Search clinical trials for: anti TNFa

Total 159902 results

University of Calgary
Alimentiv Inc.

Recruiting

PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn's Disease

Crohn Disease

Canada
University Hospital, Montpellier

Recruiting

Study of the Functional Status Neutrophils in Rheumatoid Arthritis Patients to Identify New Biomarkers of Response to Anti-TNFalpha Therapy (NeutroARTherap)

Rheumatoid Arthritis

France
TILT Biotherapeutics Ltd.

Recruiting

Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1 (AVENTIL)

Melanoma | Head and Neck Squamous Cell Carcinoma

United States, Finland
TILT Biotherapeutics Ltd.

Recruiting

TNFα and IL-2 Coding Oncolytic Adenovirus TILT-123 Monotherapy (TUNIMO)

Solid Tumor

Finland
Janssen Research & Development, LLC

Active, not recruiting

A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy (GO-VIVA)

Arthritis, Juvenile

United States, Israel, Mexico, South Africa, Canada, Brazil, Argentina, Russian Federation, Chile
Ataturk University

Completed

Effect of Calcium Silicate Based Root Canal Medicament on Inflammatory Mediators

Periapical; Infection

Turkey
TILT Biotherapeutics Ltd.

Active, not recruiting

TNFalpha and Interleukin 2 Coding Oncolytic Adenovirus TILT-123 During TIL Treatment of Advanced Melanoma (TUNINTIL)

Metastatic Melanoma

France, Denmark
Institut Claudius Regaud

Completed

TNF-Inhibitor as Immune Checkpoint Inhibitor for Advanced MELanoma (TICIMEL)

Melanoma

France
Janssen Research & Development, LLC

Completed

A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis

Colitis, Ulcerative

United States, France, Belgium, Israel, Canada, Netherlands, Austria, Poland, Denmark, Germany
IRCCS Burlo Garofolo

Completed

Infliximab Efficacy in Relation to Therapeutic Drug Monitoring and Serum TNFα Levels in Pediatric HSCT

Acute Graft-versus-host Disease

Italy
Centre Hospitalier Universitaire de Saint Etienne

Terminated

Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps (OIPN)

Nasal Polyps | Chronic Rhinosinusitis With Nasal Polyps | Olfaction Disorders

France
Boston Scientific Corporation

Terminated

A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)

Relapsing Remitting Multiple Sclerosis

Spain, Germany, Belgium, Poland, France, Russian Federation
Philogen S.p.A.
Eudax S.r.l.; InnoPharma Inc.

Completed

Phase 1 Dose-finding Study of L19TNFα Plus Melphalan Using Isolated Inferior Limb Perfusion (ILP) in Subjects With Intransit Stage III/IV Melanoma

Patients With Intransit Stage III/IV Melanoma

Italy
Philogen S.p.A.

Completed

L19TNFα in Combination With Doxorubicin in Patients With Advanced Solid Tumours

Advanced Solid Tumors Amenable to Anthracycline Therapy | Sarcoma, Breast Cancer, Lung Carcinomas, and Gynecological Cancer Amenable to Anthracycline Therapy

Germany, Italy
Sandoz

Completed

Real-world Study of Anti-TNFa Treatment Regimes of Hyrimoz or Zessly in Patients With Crohn´s Disease (GIANT)

Crohn´s Disease

Austria, Germany, Poland, Spain, Sweden
Central Hospital, Nancy, France

Completed

Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences (FISTULE)

Crohn's Disease | Anal Fistula
Mansoura University Children Hospital

Completed

Role of Montelukast in Modulation of Response to Sepsis in Preterm Infants

Neonatal Sepsis

Egypt
Wroclaw Medical University

Completed

Chloroquine as Antiviral Treatment in Coronavirus Infection 2020

COVID-19

Poland
All India Institute of Medical Sciences, New Delhi

Completed

Candida Associated Cytokines in Oral Leukoplakia

Oral Leukoplakia

India
UCB Pharma

Completed

Efficacy Study of CDP870 in Subjects With Chronic Plaque Psoriasis Who Are Candidate for Systemic Therapy and/or Phototherapy/Photochemotherapy

Chronic Plaque Psoriasis

France, Germany
UCB Pharma SA
Parexel

Completed

An Open-label Extension Study of Certolizumab Pegol in Chinese Patients With Rheumatoid Arthritis Who Enrolled in RA0044 (RAPID-C OLE)

Rheumatoid Arthritis

China
Novo Nordisk A/S

Terminated

A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa Biologics

Inflammation | Rheumatoid Arthritis

United States, Mexico, France, Italy, Spain, Argentina, Belgium, Brazil, Czechia, Germany, Hungary, Poland, United Kingdom
CHU de Quebec-Universite Laval

Unknown

Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Canada
UCB Pharma SA, Belgium
Parexel

Completed

A Study of Certolizumab Pegol as Additional Therapy in Chinese Patients With Active Rheumatoid Arthritis (RAPID-C)

Rheumatoid Arthritis

China
Biocad

Completed

First-in-human Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Various Doses of BCD-121 in Healthy Subjects

Healthy
GlaxoSmithKline

Completed

A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability, Immunogenicity, and Pharmacodynamics (PD) of GSK2800528 in Healthy Subjects.

Psoriasis

United Kingdom
Seoul National University Hospital
Chonbuk National University Hospital; Chonnam National University Hospital; Korea... and other collaborators

Terminated

Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFα

Rheumatoid Arthritis | Chronic Hepatitis B | Juvenile Idiopathic Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis

Korea, Republic of
University Hospital, Clermont-Ferrand

Unknown

Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα (OSE-JIA)

Juvenile Idiopathic Arthritis

France
Hoffmann-La Roche
Biogen

Completed

A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies

Rheumatoid Arthritis

Belgium, Germany, Norway, United Kingdom, United States, Ireland, France, Canada, Israel, Netherlands, Italy
Yang Beibei

Completed

Rhupus Syndrome and Efficacy of Etanercept Treatment

Rhupus Syndrome, Etanercept
Ottawa Hospital Research Institute

Completed

TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

COPD Exacerbation
Janssen Pharmaceutical K.K.
Mitsubishi Tanabe Pharma Corporation

Completed

A Safety and Efficacy Study of Golimumab (CNTO148) in Patients With Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis

Japan
Chung Shan Medical University

Unknown

Anti-Tumor Necrosis Factor Therapy In Patients With Ankylosing Spondylitis

Ankylosing Spondylitis

Taiwan
Philogen S.p.A.

Completed

Intratumoral Administration of L19IL2/L19TNF

Malignant Melanoma, Skin

Italy
Neovacs

Completed

Immunogenicity and Safety of TNFa Kinoid in Rheumatoid Arthritis With Secondary Resistance to TNFa Antagonists

Rheumatoid Arthritis

Belgium, France, Bulgaria, Argentina, Croatia, Chile, Romania
Centocor, Inc.
Schering-Plough

Completed

An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy (GO-FORWARD)

Rheumatoid Arthritis

Australia, Poland, United States, Germany, Argentina, Canada, Korea, Republic of, Chile, New Zealand, Taiwan, Mexico, Hungary
Lawson Health Research Institute

Withdrawn

Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Docetaxel (TNFactor)

Breast Cancer

Canada
Janssen Research & Development, LLC

Completed

A Study of the Safety and Efficacy of Ustekinumab in Patients With Psoriatic Arthritis With and Without Prior Exposure to Anti-TNF Agents

Arthritis, Psoriatic

United States, France, Poland, United Kingdom, Germany, Canada, Sweden, Russian Federation, Austria, Hungary
Centocor, Inc.
Schering-Plough

Completed

A Study of the Safety and Efficacy of Golimumab (CNTO 148) in Subjects With Active Rheumatoid Arthritis Previously Treated With Biologic Anti-TNFa Agent(s)

Arthritis, Rheumatoid

United States, Australia, United Kingdom, Germany, Spain, Canada, Finland, Austria, New Zealand, Netherlands
Centocor, Inc.
Schering-Plough

Completed

An Effectiveness and Safety Study of Intravenous Golimumab in Patients With Active Rheumatoid Arthritis Despite Treatment With Methotrexate Therapy

Arthritis, Rheumatoid

Australia, Poland, Ukraine, United States, Argentina, Colombia, Mexico, Korea, Republic of, Malaysia, Russian Federation, New Zealand, Hungary, Lithuania
House Research Institute
Janssen Services, LLC

Terminated

Intratympanic Injection for Autoimmune Inner Ear Disease (AIED)

Autoimmune Inner Ear Disease
University of Pittsburgh
Amgen

Withdrawn

Human Tumor Necrosis Factor Alpha (TNFa)-Induced Pre-B Cell Bone Marrow Emigrants

Rheumatoid Arthritis

United States
Janssen Pharmaceutical K.K.
Mitsubishi Tanabe Pharma Corporation

Completed

A Safety and Efficacy Study of Golimumab (CNTO 148) in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy

Rheumatoid Arthritis

Japan
Heidelberg University
Abbott

Unknown

Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial)

Uveitis

Germany
University of Manitoba
Hoffmann-La Roche

Completed

Treatment of TNFa Naive Patients With Poor Prognosis Rheumatoid Arthritis

Rheumatoid Arthritis

Canada
Philogen S.p.A.
Eudax S.r.l.; InnoPharma Inc.

Completed

L19TNFα in Patients With Advanced Solid Tumors

Colorectal Cancer | Solid Tumors

Italy
Neovacs

Completed

Safety and Immunogenicity of a TNFa Kinoid in Patients With Crohn's Disease

Crohn's Disease

Switzerland, South Africa
University of Athens

Unknown

Inflammatory Mediators in Obstructive Sleep Apnoea Syndrome; Mechanisms of Production and the Effect of Long Term Antioxidants Administration

Obstructive Sleep Apnea Syndrome

Greece
University College Dublin

Unknown

Study Examining the Effect of Exercise in People With Rheumatoid Arthritis Taking Anti-TNFalpha Medication

Arthritis, Rheumatoid

Ireland
ESBATech AG

Completed

Study of ESBA105 Eye Drops in Healthy Subjects

Healthy

Switzerland

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