Search clinical trials for: long-acting muscarinic antagonist

Total 33737 results

Erasme University Hospital

Completed

Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD

Pulmonary Disease, Chronic Obstructive

Belgium
GlaxoSmithKline

Completed

A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States, Germany, Czechia
GlaxoSmithKline

Completed

A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Germany, United States, Netherlands, Czechia
Daping Hospital and the Research Institute of Surgery...

Completed

Personalized Variable Versus Fixed Dose Glucocorticoid Therapy in AECOPD

Chronic Obstructive Pulmonary Disease

China
GlaxoSmithKline

Completed

Safety and Tolerability of Repeat Dosing of GSK233705/GW642444 in COPD

Pulmonary Disease, Chronic Obstructive

United States
GlaxoSmithKline

Completed

A 24 Week Efficacy Study of Inhaled Umeclidinium (UMEC) in Patients of Chronic Obstructive Pulmonary Disease (COPD) Using a Novel Dry Powder Inhaler (NDPI)

Pulmonary Disease, Chronic Obstructive

China, Korea, Republic of
AstraZeneca
Parexel

Completed

Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871

Chronic Obstructive Pulmonary Disease COPD

Germany, United Kingdom
Laval University
Novartis

Completed

Ultibro® Versus Spiriva® Alone to Reduce Exertional Dyspnea in Patients With Moderate to Severe COPD (RED)

COPD

Canada
AstraZeneca
Parexel

Completed

Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects

Chronic Obstructive Pulmonary Disease

United Kingdom
GlaxoSmithKline

Completed

A 52-Week, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Safety and Tolerability of GSK573719/GW642444 and GSK573719 in Subjects With Chronic Obstructive Pulmonary Disease (COPD) (COPD nDPI)

Pulmonary Disease, Chronic Obstructive

United States, Russian Federation, Chile, South Africa, Romania, Slovakia
GlaxoSmithKline

Completed

A 12-week Study to Evaluate the Efficacy and Safety of Umeclidinium 62.5 Microgram (mcg) Compared With Glycopyrronium 44 mcg in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Argentina, Germany, Romania, Russian Federation, Chile, Sweden, Spain, Hungary, Czechia, Norway
AstraZeneca
Parexel

Completed

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

Chronic Obstructive Pulmonary Disease - COPD

United States
GlaxoSmithKline

Completed

24-week Trial Comparing GSK573719/GW642444 With GW642444 and With Tiotropium in Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United States, Russian Federation, Ukraine, Germany, Peru, Poland, France, Romania, Italy, Mexico
GlaxoSmithKline

Completed

A 12-week Study to Evaluate the Efficacy and Safety of Umeclidinium Compared With Tiotropium in Subjects With Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

Argentina, Germany, Russian Federation, Ukraine, United States, South Africa, Korea, Republic of, Romania, Canada, France, Italy, Chile, Denmark
GlaxoSmithKline

Completed

A Phase IIIb Study to Evaluate the Efficacy of Umeclidinium/Vilanterol (UMEC/VI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States, Romania, Russian Federation, Ukraine, Germany, Hungary, Bulgaria
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Combination of GSK573719 and GW642444 in Subjects With COPD

Pulmonary Disease, Chronic Obstructive

United States
AstraZeneca
Parexel; Covance; The Doctors Laboratory; Industrias Farmacéuticas Almirall S.A.

Completed

Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Male Japanese Subjects

Chronic Obstructive Pulmonary Disease - COPD

United Kingdom
Wouter H. van Geffen
Novartis; University Medical Center Groningen

Completed

Single Dose Ultibro Breezhaler by Sd-DPI Versus Ipratropium/Salbutamol by Nebulizer in COPD (ULT01)

COPD

Netherlands
GlaxoSmithKline

Completed

24-week Trial Comparing GSK573719/GW642444 With GSK573719 and With Tiotropium in Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

Argentina, Australia, United States, Germany, Chile, Korea, Republic of, Mexico, Canada, South Africa, Romania
GlaxoSmithKline

Completed

Cross-Over Study in Subjects With COPD, Evaluating Lung Function Response After Treatment With Once Daily Umeclidinium 62.5mcg, Vilanterol 25mcg, and Umeclidinium/Vilanterol 62.5/25mcg

Pulmonary Disease, Chronic Obstructive

Germany, Estonia
AstraZeneca

Completed

The Study Will Evaluate the Effect of AZD8683 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD)

Poland
AstraZeneca

Completed

The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease (LaCrossE)

Chronic Obstructive Pulmonary Disease

Sweden
Hospital San Carlos, Madrid

Recruiting

Efficacy and Safety of Atropine and DIMS Lenses in Controlling Myopia in Children: A Randomized Clinical Trial. (DIMS)

Myopia

Spain
ASST Fatebenefratelli Sacco

Not yet recruiting

A Study to Investigate the Analgesic Efficacy of Ibuprofen Alone and Ibuprofen Plus Hyoscine-n- Butyl Bromide in Reducing Pain of Outpatient Hysteroscopy

Pain
National Taiwan University Hospital

Not yet recruiting

Sugammadex v.s. Neostigmine/Glycopyrrolate

Head and Neck Neoplasms | Chronic Sinusitis | Chronic Otitis Media

Taiwan
Post Graduate Institute of Medical Education and...

Not yet recruiting

A RCT to Compare the Effectiveness of Nebulized Anticholinergics for Cough Suppression During Flexible Bronchoscopy (NAFCOF)

Subjects Undergoing Flexible Bronchoscopy

India
AstraZeneca

Recruiting

Change in Patient-repOrted Outcomes in COPD Patients Newly Initiated on TRIXEO AEROSPHERE in Real worlD (COnCORD)

Chronic Obstructive Pulmonary Disease (COPD)

Romania
Biomedical Advanced Research and Development Authority
Rho Federal Systems Division, Inc.; Allucent

Not yet recruiting

Sublingual Atropine Bioequivalence by Route of Administration (SABER) (SABER)

Atropine Bioequivalence

United States
The Hong Kong Polytechnic University
The University of Hong Kong

Not yet recruiting

Combination Effect of Optical Defocus and Low Dose Atropine in Myopia Control

Myopia

Hong Kong
James J. Peters Veterans Affairs Medical Center

Recruiting

Transdermal Administration by a Novel Wireless Iontophoresis Device

Constipation | Spinal Cord Injuries | Neurogenic Bowel | Fecal Incontinence

United States
Ain Shams University

Recruiting

Gabapentin Versus Trospium Chloride for Prevention of a Catheter-related Bladder Discomfort Inside the ICU

Catheter-related Bladder Discomfort (CRBD)

Egypt
Essilor-Polylite Taiwan Co., Ltd.

Recruiting

Stellest Lenses and Low-concentration Atropine Myopia Control Among Children

Myopia

Taiwan
AstraZeneca
Parexel

Not yet recruiting

A Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C)

Healthy

Germany
Kasr El Aini Hospital

Recruiting

Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.

Dexmedetomidine | Intubation Complication

Egypt
AstraZeneca

Recruiting

A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C).

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom
China Medical University Hospital

Not yet recruiting

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

Obstructive Sleep Apnea of Adult
The Hong Kong Polytechnic University
The University of Hong Kong

Recruiting

Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate

Myopia

Hong Kong
Ain Shams University

Not yet recruiting

Low Dose Atropine Eye Drops in Myopic Egyptian Children (LAMP)

Myopia Progression | Axial Length, Eye | Sclera Thickness

Egypt
McGill University
Université de Montréal

Not yet recruiting

A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS

Amyotrophic Lateral Sclerosis

Canada
Eurofarma Laboratorios S.A.

Not yet recruiting

Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR) (TRIPLAR)

Chronic Obstructive Pulmonary Disease

Brazil
Aarhus University Hospital
University of Aarhus; Central Denmark Region; Vejle Hospital; TrygFonden, Denmark; Aalborg University Hospital and other collaborators

Recruiting

Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder (EDULOX)

Functional Disorder

Denmark
Matias Vested

Recruiting

Neostigmine/Glyco-pyrrolate 50 Mikrogram/kg or Sugammadex 2 mg/kg for Reversal of Neuromuscular Blockade in Elderly Patients

Neuromuscular Blockade, Residual

Denmark
Lakehead University

Recruiting

Over-the-Counter Antihistamines & Heat Stress

Allergic Rhinitis | Heat Illness | Heat Injury | Sudomotor Sympathetic Dysfunction

Canada
Rhendra Hardy Mohamad Zaini

Recruiting

Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery

Pulmonary Function; Newborn, Abnormal | Atelectasis, Postoperative

Malaysia
National Taiwan University Hospital

Not yet recruiting

Association With Low Compliance Bladder in Women With LUTS

Urinary Bladder, Overactive | Urinary Incontinence | Pelvic Organ Prolapse | Urinary Bladder Neck Obstruction

Taiwan
Xing Liu

Recruiting

Efficacy and Safety of Vitamin D in the Treatment of OAB-wet in Children

Overactive Bladder | Urinary Bladder, Overactive | Urinary Incontinence, Urge

China
National Yang Ming Chiao Tung University Hospital

Not yet recruiting

Early Intervention for Premyopic Children

Myopia | Preschool
Mackay Memorial Hospital

Recruiting

Efficacy of Combined Pharmacotherapy Versus Solifenacin With Vaginal Estrogen Cream for Women With Detrusor Overactivity

Urinary Bladder, Overactive | Effect of Drug

Taiwan
Seoul National University Hospital
Il-Yang Pharm. Co., Ltd.

Not yet recruiting

A Trial Evaluating the Clinical Efficacy and Safety of Hibero SR (Mirabegron) 50 mg and Ditropan (Oxybutynin Chloride) 10 mg in Children Between 5 and 18 Years With Overactive Bladder (OAB)

Overactive Bladder

Korea, Republic of
Jeanette Du

Not yet recruiting

Low Dose Atropine for Symptomatic Vitreous Floaters

Vitreous Floaters

United States

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