Search clinical trials for: drug interactions CYP3A4 CYP3A5 midazolam anti-rheumatic agents

Total 259454 results

Pfizer

Completed

CP-690,550 and Midazolam Drug-Drug Interaction Study

Healthy Volunteer

United States
Helwan University
Ain Shams University

Completed

Effect of Genetic Polymorphism on Calcineurin Inhibitors Levels in Egyptian Renal Transplant Patients

Renal Transplantation

Egypt
Karolinska University Hospital
AstraZeneca

Completed

Cholesterol Metabolites as Markers for CYP3A Induction

CYP3A4 Induction

Sweden
Ziqiang Li

Active, not recruiting

Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation

Complete and Accurate Statistical Data of 60 Patients | CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately | Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients | According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the... and other conditions

China
National Science Centre, Poland
Medical University of Warsaw

Recruiting

The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma (FreeTAC)

Kidney Transplant Rejection | Liver Transplant; Complications | Immunosuppression | Metabolism Medication Toxicity | Genetic Predisposition | Kidney Transplant; Complications | Liver Transplant Rejection

Poland
University of Michigan Rogel Cancer Center

Withdrawn

Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype

CYP3A4*22
Inje University

Completed

The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects (CYP3APDE5I)

Healthy Subjects | Pharmacokinetics of Three PDE5Is | Genetic Polymorphic CYP3A5
National Taiwan University Hospital

Unknown

The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism and Other Factors on Tacrolimus Blood Concentration

Liver Transplantation | Kidney Transplantation

Taiwan
Johns Hopkins University

Completed

Polymorphic Effects of Cytochrome P450 3A5 on Pharmacokinetics of Maraviroc and Its Metabolites

Healthy Subjects | Cytochrome P450 CYP3A5 Enzyme Polymorphism | Pharmacokinetics of Maraviroc

United States
Pfizer

Completed

Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects

Pharmacokinetics | Cytochrome P-450 CYP2D6 | CYP3A4 Protein, Human

United States
Indiana University
The National Center for Complementary and Integrative Health

Recruiting

Drug-gene-nutraceutical Interactions of Cannabidiol and Tacrolimus

Kidney Disease, Chronic | CBD | Transplant Complication

United States
Genelex Corporation
Harding University

Completed

Pharmacogenetic Testing Among Home Health Patients

Drug Interaction Potentiation | Adverse Drug Events | Adverse Drug Reactions | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant | Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 Enzyme... and other conditions

United States
KU Leuven

Completed

Long-Term Pharmacokinetics of Tacrolimus in Renal Recipients

Renal Transplantation

Belgium
University Hospital, Geneva

Completed

DAPHNE Study: Direct Anticoagulant PHarmacogeNEtic (DAPHNE)

Anticoagulants and Bleeding Disorders

Switzerland
Chong Kun Dang Pharmaceutical

Completed

CKD-506 Drug-Drug Interaction Study in Healthy Male Subjects

Drug Drug Interaction

Netherlands
Jazz Pharmaceuticals

Completed

Study to Evaluate the Effect of Rifampicin, Ketoconazole, and Omeprazole on the Pharmacokinetics of Sativex

Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Potent Inhibitor of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a CYP2C19...

United Kingdom
AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
Mahidol University
Astellas Pharma Inc

Unknown

Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Concentrations and Outcomes in Thai Transplant Recipients

Kidney Transplant
Inje University

Completed

The Effect of Genetic Polymorphism on Interactions of Clopidogrel and Cilostazol in Healthy Volunteers

Interaction
Zhujiang Hospital

Completed

Drug Interaction Study of Azithromycin and Theophylline

Chronic Obstructive Pulmonary Disease | Asthma

China
Unity Health Toronto

Completed

Renal Function and Pharmacogenetics in Renal Transplant Recipients Converted From Tac BID to Tac OD

Real Function Post Conversion From Prograf to Advagraf | Examin Ethnicity and Pharmacogenetics of the Cohort Requiring Dose Adjustment Post-conversion

Canada
The Second Artillery General Hospital
Capital Medical University; Shanghai Changzheng Hospital; Air Force General Hospital... and other collaborators

Completed

Initial Dosage Range of Tacrolimus by Genotyping in Chinese Renal Transplantation (PSIDRTG)

Renal Transplantation

China
University of Turku
Turku University Hospital; Sanofi; Vaasa Central Hospital, Vaasa, Finland; medbase...

Completed

Study of Usefulness of Genotyping to Predict Docetaxel Exposure and Adverse Events (Docetaxel)

CYP3A Phenotyping | CYP3A5 and MDR1 Genotyping | Docetaxel Toxicity | Associations Between Genetic Data and Docetaxel Toxicity

Finland
Singapore General Hospital

Active, not recruiting

Efficacy of Achieving Early Target Trough Levels of Tacrolimus Using CYP3A5 Guided Dosing Versus Weight-based Dosing in a Multi-ethnic Population of Kidney Transplant Recipients in Singapore

Kidney Transplant Rejection | Kidney Transplant; Complications

Singapore
Bristol-Myers Squibb

Recruiting

A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam

Healthy Participants

United States
The Netherlands Cancer Institute

Completed

CYP3A4 Activity in Patients With Prostate Cancer Versus Male Patients With Other Solid Tumours

Prostate Cancer | Solid Tumor, Adult

Netherlands
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

CYP3A4 Activity and Mineral Homeostasis

Vitamin D and Calcium Homeostasis

United States
Boehringer Ingelheim

Completed

DDI Strong CYP3A4 Inducer

Healthy

Germany
Chiesi Farmaceutici S.p.A.

Recruiting

Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers

Chronic Obstructive Pulmonary Disease

Bulgaria
Chulalongkorn University

Unknown

First Tacrolimus Dose Trough Level is Better Than CYP3A5 Genotyping in Tacrolimus Dose Prediction

Kidney Transplantation Recipients

Thailand
ViiV Healthcare
Pfizer

Completed

THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC

Healthy Subjects

United States
University Hospital Bispebjerg and Frederiksberg

Completed

Metabolism of Chlordiazepoxide in the Treatment of Alcohol Withdrawal Symptoms

Alcohol Withdrawal

Denmark
Pfizer

Completed

A Midazolam Drug Interaction Study With PF-04171327

Healthy Volunteers

United States
Khon Kaen University
National Science and Technology Development Agency, Thailand

Unknown

Clinical Trial in Assigning of Tacrolimus Dosage Regimen According to CYP3A5 Genotype in Kidney Transplant Recipients

Kidney Transplantation

Thailand
Natalia Valadares de Moraes
University of Sao Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo

Enrolling by invitation

Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

Obesity | Bariatric Surgery | Roux-en Y Gastric Bypass

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants

Healthy Participants

United States
Lawson Health Research Institute

Completed

Coffee Interaction With the Antihypertensive Drug Felodipine

Food-Drug Interactions

Canada
Shirley M. Tsunoda

Unknown

Drug Interaction With Envarsus XR and Grapefruit Juice

Kidney Transplant; Complications | Drug Interaction Food
University of Southern Denmark
Odense University Hospital

Completed

Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans

Healthy

Denmark
Pfizer

Completed

Drug-Drug Interaction Study Assessing Effect of Itraconazole on PF-07321332/Ritonavir in Healthy Participants

Healthy Participant

Belgium
Vanda Pharmaceuticals

Completed

Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 Inducer, Rifampin.

Healthy

United States
Eisai Inc.

Completed

Phase 1 Study to Determine the Effect of Lenvatinib (E7080) on the Pharmacokinetics of Midazolam in Subjects With Advanced Solid Tumors

Tumors

United States
Rennes University Hospital

Completed

Immunosuppressive Therapy Optimization: Development of a Population Pharmacokinetic-pharmacodynamic (PK-PD) Model in Liver Transplantation (OPTILTH)

Liver Transplantation

France
Seoul National University Hospital

Unknown

Influence of CYP3A5 Polymorphism on Liver Function Abnormality and the Trough Level Change After Conversion

Liver Dysfunction

Korea, Republic of
Rennes University Hospital

Completed

Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)

Hepatic Transplantation

France
Pfizer

Completed

Drug-Drug Interaction Study Assessing Effect of Carbamazepine on PF-07321332 Boosted With Ritonavir

Healthy Participant

United States
LI YAN

Completed

Effect of Azole/Echinocandin Use on Tacrolimus Pharmacokinetics

Kidney Transplant Patients

China
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

A Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Healthy Volunteers

United States
Odense University Hospital
Novartis; Danish Research Agency

Completed

Induction of Drug Metabolism: In Vivo Comparison of Carbamazepine and Oxcarbazepine.

Metabolic Clearance Rate

Denmark

Search clinical trials for: drug interactions CYP3A4 CYP3A5 midazolam anti-rheumatic agents

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