Search clinical trials for: TSC2 gene

Total 268945 results

Aadi Bioscience, Inc.

Approved for marketing

Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation

TSC1 | TSC2 | PEComa, Malignant | mTOR Pathway Abberation
Dana-Farber Cancer Institute
Novartis Pharmaceuticals

Completed

Everolimus for Cancer With TSC1 or TSC2 Mutation

Tuberous Sclerosis Complex | TSC1 | TSC2 | MTOR

United States
Aadi Bioscience, Inc.

Recruiting

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Malignant Solid Neoplasm | Neoplasms | Cancer | Neoplasm Metastasis | Solid Tumor | Metastatic Cancer | Metastasis | Advanced Solid Tumor | Metastatic Solid Tumor | Advanced Cancer | Tumor | Malignant Neoplasm | Malignant Tumor | Tumors | Cancer Metastatic | Tumor, Solid | Malignant Solid Tumor | TSC | TSC1 | TSC2 | Metastatic Neoplasm

Korea, Republic of, United States, Puerto Rico
Novartis Pharmaceuticals

Completed

Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) (EXIST-2)

Lymphangioleiomyomatosis (LAM) | Tuberous Sclerosis Complex (TSC)

United States, United Kingdom, Germany, Italy, Russian Federation, Netherlands, Japan, Canada, Poland, France, Spain
Jazz Pharmaceuticals

Recruiting

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Seizure in Participants With Tuberous Sclerosis Complex | Seizure in Participants With Dravet Syndrome | Seizure in Participants With Lennox-Gastaut Syndrome

United States
National Cancer Institute (NCI)

Active, not recruiting

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Recurrent Bladder Carcinoma | Metastatic Urothelial Carcinoma | Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Locally Advanced Bladder Urothelial Carcinoma | Metastatic Transitional Cell Carcinoma

United States
Washington University School of Medicine

Completed

Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations

Solid Tumor | Solid Malignancy

United States
Emory University
Novartis Pharmaceuticals

Completed

A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies

Lung Cancer | Solid Tumors

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
M.D. Anderson Cancer Center
Aadi Bioscience

Not yet recruiting

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Leiomyosarcoma | Soft-tissue Sarcomas

United States
Yeditepe University

Not yet recruiting

Effect of Self-Acupressure on Peripheral Neuropathic Pain and HbA1c

Diabetes Mellitus, Type 2

Turkey
Hospital de Clinicas de Porto Alegre
Vifor Pharma

Not yet recruiting

IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron Deficiency (COMBINED-HF)

Heart Failure, Systolic | Iron Deficiencies

Brazil
CellinCells

Not yet recruiting

Long-Term Follow-up of Adult With Atorpphic Scars Treated With TRTP-101

Atrophic Scar
Istanbul Medipol University Hospital

Recruiting

Cervical Manual Therapy and Vagus Nerve Stimulation in Patients With Nonspecific Neck Pain

Pain Syndrome

Turkey
Sun Yat-sen University

Recruiting

The Efficacy of Bevacizumab and Serplulimab Combined With Recombinant Mutant HumanTumor Necrosis Factor(rmhTNF-NC) in the Treatment of Malignant Ascites

Malignant Ascites

China
Istituto Clinico Humanitas

Not yet recruiting

Efficacy, Safety and Recurrence After Cold-EMR Plus APC for Large Colonic Lesions (EMR+APC)

Colonic Disease

Italy
Hong Kong Baptist University

Not yet recruiting

The Effect of Traditional Chinese Cervical Manipulation for Cervicogenic Headache: a Pilot Randomized, Single-blind, Placebo-controlled Trial

Cervicogenic Headache

Hong Kong
S.LAB (SOLOWAYS)
Center of New Medical Technologies

Not yet recruiting

Clinical Trial Protocol: Randomized Placebo-Controlled Pilot Study of GcMAF (Soloways TM) in Patients With Metastatic Breast Cancer

Breast Cancer

Russian Federation
University Hospital, Brest

Not yet recruiting

Efficacy and Tolerance of Cannabidiol in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study (CANNABITCH)

Pruritus
Ruijin Hospital

Not yet recruiting

Effect of Oxycodone on Anxiety State in Painless Abortion

Abortion Complication
Peking University Cancer Hospital & Institute

Not yet recruiting

Molecular Imaging of Gastric Cancer Metastatic Lymph Nodes with 99mTc-3PRGD2 Probe.

Stomach Neoplasm | Lymph Node Metastasis | RADIONUCLIDE IMAGING
Sir Run Run Shaw Hospital

Not yet recruiting

A Study of SBRT Combined With Puterizumab in Intrapulmonary Metastasis From NSCLC

Non-Small-Cell Lung Cancer
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Study and Modulation of Immune Responses in Primary and Metastatic Colon Cancers (I-COMET)

Colon Cancer | Peritoneal Carcinoma

France
University of Tennessee

Not yet recruiting

Enteral Zinc Supplementation in VLBW Infants

Nutritional Deficiency | Very Low Birth Weight Infant
University Hospital, Gentofte, Copenhagen
Rigshospitalet, Denmark; The Novo Nordic Foundation; Region Capital Denmark; VIVE... and other collaborators

Not yet recruiting

Cross-sectorial Use of Patient-Reported Outcomes in Chronic Degenerative Shoulder Conditions (C-PRO)

Shoulder Impingement Syndrome | Shoulder Osteoarthritis | Shoulder Capsulitis | Shoulder Impingement | Shoulder Bursitis | Shoulder Disease | Rotator Cuff Syndrome | Rotator Cuff Syndrome of Shoulder and Allied Disorders | Shoulder Frozen

Denmark
TCROSS Co., Ltd.
Kaneka Corporation

Recruiting

Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry)

Stable Angina | Unstable Angina | Non-ST-elevation Acute Coronary Syndrome

Japan
University of Missouri-Columbia

Not yet recruiting

The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery

Postoperative Delirium
Cagent Vascular LLC

Not yet recruiting

Serrantor OCT Study

Critical Limb Ischemia
National Jewish Health

Not yet recruiting

Enhancing Hypnotic Medication Discontinuation in Primary Care

Insomnia | Hypnotic Dependence
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Benefits of Immersive Virtual Reality on Dyspnoea During a Weaning Test in the Intensive Care Unit. (RVI-ERS)

Spontaneous Breathing Trial in ICU
Shanghai Hengrui Pharmaceutical Co., Ltd.

Not yet recruiting

The Trial of SHR6508 in Secondary Hyperparathyroidism

Secondary Hyperparathyroidism

China
American British Cowdray Medical Center

Not yet recruiting

The Effect of Accompainment by Older Adults on Anesthetic Recovery (AAR)

Old Age; Debility

Mexico
University of Kansas Medical Center

Not yet recruiting

Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection (CLEAR)

Multiple Sclerosis | Insomnia
Splice Bio

Recruiting

An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene (POLARIS)

Stargardt Disease | Stargardt's Disease | STGD1 | Stargardt
Shanghai Pharmaceuticals Holding Co., Ltd

Not yet recruiting

A Clinical Study of SPH5030 Tablets in the Treatment of Her2-positive/Mutated Biliary Tract OR Colorectal Cancer Patients.

Biliary Tract or Colorectal Cancer With Her2-positive/Mutated

China
Apollo Therapeutics Ltd

Recruiting

A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis

Dermatitis | Eczema | Atopic Dermatitis | Atopic | Eczema, Atopic | Dermatologic Disease | Eczema Atopic Dermatitis

United States, Canada
TG Therapeutics, Inc.

Not yet recruiting

A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

Multiple Sclerosis
Hadassah Medical Organization
London North West Healthcare NHS Trust

Not yet recruiting

Severe COVID-19 Infection in Children Presenting to EDs in Israel and England (SPICE)

COVID-19 | Inflammatory Response
AstraZeneca

Not yet recruiting

A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma (ARTEMISIA)

Asthma

Canada, Denmark, Germany, Spain, United Kingdom
Hanlim Pharm. Co., Ltd.

Recruiting

Study to Evaluate Efficacy and Safety of Bronpass Tab. in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

Korea, Republic of
UCB Biopharma SRL

Not yet recruiting

An Open-label Extension Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis (ziMyG+)

Generalized Myasthenia Gravis
Shanghai Jiaolian Drug Research and Development...
Shanghai Pharmaceuticals Holding Co., Ltd

Not yet recruiting

A Study of B013 in Combination With Paclitaxel in Patients With Platinum-resistant Recurrent Ovarian Cancer.

Platinum-resistant Recurrent Ovarian Cancer

China
Izmir Katip Celebi University

Recruiting

Comparison of Open and Closed Aspiration in Newborns

Newborn

Turkey
Inova Fairfax Hospital

Not yet recruiting

Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator

Cesarean Section | Opioid Use Disorder | Post-operative Pain, Acute | Opioids; Harmful Use

United States
Michael Hoelscher
Jimma University; St. Paul's Hospital Millennium Medical College, Ethiopia

Recruiting

SARS-CoV-2 Specific Antibody Responses and Impact for COVID-19 Disease in Ethiopia (CoVICIS)

COVID-19 Recurrent | SARS CoV 2 Infection | COVID-19 Breakthrough

Ethiopia
Papworth Hospital NHS Foundation Trust

Not yet recruiting

Radial Artery Assessment in Surgical Coronary Revascularisation

Coronary Artery Disease | Coronary Artery Bypass Grafting

United Kingdom
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

A Point-of-care Electrochemical-based Device for Rapid Detection of Fibrinogen on Type A Aortic Dissection Surgery

Hypofibrinogenemia

China
University of Pennsylvania

Not yet recruiting

Imaging Predictors of Cryolysis Efficacy for Treatment of Obstructive Sleep Apnea (ICE-OSA)

Obstructive Sleep Apnea of Adult

United States
M.D. Anderson Cancer Center

Not yet recruiting

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Systemic Sclerosis | Autoimmune Disorders

United States
The Second Hospital of Nanjing Medical University

Recruiting

Impact of RIVP on GI Function in Patients Undergoing Surgical Repair for ATAAD

Type A Aortic Dissection

China

Search clinical trials for: TSC2 gene

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