Search clinical trials for: base editing

Total 40416 results

National Institute of Allergy and Infectious Diseases...

Recruiting

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

Chronic Granulomatous Disease (CGD) | X-Linked Chronic Granulomatous Disease

United States
Verve Therapeutics, Inc.

Not yet recruiting

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Heterozygous Familial Hypercholesterolemia | Premature Coronary Heart Disease
Verve Therapeutics, Inc.

Not yet recruiting

Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular Disease

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease | Heterozygous Familial Hypercholesterolemia

New Zealand, United Kingdom
The 923rd Hospital of Joint Logistics Support Force...
Guangzhou Reforgene Medicine Co., Ltd.

Recruiting

Safety and Efficacy of RM-004 Cells for Hemoglobin H-Constant Spring Disease

Hemoglobinopathies | Hereditary Diseases | Alpha Thalassemia Hemoglobin H Constant Spring

China
HuidaGene Therapeutics Co., Ltd.
Eye & ENT Hospital of Fudan University

Not yet recruiting

a Study in Subjects With Otoferlin Mutation-related Hearing Loss Using RNA Base-eDiting Therapy(SOUND) (SOUND)

Congenital Hearing Loss

China
Beam Therapeutics Inc.

Recruiting

A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)

Lymphoblastic Lymphoma | Lymphoblastic Leukemia | T-Cell Lymphoblastic Leukemia/Lymphoma

United States
Alcediag
Hospital Clinic of Barcelona; Fundacion Clinic per a la Recerca Biomédica; Fundació... and other collaborators

Recruiting

Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers (EDIT-B)

Bipolar Disorder | Major Depressive Disorder

Spain, France, Denmark
Verve Therapeutics, Inc.

Active, not recruiting

A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular Disease

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease | Heterozygous Familial Hypercholesterolemia

New Zealand, United Kingdom
Grupo Lusófona
Centro Hospitalar Universitario do Algarve; Universidade Lusófona de Humanidades... and other collaborators

Not yet recruiting

Home-Combo: an Online Home-based Combined Exercise Intervention for Women With Breast Cancer

Breast Cancer | Chemotherapy Effect

Portugal
The First Affiliated Hospital of Soochow University

Recruiting

Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML

Acute Myeloid Leukemia

China
I.R.C.C.S. Fondazione Santa Lucia

Not yet recruiting

REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study (SCD-ReCODED)

Subjective Cognitive Decline
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites

Rhinitis, Allergic
Duke University

Not yet recruiting

Integration of Mindfulness and Acupuncture After Spine Surgery (I-MASS)

Laminectomy | Single Level Spinal Fusion | Discetomy

United States
Olipop, PBC
BioFortis

Recruiting

Studying Glucose and Appetite Response With Alternatives to Soda Pop (SODA-SWAP)

Healthy Nutrition

United States
Beijing Tiantan Hospital

Not yet recruiting

Efficacy and Safety of Chinese Herbal Formula HuoXue LiShui for Chronic Subdural Hematoma (CHARM)

Chronic Subdural Hematoma

China
KTO Karatay University

Recruiting

Providing Hygiene Education Using the Teach-back Method to Pregnant Women Diagnosed With Urinary Tract Infections

Urinary Tract Infections During Pregnancy

Turkey
Duke University
Temple University

Not yet recruiting

ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments

Amyotrophic Lateral Sclerosis ALS

United States
Xiao-Ming Mao
National Natural Science Foundation of China

Not yet recruiting

Graves' Disease Induced by Epstein-Barr Virus Lytic Reactivation

Graves Disease | Epstein-Barr Virus | Graves' Disease in Remission

China
Koç University

Not yet recruiting

Feasibility and Acceptability of Biofeedback-based Virtual Reality Game for Children

Pediatric Population
Johns Hopkins Bloomberg School of Public Health

Not yet recruiting

Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland (NPH)

Normal Pressure Hydrocephalus | Hakim Syndrome

United States
Ewha Womans University

Not yet recruiting

Development and Feasibility of a Metaverse-based Blended Online Intervention to Prevent Employees' Depression

Depression and Suicide
The Affiliated Hospital Of Guizhou Medical University
Affiliated Hospital of Guizhou Medical University; Chinese nursing association

Recruiting

Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study

Developmental Trajectory of Patients With Post-ICU Syndrome | Development and Application of Post-ICU Syndrome Prediction Model

China
Ping An

Not yet recruiting

A Multimodal Wearable Device-based Study to Evaluate the Efficacy of an Exercise Prescription Intervention in IBD

Inflammatory Bowel Diseases
University Hospital, Basel, Switzerland

Not yet recruiting

Load Limits After Orthopaedic Surgery: Biofeedback vs. Conventional Method (AppPWB)

Surgery

Switzerland
Istanbul University - Cerrahpasa (IUC)

Not yet recruiting

An Intervention on Psychosocial Health in Women With Unsuccessful IVF Experience

Infertility | Failed in Vitro Fertilisation
Istanbul University - Cerrahpasa (IUC)

Recruiting

Effect of Hybrid Simulation Method on Advanced Life Support Application of Nursing Students

Nursing Education | Simulation Training | Advanced Life Support

Turkey
China Medical University Hospital

Recruiting

Integrated Traditional Chinese and Western Medicine to Care for the Late Stage of Mild to Moderate Burns and Scalds

Burns and Scalds

Taiwan
University Hospital, Bordeaux

Not yet recruiting

COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial (COLTRANE)

On-pump Cardiac Surgery | High Risk for Bleeding | Autotransfusion

France
European Association of Urology Research Foundation
National Cancer Institute (NCI); UMC Utrecht; Erasmus Medical Center; University... and other collaborators

Not yet recruiting

Prostate Cancer Awareness and Initiative for Screening in the European Union (PRAISE-U)

Prostate Cancer
Centre Hospitalier Universitaire de Besancon
Groupement Interrégional de Recherche Clinique et d'Innovation

Not yet recruiting

Regorafenib in Combination With Multimodal Metronomic Chemotherapy for Chemo-resistant Metastatic Colorectal Cancers (CARE)

Metastatic Colorectal Cancer

France
Northeastern University
Mark Morris Dance Group

Recruiting

Dance and Energy Expenditure Among Adults With Parkinson's

Parkinson Disease

United States
Samsung Medical Center

Not yet recruiting

Pilot Study for the Validity of a Content-based Information Provision Tool Aimed at Improving the Hospitalization Experience of Liver Transplant Patients

Liver Transplantation | Inpatients
Dartmouth-Hitchcock Medical Center
Dartmouth College; University of Massachusetts, Worcester

Not yet recruiting

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application (SONATA)

Epilepsy | Refractory Epilepsy | Music

United States
Unity Health Toronto
Covenant House Toronto; The Resource Association for Teens (RAFT); StepStones...

Not yet recruiting

Transitioning Youth Out of Homelessness 2.5 (TYOH 2.5)

Homelessness | Youth

Canada
Wake Forest University Health Sciences

Not yet recruiting

Team Based Equity Conscious Telemedicine Approach to Hypertension

Hypertension

United States
University of Alberta
Heart and Stroke Foundation of Canada

Not yet recruiting

Fish Oil, Metformin and Heart Health in PCOS

Cardiovascular Disease | PCOS | Cardiac Hypertrophy | Atherosclerotic Cardiovascular Disease | Atherosclerotic Plaque
DSM Nutritional Products, Inc.
Universiteit Antwerpen

Not yet recruiting

Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosilactobacillus Reuteri AMBV339 on Intestinal and Vaginal Microbiome and Health of Healthy Adult Women (The VIAB2L Project) (VIAB2L)

Microbial Colonization

Belgium
Zeng Jian

Recruiting

A Study Comparing Neoadjuvant Chemoimmunotherapy and Immuno-consolidationafter Compared With Immunoconsolidation After Radical Chemoradiotherapy for Stage III Potentially Resectable NSCLC

Non Small Cell Lung Cancer

China
Mayo Clinic

Not yet recruiting

Insulin and Insulin Pulses During Fasting

PreDiabetes

United States
Instituto Nacional de Cancerologia de Mexico

Recruiting

Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients

Hematologic Neoplasms | Neutropenia

Mexico
Universiteit Leiden
University of Amsterdam; Maastricht University; Utrecht University; VU University... and other collaborators

Recruiting

RCT: the Effectiveness of LifeHack in Improving Mental Wellbeing in University Students.

Depression | Quality of Life | Stress | Anxiety | Resilience | Internet-based Intervention | Mental Wellbeing | Waiting List Control Group

Netherlands
Fundació Eurecat
University Rovira i Virgili

Not yet recruiting

Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers (CIRCAFENOL)

Cardiovascular Diseases | Cholesterol Level, High | Circadian Rhythm Sleep Disorder, Shift Work Type

Spain
H. Lee Moffitt Cancer Center and Research Institute
National Pediatric Cancer Foundation

Recruiting

Generating Novel Translational and Therapeutic Strategies Based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board (pedsETB)

Pediatric Cancer

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Recruiting

Effect of Nigella Sativa in Atorvastatin Treated Hyperlipidaemia

Hyperlipidemia

Bangladesh
Istituto Clinico Humanitas

Not yet recruiting

Efficacy and Safety of Oral Administration of Postibiotic by FOS Fermentation From Lactobacillus Paracasei in the Treatment of Irritable Bowel Syndrome. (prePO23)

IBS - Irritable Bowel Syndrome

Italy
Halic University
Medipol University

Recruiting

Effect of Exergame-Based Exercise on Hamstring and Quadriceps Isokinetic Muscle Parameters

Sedentary Behavior | Muscle Strength | Exergaming

Turkey
MOSS S.p.A.

Not yet recruiting

NovoX®Cup as Primary Dressing After Breast Reduction

Mammaplasty | Wound Healing Disorder | Post-Surgical Complication

Austria
Alexandria University

Recruiting

Mindfulness-based Educational Intervention on Anxiety, Depression, Stress and Quality of Life on Menopausal Woman (mindmenopaus)

Menopause

Egypt
Penelope J. Hallett, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)

Not yet recruiting

Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease

Parkinson Disease

United States
Clinical Nutrition Research Centre, Singapore

Recruiting

Functional and Nutritional Plant-based Mixed Protein Study (FuN Protein Study)

Nutrition, Healthy

Singapore

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