Search clinical trials for: Somatic driver alterations

Total 939 results

Oscar Gerardo Arrieta Rodríguez

Recruiting

Pathogenic Variants in Genes Associated With Lung Adenocarcinoma

Lung Adenocarcinoma

Mexico
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Toripalimab Therapy After Resection in High-risk Stage IA2-IB NSCLC With no Driver Alterations (EGFR or ALK)

NSCLC
Hospices Civils de Lyon

Not yet recruiting

Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa (DEMO)

Carcinoma, Squamous Cell

France
Seagen Inc.

Active, not recruiting

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Urologic Neoplasms | Uterine Cervical Neoplasms | Uterine Neoplasms | Carcinoma, Non-Small-Cell Lung | Biliary Tract Neoplasms | HER2 Mutations Breast Neoplasms

United States, United Kingdom, Spain, Korea, Republic of, Italy, Belgium, Germany, Japan, Netherlands, Poland
Yale University

Completed

Active Surveillance of the Small Renal Mass

Small Renal Mass, Kidney Cancer

United States
Central Hospital, Nancy, France

Completed

Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center

Adenocarcinoma of Lung Stage IV | Adenocarcinoma of Lung, Response to Tyrosine Kinase Inhibitor in, Somatic

France
University Hospital, Rouen

Completed

Simultaneaous Detection of Quantitative Somatic Alterations Using the Qantitative Multiplex Pcr of Short Fluorescent Fragments Method (QMPSF) in Stage II-III Colon Cancer: a Prospective Study (Code Barre)

Colorectal Cancer | Stage II and III

France
Hospital Universitari Vall d'Hebron Research Institute
Universitat Pompeu Fabra; IDIAPJgol

Recruiting

Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden. (StopALD)

Alcohol Use Disorder | Alcohol-related Liver Disease | Metabolic and Alcohol Related/Associated Liver Disease | Metabolic Disfunction Associated Steatotic Liver Disease

Spain
Changzhou No.2 People's Hospital

Not yet recruiting

FMT+Immunotherapy+Chemotherapy as First-line Treatment for Driver-gene Negative Advanced NSCLC

Non-small Cell Lung Cancer
Qian Qin
Janssen, LP; UT Southwestern Comprehensive Cancer Center

Not yet recruiting

Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations (HARMONY)

BRCA1 Gene Mutation | BRCA2 Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | CHEK2 Gene Mutation | FANCA Gene Mutation | RAD51B Gene Mutation | RAD54L Gene Mutation | Metastatic Hormone-sensitive Prostate Cancer (mHSPC) | Deleterious HRR Gene Mutation
3H (Suzhou) Pharmaceuticals Co., Ltd.

Not yet recruiting

A Study of 3HP-2827 in Treatment of Unresectable or Metastatic Solid Tumors With FGFR2 Alterations

Solid Tumors With FGFR2 Alterations, Adult

China
Bartosz M. Radtke

Recruiting

Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective

Aphasia | Neuropathology | Development, Human

Poland
Ruijin Hospital

Not yet recruiting

CAR-T Following ASCT for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (R/R B-NHL) With High-Risk Prognostic Factors

B-NHL, Extranodal, TP53 Alterations, Bulky Mass
Case Comprehensive Cancer Center
National Institutes of Health (NIH); National Institute of Environmental Health...

Not yet recruiting

Linking Somatic Mutation Rate With Baseline Exposure in East Palestine

Somatic Mutation
The First Affiliated Hospital, Guangzhou University...

Not yet recruiting

A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With Advanced NSCLC With Driver-negative After Progression to Immunotherapy

Advanced NSCLC
AstraZeneca
Daiichi Sankyo

Not yet recruiting

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)

Non-Small Cell Lung Cancer

Italy, Spain, Poland, Canada, Korea, Republic of, Hungary, Turkey, Taiwan, United Kingdom, Japan, Austria, Australia, Germany, Brazil
Jolanda Luime
University of Oxford - Nuffield Department of Orthopaedics, Rheumatology... and other collaborators

Not yet recruiting

PsA Digital Phenotyping and Inflammation Drivers Study (PDPID)

Psoriatic Arthritis | Flare Up, Symptom | Psoriatic Arthritis Aggravated
University of California, Berkeley
University of California, San Francisco; Liverpool School of Tropical Medicine and other collaborators

Recruiting

Pharmacy-based PrEP for Young Women Who Sell Sex in Zimbabwe (TOPAZ)

HIV Prevention | Adherence, Medication

Zimbabwe
Virginia Polytechnic Institute and State University

Not yet recruiting

Investigation of Low-intensity Focused Ultrasound Pressure

Somatic Pain

United States
University Hospital Tuebingen

Recruiting

Interdisciplinary E-health Based Follow-up of Preterm Born Children (NeoUp)

Preterm Birth

Germany
Fondazione del Piemonte per l'Oncologia

Recruiting

INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations (INSIDE)

Prostate Cancer

Italy
Baylor College of Medicine
University of Washington; Fogarty International Center of the National Institute... and other collaborators

Not yet recruiting

Microbiome Alterations With Xylitol (MAX) in Pregnancy (MAX)

Dysbiosis | Inflammation Gum

Malawi
Karolinska Institutet
Karolinska Universitetssjukhuset

Not yet recruiting

Condensed Digital Prolonged Exposure for Individuals Treated Within Somatic Trauma Care. (CiPE)

Post Traumatic Stress Disorder | Acute Stress Disorder

Sweden
Peking University First Hospital

Recruiting

Fruquintinib Plus Everolimus as 2nd Line Therapy of ccRCC Patients Progressed Post IO and TKI Therapy

Renal Cell Carcinoma, Clear Cell, Somatic

China
Guangzhou Institute of Respiratory Disease

Recruiting

Oral Chemotherapeutic Drugs Were Analyzed in Patients With Driver Gene Negative Locally Advanced/Advanced Non-small Cell Lung Cancer With PS Score 2 A Prospective, Single-arm, Multicenter, Observational Study on the Efficacy and Safety of Radiochemotherapy Combined With PD-1 Inhibitor

Non-small Cell Lung Cancer Stage IIIB/IV

China
Medical College of Wisconsin

Not yet recruiting

Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

Non Small Cell Lung Cancer

United States
Daniel Maroti
Wayne State University

Recruiting

Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist Support

Somatic Symptom Disorder | Functional Somatic Disorder | Functional Somatic Syndromes

Sweden
Liaoning Tumor Hospital & Institute

Not yet recruiting

Adebrelimab Plus Chemotherapy as Neoadjuvant Therapy in Resectable NSCLC Harboring Driver Gene Mutations

Non Small Cell Lung Cancer
Sakarya Applied Sciences University

Not yet recruiting

Effects of Telerehabilitation-Based Interventions on the Musculoskeletal System in Drivers

Musculoskeletal Diseases | Postural; Defect | Drive

Turkey
Seoul National University Hospital

Recruiting

Driving Ability Evaluation System to Improve the Conditional Driving License System: Feasibility Study of High-risk Drivers.

Automobile Driving

Korea, Republic of
3H (Suzhou) Pharmaceuticals Co., Ltd.

Not yet recruiting

A First-in-human Study of 3HP-2827 in Patients With Unresectable or Metastatic Solid Tumors With FGFR2 Alterations

Solid Tumors With FGFR2 Alterations, Adult

United States
Seoul National University Hospital

Recruiting

Driving Ability Evaluation System to Improve the Conditional Driving License System: Safety and Feasibility Study.

Automobile Driving

Korea, Republic of
Tashkent Pediatric Medical Institute

Recruiting

Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children

Congenital Heart Defects | Respiratory Diseases

Uzbekistan
The Touro College and University System

Not yet recruiting

Unilateral vs Bilateral Application of Muscle Energy Techniques in Pelvic Somatic Dysfunction (PMEOMT)

Pelvic Somatic Dysfunction
Yale University
University of Pennsylvania

Recruiting

Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System

Opioid Use Disorder

United States
University Hospital, Essen

Not yet recruiting

Optimization of Radiation Protection Through Genomic Analyses (ORtogether)

Cancer | Radiation | DNA

Germany
AstraZeneca

Recruiting

Treatment and Biomarker Testing Patterns,Treatment Outcomes in a/m NSCLC With and Without Actionable Genomic Alterations

Non-small-cell Lung Cancer

Russian Federation
VA Office of Research and Development

Not yet recruiting

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty (T2CR)

Cardiovascular Diseases | Cardiac Rehabilitation | Transition of Care

United States
Mayo Clinic

Recruiting

Relationship Between Alterations in the GI Microbiome and GI Inflammation on Symptom Burden in Women With Breast Cancer Receiving Chemotherapy

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Longitudinal Assessment of Genomic Alterations and Clonal Evolution in ALK-positive NSCLC (Galileo Project) (GALILEO)

NSCLC Stage IV | ALK Gene Mutation | ALK Sensitizing Mutation

Italy
Aarhus University Hospital
University of Aarhus; Central Denmark Region; Vejle Hospital; TrygFonden, Denmark; Aalborg University Hospital and other collaborators

Recruiting

Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder (EDULOX)

Functional Disorder

Denmark
Xijing Hospital of Digestive Diseases

Recruiting

Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation

Brain Connectivity | Constipation - Functional | fMRI | Treatment Efficacy | Fluoxetine | Somatic Symptom | Refractory Constipation | Mental Symptom

China
University of Michigan
National Institute on Aging (NIA)

Recruiting

Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm (RES)

Parkinsonian Signs in Older Persons

United States
Çanakkale Onsekiz Mart University

Not yet recruiting

Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity

Dentin Sensitivity
National University Hospital, Singapore
National University of Singapore

Not yet recruiting

Redirecting Immune, Lipid and Metabolic Drivers of Early Cardiovascular Disease: The RESET Cohort Study (RESET)

Cardiovascular Diseases | Metabolic Syndrome | Non-Alcoholic Fatty Liver Disease
IRCCS San Raffaele
Università Vita-Salute San Raffaele

Recruiting

Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells (SoMuKT)

Carcinoma, Renal Cell | Von Hippel-Lindau Disease

Italy
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

RC48 Combined With EGFR or HER2 TKI for Locally Advanced or Metastatic NSCLC Patients With HER2 Alterations

Non Small Cell Lung Cancer | ERBB2 Mutation-Related Tumors | Disitamab Vedotin | ERBB2 Gene Duplication
Washington University School of Medicine

Not yet recruiting

Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Brain Tumor, Primary

United States
Centro di Riferimento Oncologico - Aviano

Not yet recruiting

Incidence and Characterization of Drivers Oncogenes in the Population With Lung Cancer Afferents to the Cancer Institute in Aviano (IN.ON.D.) (INOND)

Non Small Cell Lung Cancer

Italy
Tyra Biosciences, Inc

Recruiting

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations (SURF201)

Solid Tumor | Intrahepatic Cholangiocarcinoma | Metastatic Cholangiocarcinoma | Locally Advanced Cholangiocarcinoma

United States

Search clinical trials for: Somatic driver alterations

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Azerbaijan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations