Search clinical trials for: Severe congenital Alpha1-Proteinase Inhibitor (Alpha1-PI) deficiency

Total 91021 results

Baxalta now part of Shire
Baxter Healthcare, Ltd. (New Zealand), Baxter Healthcare Pty. Ltd. (Australia)

Completed

Pharmacokinetic Study of ARALAST (Human Alpha1- PI)

Alpha 1-Antitrypsin Deficiency

Australia, New Zealand
Grifols Therapeutics LLC

Terminated

Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

United States
Shire

Withdrawn

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency
Takeda

Withdrawn

A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema

Chronic Obstructive Pulmonary Disease (COPD) | Alpha1-Antitrypsin Deficiency
Grifols Therapeutics LLC

Completed

A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency

Alpha₁-Antitrypsin Deficiency

United States
Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Chronic Pancreatitis

United States
Grifols Therapeutics LLC

Completed

Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis

Cystic Fibrosis

United States
Spero Therapeutics
Covance

Completed

Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male Subjects

Healthy Volunteers

United States
University Tunis El Manar

Unknown

Uterine Artery Pulsatility Index and Materno Fetal Outcomes (UADLAB)

Labor Complication

Tunisia
University of Alabama at Birmingham
National Institutes of Health (NIH); Mereo BioPharma

Completed

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

Emphysema or COPD | Alpha-1 Antitrypsin Deficiency (AATD) | Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Alpha1-antitrypsin Deficiency Registry

Lung Diseases | Chronic Obstructive Pulmonary Disease | Emphysema | Alpha-1 Antitrypsin Deficiency
Peking University Third Hospital

Completed

Relationship Between Spinopelvic Parameters and Clinical Symptoms of Low-grade Lumbar Isthmic Spondylolisthesis

Isthmic Spondylolisthesis

China
Spero Therapeutics
Clinartis

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Healthy Volunteers

United States
Spero Therapeutics

Completed

Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects

Healthy Volunteers

United States
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)

Alpha1-Antitrypsin Deficiency

Japan
Grifols Therapeutics LLC

Enrolling by invitation

Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency (SPARTA-OLE)

Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency

United States, New Zealand, Denmark, Australia, Finland, Estonia, Canada, Poland, Russian Federation, Sweden, France
Spero Therapeutics

Completed

Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal Function

Renal Impairment

United States
Vedic Lifesciences Pvt. Ltd.

Completed

Pilot Study to Evaluate Efficacy of Botanical Extracts as Protein Amplifier for Skeletal Muscle Strength & Growth.

Muscle Strength

India
Baxalta now part of Shire

Terminated

Aralast alpha1-proteinase Inhibitor Surveillance Study

Alpha1-antitrypsin Deficiency

United States
Cellxpert Biotechnology Corp.
Medigen Biotechnology Corporation

Completed

Study of PI-88 in Patients With Advanced Melanoma

Melanoma

United States
Cellxpert Biotechnology Corp.
Medigen Biotechnology Corporation

Completed

PI-88 in Hepatocellular Carcinoma After Hepatectomy

Carcinoma, Hepatocellular

Taiwan
Minia University

Recruiting

AS-OCT Evaluation of Iridocorneal Angle of Patients of Angle Closure Glaucoma After Phacoemulsification

Glaucoma, Angle-Closure

Egypt
Jae Seung Kim

Completed

Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease

Alzheimer Disease | Mild Cognitive Impairment | Cognitively Normal

Korea, Republic of
Peptimmune

Completed

Safety Study of PI-0824 to Treat Pemphigus Vulgaris

Pemphigus Vulgaris

United States
RWTH Aachen University

Unknown

Liver Disease in Patients With alpha1-antitrypsin Deficiency

alpha1-antitrypsin Deficiency

Germany
Grifols Therapeutics LLC

Terminated

Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) in Hospitalized Participants With Coronavirus Disease (COVID-19)

COVID-19

United States, Brazil, Chile, Colombia, Mexico
Assiut University

Recruiting

Perfusion Index in Assessment of Postoperative Pain in Children.

Postoperative Pain

Egypt
Spero Therapeutics

Completed

A Study to Compare Two Bioanalytical Assays for Tebipenem

Healthy Volunteers

United States
Life Molecular Imaging Ltd

Recruiting

[18F]PI-2620 Phase 3 Histopathological Study

Alzheimer Disease

United States
Life Molecular Imaging SA
Walter Reed National Military Medical Center

Active, not recruiting

Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury

Mild Traumatic Brain Injury

United States
Oslo University Hospital

Completed

A Multi-disciplinary Pain Intervention (MUD-PI) for Patients With Chronic Widespread Primary Pain (MUD-PI)

Chronic Pain, Widespread
Bright Cell, Inc.

Not yet recruiting

Safety and Efficacy of YB-1113 in Treatment of POI

POI
Amgen

Completed

FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy

Neutropenia
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

Japan
Hospital Universitari Vall d'Hebron Research Institute
Bayer; Sociedad Española de Neumología y Cirugía Torácica; Instituto de Salud...

Completed

Inhaled A1AT in Adult Stable Bronchiectasis

Bronchiectasis Adult
Peter MacCallum Cancer Centre, Australia

Terminated

Phase 0 of 18F FPM Using PET/CT in Patients With a Variety of Malignancies

Squamous Cell Carcinoma

Australia
Asan Medical Center
Korea Health Industry Development Institute

Completed

Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain

Parkinson Disease | Alzheimer Disease | Healthy Volunteer | Frontotemporal Dementia

Korea, Republic of
Grifols Therapeutics LLC

Completed

Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency (SPARK)

Emphysema | Alpha 1-antitrypsin Deficiency (AATD)

United States
Université de Sherbrooke

Terminated

Alpha1 Antitrypsin Aerosol Therapy in Cystic Fibrosis

Cystic Fibrosis

Canada
Macquarie University, Australia
Life Molecular Imaging GmbH; Omniscient Neurotechnology

Active, not recruiting

Tau And Connectomics In TES Study (TACIT)

Neurodegenerative Diseases | Cognitive Impairment | Head Injury Trauma | Chronic Traumatic Encephalopathy | Traumatic Encephalopathy

Australia
Cubist Pharmaceuticals LLC

Completed

A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy

Postoperative Ileus

United States
Techfields Inc

Terminated

Evaluate the Efficacy and Safety of TF0023 in Treatments for COVID-19 in Hospitalized Adults

COVID-19 Pneumonia

United States, South Africa
Johannes Gutenberg University Mainz

Completed

Perfusion Index (PI) and Pleth Variability Index (PVI) in Patients With Interscalene Blocks in Orthopedic Surgery (PI-PVI)

Orthopedic Surgery | Perfusion Index and Pleth Variability Index | Interscalene Blocks

Germany
Grifols Therapeutics LLC

Completed

Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)

Alpha 1-Antitrypsin Deficiency

Denmark, Sweden, United Kingdom
Galenic Research Institute Ltd

Completed

Local mEHT + TCM Versus Intraperitoneal Chemoinfusion in Treatment of Malignant Ascites: Phase II RCT (OTMA-RII)

Peritoneal Neoplasms | Ascites | Yin Deficiency | Yang Deficiency

China
Chonbuk National University Hospital

Completed

Efficacy and Safety of Nokyong Mixture Extract(CME-PI) on Promotion of Immunity

Immunity

Korea, Republic of
CSL Behring

Completed

Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency

Emphysema | Alpha1-proteinase Inhibitor Deficiency

Australia, Russian Federation, United States, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden, Canada, Czech Republic
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children

HIV Infections

United States, Puerto Rico
Genentech, Inc.

Completed

Evaluation Comparing Tau PET Radiotracers, [18F]GTP1 and [18F]PI-2620 or [18F]MK-6240 in Subjects With Normal Cognition or Prodromal to Moderate Alzheimer's Disease

Alzheimer Disease (AD)

United States
University of Pennsylvania
Yale University

Recruiting

Tau PET Imaging in Opioid Use Disorder

Opioid-Related Disorders

United States

Search clinical trials for: Severe congenital Alpha1-Proteinase Inhibitor (Alpha1-PI) deficiency

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