Search clinical trials for: Persistent immune activation

Total 60992 results

Rockefeller University
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Effects of Persistent Innate Immune Activation on Vaccine Efficacy

Hepatitis C Infection

United States
Radboud University Medical Center
Merck Sharp & Dohme LLC

Completed

Effects of Raltegravir Based Regimen on Platelet Reactivity, Platelet-monocyte Aggregation and Immune Activation (RAPID)

HIV
California Allergy and Asthma Medical Group, Inc.

Unknown

Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma.

Mild to Moderate Persistent Asthma

United States
Westat
National Institute on Drug Abuse (NIDA); Eunice Kennedy Shriver National Institute... and other collaborators

Not yet recruiting

Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Young Gay/Bisexual Minority Men (IMPACT) (IMPACT)

HIV

United States
Medical University of Lublin

Recruiting

Relationship Between Circulating Sclerostin and Bone Lesions in Patients With Mastocytosis

Mastocytosis | Bones

Poland
University Hospital, Toulouse

Not yet recruiting

Study of Cellular Heterogeneity in Patients With Mastocytosis (MastCellHet)

Mastocytosis

France
University Hospital, Antwerp
Universiteit Antwerpen; AZ Jan Palfijn Gent

Not yet recruiting

Diagnosing Drug Allergy: the T is the Key (TAT)

Amoxicillin Allergy
Swedish Orphan Biovitrum

Recruiting

Assessment of Macrophage Activation syndromE in STill's Disease (AMETHYST)

Still's Disease, Adult-Onset | Macrophage Activation Syndrome | Stills Disease, Juvenile-Onset

United States, Canada, France, Germany, Italy, Netherlands, Spain
Imperial College London
Imperial College Healthcare NHS Trust

Recruiting

Ablation of Focal Activation in Atrial Fibrillation (RETRO-AF)

Atrial Fibrillation | Arrhythmias, Cardiac | Arrhythmia | Atrial Fibrillation, Persistent | Cardiac Arrhythmia

United Kingdom
National Institute of Allergy and Infectious Diseases...

Recruiting

Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study

Lymphohistiocytosis, Hemophagocytic | Macrophage Activation Syndrome | Secondary Hemophagocytic Lymphohistiocytosis | Hyperinflammatory Syndromes

United States
H. Lee Moffitt Cancer Center and Research Institute
Blueprint Medicines Corporation

Recruiting

Avapritinib With Decitabine in Patients With SM-AHN

Systemic Mastocytosis With an Associated Hematologic Neoplasm

United States
National Cancer Institute (NCI)

Not yet recruiting

Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Recurrent Glioblastoma
Senti Biosciences

Recruiting

SENTI-202: Off-the-shelf Logic Gated CAR NK Cell Therapy in Adults With CD33 and/or FLT3 Blood Cancers Including AML/MDS

AML/MDS | CD33 Expressing Hematological Malignancies | FLT3 Expressing Hematological Malignancies

United States, Australia
IRCCS San Raffaele

Recruiting

Immune Activation, Neural Plasticity and Depression

Mood Disorders | Sleep Deprivation | Major Depressive Disorder

Italy
University of Wisconsin, Madison
National Institute on Aging (NIA)

Recruiting

Comparison of Microglial Activation in Severe Asthma and Healthy Controls (MAIA-SC)

Asthma

United States
Assiut University

Not yet recruiting

Coagulation Activation in Patients With Pemphigus

Pemphigus
EMS

Not yet recruiting

Efficacy and Safety of DEP114 in the Treatment of Moderate to Severe Persistent Allergic Rhinitis in Children. (SIERRA)

Allergic Rhinitis
Chongqing Medical University

Recruiting

Prospective Multicenter Observational Study and Promotion of the Application of Focused Ultrasound in Allergic Rhinitis

Allergic Rhinitis

China
Genetic Disease Investigators

Not yet recruiting

Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves

Dry Eye | Dry Eye Disease
University of Nairobi
Johns Hopkins University; University of Washington; Kenyatta National Hospital

Not yet recruiting

Psychoeducation, Relaxation, PrOblem Solving, Activation, Cognitive Coping Therapy for Adolescents and Youth in HIV Care (PROACT)

Trauma | Depression, Anxiety | HIV-1-infection

Kenya
IRCCS Centro Neurolesi "Bonino-Pulejo"

Recruiting

Study of Brain Activations and Physiological Responses Using NeuroBiofeedback in Patients With Multiple Sclerosis (NBF2023)

Mood Disorders | Multiple Sclerosis | Cognitive Impairment

Italy
University of Maryland, Baltimore
National Institute on Aging (NIA)

Not yet recruiting

Behavioral Activation, Nutrition, and Activity Intervention

HIV

United States
Foundation For Rare Disease Research
Institute for Asthma & Allergy; Virant Diagnostics, Inc.; MedBio Reference Laboratories...

Not yet recruiting

Angioedema Biomarker Research Study

Angioedema | Urticaria | C1 Inhibitor Deficiency | Angioedemas, Hereditary | Mastocytosis | Indolent Systemic Mastocytosis | Systemic Mastocytoses | ACE Inhibitor-Induced Angioedema
University Health Network, Toronto
Canadian Cancer Society (CCS); Young Adult Cancer Canada

Not yet recruiting

Digital Peer Navigation for Adolescents and Young Adults With Cancer

Sarcoma | Lymphoma | Breast Cancer | Testicular Cancer
Dr. Anne Ellis

Recruiting

Tezepelumab in Allergic Rhinitis and Asthma Study (TEZARS) (TEZARS)

Asthma With Allergic Rhinitis

Canada
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

REGulatory T Cells in Autism Induced by Maternal Immune Activation (REGAIN)

Autism Spectrum Disorder

France
Hospices Civils de Lyon

Recruiting

Characterisation of TLR4+ Blood Cells in Patients With Solid Cancer (ODYSSEE)

All Types of Solid Cancer

France
City of Hope Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer

Breast Carcinoma | Colorectal Carcinoma

United States
National Cancer Institute (NCI)

Not yet recruiting

A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL)

B Acute Lymphoblastic Leukemia
FengYan Jin

Not yet recruiting

A Perspective Study of the MRD-tailored Therapy in Patients With Newly Diagnosed Multiple Myeloma With Persistent Minimal Residual Disease After Initial Treatment (MRD)

Multiple Myeloma | Minimal Residual Disease
Jules Bordet Institute

Recruiting

Molecular Imaging of FAP Expressing Cancer-associated Fibroblasts in NSCLC Treated With Immune-checkpoint Inhibitors (LIFE)

Non Small Cell Lung Cancer

Belgium
Uppsala University
Karolinska Institutet

Recruiting

Quality of Life and Disease-related Symptoms in Individuals With Systemic Mastocytosis

Mastocytosis, Systemic

Sweden
St. Jude Children's Research Hospital

Recruiting

Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors

Lymphoma | Leukemia | Childhood Cancer

United States
Merck Sharp & Dohme LLC

Recruiting

Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)

Solid Tumor | Endometrial Cancer | Cutaneous Squamous Cell Carcinoma

Canada, Australia, Taiwan, Malaysia, United States, Netherlands, Turkey, France
National Cancer Institute (NCI)

Recruiting

Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

Recurrent Nasopharyngeal Carcinoma | Stage IV Nasopharyngeal Carcinoma AJCC v8 | Metastatic Nasopharyngeal Carcinoma

United States, Hong Kong
The First Affiliated Hospital of Soochow University

Recruiting

A Registry for Patients With Systemic Mastocytosis in China

Systemic Mastocytoses

China
National Cancer Institute (NCI)

Recruiting

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study

Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Stage II Bladder Urothelial Carcinoma AJCC v6 and v7 | Muscle Invasive Bladder Urothelial Carcinoma

United States
Medisch Spectrum Twente
Leiden University Medical Center; University of Twente

Not yet recruiting

EMDR for Persistent Pain in RA

Rheumatoid Arthritis

Netherlands
Region Örebro County
Uppsala University; The Swedish Research Council; Swedish Heart Lung Foundation; Erling-Persson Stiftelse

Not yet recruiting

First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation

Atrial Fibrillation, Persistent

Hungary, Slovakia, Sweden, United Kingdom
University Hospital, Toulouse

Recruiting

Evaluation of the DALY on a Cohort of Patients With Indolent Systemic Mastocytosis (DALY-MAST)

Mastocytosis, Indolent Systemic

France
AGO Research GmbH

Not yet recruiting

Pembrolizumab in Combination With Lenvatinib in Patients With Recurrent, Persistent, Metastatic or Locally Advanced Vulvar Cancer Not Amenable to Curative Surgery or Radiotherapy (PIERCE)

Recurrent Vulvar Cancer | Persistent Vulvar Cancer | Metastatic Vulva Cancer | Locally Advanced Vulvar Cancer
LeKos LLP

Recruiting

EVALUATION OF THE EFFECTIVENESS AND SAFETY OF DOSPRAY® NAZAL SPRAY IN THE SYMPTOMATIC TREATMENT OF PERSISTENT ALLERGIC RHINITIS: A POST-REGISTRATION OBSERVATION STUDY

Allergic Rhinitis

Kazakhstan
Colorado State University
National Multiple Sclerosis Society

Recruiting

The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis

Multiple Sclerosis

United States
University of Washington

Recruiting

Prospective Case Series to Refine Standalone Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue

Multiple Sclerosis | Fatigue

United States
Henan University of Traditional Chinese Medicine
The First Affiliated Hospital of Henan University of Traditional Chinese... and other collaborators

Not yet recruiting

Huang-long Zhi-xiao Granule Improves the Control Rate of Chronic Persistent of Asthma

Asthma Chronic
Stanford University

Not yet recruiting

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Insulin Resistance | Insulin Sensitivity | Long COVID

United States
Wake Forest University Health Sciences

Recruiting

Antimicrobial Revision in Persistent Febrile Neutropenia

Febrile Neutropenia

United States
Fundació Institut Germans Trias i Pujol
Germans Trias i Pujol Hospital; University of Turin, Italy; Instituto de Salud... and other collaborators

Recruiting

Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment

HIV Infection Primary

Spain
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol (DETERMINE)

Solid Tumor | Haematological Malignancy

United Kingdom
EMS

Not yet recruiting

Efficacy and Safety of MAZ-101 in the Treatment of Persistent Allergic Rhinitis (PER)

Allergic Rhinitis

Search clinical trials for: Persistent immune activation

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