803
      • Recruiting
      • Central Florida Pulmonary Group, PA
    • Orlando, Florida, United States, 32825-4454
      • Recruiting
      • Florida Institute for Clinical Research, LLC
    • Winter Park, Florida, United States, 32789-4681
      • Recruiting
      • Flourish Research - Orlando - PPDS
  • Georgia
    • Stonecrest, Georgia, United States, 30038-2649
      • Recruiting
      • Pivotal Research Solutions
  • Illinois
    • Chicago, Illinois, United States, 60611
      • Recruiting
      • Northwestern Center for Clinical Research
  • Indiana
    • Hammond, Indiana, United States, 46324-2213
      • Recruiting
      • ASHA Clinical Research - ClinEdge - PPDS
  • Louisiana
    • New Orleans, Louisiana, United States, 70115-3628
      • Recruiting
      • Best Clinical Trials
  • Maine
    • Bangor, Maine, United States, 04401-5691
      • Recruiting
      • Paul A. Shapero, MD, PA
  • Massachusetts
    • Fall River, Massachusetts, United States, 02723-1511
      • Recruiting
      • Exordia Medical Research, Inc.
  • Michigan
    • Farmington Hills, Michigan, United States, 48336-2817
      • Recruiting
      • Pulmonary Research Institute of Southeast Michigan
    • Flint, Michigan, United States, 48504-4730
      • Recruiting
      • Flushing Road Internal Medicine and Pediatrics - F
    • Southfield, Michigan, United States, 48075
      • Recruiting
      • Revive Research Institute
    • Troy, Michigan, United States, 48085
      • Recruiting
      • Oakland Medical Research
  • Missouri
    • Chesterfield, Missouri, United States, 63017-3625
      • Recruiting
      • The Lung Research Center
    • Hannibal, Missouri, United States, 63401-6890
      • Active, not recruiting
      • Hannibal Regional Healthcare System HRMG Hannibal
    • Saint Charles, Missouri, United States, 63301
      • Recruiting
      • Midwest Chest Consultants
    • St Louis, Missouri, United States, 63110
      • Recruiting
      • Washington University School of Medicine in St. Louis
    • St Louis, Missouri, United States, 63141
      • Recruiting
      • Midwest Clinical Research LLC
  • Nevada
    • Las Vegas, Nevada, United States, 89106-4159
      • Recruiting
      • Sierra Clinical Research - ClinEdge - PPDS
    • Las Vegas, Nevada, United States, 89101-3485
      • Recruiting
      • The Machuca Foundation Inc
    • Reno, Nevada, United States, 89502-1576
      • Recruiting
      • Renown Regional Medical Center Hospital
  • New York
    • New York, New York, United States, 10017-4008
      • Completed
      • AES - DRS - Synexus Clinical Research US, Inc. - New York
  • North Carolina
    • Charlotte, North Carolina, United States, 28277
      • Recruiting
      • American Health Research Inc.
    • Denver, North Carolina, United States, 28037-7929
      • Recruiting
      • Research Carolina Elite
    • Gastonia, North Carolina, United States, 28054
      • Recruiting
      • Clinical Research of Gastonia
    • Greensboro, North Carolina, United States, 27403-4443
      • Recruiting
      • PulmonIx LLC
    • Shelby, North Carolina, United States, 28150-3803
      • Recruiting
      • Carolina Research Center
    • Winston-Salem, North Carolina, United States, 27103-4029
      • Recruiting
      • Southeastern Research Center
  • Oklahoma
    • Edmond, Oklahoma, United States, 73034-3258
      • Recruiting
      • OK Clinical Research
  • Oregon
    • Portland, Oregon, United States, 97220
      • Recruiting
      • The Oregon Clinic.
  • Pennsylvania
    • DuBois, Pennsylvania, United States, 15801-2277
      • Recruiting
      • Clinical Research Associates Of Central Pa , Llc
    • Philadelphia, Pennsylvania, United States, 19140
      • Completed
      • Temple University Hospital
    • Pittsburgh, Pennsylvania, United States, 15241
      • Recruiting
      • Allergy & Clinical Immun Assoc
  • South Carolina
    • Columbia, South Carolina, United States, 29204
      • Recruiting
      • Medtrial, LLC
    • Gaffney, South Carolina, United States, 29340-4737
      • Recruiting
      • Velocity Clinical Research - Gaffney - PPDS
    • North Charleston, South Carolina, United States, 29406
      • Recruiting
      • Lowcountry Lung and Critical Care
    • Rock Hill, South Carolina, United States, 29732
      • Recruiting
      • Clinical Research of Rock Hill
  • Tennessee
    • Chattanooga, Tennessee, United States, 37421
      • Recruiting
      • ClinSearch, LLC
    • Hendersonville, Tennessee, United States, 37075-3085
      • Recruiting
      • Tennessee Comprehensive Lung & Sleep Center
  • Texas
    • Boerne, Texas, United States, 78006-1993
      • Active, not recruiting
      • South Texas Medical Research Institute, Inc., dba TTS Research ? ClinEdge ? PPDS
    • Corsicana, Texas, United States, 75110-2471
      • Recruiting
      • Corsicana Medical Research
    • Houston, Texas, United States, 77008-1772
      • Recruiting
      • Trio Clinical Trials
    • Houston, Texas, United States, 77030-4202
      • Recruiting
      • Baylor College of Medicine
    • Houston, Texas, United States, 77089-6097
      • Recruiting
      • Houston Pulmonary Medicine Associates, PA - Biopharma Informatic, LLC
    • McKinney, Texas, United States, 75069
      • Recruiting
      • Metroplex Pulmonary and Sleep Medicine Center
    • Sherman, Texas, United States, 75090
      • Recruiting
      • Sherman Clinical Research - ClinEdge - PPDS
  • Vermont
    • Colchester, Vermont, United States, 05446-3052
      • Recruiting
      • Vermont Lung Center at the University of Vermont
  • Virginia
    • Charlottesville, Virginia, United States, 22903
      • Recruiting
      • University of Virginia Health System
  • Washington
    • Everett, Washington, United States, 98208
      • Recruiting
      • Western Washington Medical Group
  • Wisconsin
    • Greenfield, Wisconsin, United States, 53228
      • Recruiting
      • Allergy Asthma and Sinus Center-Greenfield

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Completion of the 52-week treatment period in either parent GB43311 or GB44332

Exclusion Criteria:

• Withdrawal of consent and/or premature discontinuation from parent study
• Any permanent discontinuation of study drug in parent study
• Significant non-compliance in the parent study, specifically defined as missing scheduled visits, per investigator's judgment
• Any new diagnosis of asthma according to the Global Initiative for Asthma guidelines or other accepted guidelines since enrolling in the parent study
• Any new clinically significant pulmonary disease other than COPD (e.g., pulmonary fibrosis, sarcoidosis, chronic pulmonary embolism or primary pulmonary hypertension, alpha-1-antitrypsin deficiency) since enrolling in the parent study
• Any new unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure since enrolling in the parent study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Open-Label Extension; Eligible participants from parent studies GB43311 and GB44332 will receive subcutaneous (SC) astegolimab every 2 weeks (Q2W) until the end of the study	Drug: Astegolimab; Participants will receive SC astegolimab Q2W

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Incidence of all adverse events (AEs)	Up to 12 weeks after last dose of study treatment

Collaborators and Investigators

• Sponsor: Hoffmann-La Roche
• Investigators: Study Director: Clinical Trials, Hoffmann-La Roche

Publications and helpful links

Helpful Links

• Please use this form to submit your questions for a faster response: https://www.gene.com/contact-us/submit-medical-inquiry. Do not include or attach any medical records when emailing or completing the form. A nurse will respond within 24 business hours.

Study record dates

Study Major Dates

• Study Start (Actual): June 28, 2023
• Primary Completion (Estimated): July 1, 2034
• Study Completion (Estimated): July 1, 2034

Study Registration Dates

• First Submitted: May 19, 2023
• First Submitted That Met QC Criteria: May 19, 2023
• First Posted (Actual): May 26, 2023

Study Record Updates

• Last Update Posted (Actual): June 3, 2026
• Last Update Submitted That Met QC Criteria: June 1, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Keywords: chronic obstructive pulmonary disease, COPD
• Additional Relevant MeSH Terms: Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pathological Conditions, Signs and Symptoms; Pulmonary Disease, Chronic Obstructive; Tumor Necrosis Factor Inhibitors; Anti-Infective Agents; Anti-Inflammatory Agents; Antiviral Agents; astegolimab
• Other Study ID Numbers: GB43374

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data_sharing

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No