Search clinical trials for: Open-label dose escalation

Total 21989 results

SURGE Therapeutics

Not yet recruiting

SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery

Breast Cancer
Tenaya Therapeutics
Johns Hopkins University; Mayo Clinic

Recruiting

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC (RIDGE-1)

Arrhythmogenic Right Ventricular Cardiomyopathy

United States
Erasmus Medical Center

Recruiting

TEIPP Immunotherapy in Patients With NSCLC (TEIPP)

Non Small Cell Lung Cancer

Netherlands
Ichnos Sciences SA

Not yet recruiting

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

Australia
SURGE Therapeutics

Recruiting

A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

Non-muscle-invasive Bladder Cancer

United States
Ichnos Sciences SA

Recruiting

Phase 1/2 Study of ISB 1442 in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

United States, Australia
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

A Study of PRS-344/S095012 (PD-L1x4-1BB Bispecific Antibody-Anticalin Fusion) in Patients With Solid Tumors

Solid Tumor

Spain, Australia, Belgium, United States
Agenus Inc.

Recruiting

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Melanoma | Ovarian Cancer | Prostate Cancer | Non-small-cell Lung Cancer | Endometrial Cancer | Advanced Cancer | Angiosarcoma | Fibrolamellar Carcinoma | Colorectal Cancer Without Liver Metastases

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults

Schistosomiasis

United States
Agenus Inc.

Active, not recruiting

Study of AGEN1571 in Participants With Advanced Solid Tumors

Advanced Solid Tumor

United States
AstraZeneca

Completed

AZD9833 China PK Study (AZD9833)

ER+, HER2-, Metastatic Breast Cancer

China
Syndax Pharmaceuticals
Merck Sharp & Dohme LLC

Completed

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in NSCLC With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer

Melanoma | Non-Small Cell Lung Cancer | Mismatch Repair-Proficient Colorectal Cancer

United States
AstraZeneca

Terminated

A Phase I/II Study of AZD0466 as Monotherapy or in Combination With Anticancer Agents in Advanced Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

Spain, United States, Korea, Republic of, France, Portugal, Australia, Italy
Swiss Group for Clinical Cancer Research

Active, not recruiting

Open-label Dose Escalation Phase 1b Trial of a New Micellar Docetaxel Compound in Patients With mCRPC

Metastatic Castration-resistant Prostate Cancer

Switzerland
German Breast Group
Novartis

Completed

Dose EScalation Induction of EvERolimus (Desiree)

Breast Cancer | Hormone Receptor Positive Tumor

Germany
Pfizer

Completed

Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer

Colorectal Cancer

United States, Canada, Australia, Germany, Japan, Netherlands, Spain, France, Belgium, Korea, Republic of, Italy, Norway
Neupharma Srl
Sintesi Research Srl; Pari Pharma GmbH; Aptuit

Completed

Open-label, Dose-escalation Study to Evaluate the Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients

Cystic Fibrosis

Italy
ImmunoGen, Inc.

Completed

Open-label Study of IMGN779 in Adult Patients With Relapsed/Refractory CD33-positive Acute Myeloid Leukemia

Acute Myeloid Leukemia

United States
Amgen

Completed

A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors

Cancer | Advanced Solid Tumors | Solid Tumors | Tumors | Advanced Malignancy

United States, Australia
The Lymphoma Academic Research Organisation
Celgene Corporation

Completed

A Phase IB Study Of The BTKi CC-292 Combined With Lenalidomide In Adults Patients With Relapsed/Refractory B-Cell Lymphoma (CLEAR)

Relapsed/Refractory B-cell Lymphoma

France
Array BioPharma

Terminated

Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.

Locally Advanced Metastatic BRAF Mutant Melanoma

Australia, Canada, Netherlands, United States
Threshold Pharmaceuticals

Unknown

Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib or Pomalidomide in Subjects With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
University of Kansas Medical Center

Not yet recruiting

Dose-escalation Study of Ultra-high Dose Ablative Radiosurgery With Immunotherapy for Bulky Metastatic Cancer Patients

Solid Tumor

United States
Osel, Inc.
City of Hope Comprehensive Cancer Center; Miyarisan Pharmaceutical Co., Ltd.

Recruiting

Dose Finding Study of CBM588 in Combination With Nivolumab/Ipilimumab in Advanced Stage Renal Cell Carcinoma

Advanced or Metastatic Renal Cell Carcinoma

United States
Keymed Biosciences Co.Ltd

Not yet recruiting

Single Dose Escalation Study of CM383 in Healthy Volunteers

Alzheimer Disease
Bill & Melinda Gates Medical Research Institute

Not yet recruiting

Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population

Healthy Volunteers

Kenya, Uganda
GE Healthcare
PPD; Fortrea

Not yet recruiting

A Phase 1, Dose-Escalation, Positron Emission Tomography Study to Assess the Safety, Pharmacokinetics, Dosimetry and Biodistribution of GEH200521 (18F) Injection Co-Administered With GEH200520 Injection in Healthy Volunteers

Healthy Volunteers

United States
Vertex Pharmaceuticals Incorporated

Not yet recruiting

A Phase 1 Dose Escalation Study of Intravenous VX-993 in Healthy Adults

Pain
University of Wisconsin, Madison

Not yet recruiting

Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

Xerostomia | Graft-versus-host-disease | Sjogren's Disease

United States
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Not yet recruiting

A Single Dose Escalation Study of HHT201 in Healthy Subjects

Alzheimer Disease

China
Eilean Therapeutics

Not yet recruiting

Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated Relapsed or Refractory Acute Myeloid Leukemia

AML With Gene Mutations

Australia
ITB-Med LLC

Recruiting

A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Kidney Transplantation

Spain, Sweden, Austria
Kylonova (Xiamen) Biopharma co., LTD.

Recruiting

Dose Escalation Study of Kylo-0603 in Healthy Subjects

Nonalcoholic Steatohepatitis

China
M.D. Anderson Cancer Center
Bellicum Pharmaceuticals, Inc.

Not yet recruiting

Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)

Colorectal Cancer | Minimal Residual Disease

United States
Jasper Therapeutics, Inc.

Recruiting

A Dose Escalation Trial of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of Briquilimab in Adult Patients With Chronic Inducible Urticaria (CIndU) Who Remain Symptomatic Despite Treatment With H1- Antihistamines (SPOTLIGHT)

Chronic Inducible Urticaria

Germany
University Hospital, Basel, Switzerland

Not yet recruiting

Targeted Radionuclide Therapy in Metastatic Prostate Cancer Using a New PSMA Ligand Radiolabelled With Terbium-161 (161Tb-SibuDAB) - Dose Identification/Escalation Phase Ia/b Study (PROGNOSTICS)

Castration-resistant Prostate Cancer

Switzerland
University Hospital Freiburg
German Federal Ministry of Education and Research

Recruiting

Image-guided Focal Dose Escalation- Primary pc Treated With Primary External Beam Hypofract.Stereotactic rt (HypoF-SBRT)

Prostate Cancer

Germany
Intelligem Therapeutics Australia Pty Ltd.

Not yet recruiting

A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease

Hyperuricemia | Hypouricemia, Renal
Shanghai Henlius Biotech

Not yet recruiting

A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Escalation Phase I Clinical Study to Assess the Safety, Pharmacokinetics, and Immunogenicity of HLX6018 in Healthy Subjects

IPF
Royal North Shore Hospital

Not yet recruiting

De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) (DE-RADIATE)

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Australia
Advesya SAS

Not yet recruiting

An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia (RESOLVE AML001)

Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory

France, Sweden, Spain, Germany
The Netherlands Cancer Institute

Recruiting

A Pilot Study of Dose dE-eScalaTion IN prostATe radIOtherapy usiNg the MRL (DESTINATION)

Prostate Cancer

Netherlands
Vigonvita Life Sciences

Recruiting

Safety and Pharmacokinetics Study of Multiple Ascending Doses and Food Effect of LV232 Capsules

Healthy Subjects

China
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Not yet recruiting

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Advanced Small Cell Lung Cancer

Small Cell Lung Cancer | Neuroendocrine Cancer

China
GigaGen, Inc.
National Cancer Institute (NCI)

Recruiting

A Dose Escalation and Expansion Study of GIGA-564 in Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Advanced or Metastatic Solid Tumor Malignancies

United States
Aummune Ltd.

Recruiting

Study of AM003 in Patients With Locally Advanced and Metastatic Solid Tumors

Solid Tumor

Israel
BrodenBio Co., Ltd.

Recruiting

A Phase 1 Study of BB102 in Participants With Advanced Solid Tumors

Advanced Solid Tumor

China
The First Affiliated Hospital with Nanjing Medical...
Anhui Provincial Cancer Hospital; Affiliated Hospital of Jiangnan University; The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School and other collaborators

Recruiting

The Dosing Regimen of Pyrotinib in HER2-positive Advanced First-line Breast Cancer: a Phase II Clinical Study

Breast Cancer

China
NextPoint Therapeutics, Inc.

Recruiting

A Study of NPX887 for Participants With Solid Tumors Known to Express HHLA2/B7-H7

Metastatic Malignant Neoplasm

United States

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