Search clinical trials for: maximum tolerable dose

Total 21149 results

ViiV Healthcare
GlaxoSmithKline

Not yet recruiting

First Time in Human Study of Long Acting VH4524184 Formulations

HIV Infections

United States
University of Arkansas
University of Iowa

Not yet recruiting

High Dose Ascorbic Acid (HDAA) in Patients With Plasma Cell Disorders

Plasma Cell Disorder
Intelligem Therapeutics Australia Pty Ltd.

Not yet recruiting

A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney Disease

Hyperuricemia | Hypouricemia, Renal
Xentria, Inc.

Not yet recruiting

Single Dose, Three-arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia®

Healthy Participants
AstraZeneca

Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of a Single Ascending Dose of AZD0292 In Healthy Participants

Healthy Participants Study

United States
Tanta University

Recruiting

Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock

Hemorrhagic Shock | Norepinephrine | Hypotensive Resuscitation

Egypt
Sohag University

Recruiting

Syndesmotic Screw in Neutral Position Versus Maximum Ankle Dorsiflexion in Ankle Fractures; Comparative Study.

Syndesmotic Injuries

Egypt
Shanghai Henlius Biotech

Not yet recruiting

A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Escalation Phase I Clinical Study to Assess the Safety, Pharmacokinetics, and Immunogenicity of HLX6018 in Healthy Subjects

IPF
Shanghai Henlius Biotech

Not yet recruiting

A Randomized, Single Intravenous Dose, Parallel Phase I Clinical Study to Compare the Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX05 Vs. Erbitux® (Cetuximab) in Healthy Adult Male Chinese Subjects

EGFR Overexpression
AstraZeneca
Parexel

Not yet recruiting

Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma (ACADIA)

Asthma

United States
MedRegen LLC
Vanderbilt University Medical Center

Not yet recruiting

MRG-001 as an Immunoregulatory and Regenerative Therapy for ARDS Patients (SUMMIT)

Respiratory Tract Diseases | Respiratory Failure | Acute Respiratory Distress Syndrome | Respiratory Distress Syndrome | Cytokine Storm
Brigham and Women's Hospital
Boston Scientific Corporation

Not yet recruiting

Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE (SONIC-PE)

Pulmonary Embolism | Right Ventricular Dysfunction | Right Ventricular Failure
Incyte Corporation

Recruiting

A Study Assessing the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]INCB099280 in Healthy Male Participants

Healthy Participants

United Kingdom
Boehringer Ingelheim

Recruiting

A Study in Healthy Japanese Men to Test How Well Different Doses of BI 3006337 Are Tolerated

Healthy

Japan
Gilgamesh Pharmaceuticals

Recruiting

A Clinical Study to Evaluate of Single and Multiple Oral Doses of GM-1020 in Patients With MDD

Major Depressive Disorder

United Kingdom
Omar Mahmoud

Not yet recruiting

Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly ((DACHOC-E))

Frailty | Oropharynx Cancer
Zhejiang Haichang Biotech Co., Ltd.

Not yet recruiting

Phase 2 Study of WGI-0301 in Combination With Sorafenib for Advanced HCC

Advanced Hepatocellular Carcinoma (HCC)
M.D. Anderson Cancer Center
Elevar Therapeutics

Not yet recruiting

A Phase II Study of Rivoceranib for Patients With Recurrent or Metastatic Olfactory Neuroblastoma

Metastatic Olfactory Neuroblastoma | Recurrent Olfactory Neuroblastoma

United States
Second Affiliated Hospital of Wenzhou Medical University

Not yet recruiting

Effect of Esketamine on 95% Induction Dose of Remimazolam (EEIDR)

Sedation | Pediatric | Gastroscopy | ED95

China
James Tarbox, MD
Texas Tech University Health Sciences Center

Recruiting

Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge

Penicillin Allergy

United States
OX2 Therapeutics

Recruiting

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent High Grade Glioma

United States
Hospital for Special Surgery, New York

Not yet recruiting

Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome (LDN-CRPS)

Chronic Pain | Complex Regional Pain Syndrome | Causalgia | Complex Regional Pain Syndrome Type I | Complex Regional Pain Syndrome Type II

United States
Transcend Therapeutics

Recruiting

A Single, Ascending Dose Evaluation of the Safety, Pharmacokinetics of Methylone in Healthy Subjects

Post Traumatic Stress Disorder

Australia
Royal North Shore Hospital

Not yet recruiting

De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) (DE-RADIATE)

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Australia
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Recruiting

A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma

China
Iama Therapeutics S.r.l.

Recruiting

IAMA-6 Oral Dose Study in Healthy Adults

Neurodevelopmental Disorders

Italy
Vertex Pharmaceuticals Incorporated

Recruiting

A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA)

Cystic Fibrosis

United States
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease (PPi-DIA)

Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control

France
IRCCS Sacro Cuore Don Calabria di Negrar

Recruiting

Understanding Adaptive Immune Response After COVID-19 Vaccination Boosters to Improve Vaccination Strategies in Vulnerable Groups. (COVaxFragile)

COVID-19

Italy
Assiut University

Not yet recruiting

Treatment of Ectopic Pregnancy by Low Dose of Methotrexate

Ectopic Pregnancy
SURGE Therapeutics

Not yet recruiting

SRG-514 Administered Intraoperatively to Patients Undergoing Breast-conserving Cancer Surgery

Breast Cancer
A.O.U. Città della Salute e della Scienza

Recruiting

Effectiveness of a Single Dose of Betamethasone in Children With Symptomatic Adenovirus Infection (Adeno-beta)

Adenovirus

Italy
Oslo University Hospital
Haukeland University Hospital; St. Olavs Hospital; Norwegian University of Life...

Not yet recruiting

RAdiotherapy With FDG-PET Guided Dose-PAINTing Compared With Standard Radiotherapy for Primary Head and Neck Cancer-3 (RADPAINT-3)

Head and Neck Cancer | Radiotherapy Side Effect
Gustave Roussy, Cancer Campus, Grand Paris
Daiichi Sankyo

Recruiting

Dose-Expansion Modular Study To Explore the Safety, Tolerability, and Anti-tumor Activity of HER3- DXd Monotherapy and Combinations in Patients With Inoperable Advanced Breast Cancer (ABC) After Progression on T-DXd (ICARUSBREAST02)

Advanced Breast Cancer | HER2-positive Metastatic Breast Cancer | Breast Cancer Metastatic | HER2 Low Breast Carcinoma

France
AstraZeneca

Recruiting

A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C).

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Personalized Medication Software for BCL-2 Inhibitor in AML Patients Using Machine Learning and Genomics

Acute Myeloid Leukemia
Murdoch Childrens Research Institute

Recruiting

Analysing HIgh Dose Probiotic Peanut Oral Immunotherapy (PPOIT) and High Dose Peanut Oral Immunotherapy (OIT) Versus LOw Dose Peanut OIT for Peanut Allergy (HILO)

Peanut Allergy

Australia
Longbio Pharma

Recruiting

A Study of Single and Multiple Doses of LP-005 in Healthy Adult Participants

Paroxysmal Nocturnal Hemoglobinuria (PNH)

China
Centre Hospitalier Universitaire Vaudois
Unisanté Centre universitaire de médecine générale et santé publique; FORCE...

Not yet recruiting

Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance (DAR-ARC)

Febrile Neutropenia

Switzerland
Air Force Military Medical University, China

Not yet recruiting

ED50 of Esketamine for Laser Treatment in Children (ESCALATE)

Anesthesia
Second Hospital of Shanxi Medical University

Recruiting

the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People

Knee Arthroplasty | Sedation | ED95

China
University of Toronto
Unity Health Toronto

Recruiting

A Dose Response Investigation of Docosahexaenoic Acid (DHA) (DRI-DHA)

Nutrition, Healthy

Canada
University of Monastir

Not yet recruiting

Efficacy and Safety of Intravenous Diazepam Given at 2 Different Doses Compared to Placebo in Acute Peripheral Vertigo (Vertigo)

Vertigo, Peripheral
University of Utah
National Cancer Institute (NCI); Kaiser Permanente; University of Arizona; Sea...

Not yet recruiting

PREVENT HPV-Related Cancers (PREVENT)

Vaccine Hesitancy | HPV Vaccination | Vaccine Refusal | Vaccine; Uptake | Vaccination; Series Completion

United States
University Hospital Tuebingen

Not yet recruiting

First-in-man Single-dose and Multiple Dose Study to Evaluate the Safety, Tolerability and Efficacy ofHY-133 (HY-133)

Staphylococcus Aureus
University Hospital, Rouen

Not yet recruiting

Efficacy of Glutamine Supplementation in Patients Suffering From Irritable Bowel Syndrome With Impaired Intestinal Permeability (MISSISIIPI)

Irritable Bowel Syndrome
Boryung Pharmaceutical Co., Ltd

Recruiting

A Study to Compare the Pharmacokinetics and the Safety Between a Fixed-dose Combination Administration of "BR3005" and Co-administration of "BR3005-1" and "BR3005-2" Under Fasting Conditions in Healthy Adult Volunteers

Type 2 Diabetes Mellitus

Korea, Republic of
Boryung Pharmaceutical Co., Ltd

Recruiting

A Study to Compare the Pharmacokinetics and the Safety Between a Fixed-dose Combination Administration of "BR3005" and Co-administration of "BR3005-1" and "BR3005-2" Under Fed Conditions in Healthy Adult Volunteers

Type2 Diabetes Mellitus

Korea, Republic of
air up GmbH
Citruslabs

Recruiting

A Three-Group Study to Examine the Efficacy of the Air up® Drinking System at Improving Hydration and Associated Health Outcomes

Water Intake

United States
Yonsei University

Recruiting

The Appropriate Remifentanil Dose for Optimal Insertion of Laryngeal Mask Airway in Adult Patients During Induction of General Anesthesia Using Remimazolam.

Adult, Laryngeal Masks, Remimazolam, Remifentanil

Korea, Republic of

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