Search clinical trials for: modified release

Total 6632 results

Leiden University Medical Center
NMD Pharma A/S

Recruiting

Pyridostigmine and Amifampridine for Myasthenia Gravis (IMPACT-MG)

Myasthenia Gravis

Netherlands
Overseas Pharmaceuticals, Ltd.
Virginia Contract Research Organization Co., Ltd.

Recruiting

RCT, Blinded, 2-Arm Efficacy Study of IP and Placebo in Patients With Chronic Pain Related to Osteoarthritis of the Knee

Degenerative Arthritis

United States
Jonsson Comprehensive Cancer Center
Novartis; Seagen Inc.

Recruiting

Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC... and other conditions

United States
University of Michigan
Food and Drug Administration (FDA)

Recruiting

Pharmacokinetic Study of Single-Dose Modified Release Glipizide in Healthy Volunteers

Human Gastrointestinal Physiology Data

United States
Neutec Ar-Ge San ve Tic A.Ş

Recruiting

Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.

Sinusitis | Rhinosinusitis | Sinus Infection | Sinusitis, Acute | Rhinosinusitis Acute

Turkey
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens (CORRECT)

Diabetic Retinopathy

China
Alexion Pharmaceuticals, Inc.

Completed

A Study to Investigate the Pharmacokinetic Profile of ALXN2050 Modified Release Prototype Formulations and Immediate Release Reference Tablet in Healthy Adult Participants

Healthy Participants

United Kingdom
Astellas Pharma Europe Ltd.

Active, not recruiting

Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®

Liver Transplantation | Kidney Transplantation | Heart Transplantation | Lung Transplantation | Intestine Transplantation

Belgium, Czechia, France, Germany, Italy, Poland, United Kingdom
Diurnal Limited

Completed

Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency (CHAMPAIN)

Primary Adrenal Insufficiency

Germany, United Kingdom
UNION therapeutics

Completed

Study to Assess the Efficacy and Safety of Orismilast in Psoriasis (IASOS)

Skin Diseases | Psoriasis

United Kingdom, Poland, United States, Germany
Pfizer

Completed

Comparative Analysis of Adherence and Effectiveness Outcomes Between Rheumatoid Arthritis (RA) Patients Treated With Tofacitinib Modified Release (MR)

Rheumatoid Arthritis

United States
Diurnal Limited

Enrolling by invitation

Long-term Safety Study of Chronocort in the Treatment of Participants With Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia

United States, France, Japan
Diurnal Limited

Completed

Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia (CONnECT)

Congenital Adrenal Hyperplasia

France, United States, Japan
GlaxoSmithKline

Completed

A Study to Evaluate the Benefit and Safety of GSK2982772 in Moderate to Severe Psoriasis Participants

Psoriasis

Canada, Poland
Kayseri City Hospital
Saglik Bilimleri Universitesi

Completed

Efficacy of Extracorporeal Shock Wave Therapy on Spasticity

Stroke | Spasticity, Muscle

Turkey
NewAmsterdam Pharma
Pharma Medica Research, Inc.

Completed

A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin

Healthy Volunteers

Canada
Minneapolis Veterans Affairs Medical Center
United States Department of Defense

Completed

Gulf War Illness Inflammation Reduction Trial (GWIIRT)

Fatigue | Chronic Pain | Cognitive Impairment | Chronic Inflammation

United States
Mansoura University

Completed

Comparing a Modified Mini-incision Approach Versus the Conventional Approach for Carpal Tunnel Release

Carpal Tunnel Syndrome | Incision

Egypt
UNION therapeutics

Active, not recruiting

Study to Assess the Efficacy and Safety of Orismilast in Atopic Dermatitis (ADESOS)

Skin Diseases | Atopic Dermatitis

Poland, United States, Hungary, Germany
Calliditas Therapeutics AB

Completed

Efficacy and Safety of Nefecon in Patients With Primary IgA (Immunoglobulin A) Nephropathy (Nefigard)

Primary IgA Nephropathy

United States, Australia, Taiwan, Spain, Canada, Argentina, Belarus, Belgium, Czechia, Finland, France, Germany, Greece, Italy, Korea, Republic of, Poland, Sweden, Turkey, United Kingdom
Marina F Fahmy, MD

Completed

Fluoride Release,Compressive Strength and Clinical Performance of a Bioactive Restorative Material in ART

Dental Caries

Egypt
XWPharma

Completed

Safety, Tolerability and Pharmacokinetics of XW10508 Immediate and Modified Release Formulations in Healthy Adults

Healthy Volunteers

Australia
Ipsen

Terminated

Comparing Lower-concentration Dysport Treatment Targeted to the Neuromuscular Junction With Current Clinical Practice (NMJ)

Arm Spasticity

Sweden, Norway, Denmark, Finland
Galderma R&D

Completed

ORCA - Oracea® for Rosacea: A Community-based Assessment

Rosacea

United States
Genzyme, a Sanofi Company

Completed

Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter

Multinodular Goiter

Canada, United States, France, Brazil, Italy, Denmark, Germany, Netherlands
Diurnal Limited
Simbec Research

Completed

Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only

Healthy
Cerevel Therapeutics, LLC

Completed

Pharmacokinetics of CVL-231 Following Single Oral Administration of Modified- and Immediate-release Formulations in Fasted and Fed Healthy Participants

Schizophrenia

United States
Diurnal Limited
National Institutes of Health Clinical Center (CC)

Completed

Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia

Adrenogenital Syndrome | Congenital Adrenal Hyperplasia | 21-Hydroxylase Deficiency

United States
Overseas Pharmaceuticals, Ltd.

Completed

To Evaluate the Food Effect and the Absorption Profile of Ibuprofen Modified-Release Tablets 800 mg

Chronic Pain

China
Diurnal Limited
National Institutes of Health (NIH)

Withdrawn

Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy (RESTORE)

Congenital Adrenal Hyperplasia

United States
Eidos Therapeutics, a BridgeBio company

Completed

A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects

Amyloidosis

United Kingdom
King Saud University

Completed

Effect of Myofascial Release With Tennis Ball on Spasticity and Motor Functions

Stroke

Saudi Arabia
Pfizer

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PF-06842874 in Healthy Participants

Healthy Participants

United States
Galapagos NV

Completed

A Study to Evaluate How Well Single and Multiple Doses of GLPG3121-modified Release Formulation Are Tolerated in Healthy, Adult Subjects

Healthy

Germany
KalVista Pharmaceuticals, Ltd.

Completed

Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations

Hereditary Angioedema

United Kingdom
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Study of Modified Release Formulations of Danicopan in Healthy Adult Participants

Healthy

United Kingdom
GlaxoSmithKline
Quotient Clinical

Completed

A Study to Compare the Pharmacokinetics (PK) of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule and MR Tablet Formulations Relative to an Immediate Release (IR) Tablet Formulation and to Check the PK of MR Formulation in Capsule Following Repeat Doses

Autoimmune Diseases

United Kingdom
Cytokinetics

Completed

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF)

Chronic Heart Failure | Pharmacokinetics | Left Ventricular Systolic Dysfunction | Left Ventricular Ejection Fraction | Modified Release Oral Formulation | History of Chronic Heart Failure | Echocardiogram

United States, Canada, Italy, Netherlands, United Kingdom, Belgium, Czechia, Australia, Hungary, Poland, Bulgaria, Lithuania, Germany
Shire

Completed

THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone

Adrenal Insufficiency
Amgen

Completed

Study to Evaluate Pharmacokinetics of Prototype Modified-Release Formulations Of Apremilast in Healthy Men

Healthy Volunteers

United States
Pfizer

Completed

Clinical Study to Evaluate Pharmacokinetics and Safety of PF-06700841 After Single and Multiple Oral Doses as Modified Release Formulations

Healthy Participants

United States
Noorik Biopharmaceuticals AG

Terminated

A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis

Cirrhosis | Ascites | Portal Hypertension

Spain
Cosmo Technologies Ltd
Cross S.A.

Completed

Colon Staining Efficacy of Single Oral Doses of Methylene Blue MMX (CRO-11-108)

Colon Staining in Preparation for Colonoscopy
Novartis Pharmaceuticals

Completed

Evaluation of the Efficacy and Safety of Modified Release AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias

Parkinson Disease | Parkinsonian Disorders | Movement Disorders | Dyskinesias | Anti-Dyskinesia Agents

Spain, United States, Austria, Switzerland, France, Germany, Italy, Hungary, Canada, Slovakia
Novartis Pharmaceuticals

Completed

Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months), in Renal Transplant Patients

Kidney Transplantation

France, Germany, United Kingdom, Spain, Switzerland, United States, Canada, Italy
Labatec Pharma SA

Unknown

Effect of Alendronate 70mg Formulation on Bone Turnover Markers and Patient Reported Outcomes

Osteoporosis, Postmenopausal

Switzerland
Shire

Completed

Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

Adrenal Insufficiency
Shire

Terminated

A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)

Chronic Adrenal Insufficiency

United Kingdom, Germany, Italy, Netherlands, Sweden
Pfizer

Completed

A Study In Adult Healthy Volunteers To Asses Once Daily (QD) Dosing With The Selected Age-Appropriate Modified Release (MR) Formulations

Healthy

United States
Bayside Health

Unknown

Modified Release Posaconazole in Patients With Cystic Fibrosis

Cystic Fibrosis

Australia

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