Search clinical trials for: Previously treated metastatic colorectal cancer

Total 92938 results

AbbVie

Recruiting

Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab

Unresectable Metastatic Colorectal Cancer

Israel, United States, Japan, Korea, Republic of, Taiwan
Enterome

Recruiting

EO4010 in Previously Treated Metastatic Colorectal Carcinoma (AUDREY)

Colorectal Cancer Metastatic

United States, Spain, France
The Third Affiliated Hospital of Guangzhou Medical...
Hangzhou Cheetah Cell Therapeutics Co., Ltd

Recruiting

NKG2D CAR-T Cells to Treat Patients With Previously Treated Liver Metastatic Colorectal Cancer

Refractory Metastatic Colorectal Cancer

China
Eisai Inc.
Merck Sharp & Dohme LLC

Recruiting

A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

Melanoma | Carcinoma, Hepatocellular | Colorectal Neoplasms

Spain, United States, United Kingdom, Japan, France
Fudan University

Recruiting

Cryoablation Combined With Sintilimab Plus Regorafenib In Previously Treated Colorectal Cancer Liver Metastasis

Colorectal Cancer Metastatic | Liver Metastases

China
Gilead Sciences

Active, not recruiting

Study of Magrolimab Given Together With FOLFIRI/BEV in Patients With Previously Treated Advanced Inoperable Metastatic Colorectal Cancer (mCRC) (ELEVATE CRC)

Metastatic Colorectal Cancer

United States, Spain, Australia, Hong Kong, France, Belgium, Canada, Puerto Rico, Germany, Italy
MEI Pharma, Inc.

Active, not recruiting

ME-344 and Bevacizumab in Previously Treated Metastatic Colorectal Cancer

Colorectal Cancer

United States
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)

Colorectal Cancer

United States, Australia, Canada, Chile, China, Czechia, France, Germany, Israel, Italy, Japan, Korea, Republic of, Malaysia, Norway, Russian Federation, South Africa, Spain, Taiwan, Turkey, Ukraine, United Kingdom
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study

Colorectal Cancer

China
Hoffmann-La Roche

Completed

A Phase Ib Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Cibisatamab in Combination With Atezolizumab After Pretreatment With Obinutuzumab in Participants With Previously Treated Metastatic Colorectal Adenocarcinoma

Colorectal Cancer

United States, France, Denmark, Spain
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Terminated

Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer (COLSTAR)

Metastatic Colorectal Cancer

Denmark, Japan, Belgium, Finland, Hungary, United States
National Cancer Institute (NCI)

Completed

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

Canada
Gilead Sciences

Terminated

Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer | Rectal Cancer | Colon Cancer

United States
Sumitomo Pharma America, Inc.

Completed

A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer (CanStem303C)

Colorectal Cancer

United States, Canada, Spain, Australia, China, Hong Kong, Israel, Czechia, France, Japan, Belgium, Germany, Netherlands, Italy, Korea, Republic of, Singapore
Karyopharm Therapeutics Inc

Terminated

A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations

Metastatic Colorectal Cancer

United States
Merck Sharp & Dohme LLC

Completed

Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unresectable or Metastatic Colorectal Cancer (MK-3475-164/KEYNOTE-164)

Colorectal Carcinoma
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

Donafenib for Previously Treated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

China
Pfizer
Bristol-Myers Squibb

Completed

Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation

MSS | RAS-mutant Colorectal Cancer

United States, Spain, Belgium, United Kingdom, Netherlands
National Cancer Institute (NCI)

Terminated

Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004

Colorectal Neoplasms | Colorectal Cancer | Colorectal Tumors | Colorectal Carcinoma | Colorectal Adenocarcinoma

United States
Gilead Sciences

Withdrawn

A Phase II Study of IMMU 130 in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer
AbbVie

Terminated

A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab

Cancer

United States, Belgium, Canada, Korea, Republic of, Spain, Taiwan
Novartis Pharmaceuticals

Completed

Phase Ib Study of PDR001 in Combination With Regorafenib in Adult Patients With Previously Treated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Spain, Italy, Singapore, Canada, Israel, Korea, Republic of, Netherlands, Australia
Sidney Kimmel Comprehensive Cancer Center at Johns...
Astex Pharmaceuticals, Inc.; Van Andel Research Institute

Completed

Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal Cancer

Previously Treated Metastatic Colorectal Cancer

United States, Netherlands
OncoMed Pharmaceuticals, Inc.

Completed

A Study of Brontictuzumab With Chemotherapy for Subjects With Previously Treated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

United States
OncoMed Pharmaceuticals, Inc.

Completed

A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10

Refractory Solid Tumors | Advanced Relapsed Tumors

United States
University of Florida
Bayer

Completed

Sorafenib Plus Capecitabine (SorCape) in Previously Treated Metastatic Colorectal Cancer (SorCape)

Colorectal Cancer Metastatic

United States
Chinese University of Hong Kong

Completed

Cetuximab Rechallenge Study

Metastatic Colorectal Cancer

Hong Kong
Dr. Reddy's Laboratories Limited
Amgen

Unknown

Phase IV Panitumumab Study in Indian Subjects With Metastatic Colorectal Cancer

Cancer

India
National Cancer Institute (NCI)

Completed

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Recurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Stage IIIA Colon Cancer | Stage IIIB Colon Cancer | Stage IIIC Colon Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal... and other conditions

United States
National Cancer Institute (NCI)

Terminated

AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Adenocarcinoma of the Rectum | Adenocarcinoma of the Colon

United States
1Globe Health Institute LLC

Unknown

A Phase III Clinical Study of Napabucasin (GB201) Plus FOLFIRI in Adult Patients With Metastatic Colorectal Cancer

Previously Treated Metastatic Colorectal Cancer

China
Dynavax Technologies Corporation

Terminated

A Study of 1018 Immunostimulatory Sequence (ISS) Administered With Irinotecan and Cetuximab to Treat Patients With Previously Treated Metastatic Colorectal Cancer

Colorectal Neoplasms

United States
Spanish Cooperative Group for the Treatment of...
Roche Pharma AG

Completed

Study of 5-Fluorouracil/Leucovorin/Oxaliplatin (FOLFOX) + Bevacizumab Versus 5-Fluorouracil/Leucovorin/Oxaliplatin/Irinotecan (FOLFOXIRI) + Bevacizumab as First Line Treatment of Patients With Metastatic Colorectal Cancer Not Previously Treated and With Three or More Circulating Tumoral Cells (VISNU-1)

Metastatic Colorectal Cancer

Spain
City of Hope Medical Center

Completed

Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery

Liver Metastases | Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
Kaohsiung Medical University Chung-Ho Memorial...

Unknown

Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated in Patients With Previously Treated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Taiwan
Hoffmann-La Roche
Merck KGaA, Darmstadt, Germany

Withdrawn

A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With Previously Untreated Metastatic Colorectal Cancer.

Colorectal Cancer

Brazil
Sanofi
Regeneron Pharmaceuticals

Completed

Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen

Colorectal Cancer Metastatic

Italy, Spain, United Kingdom, Czechia, Russian Federation, Norway, Thailand, Chile, Israel, Brazil, United States, Belgium, Canada, Denmark, Finland, Germany, Ireland, Lebanon, Mexico, Netherlands, Puerto Rico, Sweden, Turkey
Spanish Cooperative Group for the Treatment of...
Bayer

Terminated

Regorafenib as Single Agent in Patients With Metastatic Colorectal Cancer (mCRC) With Any RAS or BRAF Mutation Previously Treated With FOLFOXIRI Plus Bevacizumab (PREVIUM)

Colorectal Neoplasms | Metastatic Disease

Spain
Genentech, Inc.

Completed

A Study of PRO95780 in Combination With Cetuximab and Irinotecan Chemotherapy or the FOLFIRI Regimen With Bevacizumab in Patients With Previously Treated Metastatic Colorectal Cancer (APM4187g)

Colorectal Cancer
Novartis Pharmaceuticals
Bayer

Completed

Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer

Colorectal Neoplasms | Rectal Neoplasms | Colonic Neoplasms

United States, Germany, Belgium, Canada, Spain, United Kingdom, Taiwan, France, Switzerland, Sweden, Portugal, New Zealand, Italy, Slovakia, Australia, Austria, Brazil, Hong Kong
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal Cancer

Colorectal Cancer

United States, Canada
Celgene Corporation
Pfizer

Terminated

A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer

Diarrhea | Colorectal Neoplasms

United States
Hoffmann-La Roche

Completed

OPAL Study: A Study of Avastin (Bevacizumab) in Combination With FOLFOXIRI in Patients With Previously Untreated Metastatic Colorectal Cancer

Colorectal Cancer

Germany
Genentech, Inc.

Completed

A Study of Dulanermin Administered in Combination With Camptosar®/Erbitux® Chemotherapy or FOLFIRI (With or Without Bevacizumab) in Subjects With Previously Treated Metastatic Colorectal Cancer

Colorectal Cancer

United States
Sanofi
Regeneron Pharmaceuticals

Completed

A Study of Aflibercept Versus Placebo With FOLFIRI in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin Chemotherapy (AFLAME)

Colorectal Cancer Metastatic

Taiwan, China, Hong Kong, Japan, Singapore
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

Donafenib Monotherapy for Previously Treated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

China
Amgen

Completed

A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma

Carcinoma | Cancer | Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Metastatic Cancer | Colon Cancer | Gastrointestinal Cancer | Oncology | Metastases
National Cancer Institute (NCI)

Completed

Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Adenocarcinoma of the Rectum | Stage III Colon Cancer | Stage III Rectal Cancer | Adenocarcinoma of the Colon

United States
National Cancer Institute (NCI)

Completed

Dasatinib in Treating Patients With Previously Treated Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

FR901228 in Treating Patients With Previously Treated Unresectable Locally Advanced or Metastatic Colorectal Cancer

Colorectal Cancer

United States

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