Search clinical trials for: gene-modified Stem Cells

Total 23827 results

Memorial Sloan Kettering Cancer Center

Active, not recruiting

Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Leukemia | Acute Lymphoblastic Leukemia

United States
Universitätsklinikum Hamburg-Eppendorf

Terminated

High-dose Chemotherapy With Transplantation of Gene-modified Haematopoietic Stem Cells for HIV-positive Patients With Malignant Diseases Indicating an HSCT

HIV Infections | AIDS-related Lymphoma

Germany
Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
The First Affiliated Hospital of Soochow University

Not yet recruiting

Evaluate the Distribution and Dynamic Behavior of TH-SC01 Cells in Vivo in Patients With Perianal Fistula

Crohn's Disease | Anal Fistula | Complex Perianal Fistulas
Shandong Qilu Stem Cells Engineering Co., Ltd.
Qilu Children's Hospital of Shandong University

Recruiting

Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases

Bronchopulmonary Dysplasia | Hypoxic-Ischemic Encephalopathy | Short Bowel Syndrome

China
Cell Energy Life Sciences Group Co. LTD
Beijing 302 Hospital

Recruiting

Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases

Lung Injury

China
M.D. Anderson Cancer Center
RUNX1 Foundation

Recruiting

Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder

RUNX1 Familial Platelet Disorder

United States
Sun Yat-sen University

Recruiting

Safety & Efficacy of Peg-ASP-based CCRT in Early Stage ENKTL (ENKTL)

Extranodal NK/T-cell Lymphoma

China
University of Missouri-Columbia

Recruiting

Baker Gordon Syndrome Natural History Study (BAGOS)

Epilepsy, Generalized | Sleep Disorder | Rare Diseases | Development Delay | Motor Delay | Autism or Autistic Traits | SYT-SSX Fusion Protein Expression

United States
Beijing Tiantan Hospital

Not yet recruiting

Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma (CSAγδTBMG)

Medulloblastoma | GBM | DIPG Brain Tumor

China
Eyestem Research Pvt. Ltd.

Not yet recruiting

Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.

Eye Diseases | Age-Related Macular Degeneration | Macular Degeneration | Geographic Atrophy | Retinal Disease
The First Affiliated Hospital of Soochow University
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd; Suzhou Hongci Hematology...

Recruiting

Clinical Study of CAR-T Cell Therapy Following ASCT for R/R B-cell Non-Hodgkin's Lymphoma

Lymphoma, B-Cell | Autologous Stem Cell Transplantation

China
The First Affiliated Hospital of Soochow University
First Affiliated Hospital Xi'an Jiaotong University; Ruijin Hospital; Wuhan Union... and other collaborators

Recruiting

Haplo-cord HCT vs. Haplo-HCT for T-ALL Patients

Haploidentical Hematopoietic Stem Cell Transplantation | Cord Blood | Acute T Cell Lymphoblastic Leukemia

China
Ruijin Hospital

Not yet recruiting

CAR-T Following ASCT for Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (R/R B-NHL) With High-Risk Prognostic Factors

B-NHL, Extranodal, TP53 Alterations, Bulky Mass
Johns Hopkins University
ON Foundation

Not yet recruiting

Varying Bone Marrow-Derived Mesenchymal Stem Cells Concentrations' Impact on Rotator Cuff Repair Outcomes

Rotator Cuff Tears

United States
Center of New Medical Technologies

Not yet recruiting

Nanofat Grafting as a Method of Treating Critical Limb Ischemia

Limb Ischemia

Russian Federation
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness

Glioma | Glioblastoma | Glioma Glioblastoma Multiforme

Italy
Casa Sollievo della Sofferenza IRCCS
Ministry of Health, Italy

Recruiting

Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) (STEMALS)

Amyotrophic Lateral Sclerosis

Italy
Beijing GoBroad Hospital

Recruiting

Clinical Trial of CD19 and CD22 CAR Sequential Therapy Versus Single CD19 CAR Bridging to HSCT for r/r B-ALL Patients

Acute Lymphoblastic Leukemia, in Relapse | B-cell Acute Lymphoblastic Leukemia | Refractory Acute Lymphoid Leukemia

China
Suping ZHANG

Recruiting

Blinatumomab for Relapsed Acute B Lymphoblastic Leukemia After Transplantation

Acute B-cell Lymphoblastic Leukemia

China
ENCell

Recruiting

Evaluate the Safety and Efficacy of EN001 in Patients With Charcot-Marie-Tooth Disease Type 1A

Charcot-Marie-Tooth Disease Type 1A

Korea, Republic of
ENCell

Not yet recruiting

Evaluate the Efficacy and Safety of EN001 in Patients With Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Recruiting

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

Chronic Granulomatous Disease (CGD) | X-Linked Chronic Granulomatous Disease

United States
Senti Biosciences

Recruiting

SENTI-202: Off-the-shelf Logic Gated CAR NK Cell Therapy in Adults With CD33 and/or FLT3 Blood Cancers Including AML/MDS

AML/MDS | CD33 Expressing Hematological Malignancies | FLT3 Expressing Hematological Malignancies

United States, Australia
Beijing GoBroad Hospital

Not yet recruiting

CD5 Chimeric Antigen Receptor (CAR) T Cells in Subjects With Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia, in Relapse | Refractory Acute Lymphoblastic Leukemia | T-Cell Acute Lymphocytic Leukemia
Centre Hospitalier Universitaire de Liege

Recruiting

Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease?

Efficacy | Safety Issues

Belgium
MedRegen LLC

Not yet recruiting

MRG-001 in Patients With Amyotrophic Lateral Sclerosis

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Lou Gehrig Disease | Motor Neuron Atrophy
MedRegen LLC
Vanderbilt University Medical Center

Not yet recruiting

MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients (SUMMIT)

Respiratory Tract Diseases | Respiratory Failure | Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome | Cytokine Storm
MedRegen LLC

Not yet recruiting

MRG-001 in Patients With Alcoholic Hepatitis

Alcoholic Hepatitis | Acute Alcoholic Hepatitis
Fundación Oftalmológica de Santander Clínica Carlos...
Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud - IDCBIS

Not yet recruiting

Sequential Administration of WJ-MSCs for the Treatment of GvHD Refractory to Second Line Treatment (GvHD)

Graft Versus Host Disease
Liaocheng People's Hospital

Recruiting

Platelet Rich Plasma Combined With Human Umbilical Cord Mesenchymal Stem Cells for Stage 3 and 4 Stress Injury

Pressure Injuries - Stage 3 | Pressure Injuries - Stage 4

China
University of Southern Denmark

Not yet recruiting

Tissue Therapy of Transsphincteric Anal Fistula (REP-PAF)

Anal Fistula

Denmark
Bioray Laboratories
First Affiliated Hospital of Guangxi Medical University

Not yet recruiting

Clinical Study of BRL-101 in Severe SCD

Sickle Cell Disease

China
abdulmajeed hammadi

Recruiting

Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells (alfarah)

Premature Ovarian Insufficiency

Iraq
Suhu Liu

Recruiting

Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)

Acute Myeloid Leukemia

United States
Bioray Laboratories
Chinese Academy of Medical Sciences

Not yet recruiting

Clinical Study on the Safety and Efficacy of BRL-101 in the Treatment of Sickle Cell Disease

Sickle Cell Disease
Bioray Laboratories
Nanfang Hospital, Southern Medical University

Not yet recruiting

Clinical Study of BRL-101 in the Treatment of Sickle Cell Disease

Sickle Cell Disease
Sanjeet S. Grewal

Not yet recruiting

Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery

Epilepsy
China-Japan Friendship Hospital

Not yet recruiting

Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD

Chronic Obstructive Pulmonary Disease
Fundacion para la Investigacion Biomedica del Hospital...

Recruiting

Use of Mesenchymal Stem Cells in Pre-term Patients With Bronchopulmonary Dysplasia.

Bronchopulmonary Dysplasia

Spain
Tasly Pharmaceutical Group Co., Ltd

Recruiting

A Study of the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression

Depression

China
Nantes University Hospital

Not yet recruiting

Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation (CY-MET-RIC)

Hematologic Malignancy | Graft Versus Host Disease
University of Florida
Oligo Nation, Inc

Not yet recruiting

ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients (ADAGiO)

Recurrent Oligodendroglioma | Progressive Oligodendroglioma

United States
Seoul National University Hospital

Recruiting

Treatment of CD19 Chimeric Antigen Receptor T Cells for Pediatric Patients With CD19-positive B-cell Acute Lymphoblastic Leukemia Who Are Indicated for Hematopoietic Stem Cell Transplantation

Very High Risk Acute Lymphoblastic Leukemia | CD19 CAR-T Therapy

Korea, Republic of
Wuhan Union Hospital, China

Not yet recruiting

UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia

Infections | Acute Myeloid Leukemia | Anemia | Bleeding | Thrombocytopenia | Neutropenia
General Hospital of Shenyang Military Region

Not yet recruiting

Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD

End-Stage Liver DIsease

China
Wuhan Optics Valley Vcanbiopharma Co., Ltd.

Recruiting

Safety, Tolerability and Efficacy of VUM02 Injection in Treatment of Idiopathic Pulmonary Fibrosis (IPF) (DEVIF-I)

Idiopathic Pulmonary Fibrosis

China
Supergenics Life Science Sdn. Bhd.

Not yet recruiting

Safety and Efficacy of Stem Cells for Diabetic Foot Ulcer

Diabetic Foot Ulcer
Samsung Medical Center

Not yet recruiting

Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E

Charcot-Marie-Tooth Disease, Type 1
CellinCells

Recruiting

Safety and Tolerability of Autologous Adipose-derived Mesenchymal Stem Cells Therapy in Adults With Atrophic Scars

Atrophic Scar

Korea, Republic of
Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain (STEMCAP-1)

Chronic Pain | Chronic Pancreatitis

United States

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