Search clinical trials for: QT/QTc interval prolongation

Total 2010 results

GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of GMI-1070 on Qtc Intervals in Healthy African-American Adult Subjects

Healthy

United States
Bayer
Merck Sharp & Dohme LLC

Completed

Study to Evaluate the QT / QTc Interval Prolongation Potential of Vericiguat

Coronary Artery Disease

Germany, Moldova, Republic of, Netherlands
Novartis Pharmaceuticals

Completed

CAEB071 Thorough QTc Study in Healthy Volunteers

Healthy

United States
AstraZeneca
Quintiles, Inc.

Completed

A Study to Investigate the Potential for AZD5672 to Affect the Electrical Conduction Pathways in the Heart

Rheumatoid Arthritis

United Kingdom
J. Uriach and Company

Completed

Evaluation of Possible Effects on the QT/ QTc Interval of Rupatadine in Healthy Volunteers

Human Experimentation (Human Volunteers)

Spain
Amgen

Not yet recruiting

A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants

Basic Science
Novartis Pharmaceuticals

Recruiting

Study of Lutetium (177Lu) Vipivotide Tetraxetan in mCRPC Participants With Moderately and Severely Impaired and With Normal Renal Function

Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Spain, France
Universitaire Ziekenhuizen KU Leuven
Fonds voor Wetenschappelijk Reumaonderzoek (FWRO)

Not yet recruiting

Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis (RITUXERA)

Rheumatoid Arthritis

Belgium
Thryv Therapeutics, Inc.

Recruiting

Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).

Long QT Syndrome

United States
Murdoch Childrens Research Institute

Recruiting

Beat to Beat A Study in Paediatric, Adolescent and Young Adult Patients Who Are Undergoing or Have Undergone Cancer Therapy to Evaluate the Agreement Between QTc Measured Using 12 Lead Electrocardiogram (ECG) and a Wearable Device ECG

Neoplasms | Cardiac Arrhythmia

Australia
Burzynski Research Institute

Not yet recruiting

Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma (DBSG)

Brain Stem Glioma
AstraZeneca

Completed

A Study to Investigate the Effect on QTcF of Baxdrostat Compared With Placebo, Using Moxifloxacin as a Positive Control, in Healthy Participants

Healthy Participants

Germany
Istituto Auxologico Italiano

Completed

QT Interval in Athletes (ERAS)

QT Prolongation

Italy
Bayer
Regeneron Pharmaceuticals

Terminated

A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment (XPAND)

Neovascular (Wet) Age-related Macular Degeneration

Canada, United Kingdom
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Electrophysiological Effects of Potential QT Prolonging Drugs

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation

United States
Vigonvita Life Sciences

Completed

Evaluate the Effect of TPN171H on the QT/QTc Interval in Healthy Volunteers

Healthy Subjects

China
University of Utah
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Methadone Pharmacokinetics and Cardiac Effects in Newborns

Pain

United States
Pfizer

Completed

Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML

Pharmacokinetics | Safety | ECG

Canada, Spain, United States, Hungary, Poland, United Kingdom
Tris Pharma, Inc.
Forest Laboratories

Completed

Evaluation of the Effects of Multiple Doses of Cebranopadol on the Electrical Activity of the Heart in Healthy Subjects

Prolonged QTc Interval | Pharmacokinetic

United States
Indiana University
Purdue University

Completed

Methadone-Induced QT Interval Prolongation in a Narcotic Treatment Center

QT Interval Prolongation

United States
University of British Columbia
Canadian Institutes of Health Research (CIHR)

Completed

5-HT3 Antagonists (Antiemetics) and Cardiac Safety

Adverse Reaction to Other Drugs and Medicines

Canada
Richmond Research Institute
Richmond Pharmacology Limited

Completed

Effect of Glucose on QTc Interval in Type 1 Diabetes

Diabetes

United Kingdom
Nantes University Hospital

Completed

CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death (IQARE-SCD)

Sudden Cardiac Death

France
Rabin Medical Center

Unknown

Voriconazole-Induced QT Interval Prolongation: A Prospective Study

Voriconazole Induced QT Interval Prolongation

Israel
Beni-Suef University

Completed

Effect of Ciprofloxacin Versus Levofloxacin on QTc-interval and Dysglycemia

QTc Prolongation, Hyperglycemia, Hypoglycemia

Egypt
AstraZeneca
Parexel

Completed

A Study to Investigate the Effect of Single Dose of AZD6094 (600 mg) on Cardiac Repolarization in Healthy Volunteers

Solid Tumors

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

CiPA Phase 1 ECG Biomarker Validation Study

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation

United States
University of the Pacific

Completed

The Effect of Energy Drink on Cardiovascular Variables: A Randomized Controlled Trial

Cardiovascular Diseases

United States
NorthShore University HealthSystem

Unknown

Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery

EKG-QT Prolongation

United States
Indiana University
American Heart Association; Purdue University

Completed

Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes

Long QT Syndrome

United States
Grünenthal GmbH

Completed

Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women

Prolonged QTc Interval | Pharmacokinetic

Germany
Herlev and Gentofte Hospital

Completed

Exploring Mechanisms and Morphology of QT Interval Prolongation (TriQarr)

Sudden Cardiac Death | Long Qt Syndrome 1-2

Denmark
Cassiopea SpA

Completed

A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart

Healthy Volunteers

United Kingdom
Hamilton Health Sciences Corporation
The Physicians' Services Incorporated Foundation

Completed

Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients

Venous Thrombosis | Atrial Fibrillation | Heart Valve Diseases

Canada
Nobelpharma

Completed

Investigation of Arrhythmogenic Effect of NPC-15 (NPC-15-7)

Qt Interval, Variation in

Japan
Wockhardt

Completed

Evaluate the Effect of WCK 5222 on the QT/QTc Interval in Healthy Volunteers

QT/QTc Interval in Healthy Volunteers

United States
Konkuk University Medical Center

Completed

Ramosetron Pre-treatment for PONV and QT Prolongation

PONV | Prolonged QTc Interval

Korea, Republic of
Tel-Aviv Sourasky Medical Center

Completed

Abnormal QT-Response to the Sudden Tachycardia Provoked by Standing in Individuals With Drug-induced Long QT Syndrome

Long QT Syndrome

Israel
Emory University
Children's Healthcare of Atlanta

Terminated

Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients (LEAP)

Congenital Disorders

United States
Cubist Pharmaceuticals LLC

Completed

Safety Study Designed to Study the Effects of Two Different Doses of CXA-101/Tazobactam, a Low Dose and a High Dose, on the QT/QTc Intervals in Healthy Subjects

Healthy

United States
HaEmek Medical Center, Israel

Completed

Does Azithromycin Cause QT Prolongation in Hospitalized Patients With Severe Community Acquired Pneumonia?

Pneumonia

Israel
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess Electrocardiogram Results in Healthy Volunteers Receiving Canagliflozin (JNJ-28431754)

Healthy

United States
University Hospital, Caen

Unknown

Hydroxyzine and Risk of Prolongation of QT Interval (HYDROXYZINE-QT)

Long QT Syndrome | Hydroxyzine

France
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation
Seoul National University Hospital
Seoul National University Bundang Hospital; The Catholic University of Korea; Korea National Enterprise for Clinical Trials

Completed

A Study Study to Investigate the Effect on QT/QTc Interval of Moxifloxacin After a Single Dose in Healthy Male Subjects

the Effect of Moxifloxacin on QT/QTc Interval

Korea, Republic of
Yonsei University

Completed

Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-

Prostate Cancer | Robotic Surgery

Korea, Republic of
Alkermes, Inc.

Completed

A Study to Evaluate the Effect of ALKS 5461 on QT Intervals in Healthy Volunteers

Healthy

United States
KU Leuven
Agentschap voor Innovatie door Wetenschap en Technologie

Completed

Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital (RISQ-PATH)

Delirium | QT-prolongation

Belgium
KU Leuven
Agentschap voor Innovatie door Wetenschap en Technologie

Completed

QT-prolongation in Psychiatric Hospitals

QT-prolongation

Belgium
Gilead Sciences

Completed

Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults

Long QT Syndrome

United States

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