Search clinical trials for: phase 1 dose escalation

Total 76423 results

AstraZeneca

Completed

Effect of a Pharmaceutical Intervention on the Level of Control of the Asthmatic Patient

Asthma

Spain
University of Colorado, Denver

Recruiting

Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes (BURST2D)

Pre-diabetes

United States
Ruijin Hospital

Recruiting

Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation (Cryo-InitialAF)

Arrhythmias, Cardiac | Atrial Fibrillation, Persistent

China
Tan Tock Seng Hospital
National University Hospital, Singapore; Singapore General Hospital; Changi General...

Withdrawn

Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria (XDR-GNB)

Bacteremia | Ventilator-associated Pneumonia | Healthcare-associated Pneumonia

Singapore
Gilead Sciences

Completed

Sofosbuvir/Velpatasvir Fixed-Dose Combination and Ribavirin for 12 or 24 Weeks in Participants With Chronic Genotype 1 or 2 Hepatitis C Virus Infection Who Have Previously Failed a Direct-Acting Antiviral-Containing Regimen

Hepatitis C Virus Infection

Japan
Belén Retamal-Valdes

Unknown

Amoxicillin and Metronidazole During Periodontal Treatment (MOMENT)

Chronic Periodontitis

Brazil
CAR-T (Shanghai) Biotechnology Co., Ltd.

Unknown

Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis

Knee Osteoarthritis

China
Novartis Pharmaceuticals

Completed

Multicenter, Randomized, Open-label Study to Assess Whether Treatment With Mycophenolate Sodium (MPS) Allows Higher Dose Optimization Versus Mycophenolate Mofetil (MMF) Leading to a Dose Reduction of Tacrolimus. Maximiza Study. (MAXIMIZA)

Prophilaxis of Acute Rejection in Patients Receiving a Renal Allograft

Spain
Johns Hopkins University

Completed

Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder

Smoking | Smoking Cessation | Treatment Resistant Depression | MDD

United States
Jordi Gol i Gurina Foundation
Spanish Clinical Research Network - SCReN

Completed

Effectiveness of Antitussives, Anticholinergics and Honey Versus Usual Care in Adults With Acute Bronchitis. (AB4T)

Acute Bronchitis

Spain
Bristol-Myers Squibb

Completed

Drug Interaction Study With a Potential Alzheimer's Disease Compound

Alzheimer Disease

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Cadonilimab + FOLFOX Versus FOLFOX in the Neoadjuvant Treatment of pMMR/MSS Locally Advanced Colorectal Cancer

Locally Advanced Colorectal Carcinoma

China
Seoul National University Hospital

Unknown

Verify the Effectiveness rTMS Using MEG (rTMS)

Tinnitus

Korea, Republic of
Fuzhou General Hospital

Unknown

DC Vaccine Therapy Combined With Cytokine-Induced Killer Cell in Treating Patients With Renal Cell Carcinoma

Renal Cell Carcinoma

China
European Organisation for Research and Treatment...

Active, not recruiting

Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma

Lymphoma
University of Cologne
Umm Al-Qura University

Completed

Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein

AOD Effects and Consequences

Germany
Swedish University of Agricultural Sciences
Uppsala University

Completed

The Effect of Dietary Fibre and Plant Protein on Appetite and Metabolic Function

Appetite Regulation

Sweden
Gilead Sciences

Completed

Safety and Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination With or Without Ribavirin in Participants With Chronic Genotype 1 HCV Infection Previously Treated With a Direct Acting Antiviral Regimen

Hepatitis C Virus Infection

United States
Gilead Sciences

Completed

Sofosbuvir/Velpatasvir Fixed-Dose Combination in Adults With Chronic HCV Infection

Hepatitis C Virus Infection

Hong Kong, United States, France, Canada, Germany, United Kingdom, Belgium, Italy, Puerto Rico
European Organisation for Research and Treatment...

Active, not recruiting

RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease

Lymphoma

France, Poland, Belgium, Netherlands, Slovenia, Italy, Egypt, Portugal, Germany
GlaxoSmithKline

Completed

Safety and Immunogenicity of a Booster Dose of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744)

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Haemophilus Influenzae Type b

Finland, Dominican Republic
Janssen Scientific Affairs, LLC

Completed

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) (FIRST)

Schizophrenia

United States
Mansoura University

Completed

Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones (ERCP)

Gallbladder and Bile Duct Calculi
NYU Langone Health
Perlmutter Cancer Center

Completed

A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations

Myelodysplastic Syndromes

United States
Jazz Pharmaceuticals

Completed

Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1)

Epilepsy | Dravet Syndrome

France, United States, United Kingdom, Poland
Shanghai Zhongshan Hospital

Not yet recruiting

A Risk Prediction Model of Postoperative Nausea and Vomiting in Patients With Liver Cancer

Liver Cancer | Nausea and Vomiting, Postoperative
University Hospital, Umeå

Recruiting

Multicenter Study for Diagnosis and Treatment of Perianal Abscesses

Perianal Abscess | Incontinence | Anal Fistulas

Sweden
Fudan University

Unknown

Incision Pain and Uterine Contraction Pain After Cesarean Section

C.Delivery; Surgery (Previous), Gynecological
Duke University

Completed

Retisert and Cataract Surgery in Patients With Severe Uveitis

Posterior Uveitis | Intermediate Uveitis

United States
Seoul National University Hospital

Not yet recruiting

Effect of Sufentanil on the Postoperative Pain

Postoperative Pain, Acute

Korea, Republic of
University of Michigan Rogel Cancer Center
American Society of Clinical Oncology

Completed

Cannabidiol (CBD) for Treatment of Aromatase Inhibitor-Associated Arthralgias

Breast Cancer | Arthralgia

United States
Kenneth Hargreaves
University of Maryland, Baltimore; Loma Linda University; University of North... and other collaborators

Completed

Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots

Regeneration | Pulp Necrosis

United States
HRA Pharma

Completed

Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception

Contraception

United States, Ireland, United Kingdom
Riyadh Fertility and Reproductive Health center

Unknown

Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response

Infertility, Female

Egypt
Torrent Pharmaceuticals Limited

Completed

Study Comparing Citalopram Hydrobromide Tablets 40 mg (Torrent Pharmaceuticals Ltd) and RLD Tablets 40 mg (Manufactured By Forest Pharmaceuticals Inc, Missouri) in 24+2 Normal Healthy Male Subjects Under Fasting Condition

Healthy

India
UCB BIOSCIENCES GmbH

Completed

Study to Evaluate the Pharmacokinetics, Safety, Tolerability of Repeated Dose Transdermal Rotigotine in Japanese and Caucasian Subjects

Healthy

Germany
UCB BIOSCIENCES GmbH

Completed

Study to Evaluate the Pharmacokinetics, Safety, Tolerability of Single Dose Lacosamide in Subjects With Renal Impairment Compared to Healthy Subjects

Healthy | Renal Impairment

Germany
UCB Pharma SA

Completed

Single-site, Open-label, Randomized, Cross-over Study in Healthy Chinese Subjects to Evaluate the Bioequivalence of Single-dose Rotigotine Transdermal Patch Comparing 2 Different Formulations

Healthy

China
UCB Pharma

Completed

A Randomized, Double-blind, Pharmacokinetics Study to Assess Safety, Tolerability of Levetiracetam 45 Minutes Intravenous Infusion During 4 Days of Bid Dosing in Chinese Healthy Volunteers

Human Volunteers

China
NovoCure GmbH

Recruiting

EF-39 PANOVA-4: Study of Tumor Treating Fields Concomitant With Atezolizumab, Gemcitabine and Nab-Paclitaxel as First-LineTreatment for Metastatic Pancreatic Ductal Adenocarcinoma

Metastatic Pancreatic Ductal Adenocarcinoma

Spain
Boston Children's Hospital
Boston University; National Institute of Diabetes and Digestive and Kidney...

Completed

Nutrition Study for School Age Children

Obesity

United States
Rigshospitalet, Denmark
Danish Cancer Society; Danish Breast Cancer Cooperative Group

Unknown

Chronic Pain After Operation for Breast Cancer

Pain Threshold

Denmark
Joshua Woolley, MD/PhD

Recruiting

Psilocybin Therapy for Chronic Low Back Pain (POP)

Chronic Low-back Pain

United States
University Hospital, Bordeaux

Active, not recruiting

Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes (STOP)

Ankylosing Spondylitis

France, Monaco
National Institute on Drug Abuse (NIDA)
University of Pennsylvania

Completed

Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1

Substance-Related Disorders | Opioid-Related Disorders

United States
National Cheng-Kung University Hospital

Completed

Vascular Endothelial Protection Effects of Dextromethorphan

Smoking | Inflammation | Atherosclerosis

Taiwan
Chulalongkorn University

Unknown

Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage

Hordeolum

Thailand
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy (KIN-ATTACK-FMF)

FMF

France
University of Chicago
National Cancer Institute (NCI)

Terminated

Afatinib in Advanced Refractory Urothelial Cancer

Recurrent Bladder Cancer | Stage III Bladder Cancer | Stage IV Bladder Cancer | Ureter Cancer | Distal Urethral Cancer | Proximal Urethral Cancer | Recurrent Urethral Cancer | Stage III Urethral Cancer | Stage IV Urethral Cancer

United States
Beneo-Institute

Completed

Effect of Prebiotic Fructans to Reduce Number of Febrile Infections in Children

Infectious Disease | Diet Modification | Children, Only

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