Search clinical trials for: aflibercept,

Total 518 results

Sandoz

Completed

Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Vial Kit

Neovascular Age-related Macular Degeneration (nAMD)

United States
Sandoz

Completed

Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Prefilled Syringe

Neovascular Age-related Macular Degeneration (nAMD)

United States
Regeneron Pharmaceuticals
Sanofi

Completed

Nesvacumab (REGN910/ SAR307746) and Aflibercept ("Ziv-aflibercept" in the U.S.) in Patients With Advanced Solid Malignancies

Solid Tumors

United States, Canada
Vista Klinik
Novartis

Terminated

Intravitreal Brolucizumab in Neovascular Age-related Macular Degeneration With Limited Response to Aflibercept (ROBIN)

Neovascular Age-related Macular Degeneration

Switzerland
GCS IHFB Cognacq-Jay
Fondation ARCAD

Active, not recruiting

TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study. (TWICE-IRI)

Metastasis | Cancer Colorectal

France
Bayer
Regeneron Pharmaceuticals

Completed

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Eylea for Central Retinal Vein Occlusion (CRVO) (JPMS-CRVO)

Retinal Vein Occlusion

Japan
Unity Health Toronto

Terminated

Intravitreal Aflibercept in Wet Age Related Macular Degeneration Patients With an Incomplete Response to Routine Ranibizumab Injections (SHIFT-2)

Age Related Macular Degeneration

Canada
Azienda Ospedaliera Universitaria Policlinico Paolo...

Completed

Treatment of Polypoidal Choroidal Vasculopathy in Pachychoroid

Choroidal Neovascularization | Choroid Disease

Italy
Sunnybrook Health Sciences Centre

Unknown

PRedictive Factors and Changes From Treatment in iPCV Versus CSR Versus nAMD With afLibercept (PRaCTICAL)

Age Related Macular Degeneration | Central Serous Chorioretinopathy | Idiopathic Poplypoidal Choroidal Vasculopathy

Canada
Al Hadi Hospital

Completed

Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema (MPL)

Diabetic Macular Edema

Kuwait
Sanofi
Regeneron Pharmaceuticals

Completed

Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer

Neoplasms | Cancer of the Ovary

United States, France, Canada, Australia, Germany, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland
Sanofi
Regeneron Pharmaceuticals

Completed

AVE0005 (VEGF Trap) in Patients With Recurrent Symptomatic Malignant Ascites

Ovarian Neoplasms

United States, Italy, Sweden
Sanofi
Regeneron Pharmaceuticals

Completed

Study of AVE0005 (VEGF Trap) in Locally Advanced or Metastatic Platinum- and Erlotinib- Resistant Non-small-cell-lung Adenocarcinoma

Neoplasms, Lung | Pulmonary Diseases

United States, France, Canada
Bayer

Completed

Special Drug Use Investigation of EYLEA for Diabetic Macular Edema

Macular Edema

Japan
Oslo University Hospital

Completed

Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept (Eylea-2014)

Exudative Age-related Macular Degeneration
Bayer
Regeneron Pharmaceuticals

Completed

Special Drug Use Investigation of EYLEA for Myopic Choroidal Neovascularization

Choroidal Neovascularization

Japan
Mabwell (Shanghai) Bioscience Co., Ltd.

Recruiting

Efficacy and Safety of 9MW0813 in Subjects With Diabetic Macular Edema

Diabetic Macular Edema

China
Unity Health Toronto

Completed

Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Diabetic Macular Edema

Diabetic Macular Edema

Canada
Nihon University

Completed

Study of PRN and Every 2months Intravitreal Aflibercept for Age Related Macular Degeneration

Age-related Macular Degeneration

Japan
Larkin Community Hospital

Completed

Role of Intravitreal Aflibercept Injection for the Treatment of Radiation Maculopathy

Adverse Effect of Radiation Therapy
Asan Medical Center

Unknown

The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy

Diabetic Retinopathy

Korea, Republic of
Singapore National Eye Centre
Bayer

Completed

An Open Label-study to Compare the Efficacy of Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy

Age Related Macular Degeneration | Polypoidal Choroidal Vasculopathy

Singapore
Peking Union Medical College Hospital
Bayer

Recruiting

Clinical Implication of Aflibercept in PCV Treatment in China

Polypoidal Choroidal Vasculopathy

China
Bayer

Completed

Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO (CENTERA)

Central Retinal Vein Occlusion

France, Canada, Denmark, Germany, Italy, Spain, United Kingdom, Australia
University of Alexandria

Completed

Aflibercept Plus Micropulse Laser Versus Aflibercept Monotherapy for Diabetic Macular Edema

Diabetic Macular Edema
CR-CSSS Champlain-Charles-Le Moyne
Sanofi; Regeneron Pharmaceuticals; Quebec Clinical Research Organization in Cancer

Terminated

Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Canada
Al Hadi Hospital

Completed

IVI Aflibercept Before and After Phaco in DME.

Diabetic Macular Edema

Kuwait
Unity Health Toronto

Unknown

Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study

Diabetic Macular Edema
Lille Catholic University
Bayer

Completed

Intravitreal Aflibercept InjectiOn in Vitrectomized Eyes for Treatment of Diabetic Macular Edema (MODEVA)

Diabetic Macular Edema

France
Kim's Eye Hospital
Nune Eye Hospital, Seoul, Korea; HanGil Eye Hospital

Not yet recruiting

Choroidal Morphology Changes After Aflibercept Therapy in Pachychoroid Neovasculopathy

Pachychoroid Neovasculopathy
Hellenic Oncology Research Group

Unknown

Trial in Metastatic Colorectal Cancer With FOLFIRI Plus Aflibercept as First Line Treatment (MINOAS)

Metastatic Colorectal Cancer

Greece
Instituto de Olhos de Goiania

Unknown

Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization (AflibxMyopia)

Choroidal Retinal Neovascularization

Brazil
Emory University

Withdrawn

Cataract DME - Peri vs. Intraop

Diabetic Macular Edema | Cataract

United States
Rishi Singh
Regeneron Pharmaceuticals

Completed

Wet Macular Degeneration Study to Compare Ranibizumab or Bevacizumab to Aflibercept

Exudative Macular Degeneration

United States
University of Sydney
Center for Eye Research Australia

Completed

Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) (LADAMO)

Diabetic Retinopathy

Australia
Medical University of Lublin

Completed

Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy.

Eye Diseases | Glaucoma Surgery | Optic Nerve Damage

Poland
Al Hadi Hospital

Completed

Intravitreal Aflibercept Injection or Early Vitrectomy for Diabetic Vitreous Hemorrhage

Diabetic Vitreous Hemorrhage

Kuwait
Samsung Bioepis Co., Ltd.

Completed

A Study to Compare SB15 (Proposed Aflibercept Biosimilar) to Eylea in Subjects With Neovascular Age-related Macular Degeneration (AMD)

Neovascular Age-related Macular Degeneration

Czechia, Estonia, Hungary, Korea, Republic of, Latvia, Poland, United States, Croatia, Japan, Russian Federation
Alvotech Swiss AG

Active, not recruiting

Clinical Study to Compare Efficacy and Safety of AVT06 and EU-Eylea (ALVOEYE) (ALVOEYE)

Neovascular (Wet) AMD

Slovakia, Czechia, Georgia, Japan, Latvia
Mabwell (Shanghai) Bioscience Co., Ltd.

Completed

Safety and Efficacy of 9MW0813 in Subjects With Diabetic Macular Edema

Diabetic Macular Edema

China
SCRI Development Innovations, LLC
Sanofi

Completed

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

Rectal Cancer

United States
John Hays
Sanofi

Unknown

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Stage IV Colon Cancer | Stage IV Rectal Cancer

United States
Regeneron Pharmaceuticals
Bayer

Completed

Safety, Tolerability, and Efficacy of Aflibercept in Patients With Neovascular Age-Related Macular Degeneration (CANDELA)

Neovascular (Wet) Age-Related Macular Degeneration

United States, Puerto Rico
Regeneron Pharmaceuticals
Bayer

Active, not recruiting

Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease (PHOTON)

Type 2 Diabetes Mellitus | Diabetic Macular Edema | Type 1 Diabetes Mellitus

United States, Puerto Rico, Japan, United Kingdom, Canada, Czechia, Germany, Hungary
Vista Klinik

Not yet recruiting

Intravitreal Faricimab in Diabetic Macular Edema With Limited Response to Aflibercept

Diabetic Macular Edema
Barts & The London NHS Trust
Sanofi

Withdrawn

Trial of Aflibercept Monotherapy With DCE-US in Chemorefractory Metastatic Colorectal Cancer (AUSCOR)

Colorectal Cancer
Novartis Pharmaceuticals

Withdrawn

CANadian Study in Patients With Wet AMD, Evaluating the Efficacy and Safety of Switching From Intravitreal Aflibercept to RanIbizumab (CANARI)

Wet Age-related Macular Degeneration (Wet AMD)
Instituto de Olhos de Goiania

Completed

Efficacy of Ranibizumab Therapy With Aflibercept in Patients With Diabetic Macular Edema

Retinal Diseases
Bioeq GmbH

Completed

Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration (MAGELLAN-AMD)

Neovascular Age-related Macular Degeneration

Bulgaria, Italy, Poland, Russian Federation, Hungary, Ukraine, Japan, Israel, Czechia
Cinnagen

Completed

Efficacy and Safety of Aflibercept in Patients With Neovascular Age-related Macular Degeneration

Age-Related Macular Degeneration | Neovascular Age-related Macular Degeneration

Iran, Islamic Republic of

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