Search clinical trials for: Replication-Competent Retrovirus

Total 74 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI); Alaunos Therapeutics; National Center for Research...

Recruiting

Long-Term Follow-Up of Recipient of Gene Transfer Research

Retroviridae Infections | Cancer

United States
Hadassah Medical Organization

Recruiting

Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers

Non Small Cell Lung Cancer | Metastatic Cancer | Triple Negative Breast Cancer | Sarcoma, Synovial | Ovary Cancer | Sarcoma,Soft Tissue | Melanoma Stage IV | Bladder Urothelial Carcinoma | Neuroblastoma, Metastatic

Israel
Xinqiao Hospital of Chongqing
TCRCure Biopharma Ltd.

Not yet recruiting

Anti-ALPP CAR-T Cells Immunotherapy for Ovarian and Endometrial Cancer

Ovarian Cancer | Endometrial Cancer
Guangzhou 8th People's Hospital
Wuhan Union Hospital, China; LiuZhou People's Hospital; Tianjin Second People... and other collaborators

Recruiting

Simplified Treatment of Anti-retrovirus in China (C-STAR)

HIV/AIDS

China
National Heart, Lung, and Blood Institute (NHLBI)
Loyola University Medical Center (LUMC)

Recruiting

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Kidney Cancer

United States
National Cancer Institute (NCI)

Recruiting

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

Kaposi's Sarcoma | Human Immunodeficiency Virus | Castleman's Disease | Viral-Associated Cancer

United States
Institut Pasteur

Recruiting

Simian Foamy Virus Transmission to Humans

Simian Foamy Virus Infection (Disorder)

Cameroon
National Institute of Allergy and Infectious Diseases...

Recruiting

Tissue Biopsy and Imaging Studies in HIV-Infected Patients

HIV | Healthy Volunteers | ICL

United States
National Cancer Institute (NCI)

Enrolling by invitation

Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell Studies

Multiple Myeloma | Hematologic Malignancies | Leukemia, B-cell | Lyphoma, B-Cell

United States
National Cancer Institute (NCI)

Enrolling by invitation

Follow-Up Evaluation for Gene-Therapy-Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials

Solid Tumors | Hematologic Malignancies | Pediatric Cancers

United States
National Cancer Institute (NCI)

Enrolling by invitation

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Cervical Intraepithelial Neoplasia | Oropharyngeal Neoplasms | Squamous Intraepithelial Lesions of the Cervix | Cervical Neoplasms | Hematologic Malignacies

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infection in Liberia (HONOR)

HIV

Liberia
GeNeuro SA

Completed

Temelimab as a Disease Modifying Therapy in Patients With Neuropsychiatric Symptoms in Post-COVID 19 or PASC Syndrome

Post-COVID-19 Syndrome

Switzerland, Italy, Spain
Aveni Foundation

Available

BLESSED: Expanded Access for DeltaRex-G for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast

Sarcoma | Soft Tissue Sarcoma | Pancreatic Cancer | Osteosarcoma | Chondrosarcoma | Chordoma | Carcinoma of Breast | MPNST (Malignant Peripheral Nerve Sheath Tumor)

United States
National Institute of Allergy and Infectious Diseases...

Active, not recruiting

PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia

HIV | Tuberculosis

Liberia, United States
Fondazione Telethon

Enrolling by invitation

Strimvelis Registry Study to Follow-up Patients With Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID)

Immunologic Deficiency Syndromes

Italy
Fondazione Telethon

Active, not recruiting

Methodology Study of Retroviral Insertion Site Analysis in Strimvelis Gene Therapy

Severe Combined Immunodeficiency Due to ADA Deficiency

Italy
Fondazione Telethon

Completed

ADA Gene Transfer Into Hematopoietic Stem/Progenitor Cells for the Treatment of ADA-SCID (Gene-ADA)

Immunologic Deficiency Syndromes

Italy, Israel
Jonsson Comprehensive Cancer Center

Active, not recruiting

Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies

Malignant Neoplasm

United States
David Williams

Active, not recruiting

Pilot and Feasibility Study of Hematopoietic Stem Cell Gene Transfer for the Wiskott-Aldrich Syndrome

Wiskott-Aldrich Syndrome

United States
Aveni Foundation

Withdrawn

CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 (CORONA)

COVID-19 | Acute Respiratory Distress Syndrome | Cytokine Storm
Baylor College of Medicine
St. Jude Children's Research Hospital; The Methodist Hospital Research Institute and other collaborators

Completed

Allogeneic Neuroblastoma Cells for Relapsed/ Refractory Neuroblastoma, CYCHEALL (CYCHEALL)

Neuroblastoma

United States
Stanton Gerson MD
National Cancer Institute (NCI)

Completed

BG & TMZ Therapy of Glioblastoma Multiforme

Glioblastoma Multiforme

United States
Hospices Civils de Lyon

Withdrawn

Endogenous Retroviruses in Acute Myeloid Leukemia (ERVAL)

Leukemia, Myeloid
GeNeuro Innovation SAS

Terminated

A Long-term Extension of Study GNC-401

Multiple Sclerosis

Sweden
GeNeuro Innovation SAS

Completed

Clinical Trial Assessing Temelimab Following Rituximab Treatment in Patients With Relapsing Forms of Multiple Sclerosis (ProTEct-MS)

Multiple Sclerosis

Sweden
National Institute of Allergy and Infectious Diseases...
AIDS Clinical Trials Group; Acute Infection and Early Disease Research Program

Completed

Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection

HIV Infections

United States, American Samoa, Australia
Institut National de la Santé Et de la Recherche...

Active, not recruiting

Ex Vivo Gene Therapy Clinical Trial for RDEB Using Genetically Corrected Autologous Skin Equivalent Grafts (EBGraft)

Epidermolysis Bullosa Dystrophica, Recessive

France
National Cancer Institute (NCI)

Terminated

Immunotherapy With E7 T Cell Receptor T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions

Neoplasms, Squamous Cell | Squamous Lntraepithelial Lesions of Vulva | Vulvar HSIL

United States
GeNeuro Innovation SAS

Completed

Safety Study of GNbAC1 in Multiple Sclerosis Patients

Multiple Sclerosis

Switzerland
GeNeuro Innovation SAS

Completed

Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis Disease (LOMBARD)

Multiple Sclerosis (MS) | Clinically Isolated Syndrome (CIS) | Secondary Progressive MS | Primary Progressive MS | Relapsing-Remitting MS

France, Spain, Switzerland
GeNeuro Innovation SAS

Completed

Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Normal Population (CONTROL)

Multiple Sclerosis

France
GeNeuro SA
Worldwide Clinical Trials; Institut de Recherches Internationales Servier; Les...

Terminated

Assessing the HERV-W Env ANtagonist GNbAC1 for Evaluation in an Open Label Long-term Safety Study in Patients With Multiple Sclerosis (ANGEL-MS)

Multiple Sclerosis, Relapsing-Remitting

Estonia, Bulgaria, Croatia, Czechia, Germany, Hungary, Italy, Poland, Russian Federation, Serbia, Spain, Ukraine
GeNeuro Innovation SAS

Completed

First-in-Human Study With GNbAC1 in Healthy Volunteers

Multiple Sclerosis
GeNeuro Innovation SAS

Completed

Safety Study of GNbAC1 Monoclonal Antibody in Healthy Male Volunteers

Healthy Volunteers

Germany
GeNeuro SA
Worldwide Clinical Trials; Institut de Recherches Internationales Servier; Les...

Completed

Clinical Trial Assessing the HERV-W Env Antagonist GNbAC1 for Efficacy in MS (CHANGE-MS)

Multiple Sclerosis, Relapsing-Remitting

Poland, Ukraine, Germany, Spain, Bulgaria, Serbia, Russian Federation, Hungary, Italy, Croatia, Czechia, Estonia
GeNeuro Australia PTY Ltd
Southern Star Research Pty Ltd.

Completed

Clinical Trial Assessing the GNbAC1 in Patients With Onset of Type 1 Diabetes Within 4 Years (RAINBOW-T1D)

Diabetes Mellitus Type 1

Australia
Tocagen Inc.

Withdrawn

A Study of the Safety of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Newly Diagnosed High Grade Glioma Receiving Standard of Care (Toca7)

Newly Diagnosed High Grade Glioma (HGG)
NRG Oncology
National Cancer Institute (NCI)

Withdrawn

Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma

Glioblastoma | Anaplastic Astrocytoma | Oligodendroglioma | Supratentorial Glioblastoma
Tocagen Inc.

Terminated

A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca 6)

Melanoma | Sarcoma | Lymphoma | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Bladder Cancer | Triple Negative Breast Cancer | IDH1 Mutated Solid Tumors | IDH1 Mutated or MGMT Methylated Recurrent HGG (Not Recruiting)

United States
National Human Genome Research Institute (NHGRI)

Completed

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency

Severe Combined Immunodeficiency Syndrome

United States
University of Pennsylvania

Completed

Redirected MazF-CD4 Autologous T Cells for HIV Gene Therapy (MazF)

HIV

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple Myeloma

Multiple Myeloma and Plasma Cell Neoplasm

United States
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies

Unspecified Adult Solid Tumor, Protocol Specific

United States
Memorial Sloan Kettering Cancer Center

Completed

Consolidation Therapy With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 in Patients With Chronic Lymphocytic Leukemia Following Upfront Chemotherapy With Pentostatin, Cyclophosphamide and Rituximab

Leukemia

United States
Universidad Autonoma de San Luis Potosí
Hospital Central "Dr. Ignacio Morones Prieto"

Completed

VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP

Eye Diseases | Premature Birth | Retinal Disease | Retinopathy of Prematurity Both Eyes

Mexico
GlaxoSmithKline

Completed

Study to Assess the Efficacy, Immunogenicity and Safety of Liquid Human Rotavirus Vaccine, in Healthy Chinese Infants

Infections, Rotavirus

China
University College, London
Deutsche Krebshilfe e.V., Bonn (Germany); European Union; The Leukemia and Lymphoma... and other collaborators

Terminated

CD19-CAR Immunotherapy for Childhood Acute Lymphoblastic Leukemia (ALL) (CD19TPALL)

Acute Lymphoblastic Leukemia

United Kingdom, Germany
Masonic Cancer Center, University of Minnesota
National Cancer Institute (NCI)

Withdrawn

Peripheral Stem Cell Transplantation With Specially Treated Stem Cells in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease

Lymphoma
National Institute of Allergy and Infectious Diseases...

Completed

Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-up

Chronic Granulomatous Disease | Communicable Disease

United States

Search clinical trials for: Replication-Competent Retrovirus

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