Search clinical trials for: dose tapering

Total 20957 results

VA Office of Research and Development

Recruiting

Dynamic Treatment Regiments for Glucocorticoid Tapering (SMART-RA)

Rheumatoid Arthritis

United States
Universitaire Ziekenhuizen KU Leuven
Fonds voor Wetenschappelijk Reumaonderzoek (FWRO)

Not yet recruiting

Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis (RITUXERA)

Rheumatoid Arthritis

Belgium
Institute of Hematology & Blood Diseases Hospital...
Beijing Health Alliance Charitable Foundation

Recruiting

The Tapering Dose of Luspatercept in Patients With Lower-risk Myelodysplastic Syndromes

Lower Risk MDS Per IPSS-R

China
Nova Scotia Health Authority

Recruiting

Personalization of Opioid Prescription Following Orthognathic Surgery

Pain, Postoperative | Opioid Use Disorder | Patient Satisfaction | Opioid Use | Orthognathic Surgery

Canada
Radboud University Medical Center
Dutch Society of Physicians for Pulmonology and Tuberculosis

Recruiting

Dose Tapering and Early Discontinuation to InCreAse cosT-effectIveness Of Immunotherapy for NSCLC (DEDICATION-1)

NSCLC

Netherlands
University Hospital, Caen
University Hospital, Rouen; Central Hospital Saint Quentin; University Hospital... and other collaborators

Not yet recruiting

Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids Tapering (CORTODOSE)

Giant Cell Arteritis
VA Office of Research and Development

Active, not recruiting

Reducing Use of Sleep Medications Assisted by a Digital Insomnia Intervention (SEDATIVE)

Insomnia

United States
University Health Network, Toronto

Active, not recruiting

Biologic Tapering Study of TNF Inhibitors in Axial Spondyloarthritis (BIOTAPE)

Axial Spondyloarthritis

Canada
University Hospital, Ghent
KU Leuven

Completed

A Non-inferiority Study on Dose Reduction of Adalimumab in Psoriasis Patients Who Are Overtreated

Psoriasis

Belgium
University Hospital, Ghent
KU Leuven; University Ghent

Terminated

Dose Tapering Study of Adalimumab in Psoriasis

Psoriasis Vulgaris

Belgium
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Medical Management of Sleep Disturbance During Opioid Tapering

Sleep Disturbance | Opioid Dependence | Opioid Withdrawal

United States
Assistance Publique - Hôpitaux de Paris

Completed

Personalised Pharmacological Approach to the Tapering of Corticosteroid Doses in Systemic Lupus Patients Treated With Prednisone (DECOR)

Lupus Erythematosus, Systemic

France
Centre de Recherche de l'Institut Universitaire...
Canadian Institutes of Health Research (CIHR)

Completed

Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population (TAPERING)

Health Behavior | Pain, Chronic | Inappropriate Dose of Drug Administered

Canada
Ottawa Hospital Research Institute

Completed

Comparing Tapering Low Dose Dexamethasone to Other Standard of Care Therapies for TAPS in Breast Cancer Patients (REaCT-TAPS)

Pain Syndrome | Early-stage Breast Cancer

Canada
AbbVie

Completed

A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA)

Rheumatoid Arthritis | Musculoskeletal and Connective Tissue Diseases

United States, Australia, Austria, Canada, France, Germany, Greece, Hungary, Ireland, Italy, Netherlands, Spain, Sweden, United Kingdom
Wex Pharmaceuticals Inc.
Premier Research Group plc

Terminated

The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From Chemotherapy Treatment (TTX-CINP-201)

Pain | Neuropathic Pain | Peripheral Neuropathy

United States
Hospital of Prato

Unknown

Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission.

Giant Cell Arteritis

Italy
GlaxoSmithKline

Completed

An Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain DAT and SERT Occupancy,Pharmacokinetics and Safety of Single Oral Doses of GSK1360707, Using 11C- PE2I and 11C-DASB as PET Ligands

Depressive Disorder

United Kingdom
Hoffmann-La Roche

Terminated

A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Severe Active Rheumatoid Arthritis, Comparing Tapering Versus Maintaining the Methotrexate Dosage

Rheumatoid Arthritis

United Kingdom
Eisai Limited

Terminated

A Study to Evaluate the Safety and Tolerability and Explore the Efficacy of Zonisamide as add-on Therapy in Elderly Patients With Refractory Partial Seizures

Epilepsy

United Kingdom, Germany, Hungary, Switzerland, Italy, Netherlands, Poland
Kissei Pharmaceutical Co., Ltd.

Completed

A Single-blind, Dose-tapering Study of KWA-0711 in Patients With Chronic Constipation

Chronic Constipation

Japan
Pfizer

Terminated

Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults

Healthy

United States
Pfizer

Completed

The Effect Of Dose Titration And Dose Tapering On The Tolerability Of DVS SR In Women With Vasomotor Symptoms

Vasomotor Symptoms

Canada, United States
Mohammad Farris Iman Leong Bin Abdullah

Not yet recruiting

Efficacy and Safety of Low-dose Laser Acupuncture on Treating Insomnia Associated With Major Depressive Disorder

Insomnia | Major Depressive Disorder
Alcon Research

Not yet recruiting

A Double-Masked Comparison of FID 123320 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness

Ocular Redness

United States
Mayo Clinic

Not yet recruiting

Deucravacitinib (BMS-986165) for Pityriasis Rubra Pilaris

Pityriasis Rubra Pilaris

United States
Guangzhou Patronus Biotech Co., Ltd.
Yantai Patronus Biotech Co., Ltd.

Not yet recruiting

A Safety and Immunogenicity Trial of a Respiratory Syncytial Virus Vaccine, LYB005 in Healthy Adults

Respiratory Syncytial Virus (RSV) | RSV Infection
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

Safety and Tolerance of Increased Doses of HRS-5346 Tablets in Healthy Subjects

Lipoprotein Disorder Disease
University of Washington

Not yet recruiting

Low Dose Mosunetuzumab for the Treatment of Patients With Indolent B-Cell Lymphoma

Ann Arbor Stage II Follicular Lymphoma | Ann Arbor Stage III Follicular Lymphoma | Ann Arbor Stage IV Follicular Lymphoma | Grade 1 Follicular Lymphoma | Grade 2 Follicular Lymphoma | Grade 3a Follicular Lymphoma | Ann Arbor Stage II Marginal Zone Lymphoma | Ann Arbor Stage III Marginal Zone Lymphoma and other conditions

United States
Fujian Cancer Hospital

Not yet recruiting

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Leptomeningeal Metastasis

China
Brigham and Women's Hospital
University of Utah

Not yet recruiting

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

Opioid Use Disorder
ITM Solucin GmbH

Not yet recruiting

Phase I Trial to Determine the Dose and Evaluate the PK of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors (KinLET)

Lymphoma | CNS Tumor | Solid Tumor, Childhood | Somatostatin Receptor Positive | NET
Sinovac Biotech Co., Ltd

Not yet recruiting

Booster Dose of sIPV Co-administered With MMR and HepA-I.

Poliomyelitis

China
University of Palermo

Not yet recruiting

SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF (DAPA-TONIC)

Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Diabetes Type 2 | Heart Failure Acute
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Not yet recruiting

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Neuroendocrine Carcinoma.

Neuroendocrine Carcinoma

China
Nuritas Ltd

Recruiting

A Study to Determine the Safety and Tolerability of a Range of Doses of PeptiControl in Pre-diabetic Individuals

Overweight | Pre Diabetes

India
West China Hospital

Recruiting

Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients

Lymphatic Malformation

China
National Jewish Health

Not yet recruiting

Enhancing Hypnotic Medication Discontinuation in Primary Care

Insomnia | Hypnotic Dependence
GlaxoSmithKline

Not yet recruiting

A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive

Asthma | Mild Asthma
GlaxoSmithKline

Not yet recruiting

A Study to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152A (Test) or HFA-134A (Reference) in Healthy Participants Aged 18 to 55 Inclusive

Asthma | Healthy Participants

Netherlands
Innovative Molecules GmbH

Recruiting

Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of IM-250 in Healthy Volunteers

Herpes Simplex Virus

Germany
SAb Biotherapeutics, Inc.

Recruiting

A Study to Assess the Safety of SAB-176 to Prevent the Flu, Given IM in Healthy Adults Compared With Placebo (SAB-176-103)

PHA1A

United States
Fujian Shengdi Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of Single and Multiple Doses HRS9531 Tablets in Healthy Subjects

Overweight or Obesity; Type 2 Diabetes

China
HealthPartners Institute
United States Department of Defense; Uniformed Services University of the Health...

Not yet recruiting

Measurement of Insulin Levels in the Cerebrospinal Fluid of Healthy Adults After a Single Intranasal Dose - Middle Age (INI-CSF-MA)

Healthy

United States
Cerevel Therapeutics, LLC

Not yet recruiting

A Trial to Assess the Absorption, Metabolism, Excretion, and Mass Balance of [14C]-Darigabat After a Single Oral Dose in Healthy Male Participants

Healthy Participants

United States
Cairo University

Recruiting

Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.

Perioperative Pain Management

Egypt
Medical University of Vienna
Lund University; Ziekenhuis Netwerk Antwerpen (ZNA); St. Antonius Hospital; Azienda... and other collaborators

Not yet recruiting

Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study (OLIGOMET)

Prostate Cancer | Prostate Cancer Metastatic | Oligometastasis | Prostate Neoplasm | Oligometastatic Disease | Prostate Cancer Metastatic to Bone
Hookipa Biotech GmbH

Not yet recruiting

Safety, Reactogenicity and Immunogenicity of HB-502 and HB-501 Versus Placebo in People With HIV on Suppressive ART

Human Immunodeficiency Virus (HIV) Infection

United States
Sichuan University

Recruiting

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

NSCLC | PD-1 Inhibitor | Leptomeningeal Metastasis | Low Dose Radiotherapy

China
GlaxoSmithKline

Recruiting

A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults

Influenza, Human

United States

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