Search clinical trials for: Variant of Uncertain Significance

Total 428796 results

Dana-Farber Cancer Institute
Nest Genomics

Recruiting

Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing

Genetic Predisposition to Disease | Genetic Predisposition

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI); University of South Florida

Recruiting

Improving Care After Inherited Cancer Testing (IMPACT)

Breast Cancer | Colorectal Cancer | Prostate Cancer | Endometrial Cancer | Inherited Cancer Syndrome

United States
Meyer Children's Hospital IRCCS

Active, not recruiting

Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases (NIKE)

Chronic Kidney Diseases

Italy
National Human Genome Research Institute (NHGRI)

Completed

Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing

Undiagnosed Disease

United States
Mario Negri Institute for Pharmacological Research

Recruiting

New Analytic Tools for aHUS and C3G Diagnosis (COMPRare)

Healthy | Hemolytic-Uremic Syndrome | Membranoproliferative Glomerulonephritis

Italy
UMC Utrecht
BeiGene

Not yet recruiting

Zanubrutinib Treatment in Patients With IgM Monoclonal Gammopathy and Antri-MAG Related Polyneuropathy (MAGNAZ)

Monoclonal Gammopathy of Uncertain Significance

Netherlands
University Hospital, Bordeaux

Recruiting

Functional Tests to Resolve Unsolved Rare Diseases. Rares. (RID)

Intellectual Disability | Cystic Fibrosis | Neurodegeneration With Brain Iron Accumulation (NBIA) | Congenital Heart Defect | Albinism | Rubinstein-Taybi Syndrome | Periventricular Nodular Heterotopia

France
Mayo Clinic

Recruiting

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Hematologic Neoplasms | Myeloid Malignancy | Cytopenia | Bone Marrow Failure Syndrome | Clonal Cytopenia of Undetermined Significance | Clonal Hematopoiesis of Indeterminate Potential | Low Risk Myelodysplastic Syndrome | Inherited Bone Marrow Failure Syndrome | Clonal Expansion | Hereditary Neoplastic... and other conditions

United States
Dana-Farber Cancer Institute
The Leukemia and Lymphoma Society

Recruiting

Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

Myelodysplastic-Myeloproliferative Diseases | Waldenstrom Macroglobulinemia | Smoldering Multiple Myeloma | Chronic Lymphocytic Leukemia (CLL) | Hematological Malignancies | Monoclonal Gammopathy of Undetermined Significance (MGUS) | B-cell Malignancy, Low-grade | Myelodysplastic Syndrome With Low-grade... and other conditions

United States
Stanford University
American Heart Association

Not yet recruiting

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries (MVP-ANOCA)

Angina Pectoris | Microvascular Angina | Vasospastic Angina | Myocardial Bridge of Coronary Artery

United States
Peking University People's Hospital

Recruiting

Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone Therapy for Patients With MIDD

Monoclonal Gammopathy of Renal Significance

China
Leslie Ballas

Not yet recruiting

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology

Muscle-Invasive Bladder Carcinoma | Tumor

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Bayer

Not yet recruiting

The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris (ViVA)

Vasospastic Angina
IRCCS Policlinico S. Matteo

Recruiting

Promoting Diagnosis and Management of AL in Italy (ProDigALIty) (ProDigALIty)

AL Amyloidosis | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

Italy
Indonesia University
Universitas Padjadjaran; Fakultas Kedokteran Universitas Indonesia; Institut... and other collaborators

Not yet recruiting

The Effect of Anthocyanin Intake From Purple Sweet Potato in Cerebral Small Vessel Disease

Cerebral Small Vessel Diseases
University of Colorado, Denver
Children's Hospital Colorado

Recruiting

Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY) (GALAXY)

Sex Chromosome Aneuploidy

United States
Massachusetts General Hospital

Not yet recruiting

Study to Determine the Clinical Significance of Intravascular OCT-NIRAF

Cardiovascular Diseases | Coronary Artery Disease

United States
Alnylam Pharmaceuticals

Recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
Wuhan Union Hospital, China

Not yet recruiting

The Clinical Significance of CT-based Biomarkers in the Classification and Prognosis of Bronchiectasis

Bronchiectasis

China
First Affiliated Hospital of Harbin Medical University

Recruiting

Study On the Expression Level and Clinical Significance of VISTA in Patients With Vascular Cognitive Impairment

Cerebrovascular Disease Small Vessel

China
Sohag University

Recruiting

Predictive and Prognostic Significance of Age,Blood Tests,Comorbidities(ABC) Score,Cologne Watch(C-watch)Score and Rockall Score for Risk of Variceal Re-bleeding Among Cirrhotic Patients

Upper Gastrointestinal Variceal Bleeding in Cirrhotic Patients

Egypt
Dalian Medical University

Not yet recruiting

Linperlisib Plus Obinutuzumab and Venetoclax for Relapsed and Refractory Blastoid Variant of Mantle Cell Lymphoma.

Mantle Cell Lymphoma

China
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

CT Features of Interrupted Inferior Vena Cava With Azygous Continuation

Anatomical Variant of the Inferior Vena Cava

France
National Cancer Institute (NCI)

Not yet recruiting

Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

Recurrent Hairy Cell Leukemia | Recurrent Hairy Cell Leukemia Variant
Radboud University Medical Center
Maastricht University Medical Center

Recruiting

TREAT Study - Improving the Interpretation of Troponin Concentrations Following Exercise and Their Clinical Significance (TREAT)

Coronary Artery Disease

Netherlands
University Hospital Tuebingen

Recruiting

Non-Invasive Plasma Treatment for Cervical Infections: Targeting High- and Low-Risk HPV Variants

Cervical Cancer | HPV Infection

Germany
Medanta, The Medicity, India

Recruiting

Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes

Type2diabetes

India
Universite du Quebec en Outaouais

Recruiting

Behavioural Experiments for Generalized Anxiety in Adolescents - Pilot Study (EC-II-Ado-P)

Generalized Anxiety Disorder | Adolescent - Emotional Problem

Canada
Geneplus-Beijing Co. Ltd.

Not yet recruiting

The Exploration of Personalized ctDNA Based MRD in the Clinical Significance of Cervical Cancer

Ovarian Cancer

China
Universidad de Colima

Recruiting

Exploring Treatments for Children's Abdominal Pain: Comparing Trimebutine and Probiotics (FAPD_RCT)

Functional Gastrointestinal Disorders | Functional Abdominal Pain Syndrome | Irritable Bowel Syndrome Variant of Childhood

Mexico
Acibadem University

Recruiting

Answerability and Minimal Clinical Significance of the Pain Questionnaires

Chronic Low-back Pain

Turkey
Interni hematologicka klinika FNKV
Charles University, Czech Republic; University Hospital Olomouc; General University... and other collaborators

Recruiting

Prognostic Significance of ctDNA in HL

Prognostic Cancer Model

Czechia
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography Evaluation in Sohag

Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography

Egypt
Assistance Publique - Hôpitaux de Paris

Recruiting

Effect of Peripheral VA-ECMO Flow Variations on the Pulmonary Arterial Occlusion Pressure (PAPO) in Patients With Refractory Cardiogenic Shock. (PAPO-Flow)

Cardiogenic Shock

France
University Hospital, Basel, Switzerland
SolidarMed Lesotho

Recruiting

Measuring Anticipated Attitudes and Behavior Towards a New Medical Treatment in Lesotho

Recruitment | Health Behavior | Motivation | Social Behavior | Health Care Utilization | Consumer Behavior | Health Care Seeking Behavior | Researcher-Subject Relations

Lesotho
Nantes University Hospital
AXA Assurances VIE Mutuelle

Not yet recruiting

Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome (BIOMINRISK)

Sudden Infant Death | Sudden Unexplained Infant Death

France
Washington University School of Medicine
Bristol-Myers Squibb; Damon Runyon Cancer Research Foundation

Not yet recruiting

Enasidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH2A Decentralized Trial

Clonal Cytopenia of Undetermined Significance | CCUS Clonal Cytopenia of Undetermined Significance

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Molecular Diagnosis of Lung Cancer Via Bronchoscopy: The Significance of Bronchial Liquid Biopsy (ctDNA and ctRNA) (BiliBro)

Non Small Cell Lung Cancer

France
University of Cambridge
Sanofi

Recruiting

Molecular Imaging in Fabry Disease of the Heart

Fabry Disease, Cardiac Variant

United Kingdom
IRCCS San Raffaele

Recruiting

Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children

Pediatric Brain Tumor

Italy
University of Copenhagen
Gentofte Hospital, Denmark

Recruiting

The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function (H-21044858)

Incretin Effect

Denmark
Oscar Gerardo Arrieta Rodríguez

Recruiting

Pathogenic Variants in Genes Associated With Lung Adenocarcinoma

Lung Adenocarcinoma

Mexico
WestVac Biopharma Co., Ltd.
WestVac Biopharma (Guangzhou) Co., Ltd.

Recruiting

A Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell)

COVID-19

China
Izmir University of Economics
The Scientific and Technological Research Council of Turkey

Recruiting

The Effectiveness of Cognitive Bias Modification on Intolerance of Uncertainty

Intolerance to Uncertainty

Turkey
Regeneron Pharmaceuticals

Not yet recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma (LINKER-MGUS1)

Monoclonal Gammopathy of Undetermined Significance (MGUS) | Smoldering Multiple Myeloma (SMM)
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by MRV Evaluation in Sohag

Anatomical Variants of Dural Sinuses by MRV

Egypt
Hospital do Rim e Hipertensão

Recruiting

Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients

Kidney Diseases | Transplant Failure

Brazil
Lexeo Therapeutics

Recruiting

Gene Therapy for ACM Due to a PKP2 Pathogenic Variant

Arrhythmogenic Cardiomyopathy | PKP2-ACM | PKP2-ARVC

United States
M.D. Anderson Cancer Center

Recruiting

Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)

Prostate Cancer

United States
Nantes University Hospital
Institut National de la Santé Et de la Recherche Médicale, France; Centre National...

Recruiting

Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects (CarDiag)

Long QT Syndrome

France

Search clinical trials for: Variant of Uncertain Significance

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Kosovo

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations