Search clinical trials for: Pharmacokinetics and pharmacodynamics

Total 470169 results

Haisco Pharmaceutical Group Co., Ltd.

Completed

A Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Dosed of HSK36273 in Healthy Volunteers

Healthy

China
Bioxodes S.A.

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ir-CPI in Healthy Male Subjects

Healthy

Belgium
RBP4 Pty Ltd
Belite Bio, Inc

Completed

Pharmacokinetics and Pharmacodynamics Study of LBS-008 in Healthy Volunteers Aged 50-85

Healthy Volunteer | Dry Age-related Macular Degeneration

Australia
Aphaia Pharma US LLC
NovaClin Medical Research Center S.R.L; ACC GmbH Analytical Clinical Concepts; SC Bioclinica... and other collaborators

Completed

Pharmacodynamics and Pharmacokinetics of Different Glucose Bead Formulations in Obese Healthy Subjects

Obese

Romania
Portola Pharmaceuticals

Completed

The Effect o f Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Betrixiban, an Oral FXa Antagonist

Hepatic Impairment

United States
Evopoint Biosciences Inc.

Completed

The the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of XNW3009 in Health Subject

Gout

Australia
Novartis Pharmaceuticals

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure

Pediatric Heart Failure

United States, Italy, Croatia, Japan, Saudi Arabia, Spain, Austria, Korea, Republic of, Germany, Thailand, Canada, Bulgaria, India, Russian Federation, Turkey, France, Switzerland, China, Taiwan, Lebanon, Poland, Argentina, Hungary, P... and more
Aphaia Pharma US LLC
BioClinica, Inc.; ACC GmbH Analytical Clinical Concepts, Germany; Nova-Clin Medical... and other collaborators

Completed

Pharmacodynamics and Pharmacokinetics of 3 New Developed Coated Glucose Beads in 20 Obese Healthy Subjects

Obesity | Metabolic Syndrome

Romania
Akros Pharma Inc.

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of JTT-662 in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States
Shaanxi Micot Technology Limited Company

Terminated

Evaluate the Effects of Renal Impairment on the Pharmacokinetics and Pharmacodynamics

ACS - Acute Coronary Syndrome

United States
Quadriga Biosciences, Inc.
Novotech (Australia) Pty Limited

Completed

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

Melanoma | Sarcoma | Kidney Cancer | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Astrocytoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Thymic Carcinoma | Lung Cancer | Prostate Cancer | Brain Cancer | Cholangiocarcinoma | Bladder Cancer | Liver Cancer | Brain Metastases | Tongue Cancer | Esophagus... and other conditions

Australia
Denali Therapeutics Inc.

Active, not recruiting

A Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

United States, Netherlands
AstraZeneca

Completed

A Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Anifrolumab in Adult Type I Interferon Test High Systemic Lupus Erythematosus Subject With Active Skin Manifestations

Systemic Lupus Erythematosus

Korea, Republic of, United States, Hungary, Poland
Hyundai Pharm

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LINO-1713 in Healthy Korean Female Subjects

Contraception

Korea, Republic of
Hoffmann-La Roche
Chugai Pharmaceutical

Completed

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A (HAVEN 4)

Hemophilia A

United States, Belgium, Spain, Japan, Poland, Australia
Rutgers, The State University of New Jersey

Completed

Pharmacokinetics and Pharmacodynamics of Anthocyanins

Gout

United States
Calibr, a division of Scripps Research
California Institute for Regenerative Medicine (CIRM)

Completed

A Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of KA34 in Subjects With Knee Osteoarthritis

Osteoarthritis, Knee

United States
Hoffmann-La Roche
Chugai Pharmaceutical Co., Ltd. (Sponsor in Taiwan and Japan)

Withdrawn

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Participants With Guillain-Barré Syndrome (GBS)

Guillain-Barré Syndrome
Durect
CTI Clinical Trial and Consulting Services

Completed

A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis (AH)

Alcoholic Hepatitis

United States
Sound Pharmaceuticals, Incorporated
Medical University of South Carolina; Cystic Fibrosis Foundation

Enrolling by invitation

SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity

Ototoxicity

United States
Janssen Research & Development, LLC

Completed

A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-63733657 in Healthy Subjects and Subjects With Alzheimer's Disease

Alzheimer Disease

Belgium, Spain, Netherlands, Germany
Cugene Inc.

Active, not recruiting

A Phase Ia Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered CUG252 in Normal Healthy Volunteers

Systemic Lupus Erythematosus

United States
Beijing Suncadia Pharmaceuticals Co., Ltd

Active, not recruiting

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single-dose Injection of SHR-2004 in Healthy Subjects

Prevention of Arterial and Venous Thrombosis

China
Samsung Bioepis Co., Ltd.

Completed

Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, and Immunogenicity Study of SB16 in Healthy Male Subjects

Healthy

France, United States
GlaxoSmithKline

Completed

Repeat Dose Subcutaneous Rhumatoid Arthritis Efficacy Study

Arthritis, Rheumatoid

Russian Federation
Seoul National University Hospital
Ministry of Food and Drug Safety, Korea

Completed

Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children

Anesthesia, General | Neuromuscular Blockade

Korea, Republic of
Janssen Pharmaceutical K.K.

Completed

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of JNJ-63723283, an Anti-Programmed Cell Death (PD)-1 Monoclonal Antibody, as Monotherapy or in Combination With Erdafitinib in Japanese Participants With Advanced Solid Cancers

Neoplasm

Japan
Trinomab Biotech Co., Ltd.
TIGERMED AUSTRALIA PTY LIMITED

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TNM002 in Healthy Adults

Healthy Adult Subjects

Australia
Celgene

Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CC-99677 in Healthy Adult Japanese Participants.

Healthy Volunteers

United States
Novo Nordisk A/S

Completed

A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes Pharmacokinetics and Pharmacodynamics: How Insulin NNC0363-0845 is Transported Throughout the Body and How It Works

Diabetes Mellitus, Type 1

Austria
Azidus Brasil
Blau Farmaceutica S.A.

Completed

Pharmacokinetics and Pharmacodynamics Assessment of Drug Eritromax Compared to Eprex in Healthy Subjects.

Renal Insufficiency, Chronic

Brazil
UCB Biopharma SRL
Parexel

Completed

A Study to Evaluate the Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Bimekizumab in Patients With Chronic Plaque Psoriasis

Chronic Plaque Psoriasis

United States, Australia, Canada, Moldova, Republic of
Ludwig Institute for Cancer Research
Daiichi Sankyo, Inc.

Completed

A Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer

Colorectal Neoplasms

Australia
Cascade Pharmaceuticals, Inc
Covance

Completed

Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CS0159

Primary Sclerosing Cholangitis (PSC)

United States
AceLink Therapeutics, Inc.
Novotech (Australia) Pty Limited

Completed

To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AL01211 in Healthy Volunteers

Autosomal Dominant Polycystic Kidney

Australia
Ludwig Institute for Cancer Research
Pfizer; Heidelberg Pharma AG

Terminated

Study of Safety and Functional Imaging of cG250 and Sunitinib in Patients With Advanced Renal Cell Carcinoma

Renal Cell Carcinoma (RCC)

Australia
Janssen Research & Development, LLC

Completed

A Study of Safety, Pharmacokinetics and Pharmacodynamics of JNJ-64457107 in Participants With Advanced Stage Tumors

Advanced Solid Neoplasms

Spain, Israel
Partner Therapeutics, Inc.

Completed

Study to Evaluate Pharmacokinetics, Pharmacodynamics, and Safety of Sargramostim Administered Subcutaneously, Intravenously, or by Inhalation

Drug Kinetics | Drug Effects on Physiology

Canada
Terns, Inc.

Completed

AVIATION Study: A Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TERN-201 in Patients With Non-Cirrhotic Non-Alcoholic Steatohepatitis

NASH - Nonalcoholic Steatohepatitis

United States
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ION547

Healthy Volunteers

Canada
Apeiron Biologics
Apeiron Respiratory Therapies GmbH

Completed

Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Inhaled APN01 Developed as Treatment for COVID-19

Covid19

Austria
UCB Biopharma SRL

Terminated

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Zampilimab in Adult Kidney Transplant Recipients With Chronic Allograft Injury

Chronic Allograft Injury

Australia, Belgium, Spain, United Kingdom
Fujian Shengdi Pharmaceutical Co., Ltd.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HRS9531 in Healthy Subjects

Type 2 Diabetes

China
University Hospital Inselspital, Berne
University of Bern

Completed

Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine

Nicotine Dependence

Switzerland
Jiangsu vcare pharmaceutical technology co., LTD

Completed

Pharmacokinetics and Pharmacodynamics Clinical Study of VC005 Tablets in Healthy Subjects

Inflammatory Bowel Diseases

China
GlaxoSmithKline

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2798745 in Participants With Diabetic Macular Edema

Macular Edema

Australia, United States, New Zealand
Radboud University Medical Center

Completed

The Pharmacokinetics and Pharmacodynamics of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria (PREPARE)

Paroxysmal Nocturnal Hemoglobinuria | Eculizumab | PK-PD

Netherlands
Molecular Templates, Inc.

Terminated

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Dose Regimens of MT-3724 With Lenalidomide for the Treatment of Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (MT-3724_NHL_003)

Non-hodgkin Lymphoma

United States
Capillary Biomedical, Inc.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Integrated... and other collaborators

Completed

Pharmacokinetics (PK)/ Pharmacodynamics (PD) of an Extended Wear Infusion Set for Continuous Subcutaneous Insulin Infusion (CSII) in Type 1 Diabetes Mellitus (T1DM) Patients ("PEXIS")

Diabetes Mellitus, Type 1 | Type 1 Diabetes

United States
ModernaTX, Inc.

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-6231 in Healthy Adults

Healthy Volunteers

Australia

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