Search clinical trials for: Proof of Mechanism

Total 428868 results

Benha University

Recruiting

Articaine Plus Dexmedetomidine in Supraclavicular Block

Post Operative Pain, Acute

Egypt
Universiteit Antwerpen
McGill University; Aragon Institute of Health Sciences

Not yet recruiting

Comparative Study of the Mechanism of Action of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity: a Proof of Concept Controlled Trial (STROKEPOC)

Stroke | Spasticity as Sequela of Stroke
National Taiwan University Hospital

Recruiting

A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis

Parkinson Disease

Taiwan
Dayton Children's Hospital

Recruiting

Intravenous Fluids in Pediatric Migraine

Migraine | Migraine in Children

United States
Novartis Pharmaceuticals

Recruiting

A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Heart Failure

Italy, Spain, United States, Japan, China, Germany, Taiwan, Bulgaria, Denmark, France, Portugal, Slovakia
University of Oxford

Recruiting

KLH Challenge to Explore the Human Immune Response

Immune Response

United Kingdom
University of Calgary

Recruiting

A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11) (POST 11)

Syncope | Vasovagal Syncope (VVS)

Canada
Austin Institute for Clinical Research

Recruiting

Proof of Concept Study to Access Superficial Basal Cell Carcinoma in Adults

Superficial Basal Cell Carcinoma

United States
H. Lee Moffitt Cancer Center and Research Institute
Turnstone Biologics, Corp.

Recruiting

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

Metastatic Melanoma | Conjunctival Melanoma | Ocular Melanoma | Unresectable Melanoma | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Iris Melanoma | Acral Melanoma | Non-Cutaneous Melanoma

United States
Hoffmann-La Roche

Recruiting

Study to Investigate the Pharmacokinetics and Safety and to Provide Proof of Mechanism of Alogabat in Children and Adolescents Aged 5-17 Years With Angelman Syndrome (AS) With Deletion Genotype. (Aldebaran)

Angelman Syndrome

Australia, United States, Spain, Italy, France, Germany
Shanghai Zhongshan Hospital

Recruiting

Brain-heart Interaction in Coronary Plaque Stability and Cardiovascular Events (Blueprint)

Coronary Artery Disease

China
Clinical Academic Center (2CA-Braga)

Not yet recruiting

Proof-of-concept Study to Evaluate the Safety and Efficacy of Tryptophan in Patients With BPH. (TryptoBPH)

BPH
Invicro

Recruiting

Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein

Parkinson Disease | Healthy Volunteer | Multisystem Atrophy

United States
University Hospital, Toulouse

Recruiting

ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase (ASPIRE)

Purpura, Thrombocytopenic

France
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID); AIDS Healthcare...

Recruiting

Community-based Venues for Delivery of Healthcare Services: Proof of Concept Pilot

STI | Contraceptive Usage | Pre-Exposure Prophylaxis

South Africa
The Christie NHS Foundation Trust
University of Manchester

Not yet recruiting

A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer (IMpALA)

Breast Cancer
National Institute of Nursing Research (NINR)

Recruiting

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

Fatigue

United States
Institut Bergonié
Bristol-Myers Squibb

Recruiting

Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study (CONGRATS)

Advanced Cancer | Soft Tissue Sarcoma Adult

France
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

Crohn's Disease

United States
Gustave Roussy, Cancer Campus, Grand Paris
National Cancer Institute, France

Recruiting

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors (ESMART)

Pediatric Cancer

Italy, France, Denmark, Germany, Netherlands, Spain, United Kingdom
Massachusetts General Hospital
Brain & Behavior Research Foundation; J Willard and Alice S. Marriott Foundation

Recruiting

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

Bipolar Disorder | Depressive Episode

United States
Organon and Co

Completed

The Single Dose Pharmacokinetics of Two and Proof of Efficacy of One New Etoricoxib Gel Formulation in Participants With Osteoarthritis (MK-0663-168)

Osteoarthritis Pain
AstraZeneca

Active, not recruiting

Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece (TRIAENA)

Pulmonary Disease, Chronic Obstructive (COPD)

Greece
University Hospital, Clermont-Ferrand
Federation Francophone de Cancerologie Digestive

Completed

Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study (DONEPEZOX)

Digestive Oncology | Supportive Care

France
Inventiva Pharma

Active, not recruiting

Placebo-controlled, Proof-of-concept Study to Evaluate the Safety and Efficacy of Lanifibranor Alone and in Combination With SGLT2 Inhibitor EmpaGliflozin in patiEnts With NASH and Type 2 Diabetes Mellitus (LEGEND)

Diabetes Mellitus, Type 2 | NASH - Nonalcoholic Steatohepatitis

United States, Belgium, France, Netherlands, United Kingdom
Yale University

Terminated

Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Tele-health Study of Stimulant-induced Improvement in Neurocognitive Functioning.

ADHD

United States
Eastern Virginia Medical School
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Project ADHERE: Clinical Proof-of-Concept of a Tenofovir (TFV) Aptamer-Based Biosensor

HIV/AIDS | Adherence, Medication | Drug Use

United States
Pacira Pharmaceuticals, Inc

Terminated

Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee

Post-traumatic Osteoarthritis of the Knee

United States
VA Office of Research and Development

Active, not recruiting

Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain

Diabetic Neuropathic Pain

United States
Shanghai Institute Of Biological Products
First Affiliated Hospital Bengbu Medical College

Completed

A Study Exploring Efficacy of Pegloticase in Subjects With Asymptomatic Hyperuricemia

Asymptomatic Hyperuricemia

China
University of Chicago
Johns Hopkins University

Active, not recruiting

Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial (AT CASH EPOC)

Cerebral Cavernous Malformation

United States
Unity Health Toronto
The Hospital for Sick Children; Sunnybrook Health Sciences Centre; National Institute... and other collaborators

Completed

Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of Concept

Hereditary Hemorrhagic Telangiectasia

Canada
Universitätsklinikum Hamburg-Eppendorf

Completed

Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study

Hypotension | Anesthesia | Hypotension on Induction

Germany
University of California, Los Angeles
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD (ACEP4)

ASD

United States
Suven Life Sciences Limited

Completed

SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

Alzheimer's Disease

United States
Baylor College of Medicine
ACADIA Pharmaceuticals Inc.

Withdrawn

Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder: Proof of Concept

Posttraumatic Stress Disorder | Insomnia Chronic

United States
Marvin McCreary, MD

Terminated

Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19

COVID-19

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Terminated

Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study (DECO)

Colon Cancer

Netherlands
Johnson & Johnson Consumer Inc., McNeil Consumer...

Completed

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

Pain

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

Ukraine, Argentina, Chile, Poland, Russian Federation, Turkey, United States, Australia, Canada, Germany
Gustave Roussy, Cancer Campus, Grand Paris
Innovative Therapies For Children with Cancer Consortium

Terminated

Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults (VINILO)

Refractory Low-grade Gliomas | Recurrent Low-grade Gliomas

Austria, Italy, France, Denmark, Netherlands, Spain, Switzerland, United Kingdom
Empros Pharma AB
CTC Clinical Trial Consultants AB

Completed

A Proof of Concept Trial in Overweight and Obese Patients, Investigating Effect of EMP16-02 on Body Weight (Primary)

Overweight or Obesity

Sweden
Kristian Kjær Petersen
Aalborg University Hospital; CCBR, Aalborg

Completed

A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain

Osteoarthritis, Knee

Denmark
Chiesi Farmaceutici S.p.A.

Completed

Functional Respiratory Imaging Study (DARWiIN)

Chronic Obstructive Pulmonary Disease

Belgium, Hungary
Sunnybrook Health Sciences Centre

Completed

Nasal Photodisinfection COVID-19 Proof of Concept Study

COVID-19 | SARS-CoV 2 | Corona Virus Infection

Canada
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Immune Complex Mediated Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis Types I, II, and III

Netherlands, Australia, Belgium
Azevan Pharmaceuticals
United States Department of Defense; Weill Medical College of Cornell University and other collaborators

Terminated

Proof-of-concept Study to Assess the Efficacy and Safety of SRX246 in Adults With PTSD

PTSD

United States
Novartis Pharmaceuticals

Completed

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant

Spain, United States
Novartis Pharmaceuticals

Terminated

A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom

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