Search clinical trials for: Vasopressin antagonist

Total 33798 results

Mayo Clinic
Hopital du Sacre-Coeur de Montreal

Recruiting

PB to Treat Hereditary Nephrogenic Diabetes Insipidus, ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium Administration (SerendipityPB1)

Autosomal Dominant Polycystic Kidney Disease | Nephrogenic Diabetes Insipidus | Acquired Nephrogenic Diabetes Insipidus | Congenital Nephrogenic Diabetes Insipidus

United States
Tiohundra AB
Sahlgrenska University Hospital, Sweden; Stockholm South General Hospital

Recruiting

VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial (VAST-A)

Cardiac Arrest;In-hospital Cardiac Arrest; Methylprednisolone; Vasopressin; Adrenaline; Randomized Clinical Trial

Sweden
Gia Dinh People Hospital
Otsuka Pharmaceutical Vietnam

Recruiting

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction (DR-AHF)

Acute Heart Failure

Vietnam
Azevan Pharmaceuticals

Completed

Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder (AVN009)

Intermittent Explosive Disorder

United States
Zagazig University

Completed

Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery

Bleeding

Egypt
Lars Wiuff Andersen
University of Aarhus

Completed

Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest (VAM-IHCA)

Heart Arrest

Denmark
Esther Meijer

Unknown

Wishing to Decrease Aquaresis in ADPKD Patients Treated With a V2Ra; the Effect of Regulating Protein and Salt (WATER)

Polycystic Kidney, Autosomal Dominant | Autosomal Dominant Polycystic Kidney | ADPKD

Netherlands
Yale University

Completed

The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration

Exercise Induced Hyponatremia

United States
Vanderbilt University

Completed

Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure

Heart Failure

United States
Vanderbilt University Medical Center
UMC Utrecht

Completed

Decision Support for Intraoperative Low Blood Pressure

Hypotension

United States
Brigham and Women's Hospital
Otsuka Pharmaceutical Co., Ltd.

Completed

The Role of Vasopressin Antagonism on Renal Sodium Handling

Healthy
Ferring Pharmaceuticals

Completed

Interventional Clinical Trial in Patients in Overactive Bladder With Nocturia in Women

Overactive Bladder

United States
Vanderbilt University

Completed

Treatment of Supine Hypertension in Autonomic Failure

Hypertension

United States
Ferring Pharmaceuticals

Completed

Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions (OVANCON)

In Vitro Fertilisation (IVF) Treatment

Belgium, Czechia, Spain
University of North Carolina, Chapel Hill
Otsuka America Pharmaceutical

Completed

Pilot Study of Using Copeptin to Predict Response to Tolvaptan

Heart Diseases | Cardiovascular Diseases | Heart Failure

United States
Mario Negri Institute for Pharmacological Research
A.O. Ospedale Papa Giovanni XXIII

Terminated

Tolvaptan for In-hospital Hyponatremia (INSERT)

Hyponatremia

Italy
University of Athens
University of Thessaly

Completed

Vasopressin, Epinephrine, and Steroids for Cardiac Arrest (VSE-2)

Cardiac Arrest

Greece
Mount Sinai Hospital, Canada
The Physicians' Services Incorporated Foundation; Baycrest

Terminated

Comparison Between Desmopressin and Fesoterodine for Treatment of Night Time Voiding in Women Aged 65 and Older (DEFEND)

Nocturia

Canada
Oakland University
Georgetown University

Completed

V2 Receptor Effects on Fluid Regulation and Performance

Hyponatremia | Hypernatremia | Electrolyte Imbalance

United States
Hormozgan University of Medical Sciences

Completed

Minirin Versus Oxybutynin for Nocturnal Enuresis in Children

Nocturnal Enuresis

Iran, Islamic Republic of
Finn Gustafsson
Rigshospitalet, Denmark

Completed

Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure Patients

Heart Failure

Denmark
Cumberland Pharmaceuticals
Astellas Pharma US, Inc.

Completed

Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia

Hyponatremia

United States, South Africa, Israel, Canada
Otsuka Pharmaceutical Co., Ltd.

Completed

A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)

Edema, Cardiac

Japan
Otsuka Pharmaceutical Co., Ltd.

Completed

A Study of OPC-41061 in Subjects With Cardiac-induced Edema (Congestive Heart Failure)

Cardiac Edema

Japan
Otsuka Pharmaceutical Co., Ltd.

Completed

A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)

Cardiac Edema

Japan
Otsuka Frankfurt Research Institute GmbH

Unknown

Post-Authorisation Safety Study of Samsca (Tolvaptan) Used in Routine Medical Practice

SIADH | Non-SIADH Hyponatremia | Non-Hyponatremia

Denmark, Germany, Italy, Norway, Spain, Sweden, United Kingdom
Konkuk University Medical Center
Samsung Medical Center; Seoul St. Mary's Hospital; Korea University Anam Hospital and other collaborators

Unknown

Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites (TONIC)

Ascites | Hyponatremia

Korea, Republic of
Sanofi

Completed

Evaluation of the Potential Effects of SSR149415 on the Hypothalamic-pituitary-adrenal Axis in Outpatients With Major Depressive Disorder (NAPA)

Major Depressive Disorder

United States
Otsuka Pharmaceutical Development & Commercialization...

Completed

EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan

Congestive Heart Failure

United States, Canada, Netherlands, United Kingdom, France, Spain, Germany, Switzerland, Italy, Brazil, Argentina, Russian Federation, Belgium, Romania, Czech Republic, Norway, Poland, Sweden
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

"SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia

Hyponatremia | Inappropriate ADH Syndrome | Water Intoxication | Water-electrolyte Imbalance

Germany
CardioKine Inc.
Biogen; Cardiokine Biopharma, LLC

Completed

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia

Hyponatremia With Normal Extracellular Fluid Volume

United States, Canada, Germany, India, Poland, Belgium
CardioKine Inc.
Biogen; Cardiokine Biopharma, LLC

Completed

THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation

Hyponatremia

Italy, United States, Argentina, Israel, Poland, Spain, Chile, India, Canada, Czech Republic, Germany, Romania, Russian Federation, Slovakia, Switzerland
CardioKine Inc.
Biogen; Cardiokine Biopharma, LLC

Withdrawn

International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia

Hypervolemic Hyponatremia
Movetis

Completed

Study of Efficacy of a Vasopressin 2 Receptor Antagonist M0002 for Treatment of Ascites in Cirrhotic Subjects With Hypo- or Normonatraemia

Cirrhotic Ascites
Sanofi

Completed

Safety Study of Vasopressin V2 Receptor Antagonist on Patients With Severe Chronic Heart Failure (AQUAVIT).

Chronic Heart Failure

Canada, United States, United Kingdom
Mahidol University
Thailand Research Fund

Terminated

Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis

Leptospirosis

Thailand
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia

Inappropriate ADH Syndrome | Water Intoxication | Hyponatremias | Water-Electrolyte Imbalances

United States
Post Graduate Institute of Medical Education and...
Indian Council of Medical Research

Not yet recruiting

Carvedilol + Simvastatin vs. Carvedilol Alone for Chronic Liver Disease and Cirrhotic Cardiomyopathy and Its Impact on Hepatic Decompensation and Survival; a Double-blind Randomized Controlled Trial (CIRROSTAT)

Decompensated Cirrhosis | Acute Kidney Injury | Cirrhosis, Liver | Left Ventricular Diastolic Dysfunction | Cirrhotic Cardiomyopathy
Shoaib Rahim
Foundation University Islamabad

Not yet recruiting

Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone.

Pain
Shenzhen Institute of Advanced Technology, Chinese...

Recruiting

Variation in the Impact of Coffee on the Metabolic Rate

Healthy

China
Hospital San Carlos, Madrid

Recruiting

Efficacy and Safety of Atropine and DIMS Lenses in Controlling Myopia in Children: A Randomized Clinical Trial. (DIMS)

Myopia

Spain
Butler Hospital
National Institute on Drug Abuse (NIDA)

Recruiting

tDCS to Decrease Opioid Relapse (UH3)

Opioid Use Disorder

United States
Radboud University Medical Center
UMC Utrecht; Catharina Ziekenhuis Eindhoven; Maasstad Hospital

Not yet recruiting

Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm (EDIT-CAS)

Coronary Spasm

Netherlands
Children's National Research Institute

Not yet recruiting

Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols

Rhabdomyolysis

United States
Octapharma

Not yet recruiting

Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

Significant Bleeding Risk | Vitamin K-Dependent Coagulation Defect
University of Colorado, Denver
Denver Health and Hospital Authority; Southern Colorado Harm Reduction Association and other collaborators

Not yet recruiting

Vending Machine Naloxone Distribution for Your Community (VENDY)

Harm Reduction | Naloxone | Opioid Overdose
Nanjing First Hospital, Nanjing Medical University

Recruiting

Safety and Efficacy of Recombinant Human Thyroid Stimulating Hormone for Adjuvant Diagnosis in Patients With Locally Advanced/Metastatic Differentiated Thyroid Cancer

Recombinant Human Thyroid Stimulating Hormone

China
Medical University of Vienna
Lund University; Ziekenhuis Netwerk Antwerpen (ZNA); St. Antonius Hospital; Azienda... and other collaborators

Not yet recruiting

Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study (OLIGOMET)

Prostate Cancer | Prostate Cancer Metastatic | Oligometastasis | Prostate Neoplasm | Oligometastatic Disease | Prostate Cancer Metastatic to Bone
Chong Kun Dang Pharmaceutical

Recruiting

Efficacy and Safety of Telmisartan Compared With Losartan

Hypertension | Diabetic Nephropathies

Korea, Republic of
Auburn University
National Institute on Drug Abuse (NIDA); Wayne State University

Not yet recruiting

Cannabinoids and Biological Reactivity to Stress (COBRAS)

Cannabis Use Disorder

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