Search clinical trials for: SIRT

Total 169 results

Necmettin Erbakan University

Not yet recruiting

Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs

Periodontitis, Adult
IRCCS SYNLAB SDN
Federico II University

Recruiting

Potential Role of Sirtuins as Epigenetic Biomarkers of the Patient With Atherosclerosis or Calcific Aortic Stenosis

Atherosclerosis and Calcific Aortic Stenosis With and Without Diabetes

Italy
Oslo University Hospital

Recruiting

HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) (TOMCAT)

Intrahepatic Cholangiocarcinoma | Chemotherapy Effect

Norway
argenx

Recruiting

A Study of Efgartigimod PH20 SC Given by Prefilled Syringe in Adults With Thyroid Eye Disease.

Thyroid Eye Disease

United States
Sirtsei Pharmaceuticals, Inc.
Rho, Inc.

Recruiting

A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder

Major Depressive Disorder

United States
UMC Utrecht

Recruiting

Deuterium Metabolic MRI and [18F]FDG PET for Assessment of Treatment Response Following Radioembolization (DEPLETE)

Fluorodeoxyglucose F18 | Phosphoric Monoester Hydrolases | Phosphoric Diester Hydrolases

Netherlands
The Netherlands Cancer Institute
Universitaire Ziekenhuizen KU Leuven

Recruiting

Radioembolisation and Chemotherapy in Liver Metastatic Breast Cancer Patients (HoLiBreast)

Breast Cancer | Liver Metastases

Netherlands, Belgium
The Christie NHS Foundation Trust

Recruiting

Introduction of Y90-PET-CT Post Radioembolisation Therapy Scans (Y90-PET-CT)

Cancer

United Kingdom
GrandPharma (China) Co., Ltd.

Not yet recruiting

Observational Study for SIR-Spheres Therapy for the Treatment of Unresectable Metastatic Liver Tumors From Primary Colorectal Cancer

Colorectal Neoplasms

China
Sohag University

Recruiting

SIRT1(rs7069102 ) Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients

Genotyping of SIRT1in Chronic Obstructive Pulmonary Disease

Egypt
Global Alliance for TB Drug Development

Recruiting

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis

Drug Sensitive Tuberculosis | Pulmonary Tuberculosis | Pulmonary TB

Philippines, South Africa, Tanzania, Georgia, Uganda
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

SIRT for Potentially Resectable HCC

Hepatocellular Carcinoma

China
Second Affiliated Hospital of Guangzhou Medical...

Recruiting

Lenvatinib, Sintilimab Plus SIRT for Unresectable HCC

Hepatocellular Carcinoma

China
Sirtex Medical

Recruiting

Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry) (SIRtain)

Unresectable Hepatocellular Carcinoma (HCC) | Liver Metastases From Colorectal Cancer (mCRC)

Spain, United Kingdom, France
Zhongda Hospital

Recruiting

Yttrium-90 Carbon Microspheres in Patients With Unresectable Hepatocellular Carcinoma

Unresectable Hepatocellular Carcinoma

China
Michael Hoelscher
Radboud University Medical Center; University College, London; University of...

Recruiting

BTZ-043 Dose Evaluation in Combination and Selection (DECISION)

Tuberculosis, Pulmonary | Other Specified Pulmonary Tuberculosis

South Africa, Tanzania
InCor Heart Institute

Recruiting

Serum Concentration of Endogenous Estrogens and Sirtuin-1 After Administration of Atorvastatin and Quercetin:

Coronary Artery Disease | Menopause

Brazil
University Medical Center Goettingen
Ludwig-Maximilians - University of Munich; University of Leipzig; University... and other collaborators

Recruiting

PROTon Pump Inhibitors and Stent OCclusion Rate Of Lumen Apposing Metal Stents (PROTOCOL)

Acute Pancreatitis

Germany, Austria
InCor Heart Institute

Recruiting

The Effects of Resveratrol on Sirtuins and Apoptosis Biomarkers (RE-AGES)

Coronary Artery Disease | Menopause | Endothelial Dysfunction

Brazil
Centers for Disease Control and Prevention
Tuberculosis Trials Consortium

Recruiting

Short-course Regimens for the Treatment of Pulmonary Tuberculosis (CRUSH-TB)

Tuberculosis, Pulmonary | Tuberculosis Infection

Canada, United States, Haiti, South Africa, Uganda, Vietnam
Manchester Metropolitan University
European Society for Clinical Nutrition and Metabolism

Recruiting

Role of Fasted Exercise on Improving Cardiometabolic Health

Cardiovascular Diseases | Obesity | Diabetes Mellitus, Type 2

United Kingdom
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

Clinical Investigation Evaluating Safety and Efficacy of Selective Intra-arterial 166Holmium Radiation Therapy in Combination With Atezolizumab and Bevacizumab for Non Resectable Hepatocellular Carcinoma (HOLMBRAVE)

Hepatocellular Carcinoma

France
Jiping Wang, MD, PhD
AstraZeneca; Sirtex Medical

Recruiting

SIRT With Tremelimumab and Durvalumab for Resectable HCC

Hepatocellular Carcinoma | Hepatocellular Cancer | Resectable Hepatocellular Carcinoma

United States
Zhongda Hospital

Recruiting

Yttrium-90 Carbon Microspheres in Patients With Unresectable Colorectal Liver Metastases (NRT-uCRLM)

Unresectable Colorectal Liver Metastases

China
Beth Israel Deaconess Medical Center
Dana-Farber Cancer Institute; AstraZeneca; Sirtex Medical

Recruiting

Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio

Cholangiocarcinoma | Bile Duct Cancer | Cholangiocarcinoma Non-resectable | Cholangiocarcinoma Metastatic | Metastatic Intrahepatic Cholangiocarcinoma

United States
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Efficacy, Safety, and Pharmacokinetics of XEMBIFY® Plus Standard Medical Treatment (SMT) Compared to Placebo Plus SMT to Prevent Infections in Participants With Hypogammaglobulinemia and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia

Bacterial Infections | B-cell Chronic Lymphocytic Leukemia | Hypogammaglobulinemia

United States, Bulgaria, Poland, Romania, Serbia
Terumo Europe N.V.

Recruiting

Holmium-166 Transarterial Radioembolization in Unresectable, Early Stage Hepatocellular Carcinoma. (HOMIE-166)

Hepatocellular Carcinoma

Germany
National Cancer Centre, Singapore
Hoffmann-La Roche; Sirtex Medical; Singapore Clinical Research Institute

Recruiting

Multinational Phase II Trial to Compare Safety and Efficacy of SIRT (Y-90 Resin Microspheres) Followed by Atezolizumab Plus Bevacizumab, vs SIRT (SIRT-Y90) Followed by Placebo in Locally Advanced HCC Patients (STRATUM)

Locally Advanced Hepatocellular Carcinoma

Korea, Republic of, Singapore
Beijing Chest Hospital

Recruiting

A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in China (PROSPECT)

Tuberculosis, Multidrug-Resistant

China
M.D. Anderson Cancer Center
Sirtex Medical

Recruiting

Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases

Metastases

United States
Sohag University

Recruiting

SIRT1 Gene Polymorphism With Premature Myocardial Infarction in Young Egyptian Patients (SIRT1)

Premature Myocardial Infarction in Young Egyptian Patients

Egypt
Brigham and Women's Hospital

Recruiting

Sirtuin-NAD Activator in Alzheimer's Disease

Dementia | Alzheimer's Disease (Incl Subtypes)

United States
Medical University of Lodz

Recruiting

Effect of Glucocorticoids on Inflammation and Bone Metabolism in Patients With Glomerular Disease

Glomerular Disease

Poland
Assiut University

Not yet recruiting

Sirtuin1 in COVID19 Patients

Covid19
Methodist Health System

Recruiting

Evaluating the Effects of Selective Treatment Utilizing Flex-dosing for Unresectable HCC With Y90 SIR-Spheres

Hepatocellular Carcinoma

United States
Universität des Saarlandes

Recruiting

Prospective REgistry of Targeted RadionucLide TherapY in Patients With mCRPC (REALITY Study)

Prostate Cancer Metastatic | Advanced Prostate Carcinoma | Castration Resistant Prostatic Cancer

Germany
Sirtex Medical
Bright Research Partners

Recruiting

Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients (DOORwaY90)

Unresectable Hepatocellular Carcinoma | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | BCLC Stage A Hepatocellular Carcinoma

United States
Federation Francophone de Cancerologie Digestive

Recruiting

Study to Evaluate Efficacy and Safety of Selective Internal Radiation Therapy Plus Xelox, Bevacizumab and Atezolizumab (Immune Chekpoint Inhibitor) in Patients With Liver-dominant Metastatic Colorectal Cancer (SIRTCI)

Metastatic Colorectal Cancer | MSS | pMMR | Immune Checkpoint Inhibitor | Internal Radiotherapy

France
Institut für Klinische Krebsforschung IKF GmbH...
Hannover Medical School; AstraZeneca

Recruiting

Durvalumab and Tremelimumab in Combination With Either Y-90 SIRT or DEB-TACE for Intermediate Stage HCC

HCC | Hepatocellular Carcinoma Non-resectable

Germany
University of Michigan Rogel Cancer Center
Department of Health and Human Services; National Institute for Biomedical...

Recruiting

Combined Y-90 Selective Internal Radiation Therapy (Y-90 SIRT) and Stereotactic Body Radiation Therapy (SBRT) in Hepatic Malignancy.

Liver Malignancy

United States
Aarhus University Hospital

Recruiting

Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases (SIRT)

Liver Metastasis Colon Cancer

Denmark
Augusta University

Recruiting

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1 (T-St1M)

Type 1 Diabetes

United States
Neurovalens Ltd.
Compliance Solutions Ltd.; RD Gardi Medical College

Not yet recruiting

Electrical Vestibular Stimulation (VeNS): Assessment of AMPK & SIRT1 Following Repeated Usage

Overweight and Obesity

India
Imperial College London
Biocompatibles UK Ltd, a BT International group company

Recruiting

TheraSphere Selective Internal Radiation Therapy (SIRT) as Treatment for Neuroendocrine Tumours With Liver Mets (ArTisaN)

Neuroendocrine Tumors | Liver Metastases

United Kingdom
Assiut University

Not yet recruiting

Sirtuin 3 and Sirtuin 7 in Systemic Sclerosis

Systemic Sclerosis
Institut für Klinische Krebsforschung IKF GmbH...
AstraZeneca

Recruiting

Immunotherapy Combined With Y-90 SIRT Therapy in Advanced Stage Intrahepatic Biliary Tract Cancer (BTC)

Intrahepatic Cholangiocarcinoma

Germany
Sherief Abd-Elsalam

Recruiting

Impact of P53 and SIRT1 in Type 2 Diabetes

DM

Egypt
Universitätsklinikum Köln
Sirtex Technology Pty LTD, Australia

Recruiting

European SIR-Spheres Surgical Registry (ESSURE)

Hepatectomy

Germany
Second Affiliated Hospital, School of Medicine,...

Recruiting

TILA-TACE in Treatment of Hepatocellular Carcinoma

Overall Survival | Tumor Response Rate

China
Boston University
Harvard Medical School (HMS and HSDM); University of Colorado, Denver; National... and other collaborators

Recruiting

Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

Tuberculosis, Multidrug-Resistant

Philippines, Vietnam

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