Search clinical trials for: Unknown primary tumor

Total 47119 results

Zachary Zumsteg

Not yet recruiting

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

Carcinoma | Oropharyngeal Cancer

United States
Sun Yat-sen University
The First Affiliated Hospital of Anhui Medical University; Peking University... and other collaborators

Recruiting

PaCIFiC-CUP Classifies Cancer of Unknown Primary

Unknown Primary Tumors | DNA Methylation

China
University Medical Center Groningen

Recruiting

Real-time Targeted Fluorescence Endoscopy for Detection of the Primary Cancer Lesion in Patients With a Metastasis of Unknown Primary Tumor in the Head and Neck (REFLECT)

Oropharynx Cancer | Unknown Primary Tumors

Netherlands
Sohag University

Recruiting

Role of Positron Emission Tomography in Detecting Primary Tumor in Cases of Metastases of Unknown Origin

Metastasis of Unknown Origin

Egypt
Regina Elena Cancer Institute
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Weizmann Institute... and other collaborators

Recruiting

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

Liquid Biopsy | Squamous Cell Carcinoma of the Oropharynx | Lymph Node Metastasis | Carcinomas of Unknown Primary Site | High-risk Human Papillomavirus Infection | Occult Tumor of the Head and Neck Area

Italy
Tango Therapeutics, Inc.

Recruiting

Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

Cervical Cancer | Breast Cancer | Pancreatic Cancer | Non Small Cell Lung Cancer | Endometrial Cancer | Solid Tumors, Adult | Carcinoma of Unknown Primary

United States
Travera Inc
xCures

Recruiting

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx) (TraveraRTGx)

Melanoma | Carcinoma, Renal Cell | Carcinoma | Carcinoma, Non-Small-Cell Lung | Carcinoma, Hepatocellular | Carcinoma, Pancreatic | Pancreatic Cancer | Mesothelioma | Cholangiocarcinoma | Carcinoma, Neuroendocrine | Carcinoma, Small Cell | Pleural Effusion, Malignant | Carcinoma, Pancreatic Ductal | Carcinoma of the... and other conditions

United States
Emory University
National Cancer Institute (NCI); NovoCure Ltd.

Recruiting

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases

Metastatic Melanoma | Melanoma of Unknown Primary | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Mucosal Melanoma | Metastatic Ocular Melanoma

United States
Wei Xu

Recruiting

Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

Chemotherapy Effect | Gene Mutation-Related Cancer | Tislelizumab | Cancer of Unknown Primary | Bone Cancer Metastatic | Immune Evasion, Tumor

China
Rapa Therapeutics LLC

Recruiting

RAPA-201 Therapy of Solid Tumors

Breast Cancer | Head and Neck Cancer | Gastric Cancer | Solid Tumor | Bladder Cancer | Triple Negative Breast Cancer | Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Malignant Melanoma | Carcinoma of Unknown Primary | Squamous Cell Carcinoma of Larynx | Squamous Cell Carcinoma of Oral Cavity | Squamous Cell Carcinoma of Nasopharynx and other conditions

United States
Munich Leukemia Laboratory
Illumina, Inc.

Recruiting

Solving Riddles Through Sequencing (SIRIUS)

Leukemia | Rare Diseases | Refractory Lymphoma | Hematologic Malignancy | Refractory Leukemia | Unknown Primary Tumors

Germany
Travera Inc
John B. Amos Cancer Center

Not yet recruiting

Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs

Carcinoma, Renal Cell | Carcinoma | Carcinoma, Non-Small-Cell Lung | Carcinoma, Hepatocellular | Carcinoma, Pancreatic | Mesothelioma | AML | Cholangiocarcinoma | Stage IV Lung Cancer | Carcinoma, Neuroendocrine | Stage IV Breast Cancer | Carcinoma, Ductal | Malignant Ascites | Carcinoma Prostate | Stage III Breast Cancer and other conditions

United States
Avacta Life Sciences Ltd

Recruiting

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

Soft Tissue Sarcoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Non-small Cell Lung Cancer | Biliary Tract Cancer | Oesophageal Cancer | Cancer of Unknown Primary Site

United States, United Kingdom
SOLTI Breast Cancer Research Group
Novartis

Recruiting

Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors (ACROPOLI)

Melanoma | Sarcoma | Small Cell Lung Cancer | Hepatocellular Carcinoma | Pancreatic Adenocarcinoma | Uterine Carcinosarcoma | Mesothelioma | Cholangiocarcinoma | Lung Adenocarcinoma | Triple Negative Breast Cancer | Epithelial Ovarian Cancer | HER2-positive Breast Cancer | Head and Neck Squamous Cell Carcinoma | Esophageal... and other conditions

Spain
Peking University
Hangzhou DIAN Medical Diagnostic Center Co., Ltd., China

Recruiting

Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics (VISIONARY)

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Gastrointestinal Stromal Tumors | Neuroendocrine Tumors | Esophageal Squamous Cell Carcinoma | Biliary Tract Neoplasms | Unknown Primary Cancer | Digestive Cancer

China
TargetCancer Foundation
Foundation Medicine

Recruiting

TCF-001 TRACK (Target Rare Cancer Knowledge) Study (TRACK)

Cholangiocarcinoma | Cancer of Unknown Primary Site | Rare Cancers

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Cancer Genetic Testing in Ethnic Populations

Malignant Solid Neoplasm | Breast Carcinoma | Digestive System Carcinoma | Head and Neck Carcinoma | Skin Carcinoma | Malignant Female Reproductive System Neoplasm | Malignant Brain Neoplasm | Carcinoma of Unknown Primary | Central Nervous System Carcinoma | Genitourinary System Carcinoma | Malignant Musculoskeletal...

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

Unresectable Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC... and other conditions

United States
Jonsson Comprehensive Cancer Center

Recruiting

Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers (FAPI PET RDRC)

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Hepatocellular Carcinoma | Cholangiocarcinoma | Cervical Carcinoma | Urothelial Carcinoma | Bladder Carcinoma | Thyroid Gland Carcinoma | Neuroendocrine Neoplasm | Malignant Skin Neoplasm | Malignant Brain Neoplasm | Cancer of Unknown Primary... and other conditions

United States
Centre Hospitalier Universitaire Dijon
National Cancer Institute, France

Recruiting

Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary (FOLFIRINEC)

Neuroendocrine Carcinoma

France
British Columbia Cancer Agency
Hoffmann-La Roche

Recruiting

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (CAPTIV-8)

Sarcoma | Breast Cancer | Head and Neck Cancer | Gynecologic Cancer | Lung Cancer | Skin Cancer | Gastrointestinal Cancer | Unknown Primary Tumors | Genitourinary Cancer

Canada
Taproot Health

Recruiting

The Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT)

Melanoma | Sarcoma | Kidney Cancer | Adenocarcinoma | Renal Cell Carcinoma | Cervical Cancer | Acute Myeloid Leukemia | Stomach Cancer | Breast Cancer | Head and Neck Neoplasms | Nasopharyngeal Carcinoma | Glioblastoma | Astrocytoma | Multiple Myeloma | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Small Bowel Cancer and other conditions

United States
SpeciCare
University of Washington; Georgia Institute of Technology; Predictive Oncology; Netnoid... and other collaborators

Recruiting

The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology) (PIONEER)

Melanoma | Sarcoma | Renal Cell Carcinoma | Breast Cancer | Hepatocellular Carcinoma | Transitional Cell Carcinoma | Glioblastoma Multiforme | Cholangiocarcinoma | Small-cell Lung Cancer | Oligodendroglioma | Cancer of Head and Neck | Cancer of Liver | Cancer of Pancreas | Cancer of Brain and Nervous System | Adrenal... and other conditions

United States
University Health Network, Toronto

Recruiting

Genomic Investigation of Unusual Responders (GENIUS)

Cancer | Breast Cancer | Colorectal Cancer | Non-small Cell Lung Cancer | Melanoma (Skin) | Genitourinary Cancer | Gynecological Cancer | Rare Cancer | Carcinoma of Unknown Primary | Pancreatobiliary Gastrointestinal Cancer | Upper Aerodigestive Tract Cancer

Canada
University Health Network, Toronto
Princess Margaret Hospital, Canada

Recruiting

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (OCTANE)

Melanoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Lung Cancer | Gastrointestinal Cancer | Genitourinary Cancer | Unknown Primary Cancer | Gynecological Cancer | Rare Cancer | Pancreatobiliary Cancer

Canada
University of Nebraska

Recruiting

Integrated Cancer Repository for Cancer Research (iCaRe2)

Melanoma | Sarcoma | Kidney Cancer | Leukemia | Breast Cancer | Laryngeal Cancer | Hypopharyngeal Cancer | Nasopharyngeal Cancer | Multiple Myeloma | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Small Intestine Cancer | Ovarian Cancer | Lynch Syndrome | Lung Cancer | Rectal Cancer | Prostate Cancer | Gastrointestinal... and other conditions

United States
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
National Cancer Institute (NCI)

Active, not recruiting

Testing Treatment With Ipilimumab and Nivolumab Compared to Treatment With Ipilimumab Alone in Advanced Melanoma

Unresectable Cutaneous Melanoma | Unresectable Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Mucosal Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
Hoffmann-La Roche
Foundation Medicine, Inc.

Active, not recruiting

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)

Cancer of Unknown Primary Site

United Kingdom, Korea, Republic of, France, Australia, Germany, Austria, Croatia, Denmark, Finland, Greece, Hungary, Italy, Portugal, Spain, Japan, Brazil, Colombia, Mexico, Romania, Czechia, Norway, Thailand, Switzerland, Turkey, Nethe... and more
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Malignant Solid Neoplasm | Nasopharyngeal Carcinoma | Adenoid Cystic Carcinoma | Transitional Cell Carcinoma | Cholangiocarcinoma | Intrahepatic Cholangiocarcinoma | Chordoma | Gestational Trophoblastic Tumor | Pseudomyxoma Peritonei | Cervical Adenocarcinoma | Vaginal Adenocarcinoma | Vaginal Squamous Cell... and other conditions

United States, Guam
National Cancer Institute (NCI)

Active, not recruiting

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

Stage IV Cutaneous Melanoma AJCC v6 and v7 | Recurrent Melanoma | Stage IIIC Cutaneous Melanoma AJCC v7 | Melanoma of Unknown Primary | Stage IIIB Cutaneous Melanoma AJCC v7

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

Sezary Syndrome | Refractory T-Cell Non-Hodgkin Lymphoma | Merkel Cell Carcinoma | Anaplastic Large Cell Lymphoma, ALK-Positive | Extramammary Paget Disease | Recurrent T-Cell Non-Hodgkin Lymphoma | Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma | Refractory Mature T-Cell and NK-Cell Non-Hodgkin... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Recurrent Hypopharyngeal Squamous Cell Carcinoma | Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Oropharyngeal Squamous... and other conditions

United States, Puerto Rico, South Africa
National Cancer Institute (NCI)

Suspended

A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy in Patients With Operable Melanoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Recurrent Cutaneous Melanoma

United States
National Cancer Institute (NCI)
Abbott

Active, not recruiting

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

Liver Failure | Melanoma | Renal Failure | Breast Carcinoma | Endometrial Carcinoma | Urothelial Carcinoma | Lung Carcinoma | Ovarian Carcinoma | Esophageal Carcinoma | Metastatic Malignant Neoplasm | Unresectable Malignant Neoplasm | Malignant Head and Neck Neoplasm | Carcinoma of Unknown Primary | Malignant Testicular...

United States
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; National Institutes...

Completed

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Metastatic Melanoma | Stage IV Skin Melanoma | Stage IV Non-Small Cell Lung Cancer | Ocular Melanoma | Melanoma of Unknown Primary | Mucosal Melanoma | Metastatic Malignant Neoplasm in the Brain

United States
Hospices Civils de Lyon

Active, not recruiting

Assessment of the Efficacy of Bevacizumab in Combination With Folfiri as Second-line Treatment in Patients Suffering From an Advanced Inoperable Poorly Differentiated Neuroendocrine Carcinoma of an Unknown or Gastroentero-pancreatic Primary Cancer (BEVANEC)

Neuroendocrine Carcinomas

France
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Lutathera in People With Gastroenteropancreatic (GEP), Bronchial or Unknown Primary Neuroendocrine Tumors That Have Spread to the Liver

Neuroendocrine Tumors | Liver-Dominant Metastatic Pancreatic Neuroendocrine Tumors

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer

Stage IIIA Non-small Cell Lung Cancer | Stage IIIB Non-small Cell Lung Cancer | Tongue Cancer | Salivary Gland Squamous Cell Carcinoma | Stage IV Non-small Cell Lung Cancer | Stage IV Squamous Cell Carcinoma of the Hypopharynx | Stage IV Squamous Cell Carcinoma of the Nasopharynx | Metastatic Squamous... and other conditions

United States
University of Southampton
BioNTech SE

Completed

HARE-40: HPV Anti-CD40 RNA vaccinE (HARE-40)

Unknown Primary Tumors | Head and Neck Neoplasm | Cervical Neoplasm | Penile Neoplasms Malignant | Human Papilloma Virus Related Carcinoma

United Kingdom
Fondazione del Piemonte per l'Oncologia

Completed

A Study of Nab-paclitaxel-based Doublet as First Line Therapy in Patients With Cancer of Unknown Primary (CUP) (AGNOSTOS)

Unknown Primary Tumors

Italy
Merus N.V.

Available

Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor

Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Prostate Cancer | Non Small Cell Lung Cancer | Cholangiocarcinoma | Solid Tumor, Unspecified, Adult | Unknown Primary Tumors | NRG1 Fusion
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Melanoma of Unknown Primary | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Recurrent Cutaneous Melanoma | Metastatic Malignant Neoplasm in Lymph Node

United States
University Health Network, Toronto
Princess Margaret Hospital, Canada

Active, not recruiting

Integrated Molecular Profiling in Advanced Cancers Trial (IMPACT)

Breast Cancer | Colorectal Cancer | Non-small Cell Lung Cancer | Genitourinary Cancer | Rare Cancers | Gynecological Cancers | Pancreatobiliary Gastrointestinal Cancer | Upper Aerodigestive Tract Cancer | Melanoma Cancers | Unknown Primary Cancers

Canada
M.D. Anderson Cancer Center

Completed

A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy

Spinal Tumor

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Skin Squamous Cell Carcinoma | Unresectable Solid Neoplasm | Metastatic Kidney Medullary Carcinoma | Metastatic Penile Carcinoma | Small Cell Carcinoma | Metastatic Adrenal Gland Pheochromocytoma | Stage IV Penile Cancer... and other conditions

United States
The Netherlands Cancer Institute
4SC

Active, not recruiting

Multicenter Phase 1b Trial Testing the Neoadjuvant Combination of Domatinostat, Nivolumab and Ipilimumab in IFN-gamma Signature-low and IFN-gamma Signature-high RECIST 1.1-measurable Stage III Cutaneous or Unknown Primary Melanoma (DONIMI)

Malignant Melanoma Stage III

Netherlands
Emory University
National Cancer Institute (NCI); Pfizer; National Institutes of Health (NIH)

Completed

Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors

Sarcoma | Head and Neck Cancer | Stage IIIA Non-Small Cell Lung Cancer | Stage IIIB Non-Small Cell Lung Cancer | Colorectal Cancer | Ovarian Cancer | Bladder Cancer | Stage IV Non-Small Cell Lung Cancer | Stage III Pancreatic Cancer | Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

Sarcoma | Metastatic Melanoma | Thyroid Gland Carcinoma | Metastatic Malignant Neoplasm of Unknown Primary | Spinal Cord Compression | Stage IV Breast Cancer AJCC v6 and v7 | Malignant Digestive System Neoplasm | Metastatic Malignant Neoplasm in the Spine | Metastatic Kidney Carcinoma | Metastatic Head... and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

Malignant Solid Neoplasm | Breast Carcinoma | Digestive System Neoplasm | Skin Carcinoma | Malignant Female Reproductive System Neoplasm | Metastatic Malignant Neoplasm of Unknown Primary | Malignant Head and Neck Neoplasm | Malignant Brain Neoplasm | Malignant Central Nervous System Neoplasm | Malignant... and other conditions

United States

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