Search clinical trials for: Phase I

Total 496667 results

Sun Yat-sen University

Not yet recruiting

HAIC Combined With Adebrelimab Plus Apatinib as the First-line Treatment for HCC in BCLC Stage C: An Open-label, Single-arm, Phase II Study

Hepatocellular Carcinoma
University of California, San Diego
Kyoto University; Sumitomo Pharma America, Inc.

Recruiting

Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II) (CT1-DAP001)

PD - Parkinson's Disease

United States
Chinese University of Hong Kong

Not yet recruiting

Empagliflozin on Residual Kidney Function in Incident Peritoneal Dialysis Patients (EMPIRIC-PD)

End Stage Renal Disease on Dialysis | Peritoneal Dialysis Complication | Residual Kidney Function | Sodium-glucose Cotransporter-2 Inhibitor
Novavax

Not yet recruiting

Phase 3 Lot Consistency Study of COVID-19 and Influenza Combination Vaccine

COVID-19
Hanmi Pharmaceutical Company Limited

Recruiting

A Phase 1 Study to Assess HM15275 in Healthy and Obese Subjects.

Obesity

United States
Alexandra Hospital

Not yet recruiting

VR-Guided Mindfulness for ESKD Caregiver Well-Being

Kidney Failure, Chronic
OBI Pharma, Inc

Recruiting

A Phase 1/2 Study of OBI-992 in Subjects With Advanced Solid Tumors

Advanced Solid Tumor

United States
Adicet Therapeutics

Not yet recruiting

A Phase 1/2 Trial of ADI-270 in ccRCC

Clear Cell Renal Cell Carcinoma
University of Texas Southwestern Medical Center
National Cancer Institute (NCI)

Not yet recruiting

INVERT - Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

Head and Neck Cancer

United States
Yunnan Cancer Hospital

Recruiting

The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial. (WINDOW)

Clinical Complete Response Rate With Negative MRD

China
The First Affiliated Hospital of Guangzhou Medical...
GE Healthcare

Recruiting

Deep Learning for Preoperative Pulmonary Assessment in Thoracic CT

Pulmonary Function | Deep Learning | Elective Thoracic Surgery

China
Institut de Recherches Internationales Servier

Not yet recruiting

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

IDH1-mutant Glioma | IDH2-mutant Glioma
Sichuan University

Recruiting

Phase 1b/2 Study of LDRT in Combination With AK104 Plus Chemotherapy as First-line Treatment for ES-SCLC

SCLC, Extensive Stage

China
Keep Hearing, Inc.

Not yet recruiting

ACEMg for Hearing Preservation and Tinnitus Mitigation (ACEMgRWD)

Sensorineural Hearing Loss | Tinnitus

United States
Fudan University

Recruiting

A Phase II Trial of Adebrelimab in Combination With NALIRIFOX in LAPC

Pancreatic Cancer

China
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study Investigating the Combination of Cladribine, Low Dose Cytarabine and Sorafenib Alternating With Decitabine in Pediatric Relapsed and Refractory Acute Leukemias

Refractory Acute Leukemia | Relapsed Acute Leukemia

United States
Yale University

Not yet recruiting

Submaximal Cardiopulmonary Exercise Testing for Detection of Myocardial Injury After Noncardiac Surgery (EnhanceMINS)

Preoperative Period | Submaximal Exercise Performance | Myocardial Injury After Non-cardiac Surgery

United States
Guard Therapeutics AB

Not yet recruiting

A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery (POINTER)

Kidney Injury Following Open-Chest Cardiac Surgery

Spain, Germany, Canada, Czechia
Shanghai Hengrui Pharmaceutical Co., Ltd.

Not yet recruiting

A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors

Advanced Solid Tumors

China
Shanghai Juncell Therapeutics

Not yet recruiting

A Phase Ⅰb Study on Autologous GC101 TIL Injection for the Treatment of NSCLC (MIZAR-005)

Non Small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic
Bayer

Not yet recruiting

A Study to Learn About the Taste of Vericiguat Given in Liquid Form in Healthy Male Participants Aged 18 to 45 Years

Heart Failure

Germany
Shanghai BDgene Co., Ltd.

Not yet recruiting

A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis

Herpes Simplex Virus Type I Stromal Keratitis

China
Centre Hospitalier Régional d'Orléans

Not yet recruiting

Assessment of T-cell Response and In-vitro Proof-of-concept of T-cell Engineering in Chronic ESKD Patients. (LYMPHOVIRCT)

Chronic Kidney Diseases
Sinovac Life Sciences Co., Ltd.

Not yet recruiting

Phase I Clinical Trial of PCV24 in Adults

Pneumococcal Infectious Disease

China
Nantes University Hospital

Not yet recruiting

Pharmaco Mechanical Thrombolysis Associated With Anticoagulation Compared With Anticoagulation in the Acute Phase of Very Symptomatic Proximal Venous Thrombosis of the Lower Limbs. (PMT-DVT)

Iliofemoral Venous Thrombosis
University of Lisbon
Fundação para a Ciência e a Tecnologia; Egas Moniz - Cooperativa de Ensino...

Not yet recruiting

A Women-Focused Cardiovascular Rehabilitation Program on Adherence, Health Related Physical Fitness, and Quality of Life

Cardiovascular Diseases
Chinese PLA General Hospital

Recruiting

A Phase ll Trial of the Combination of Zanubrutinib, Rituximab and Venetoclax in Patients With Previously Untreated Follicular Lymphoma (ZARAV)

Ann Arbor Stage II Follicular Lymphoma | Ann Arbor Stage III Follicular Lymphoma | Ann Arbor Stage IV Follicular Lymphoma | Grade 1 Follicular Lymphoma | Grade 2 Follicular Lymphoma | Grade 3a Follicular Lymphoma

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy of Methylprednisolone Pulses in Neuroendocrine Celles Hyperplasia of Infancy : An Early Phase Study (CORTICONEHI)

Neuroendocrine Cell Hyperplasia of Infancy

France
University of Hawaii
National Heart, Lung, and Blood Institute (NHLBI); National Association of... and other collaborators

Not yet recruiting

Peau o le Vasa: Analysis of the Efficacy and Feasibility of the PILI Lifestyle Program (PLP) + Social Determinants of Health (SDOH) Intervention and Adaptation of SDOH Measures Pilot Study

Hypertension | Type 2 Diabetes Mellitus | Dyslipidemia | Pre-diabetes | Cardiometabolic Syndrome | Weight Loss Trial

United States
Rophibio, Inc.

Not yet recruiting

A Phase 3 Clinical Trial to Compare RBS-001 to Eylea® in Subjects With Neovascular Age-Related Macular Degeneration

Neovascular Age-related Macular Degeneration (nAMD)

United States
Shanghai Ninth People's Hospital Affiliated to...

Recruiting

A Prospective, Randomised Controlled, Phase II Clinical Study of Tirilizumab in Combination With Albumin-bound Paclitaxel With Cisplatin for Neoadjuvant and Adjuvant Treatment of Locally Advanced Resectable Oral Squamous Cell Carcinoma (OPTimal)

Locally Advanced Head and Neck Squamous Cell Carcinoma

China
University of Colorado, Boulder
National Heart, Lung, and Blood Institute (NHLBI); Northwestern University

Recruiting

Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder

Delayed Sleep Phase Syndrome | Delayed Sleep Phase

United States
Fujian Cancer Hospital

Not yet recruiting

Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
AstraZeneca
Daiichi Sankyo Company, Limited 3-5-1 Nihonbashihoncho, Chuo-ku, Tokyo

Not yet recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer (DESTINY-BTC01)

Biliary Tract Cancer

Belgium, Canada, Brazil, Japan, Korea, Republic of, Taiwan, Germany, Austria, Netherlands
Amgen

Not yet recruiting

A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)

End-Stage Renal Disease (ESRD)
Chinese University of Hong Kong

Recruiting

Boiled Tree Nut for Oral Immunotherapy in Food-allergic Children

Food Allergy | Food Allergy in Children

Hong Kong
Xin-Hua Xu

Recruiting

A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy

Non-small Cell Lung Cancer

China
Shikai Wu

Recruiting

Development and Application Study of ePRO Software for Managing Cancer Patients Throughout the Treatment Period

Solid Tumor, Adult

China
Luye Pharma Group Ltd.

Recruiting

Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Orthopedic Surgery

Pain, Postoperative

China
Duke University

Not yet recruiting

A Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of JCXH-211 (SElf-Replicating RNA IL-12) Intratumoral Injection in Patients With Recurrent or Progressive High-Grade Glioma (SERIL)

Recurrent or Progressive High-grade Glioma
Shanghai Bovax Biotechnology Co., Ltd.

Not yet recruiting

A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males

Anal Cancer | HPV-Related Carcinoma | Penile Cancer | Genital Wart | AIN3 | AIN2 | PIN-1 | AIN1 | PIN2 | PIN3

China
Tanta University

Not yet recruiting

Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis

Hemodialysis | ESRD | Renal Replacement Therapy | End-stage Renal Disease | Uremic Pruritus | Chronic Kidney Disease-associated Pruritus

Egypt
Genexine, Inc.
PT Kalbe Genexine Biologics

Recruiting

A Phase 3 Study of Efepoetin Alfa for Treatment of Anemia in Patients With Chronic Kidney Disease on Dialysis

Anemia of Chronic Kidney Disease

Korea, Republic of, Georgia
Shanghai BDgene Co., Ltd.

Recruiting

A Phase 1 Study of Gene-modified Autologous Hematopoietic Stem Cell (BD211) Treating β-thalassemia Major

β-thalassemia

China
M.D. Anderson Cancer Center

Not yet recruiting

A Phase I Study of Hyper-CVAD In Combination With Venetoclax In Pediatric Patients With Relapsed or Refractory Acute Leukemias That Are of the Lymphoid Lineage Including Bi-Phenotypic or Undifferentiated Leukemias

Refractory Acute Leukemia | Undifferentiated Leukemia | Relapsed Acute Leukemia | Bi-Phenotypic Leukemia

United States
Second Affiliated Hospital, School of Medicine,...

Recruiting

Randomized Phase II Trial: Chest Wall RT Omission After Prosthetic Reconstruction

Breast Neoplasms

China
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

AGNOSTIC THERAPY IN A PHASE II SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA (DURVASCC)

Extrapulmonary Small Cell Carcinoma

Italy
AstraZeneca

Recruiting

STEP: Phase IIIb Study of Benralizumab to Step-down Maintenance Therapy in Patients With Severe Eosinophilic Asthma (STEP)

Severe Eosinophilic Asthma

China
Nanjing IASO Biotechnology Co., Ltd.

Recruiting

A Phase III Study of Eque-cel in Subjects With Len-refractory RRMM (FUMANBA-03) (FUMANBA-03)

Multiple Myeloma

China
HysensBio Co., Ltd

Not yet recruiting

Phase 2 Study of KH001 in Long-term Relief From Dentin Hypersensitivity

Dentin Hypersensitivity

United States

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