Search clinical trials for: Proton pump inhibitors

Total 65689 results

EndoGastric Solutions

Completed

The EndoGastric Solutions TEMPO Trial (TEMPO)

Gastroesophageal Reflux Disease (GERD)

United States
Boston Pharmaceuticals

Completed

Study to Determine the Single and Repeat Dose Pharmacokinetics, Food Effect, Proton Pump Inhibitor (PPI) Drug Interaction, Safety and Tolerability of Oral Prototype Formulations of BOS172767 in Healthy Subjects

Healthy Subjects

United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Acid-Reducing Agent(s) on JNJ-64417184 in Healthy Participants

Healthy Participants

Netherlands
University of Split, School of Medicine

Completed

Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori Infection

Helicobacter Pylori Infection

Croatia
Al-Azhar University
Ministry of Health, Kuwait

Completed

Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait

Helicobacter Pylori Infection
Ahmad Nassar Ibrahim
Assiut University

Unknown

Knowledge, Attitude and Practice of Physicians Toward The Prescription of Proton Pump Inhibitors in Egypt

Knowledge, Attitudes, Practice
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Pharmacogenetic and Pharmacokinetics of Naproxen and Associated Naproxen-esomeprazole

Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant

Brazil
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of Gastric Acid Suppression by Rabeprazole and BMS-986165 on How Fast and Complete The Drug is Absorbed Into the Body of Healthy Participants

Healthy

Netherlands
AstraZeneca
Acerta Pharma BV

Completed

A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants

Infectious Disease

United States
Takeda

Withdrawn

Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study

Crohn Disease | Colitis, Ulcerative

United States
LEO Pharma

Completed

Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4

Atopic Dermatitis

United States, France, Netherlands
Radboud University Medical Center

Completed

Influence of Cola on the Absorption of the HCV Agent Velpatasvir in Combination With PPI Omeprazole. (COPA)

Hepatitis C | Swallowing Disorder

Netherlands
Changi General Hospital

Unknown

A RCT of Triple Therapy With Proton Pump Inhibitor vs Vonoprazan for Helicobacter Pylori Gastritis (TRIVON)

Helicobacter Pylori Infection

Singapore
Universitaire Ziekenhuizen KU Leuven

Completed

PPI and Microbiome in Healthy Volunteers and Functional Dyspepsia

Dysbiosis

Belgium
Kaohsiung Veterans General Hospital.

Unknown

Comparing the Efficacy of 10-day Reverse Hybrid Therapy and 10-day Triple Therapy Plus Bismuth Therapy.

Helicobacter Pylori Infection

Taiwan
Boryung Pharmaceutical Co., Ltd

Completed

A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients

Erosive Esophagitis
Damascus Hospital

Completed

Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori

Helicobacter Pylori Infection

Syrian Arab Republic
Spero Therapeutics

Completed

Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Daewoong Pharmaceutical Co. LTD.

Unknown

Study to Evaluate the Efficacy and Safety of DWP14012 on Maintaining Healing in Subjects With Healed Erosive Esophagitis

Healed Erosive Esophagitis

Korea, Republic of
Daewoong Pharmaceutical Co. LTD.

Completed

Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 3)

Erosive Esophagitis

Korea, Republic of
Daewoong Pharmaceutical Co. LTD.

Completed

Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study)

Erosive Gastroesophageal Reflux Disease

Korea, Republic of
McMaster University
Canadian Institutes of Health Research (CIHR)

Completed

Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial (PIC-UP)

Gastrointestinal Hemorrhage

Canada
Jiangsu Sinorda Biomedicine Co., Ltd

Unknown

Study to Evaluate the Safety and Efficacy of X842 in Patients With Reflux Esophagitis

Reflux Esophagitis

China
Shanghai Jiao Tong University School of Medicine

Unknown

Intravenous Triple Therapy in the Treatment of Helicobacter Pylori Infection and Related Complications Caused by Active Peptic Ulcer Disease

Helicobacter Pylori Infection | Intravenous Drug Usage

China
Washington University School of Medicine

Completed

Assessment and Management of Chronic Dyspepsia in Eastern Uganda

Dyspepsia | Helicobacter Pylori Infection

United States
Medstar Health Research Institute
AstraZeneca

Withdrawn

Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs

Dyspepsia

United States
Celgene

Completed

Relative Bioavailability Study of CC-292

Healthy Volunteers

United States
Sihuan Pharmaceutical Holdings Group Ltd.

Completed

A Phase 2 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.

Duodenal Ulcer，DU

China
Genentech, Inc.

Completed

A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

United States, Netherlands, Canada
University of Southern Denmark
Odense Patient Data Explorative Network; Kolding Sygehus

Completed

Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort

Gastroesophageal Reflux

Denmark
Il-Yang Pharm. Co., Ltd.

Completed

Effects of Ilaprazole on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone ESD.

Gastric Cancer

Korea, Republic of
Sihuan Pharmaceutical Holdings Group Ltd.

Completed

A Multiple Ascending High Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects

Healthy Volunteers

China
Alexandria University
University of Alexandria

Completed

Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy

Helicobacter Pylori Infection

Egypt
Taipei Veterans General Hospital, Taiwan

Terminated

Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis (PU)

Liver Cirrhosis | Peptic Ulcer

Taiwan
Takeda

Completed

Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants With or Without Helicobacter Pylori Infection

Duodenal Ulcer

Taiwan, China, Korea, Republic of, Philippines
Merck Sharp & Dohme LLC

Completed

A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)

Infectious Disease
Changi General Hospital

Completed

Hypomagnesemia Associated With Proton-Pump Inhibitor Use (PPI_HypoMg)

Arrhythmias, Cardiac | Seizures | Hypocalcemia | Hypokalemia | Hypomagnesemia | Proton Pump Inhibitor Adverse Reaction

Singapore
University of Roma La Sapienza

Unknown

PPI Therapy Impact on GERD After Sleeve Gastrectomy

Gastro Esophageal Reflux | Bariatric Surgery Candidate | Barrett Esophagus

Italy
Shandong University

Completed

Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection

Helicobacter Pylori Infection

China
Augusta University
National Institute of Dental and Craniofacial Research (NIDCR)

Completed

Role of Infected Blood Dendritic Cells in Heart Disease Risk

Chronic Periodontitis

United States
HK inno.N Corporation

Completed

Triple Therapy With Tegoprazan in H. Pylori Positive Patients

Helicobacter Pylori Infection

Korea, Republic of
Celgene

Completed

Relative Bioavailability and PPI Effects of CC-92480 Test and Reference Formulations in Healthy Subjects

Healthy Volunteer

United States
AstraZeneca
Quotient Sciences

Completed

AZD4635 Relative Bioavailability Study (Rel Bio)

Healthy Volunteers

United Kingdom
National Taiwan University Hospital

Completed

Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for Rescue Treatment of Hp Infection

Helicobacter Pylori Infection

Taiwan
Medical University of Lodz

Completed

Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia

Melatonin Deficiency

Poland
Takeda

Withdrawn

Phase 1 Dexlansoprazole Delayed-Release Capsules for Acid-Related Disorders in Infants Aged 1 to 11 Months

Pediatric Gastroesophageal Reflux Disease

United States, Italy, Israel, Mexico, Poland
Shandong Luoxin Pharmaceutical Group Stock Co.,...

Completed

Efficacy and Safety of LXI-15028 Comparing With Esomeprazole in the Treatment of Erosive Esophagitis

Erosive Esophagitis (EE)

China
Kaohsiung Veterans General Hospital.

Completed

On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.

Barrett Esophagus | Reflux | Proton Pump Inhibitor | Symptom
SOFAR S.p.A.

Completed

Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor

Gastro-oesophageal Reflux Disease

Italy
Takeda

Completed

A Study to Compare the Bioavailability (BA) of Dexlansoprazole Delayed-release Capsules

Healthy Volunteers

United States

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