Search clinical trials for: TRK inhibitor

Total 68023 results

Toray Industries, Inc

Recruiting

A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

Gastric Cancer | Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

Korea, Republic of, United States, Japan
Nikolaj Frost MD
Roche Pharma AG; Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus...

Recruiting

Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma (ANTELOPE)

Non-Small Cell Lung Cancer Metastatic

Germany
Wan-Guang Zhang
BeiGene; Geneplus-Beijing Co. Ltd.; Simcere Pharmaceutical Co., Ltd; Chinese Cooperative... and other collaborators

Recruiting

Nocardia Rubra Cell Wall Skeleton (N-CWS) Plus HAIC, Lenvatinib and Tislelizumab in Treating Patients With Advanced HCC (CCGLC-007)

Hepatocellular Carcinoma

China
Toray Industries, Inc

Recruiting

A Study of TRK-950 in Patients With Advanced Solid Tumors

Solid Tumor

Japan
AIO-Studien-gGmbH
AstraZeneca

Recruiting

Radiation During Osimertinib Treatment: a Safety and Efficacy Cohort Study (ROSE)

NSCLC | EGFR Positive Non-small Cell Lung Cancer | Oligoprogression

Germany
Toray Industries, Inc

Recruiting

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Melanoma | Renal Cell Carcinoma | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Solid Tumor | Cholangiocarcinoma | Bladder Cancer | Epithelial Ovarian Cancer | Primary Peritoneal Cancer | Palpable Subcutaneous Malignant Lesions

United States, France
VM Oncology, LLC

Recruiting

Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Sarcoma | Cervical Cancer | Breast Cancer | Adenoid Cystic Carcinoma | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Thymic Carcinoma | Lung Cancer | Mesothelioma | Bladder Cancer | Head and Neck Carcinoma | Uterine Cancer | Any Solid Tumors Progressed After a Prior Immunotherapy

United States, Puerto Rico
Hoffmann-La Roche

Active, not recruiting

Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options (STARTRK-NG)

Solid Tumors | CNS Tumors

United States, Spain, Korea, Republic of, Canada, Germany, United Kingdom, China, Italy, Hong Kong, France, Taiwan
Hoffmann-La Roche

Active, not recruiting

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (STARTRK-2)

Melanoma | Renal Cell Carcinoma | Adult Solid Tumor | Breast Cancer | Head and Neck Neoplasms | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Neuroendocrine Tumors | Lymphoma, Large-Cell, Anaplastic | Cholangiocarcinoma | Papillary Thyroid Cancer | Sarcomas | Salivary Gland Cancers and other conditions

United States, China, Korea, Republic of, Australia, Taiwan, France, Spain, United Kingdom, Hong Kong, Belgium, Italy, Germany, Japan, Singapore, Netherlands, Poland
University of Cologne

Completed

EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer Harboring Activating EGFR Mutations (EATON)

Bronchial Neoplasms

Spain, Germany
AIO-Studien-gGmbH

Completed

Feasibility and Safety of Nintedanib in Combination With Nivolumab in Pretreated Patients With Advanced or Metastatic NSCLC of Adenocarcinoma Histology (NintNivo)

Adenocarcinoma of the Lung

Germany
AIO-Studien-gGmbH
Hoffmann-La Roche

Active, not recruiting

Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide (SPACE)

SCLC, Extensive Stage

Germany, Austria
Mirati Therapeutics Inc.

Completed

Phase 1/1b Study of MGCD516 in Patients With Advanced Cancer

Advanced Cancer

Korea, Republic of, United States
AIO-Studien-gGmbH
AstraZeneca

Withdrawn

Randomized Phase II, Open-label Efficacy and Safety Study of Second-line Durvalumab Plus Tremelimumab Versus Platinum-based Chemotherapy Alone in Patients With NSCLC and First-line Checkpoint-inhibitor Therapy (Re-Check)

NSCLC Stage IV

Germany
National Cancer Institute (NCI)

Completed

Methoxyamine Hydrochloride, Pemetrexed Disodium, Cisplatin, and Radiation Therapy in Treating Patients With Stage IIIA-IV Non-small Cell Lung Cancer

Stage IIIA Lung Non-Small Cell Cancer AJCC v7 | Stage IIIB Lung Non-Small Cell Cancer AJCC v7 | Stage IV Lung Non-Small Cell Cancer AJCC v7 | Stage III Lung Non-Small Cell Cancer AJCC v7 | Locally Advanced Lung Non-Squamous Non-Small Cell Carcinoma | Stage III Lung Adenocarcinoma AJCC v7 | Stage... and other conditions

United States
Hoffmann-La Roche

Completed

Study of Oral RXDX-101 in Adult Patients With Locally Advanced or Metastatic Cancer Targeting NTRK1, NTRK2, NTRK3, ROS1, or ALK Molecular Alterations. (STARTRK-1)

Locally Advanced Solid Tumors | Metastatic Solid Tumors

United States, Korea, Republic of
AIO-Studien-gGmbH
Bristol-Myers Squibb

Completed

Fostering Efficacy of Anti - PD-1 - Treatment: Nivolumab Plus Radiotherapy in Advanced NSCLC (FORCE)

Metastatic Lung Cancer | Nonsmall Cell Lung Cancer | Carcinoma，Non-Small-Cell Lung | Lung Adenocarcinoma Metastatic | Large Cell Lung Carcinoma Metastatic

Germany
Bayer

Completed

Study in Healthy Adult Male Participants to Gather Information How the Human Body Absorbs, Distributes and Excretes the Study Drug Selitrectinib Including the Effect of the Interaction of Food With the Study Drug on the Human Body

Solid Tumors Harboring NTRK Fusion

Germany
Ono Pharmaceutical Co. Ltd

Terminated

Study of ONO-7579 in Patients With Advanced Solid Tumors/ NTRK Gene Fusion Positive Advanced Solid Tumors (ONTRK)

Solid Tumor

United States, United Kingdom
Universität Duisburg-Essen

Terminated

Biomarker Study Accompanying the AIO-TRK-0114 Study (MARBLE) (Trans-MARBLE)

Non-small-cell Lung Cancer With Somatic EGFR Mutations
Tesaro, Inc.

Completed

A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas

Solid Tumors | Lymphomas

United Kingdom, United States, Taiwan, Spain, Poland
University Of Perugia
Ester Illiano, MD; Mario Rende,Full Professor; Alessandra Psitilli, Researcher; Anna Stabile, Researcher

Unknown

NGF, TrKA,p75NTR in Men With ED and Diabetes With or Without MS (ED)

Erectile Dysfunction

Italy
National Cancer Institute (NCI)

Completed

Sorafenib and TRC105 in Hepatocellular Cancer

Carcinoma, Hepatocellular | Liver Neoplasms | Hepatoma | Adenoma, Liver Cell | Liver Neoplasms, Experimental

United States
AIO-Studien-gGmbH
AstraZeneca

Terminated

Induction Therapy With Intercalated Tyrosine Kinase Inhibitor (TKI) and Chemotherapy in NSCLC With Activating Epidermal Growth Factor Receptor (EGFR) Mutation in Stages II-IIIB (NeoIntercal)

NSCLC | Non-squamous Non-small Cell Lung Cancer Stage II | Non-squamous Non-small Cell Lung Cancer Stage IIIA | Non-squamous Non-small Cell Lung Cancer Stage IIIB | Activating EGFR Mutation

Germany
AIO-Studien-gGmbH
Boehringer Ingelheim

Terminated

Maintaining ERBB Blockade in EGFR-mutated Lung Cancer (MARBLE)

Non-small-cell Lung Cancer With Somatic EGFR Mutations

Germany
Toray Industries, Inc

Completed

TRK-700 Drug-Drug Interaction Study With Digoxin and Midazolam

Healthy

Japan
Toray Industries, Inc
Astellas Pharma Inc

Completed

TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)

Renal Insufficiency, Chronic
Toray Industries, Inc
Astellas Pharma Inc

Completed

TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)

Chronic Renal Failure | Glomerular Disease | Nephrosclerosis

China, Hong Kong, Taiwan, Malaysia, Japan, Korea, Republic of, Thailand
Toray Industries, Inc

Completed

A Pharmacokinetic Study of TRK-100STP in Japanese Patients With Renal Impairment

Renal Impairment

Japan
Astellas Pharma Inc
Toray Industries, Inc

Completed

Study to Compare Pharmacokinetic Profiles of TRK-100STP in Japanese, Chinese, and South Korean Non-elderly Healthy Adult Males

Healthy Adult Male | Pharmacokinetics of TRK-100-STP

Japan
AstraZeneca

Terminated

Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD6918

Solid Tumors | Advanced Solid Malignancies | Cancer,

United States
Astellas Pharma Inc
Toray Industries, Inc

Completed

Drug-Drug Interaction Study of TRK-100STP

Healthy

Japan
Merck Sharp & Dohme LLC
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Not yet recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Cervical Cancer
Assiut University

Not yet recruiting

Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention

Acute Kidney Injury
Merck Sharp & Dohme LLC

Not yet recruiting

A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)

Neoplasm Metastasis
Lee's Pharmaceutical Limited

Not yet recruiting

Phase III Study of Socazolimab as First-Line Treatment in Persistent, Recurrent, or Metastatic Cervical Cancer

Cervical Cancer
Merck Sharp & Dohme LLC

Not yet recruiting

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Essential Thrombocythemia
Shanghai Chest Hospital
Novartis; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; BeiGene

Not yet recruiting

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

KRAS Mutation-Related Tumors | Advanced Lung Cancer | Refractory Tumor

China
Memorial Sloan Kettering Cancer Center
TransThera Sciences

Recruiting

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

Prostate Cancer

United States
Coherus Biosciences, Inc.

Not yet recruiting

A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer (TRANSPARENT)

Nasopharyngeal Cancer Recurrent
Kocaeli City Hospital
Health Institutes of Türkiye (TUSEB)

Not yet recruiting

Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy

Cholecystitis, Chronic

Turkey
Alexandria University
Tanta University

Recruiting

Impact of Curcumin and Pentoxiphylline on Chronic Kidney Disease Patients (CKD)

Chronic Kidney Disease

Egypt
Stemline Therapeutics, Inc.

Not yet recruiting

A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

Acute Myeloid Leukemia

United States
Peking Union Medical College Hospital

Recruiting

Orelabrutinib Combined With Obinutuzumab and Lenalidomide (OGL Regimen) as First-line Treatment for Marginal Zone Lymphoma.

Marginal Zone Lymphoma

China
Ningbo No. 1 Hospital

Recruiting

First-line Treatment of PCNSL With the Combination of Orelabrutinib, Rituximab, and Methotrexate (ORM Regimen)

Primary Central Nervous System Lymphoma

China
Yongyong MA

Recruiting

Daratumumab/Daratumumab and Hyaluronidase-fihj in Combination With Pomalidomide and Dexamethasone for the Treatment of Patients With Newly Diagnosed AL Amyloidosis: a Prospective, Multicenter, Single-arm Study

Amyloid Light-chain Amyloidosis

China
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Markers of Favorable Response to Complement Inhibitors Therapy (OPTIMISE)

Myasthenia Gravis, Generalized

Italy
Jilin University

Not yet recruiting

Efficacy of Upadacitinib After NECS in Vitiligo

Vitiligo
Fujian Cancer Hospital
Zhangzhou Municipal Hospital of Fujian Province

Recruiting

Nituzumab Plus Serplulimab Combined With SBRT in Cervical Cancer

Cervical Cancer

China
Fudan University

Recruiting

Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)

Rectal Cancer

China

Search clinical trials for: TRK inhibitor

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