Search clinical trials for: Progranulin (GRN)

Total 47 results

BrightPath Biotherapeutics

Completed

Phase 1 Study of GRN-1201 in HLA-A*02 Subjects With Resected Melanoma

Melanoma

United States
Denali Therapeutics Inc.
Takeda

Active, not recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)

Frontotemporal Dementia

Spain, Turkey, France, Belgium, Netherlands, Portugal, Italy, Colombia, Czechia, Brazil, United Kingdom, Serbia
The Bluefield Project to Cure Frontotemporal Dementia
Mayo Clinic; University of California, San Francisco

Active, not recruiting

Neurofilament Surveillance Project (NSP)

Frontotemporal Dementia | Frontotemporal Lobar Degeneration | FTD-GRN

United States
Heidelberg University

Completed

Coffee Trial - Does Coffee Intake Reduce Postoperative Ileus After Elective Colectomy?

Colectomy

Germany
Mayo Clinic

Not yet recruiting

NRM on Vascular Perfusion in Heathy Adults (NRM)

Vascular Stiffness

United States
University Hospital Heidelberg

Unknown

Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy (PREDICT-DCM)

Cardiomyopathy, Dilated | Sudden Cardiac Death

Germany
National Cancer Institute (NCI)

Withdrawn

GRN1005 for Brain Metastases From Breast or Lung Cancer

Breast Cancer | Breast Neoplasms | Lung Neoplasms | Lung Cancer
Inivata
Guardian Research Network, Inc.

Completed

Concordance of Inivata Liquid Biopsy With Standard Tissue Biopsy

Non-Small Cell Lung Cancer

United States
BrightPath Biotherapeutics

Terminated

GRN-1201 With Pembrolizumab in Subjects With Metastatic PD-L1+ NSCLC

Metastatic NSCLC

United States
Michael Lichtenberg, MD

Completed

Prestige Pilot - Phoenix Atherectomy and Stellarex DCB Clinical Investigation in Infrapopliteal Interventions

Peripheral Artery Disease (PAD)

Germany
Azienda Socio Sanitaria Territoriale degli Spedali...

Completed

Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects (ReRescuePGR)

Frontotemporal Dementia | GRN Related Frontotemporal Dementia

Italy
Prevail Therapeutics
Eli Lilly and Company

Recruiting

Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) (PROCLAIM)

Frontotemporal Dementia

United States, Australia, Belgium, Spain, United Kingdom, France
Cardionovum GmbH
FCRE (Foundation for Cardiovascular Research and Education)

Recruiting

SIGNATURE Study : DCB (Legflow) vs POBA in Fempop Arteries (SIGNATURE)

Peripheral Arterial Disease | Superficial Femoral Artery Stenosis | Angiopathy, Peripheral

Germany
University of California, San Francisco
The Bluefield Project to Cure Frontotemporal Dementia

Completed

Dose Finding Study of Nimodipine for the Treatment of Progranulin Insufficiency From GRN Gene Mutations

Progranulin Mutation Carriers

United States
Passage Bio, Inc.

Recruiting

A Study of PBFT02 in Patients With Frontotemporal Dementia and Progranulin Mutations (FTD-GRN) (upliFT-D)

Frontotemporal Dementia | FTD | Dementia Frontotemporal | FTD-GRN

United States, Brazil, Italy, Portugal, Canada
Green3Bio, Inc.

Suspended

First-in-Human Evaluation of GRN-300 in Subjects With Recurrent Ovarian, Primary Peritoneal, and Fallopian Tube Cancers.

Ovarian Tumors

United States
Alector Inc.

Completed

A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation

Healthy | Frontotemporal Dementia

United States, Canada, United Kingdom
Biotronik AG

Active, not recruiting

BIO REsponse Adapted Combination Therapy Pilot Study

Peripheral Arterial Disease

Australia, Belgium, France, Germany, Austria, Spain
Merck Sharp & Dohme LLC

Completed

Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED) (DISCOVER)

Ocular Hypertension | Open Angle Glaucoma
pfm medical ag

Completed

Post Market Clinical Follow Up to "Patient Reported Outcome" Using a Titanised Polypropylene Mesh (TiLOOP® Bra Pocket) (PRO-Pocket)

Breast Cancer | Breast Diseases | Breast Neoplasm | Breast Reconstruction After Mastectomy

Germany, Austria
AviadoBio Ltd

Recruiting

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) (ASPIRE-FTD)

Frontotemporal Dementia | FTD | FTD-GRN | Dementia, Frontotemporal

Netherlands, Spain, Poland, United States
University of Pennsylvania

Enrolling by invitation

Voices Of Individuals: Challenges and Experiences Of bvFTD

Frontotemporal Degeneration | Frontotemporal Dementia | Frontotemporal Dementia, Behavioral Variant | FTD

United States
University of Witten/Herdecke
KCI Europe Holding B.V.

Completed

Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments (SAWHI)

Impaired Wound Healing | Wound Healing Disorder | Abdominal Wound Healing Disorder | Abdominal Wound Healing Impairment | Acute Postsurgical Subcutaneous Wound

Belgium, Germany
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Natural History and Longitudinal Clinical Assessments in NCL / Batten Disease, the International DEM-CHILD Database

Batten Disease | Neuronal Ceroid Lipofuscinosis | CLN1 Disease | CLN2 Disease | CLN3 Disease | CLN4 Disease | CLN5 Disease | CLN6 Disease | CLN7 Disease | CLN8 Disease | CLN10 Disease | CLN11 Disease | CLN12 Disease | CLN13 Disease | CLN14 Disease

Germany
Theresien Hospital Mannheim
University Hospital Heidelberg, GER; GRN Hospital Weinheim, GER; McGill University... and other collaborators

Recruiting

Myocarditis After SARS-CoV2-Vaccination (MYOVACC)

Myocarditis and Cardiomyopathy

Germany
Mayo Clinic
National Institute of Neurological Disorders and Stroke (NINDS); National Institute... and other collaborators

Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral Sclerosis | Progressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | GRN Related Frontotemporal Dementia | Behavioral Variant Frontotemporal Dementia (bvFTD) | Semantic Variant Primary Progressive Aphasia (svPPA) | Nonfluent Variant Primary Progressive Aphasia... and other conditions

United States, Canada
Queen Mary University of London
Astellas Pharma Inc

Unknown

Short-term Preoperative Treatment With Enzalutamide, Alone or in Combination With Exemestane in Primary Breast Cancer (ARB)

Primary Breast Cancer ER+ve | Primary Breast Cancer AR+ve TNBN

Germany, United Kingdom, Spain, United States, Ireland
Jena University Hospital
Concept Medical Inc.; CoreLab Black Forest; Center for Clinical Studies, University... and other collaborators

Recruiting

Trial to Assess the Safety and Efficacy of Sirolimus-Coated Balloon vs. Uncoated Standard Angioplasty for the Treatment of Below-the-knee Peripheral Arterial Disease (LIMES)

Peripheral Artery Disease

Germany, Austria
Daiichi Sankyo, Inc.
Daiichi Sankyo Deutschland GmbH

Completed

Edoxaban in Patients With Non-valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention (ENCOURAGE-AF)

Non-valvular Atrial Fibrillation

Germany
European Organisation for Research and Treatment...
Hoffmann-La Roche; UNICANCER; Janssen Diagnostics, LLC; SUCCESS

Completed

Efficacy Study of Herceptin to Treat HER2-negative CTC Breast Cancer (TREAT-CTC)

Breast Cancer | Human Epidermal Growth Factor 2 Negative Carcinoma of Breast | Circulating Tumor Cells

France, Germany, Belgium, United Kingdom
University Hospital Tuebingen

Unknown

Therapy Management With Nab-Paclitaxel in Daily Routine (SERAPHINA)

Metastatic Breast Cancer

Germany
West German Study Group
Eli Lilly and Company; Genomic Health®, Inc.

Recruiting

Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC (ADAPTlate)

Breast Cancer Female

Germany
Children's Oncology Group

Not yet recruiting

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Recurrent Juvenile Myelomonocytic Leukemia | Refractory Juvenile Myelomonocytic Leukemia
West German Study Group
Novartis; Genomic Health®, Inc.

Recruiting

Adj. Marker-adjusted Personalized Therapy Comparing ET+Ribociclib vs Chemotherapy in Intermediate Risk, HR+/HER2- EBC (ADAPTcycle)

Breast Cancer Female

Germany
A&G Pharmaceutical Inc.
University of Maryland Greenebaum Cancer Center

Recruiting

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

Non Small Cell Lung Cancer | Mesothelioma | Triple Negative Breast Cancer | Hormone-Resistant Breast Cancer

United States
Korea University

Completed

CTRP3 and Progranulin in Patients With Coronary Artery Disease

Coronary Artery Disease

Korea, Republic of
Poznan University of Medical Sciences

Unknown

Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome (PROG-FAM)

Glucose Metabolism Disorders | Hypertension | Obesity | Nutrition Disorders | Metabolic Syndrome | Dyslipidemias | Glucose Intolerance | Overweight and Obesity

Poland
Assistance Publique - Hôpitaux de Paris

Unknown

Natural History Characterization in Symptomatic and Asymptomatic Progranuline Gene Mutation Carriers (Predict-PGRN)

Frontotemporal Lobar Degeneration

France
Ludwig-Maximilians - University of Munich
City of Munich

Completed

Validation of Progranulin as a Biomarker for Sepsis (PROGRANULIN)

Sepsis

Germany
Korea University

Completed

Progranulin and CTRP3 in Metabolic Syndrome

Metabolic Syndrome

Korea, Republic of
Pfizer

Recruiting

First-line Palbociclib and Endocrine Therapy for Patients With HR+/HER2- Advanced Breast Cancer in the Real-world Setting. (PERFORM)

Breast Neoplasms

Austria, Germany
Hoffmann-La Roche

Completed

A Study of a Combination of Trastuzumab and Capecitabine With or Without Pertuzumab in Patients With HER2-positive Metastatic Breast Cancer (PHEREXA)

Breast Cancer

Spain, United Kingdom, Belgium, Austria, Brazil, France, Germany, Hungary, Italy, Thailand, Korea, Republic of, Hong Kong, Romania, Canada, Argentina, Czechia, Peru, Estonia, Mexico, Poland, Russian Federation, Croatia, Netherlands
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Recruiting

Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia (MILOS)

Hypercholesterolemia | Mixed Dyslipidemia

Austria, United Kingdom, Italy, Germany, Belgium
Hoffmann-La Roche

Completed

A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuvant Therapy in Participants With Operable HER2-Positive Primary Breast Cancer

Breast Cancer

United States, France, Czechia, Italy, Korea, Republic of, Australia, Belgium, Brazil, Canada, Germany, Guatemala, Hong Kong, Hungary, Panama, Peru, Poland, Spain, Taiwan, United Kingdom, Colombia, Bosnia and Herzegovina, Chile, El... and more
Hoffmann-La Roche
Breast International Group; Frontier Science & Technology Research Foundation... and other collaborators

Completed

A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)

Triple Negative Breast Cancer

Russian Federation, United States, Israel, Italy, Spain, France, Korea, Republic of, United Kingdom, Denmark, Taiwan, Hungary, Argentina, Australia, Austria, Belgium, Brazil, China, Germany, Hong Kong, Japan, Mexico, Romania, Switze... and more
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Completed

Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events (SANTORINI)

Cardiovascular Diseases | Dyslipidemia | Hypercholesterolemia | Atherosclerotic Cardiovascular Disease

Finland, Netherlands, Spain, Belgium, Sweden, Austria, United Kingdom, Switzerland, Denmark, France, Germany, Portugal, Italy, Ireland
Hoffmann-La Roche

Completed

A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer (SafeHER)

Breast Neoplasms

Hungary, Italy, United Kingdom, Canada, Czechia, Bulgaria, Croatia, Dominican Republic, France, Germany, Greece, Guatemala, Hong Kong, Indonesia, Ireland, Korea, Republic of, Netherlands, Panama, Peru, Poland, Portugal, Slovakia, Spain and more

Search clinical trials for: Progranulin (GRN)

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